query_name Ko_name KEGG_Pathway KEGG_ko EC Ko_DEC level3_name:level2_name:level1_name C2_00001 ko:K07497 Integrase core domain NA C2_00007 ko00071,ko00592,ko01040,ko01100,ko01110,ko01212,ko03320,ko04024,ko04146,map00071,map00592,map01040,map01100,map01110,map01212,map03320,map04024,map04146 ko:K00232 1.3.3.6 TerB-C domain Fatty acid degradation : Lipid metabolism : Metabolism;alpha-Linolenic acid metabolism : Lipid metabolism : Metabolism;Biosynthesis of unsaturated fatty acids : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism;PPAR signaling pathway : Endocrine system : Organismal Systems;cAMP signaling pathway : Signal transduction : Environmental Information Processing;Peroxisome : Transport and catabolism : Cellular Processes C2_00009 lhr ko:K03724 helicase NA C2_00012 ko:K07483 Transposase NA C2_00013 ko:K07497 Integrase core domain NA C2_00017 yfdC ko:K02598,ko:K03459,ko:K06212,ko:K21990,ko:K21993 formate transmembrane transporter activity NA C2_00018 vacJ ko:K04754 Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane NA C2_00020 fadL ko:K06076 Involved in translocation of long-chain fatty acids across the outer membrane NA C2_00022 fadI ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 ko:K00632 2.3.1.16 Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed Fatty acid degradation : Lipid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Geraniol degradation : Metabolism of terpenoids and polyketides : Metabolism;Benzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;alpha-Linolenic acid metabolism : Lipid metabolism : Metabolism;Ethylbenzene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Fatty acid metabolism : Global and overview maps : Metabolism C2_00023 fadJ ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 ko:K01782,ko:K01825 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities Fatty acid degradation : Lipid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Geraniol degradation : Metabolism of terpenoids and polyketides : Metabolism;Lysine degradation : Amino acid metabolism : Metabolism;Benzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Tryptophan metabolism : Amino acid metabolism : Metabolism;beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Limonene and pinene degradation : Metabolism of terpenoids and polyketides : Metabolism;Caprolactam degradation : Xenobiotics biodegradation and metabolism : Metabolism;Biosynthesis of unsaturated fatty acids : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism C2_00024 sixA ko:K08296 Phosphohistidine phosphatase sixA NA C2_00025 yfcV ko05133,map05133 ko:K07345 Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes Pertussis : Infectious disease: bacterial : Human Diseases C2_00027 yfcS ko:K07346,ko:K07353,ko:K15540 Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes NA C2_00033 prmB ko:K02493,ko:K07320 2.1.1.297,2.1.1.298 Specifically methylates the 50S ribosomal protein L3 on NA C2_00034 aroC ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko:K01736 4.2.3.5 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00035 mepA ko:K07261 Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus NA C2_00036 yfcA ko:K07090,ko:K11312 membrane transporter protein NA C2_00037 yfcM ko:K09906 Is involved in the final hydroxylation step of the post- translational modification of translation elongation factor P (EF- P) on 'Lys-34'. Acts after beta-lysylation of 'Lys-34' by EpmA and EpmB. EpmC adds an oxygen atom to the C5 position of 'Lys-34' and does not modify the added beta-lysine NA C2_00039 mnmC ko00130,ko01110,map00130,map01110 ko:K00773,ko:K07319,ko:K11782,ko:K15461 2.1.1.61,2.1.1.72,2.4.2.29,4.2.1.151 Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_00040 fabB ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 ko:K00647 2.3.1.41 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids Fatty acid biosynthesis : Lipid metabolism : Metabolism;Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism C2_00043 pdxB ko00750,ko01100,map00750,map01100 ko:K03473 1.1.1.290 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00044 asd ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 ko:K00133 1.2.1.11 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Lysine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00045 truA ko:K06173 5.4.99.12 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs NA C2_00046 dedA ko:K03975 SNARE associated Golgi protein NA C2_00047 accD ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 ko:K01963 2.1.3.15,6.4.1.2 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA Fatty acid biosynthesis : Lipid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism C2_00048 folC ko00790,ko01100,map00790,map01100 ko:K11754 6.3.2.12,6.3.2.17 Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00049 dedD ko03070,ko05111,map03070,map05111 ko:K02453,ko:K03749 Non-essential cell division protein that could be required for efficient cell constriction Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_00050 cvpA ko:K03558 colicin V production NA C2_00051 purF ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 ko:K00764 2.4.2.14 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine Purine metabolism : Nucleotide metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_00052 ubiX ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 ko:K03186 2.5.1.129 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Aminobenzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Phenylpropanoid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_00053 argT ko02010,map02010 ko:K10013,ko:K10014 belongs to the bacterial solute-binding protein 3 family ABC transporters : Membrane transport : Environmental Information Processing C2_00054 hisJ ko02010,map02010 ko:K10013,ko:K10014 Part of the histidine permease ABC transporter. Binds histidine. Interacts with HisQMP and stimulates ATPase activity of HisP, which results in histidine translocation (By similarity) ABC transporters : Membrane transport : Environmental Information Processing C2_00055 hisQ ko02010,map02010 ko:K10016,ko:K10024 Part of the histidine permease ABC transporter. Also part of a lysine arginine ornithine transporter. Probably responsible for the translocation of the substrate across the membrane. Required to relay the ATPase-inducing signal from the solute-binding protein to HisP (By similarity) ABC transporters : Membrane transport : Environmental Information Processing C2_00056 hisM ko02010,map02010 ko:K10015 Part of the histidine permease ABC transporter. Also part of a lysine arginine ornithine transporter. Probably responsible for the translocation of the substrate across the membrane. Required to relay the ATPase-inducing signal from the solute-binding protein to HisP (By similarity) ABC transporters : Membrane transport : Environmental Information Processing C2_00057 hisP ko02010,map02010 ko:K10017 3.6.3.21 AAA domain, putative AbiEii toxin, Type IV TA system ABC transporters : Membrane transport : Environmental Information Processing C2_00059 yfcH ko:K07071 coenzyme binding NA C2_00060 folX ko00790,ko01100,map00790,map01100 ko:K01633,ko:K07589 1.13.11.81,4.1.2.25,5.1.99.7,5.1.99.8 Catalyzes the epimerization of carbon 2' of the side chain of 7,8-dihydroneopterin triphosphate (H2NTP) to form 7,8- dihydromonapterin triphosphate (H2MTP). Is required for tetrahydromonapterin biosynthesis Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00061 yfcG ko:K11209 Belongs to the GST superfamily NA C2_00062 yfcF ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 ko:K00799 2.5.1.18 however this activity is as low as 1 of that of GstA. Also displays a GSH-dependent peroxidase activity toward cumene hydroperoxide. Is involved in defense against oxidative stress, probably via its peroxidase activity Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolism of xenobiotics by cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Platinum drug resistance : Drug resistance: antineoplastic : Human Diseases;Pathways in cancer : Cancer: overview : Human Diseases;Chemical carcinogenesis : Cancer: overview : Human Diseases;Hepatocellular carcinoma : Cancer: specific types : Human Diseases;Fluid shear stress and atherosclerosis : Cardiovascular disease : Human Diseases C2_00063 yfcE ko:K07095 Shows phosphodiesterase activity, hydrolyzing phosphodiesters bonds in the artificial chromogenic substrates bis-p-nitrophenyl phosphate (bis-pNPP), and less efficiently thymidine 5'-monophosphate p-nitrophenyl ester (pNP-TMP) and p- nitrophenylphosphorylcholine (pNPPC). The physiological substrate is NA C2_00064 yfcD ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 ko:K00949,ko:K01823 2.7.6.2,5.3.3.2 Nudix hydrolase Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_00066 pta ko00430,ko00620,ko00640,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00710,map00720,map01100,map01120,map01200 ko:K00029,ko:K13788 1.1.1.40,2.3.1.8 belongs to the CobB CobQ family Taurine and hypotaurine metabolism : Metabolism of other amino acids : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_00067 ackA ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 ko:K00925,ko:K00932 2.7.2.1,2.7.2.15 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction Taurine and hypotaurine metabolism : Metabolism of other amino acids : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_00068 yfbV ko:K09899 UPF0208 membrane protein YfbV NA C2_00069 yfbU ko:K09161 Belongs to the UPF0304 family NA C2_00070 yfbT ko:K19270 3.1.3.23 Sugar-phosphate phosphohydrolase that appears to contribute to butanol tolerance. Catalyzes the dephosphorylation of D-mannitol 1-phosphate and D-sorbitol 6- phosphate. Is also able to dephosphorylate other sugar phosphates in vitro including ribose-5-phosphate (Rib5P), 2- deoxyribose-5-phosphate, fructose-1-phosphate (Fru1P), fructose-6- phosphate (Fru6P), and glucose-6-phosphate (Glu6P). Selectively hydrolyzes beta-D-glucose-1- phosphate (bGlu1P) and has no activity with the alpha form NA C2_00071 yfbS ko02020,map02020 ko:K03319,ko:K09477,ko:K11106 potassium ion transport Two-component system : Signal transduction : Environmental Information Processing C2_00072 yfbR ko00240,ko01100,map00240,map01100 ko:K08722 3.1.3.89 Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00073 alaA ko00220,ko00250,ko00290,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00220,map00250,map00290,map00710,map01100,map01110,map01120,map01130,map01200,map01210,map01230 ko:K00814,ko:K14260 2.6.1.2,2.6.1.66 in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor' Arginine biosynthesis : Amino acid metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00076 nuoA ko00190,ko01100,map00190,map01100 ko:K00330 1.6.5.3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00077 nuoB ko00190,ko01100,map00190,map01100 ko:K00331,ko:K13380 1.6.5.3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00078 nuoC ko00190,ko01100,map00190,map01100 ko:K00332,ko:K00333,ko:K13378,ko:K13380 1.6.5.3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00079 nuoE ko00190,ko01100,map00190,map01100 ko:K00334 1.6.5.3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00080 nuoF ko00190,ko01100,map00190,map01100 ko:K00335 1.6.5.3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00081 nuoG ko00190,ko01100,map00190,map01100 ko:K00336 1.6.5.3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00082 nuoH ko00190,ko01100,map00190,map01100 ko:K00337 1.6.5.3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00083 nuoI ko00190,ko01100,map00190,map01100 ko:K00338 1.6.5.3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00084 nuoJ ko00190,ko01100,map00190,map01100 ko:K00339 1.6.5.3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00085 nuoK ko00190,ko01100,map00190,map01100 ko:K00340 1.6.5.3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00086 nuoL ko00190,ko01100,map00190,map01100 ko:K00341 1.6.5.3 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00087 nuoM ko00190,ko01100,map00190,map01100 ko:K00342 1.6.5.3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00088 nuoN ko00190,ko01100,map00190,map01100 ko:K00343 1.6.5.3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00090 elaD ko04626,map04626 ko:K18015,ko:K18879 Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is Plant-pathogen interaction : Environmental adaptation : Organismal Systems C2_00091 rnz ko03013,map03013 ko:K00784 3.1.26.11 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA RNA transport : Translation : Genetic Information Processing C2_00092 elaA ko:K02348 Acyltransferase NA C2_00093 elaB ko:K05594,ko:K07184 ribosome binding NA C2_00094 menF ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130 ko:K02361,ko:K02552 5.4.4.2 Catalyzes the conversion of chorismate to isochorismate Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Biosynthesis of siderophore group nonribosomal peptides : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_00095 menD ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K02551 2.2.1.9 Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_00096 menH ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K08680 4.2.99.20 Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_00097 menB ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K01661 4.1.3.36 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_00098 menC ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K02549 4.2.1.113 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_00099 menE ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K01911,ko:K02549 4.2.1.113,6.2.1.26 Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_00100 pmrD ko01503,map01503 ko:K19238 Interacts with phosphorylated BasR protein to mediate transcriptional induction of BasR-activated genes to induce polymyxin resistance in some natural isolates Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_00101 arnF ko01503,map01503 ko:K12962,ko:K12963 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_00102 arnE ko01503,map01503 ko:K03297,ko:K12962,ko:K12963 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_00103 arnT ko01503,map01503 ko:K07264 2.4.2.43 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_00104 arnD ko00520,ko01503,map00520,map01503 ko:K13014 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_00105 arnA ko00052,ko00520,ko00523,ko00670,ko00970,ko01100,ko01130,ko01503,map00052,map00520,map00523,map00670,map00970,map01100,map01130,map01503 ko:K00604,ko:K01784,ko:K10011,ko:K12449,ko:K21332 1.1.1.305,2.1.2.13,2.1.2.9,5.1.3.2 Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides Galactose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Polyketide sugar unit biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing;Metabolic pathways : Global and overview maps : Metabolism;NA : NA : NA;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_00106 arnC ko00520,ko01503,map00520,map01503 ko:K10012 2.4.2.53 Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_00107 arnB ko00520,ko01503,ko02020,map00520,map01503,map02020 ko:K07806 2.6.1.87 Catalyzes the conversion of UDP-4-keto-arabinose (UDP- Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing C2_00108 ais ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 ko:K15634 5.4.2.12 Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00109 nudI ko:K12944 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) NA C2_00111 cinA ko00760,map00760 ko:K03742 3.5.1.42 Probable molybdopterin binding domain Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism C2_00112 rhmR ko:K10973,ko:K13641,ko:K19333 Transcriptional regulator NA C2_00113 ko:K07491 COG1943 Transposase and inactivated derivatives NA C2_00114 ko:K07496 Transposase NA C2_00115 rhmR ko:K10973,ko:K13641,ko:K19333 Transcriptional regulator NA C2_00117 rhmA ko00051,ko00053,ko00350,ko01120,map00051,map00053,map00350,map01120 ko:K01630,ko:K02510,ko:K12660 4.1.2.20,4.1.2.52,4.1.2.53 Catalyzes the reversible retro-aldol cleavage of 2-keto- 3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_00120 glpC ko00564,ko01110,map00564,map01110 ko:K00113 1.1.5.3 Anaerobic glycerol-3-phosphate dehydrogenase subunit C Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_00121 glpB ko00564,ko01110,map00564,map01110 ko:K00112 1.1.5.3 Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_00122 glpA ko00564,ko01110,map00564,map01110 ko:K00111 1.1.5.3 Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_00123 glpT ko:K02445 glycerol-phosphate:inorganic phosphate antiporter activity NA C2_00124 glpQ ko00564,map00564 ko:K01126 3.1.4.46 glycerophosphoryl diester phosphodiesterase Glycerophospholipid metabolism : Lipid metabolism : Metabolism C2_00127 inaA ko00540,ko00550,ko01100,ko03008,map00540,map00550,map01100,map03008 ko:K02848,ko:K07178,ko:K19302 2.7.11.1,3.6.1.27 May be an environmental sensor responsive to several stimuli, including internal pH, proton motive force, temperature, and possibly other Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Ribosome biogenesis in eukaryotes : Translation : Genetic Information Processing C2_00128 yfaE ko:K11107 ferredoxin metabolic process NA C2_00129 nrdB ko00230,ko00240,ko01100,map00230,map00240,map01100 ko:K00526 1.17.4.1 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00130 nrdA ko00230,ko00240,ko01100,map00230,map00240,map01100 ko:K00525 1.17.4.1 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00131 yfaL ko:K07279 cell adhesion involved in single-species biofilm formation NA C2_00132 ubiG ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K00568 2.1.1.222,2.1.1.64 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_00133 gyrA ko:K02469,ko:K02621 5.99.1.3 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner NA C2_00135 yfaT ko:K09934 Protein of unknown function (DUF1175) NA C2_00136 yfaS ko:K06894 Alpha-2-Macroglobulin NA C2_00140 rcsC ko02020,ko02026,ko05133,map02020,map02026,map05133 ko:K07677,ko:K07679 2.7.13.3 PhoQ Sensor Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Pertussis : Infectious disease: bacterial : Human Diseases C2_00141 rcsB ko02020,ko02024,ko02025,ko02026,ko05111,ko05133,map02020,map02024,map02025,map02026,map05111,map05133 ko:K02282,ko:K07686,ko:K07687,ko:K07689,ko:K07690,ko:K20264 Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes;Pertussis : Infectious disease: bacterial : Human Diseases C2_00142 rcsD ko00230,ko02020,ko02024,ko02025,ko02026,ko04113,ko04213,map00230,map02020,map02024,map02025,map02026,map04113,map04213 ko:K01768,ko:K07676,ko:K07687,ko:K10715,ko:K20976 2.7.13.3,4.6.1.1 Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB Purine metabolism : Nucleotide metabolism : Metabolism;Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Meiosis - yeast : Cell growth and death : Cellular Processes;Longevity regulating pathway - multiple species : Aging : Organismal Systems C2_00143 ompC ko01501,ko02020,map01501,map02020 ko:K09475 Forms pores that allow passive diffusion of small molecules across the outer membrane beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing C2_00144 apbE ko:K03734 2.7.1.180 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein NA C2_00145 ada ko03410,map03410 ko:K00567,ko:K10778,ko:K13529,ko:K13530,ko:K15051 2.1.1.63,3.2.2.21 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated Base excision repair : Replication and repair : Genetic Information Processing C2_00146 alkB ko:K03919 1.14.11.33 Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents) NA C2_00147 yojI ko02010,map02010 ko:K06159,ko:K06160 ATP-binding ABC transporters : Membrane transport : Environmental Information Processing C2_00148 mqo ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map01100,map01110,map01120,map01130,map01200 ko:K00116 1.1.5.4 malate dehydrogenase (menaquinone) activity Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_00149 eco ko:K08276 General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases NA C2_00151 napF ko:K02572 ferredoxin-type protein NapF NA C2_00152 napD ko:K02570 Plays a role in the correct assembly of subunits of the periplasmic NapAB enzyme NA C2_00153 napA ko00910,ko01120,map00910,map01120 ko:K02567 nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC Nitrogen metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_00154 napG ko:K02573 Ferredoxin-type protein NA C2_00155 napH ko:K02574 ferredoxin-type protein, NapH NA C2_00156 napB ko00910,ko01120,map00910,map01120 ko:K02568 Electron transfer subunit of the periplasmic nitrate reductase complex NapAB Nitrogen metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_00157 napC ko02020,map02020 ko:K02569,ko:K03532,ko:K07821 Mediates electron flow from quinones to the NapAB complex Two-component system : Signal transduction : Environmental Information Processing C2_00158 ccmA ko02010,map02010 ko:K02193 3.6.3.41 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_00159 ccmB ko02010,map02010 ko:K02193,ko:K02194 3.6.3.41 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ABC transporters : Membrane transport : Environmental Information Processing C2_00160 ccmC ko02010,map02010 ko:K02195 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ABC transporters : Membrane transport : Environmental Information Processing C2_00161 ccmD ko02010,map02010 ko:K02196 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ABC transporters : Membrane transport : Environmental Information Processing C2_00162 ccmE ko:K02197 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH NA C2_00163 ccmF ko:K02198,ko:K04016 Cytochrome c-type biogenesis protein NA C2_00164 dsbE ko:K02199 Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme NA C2_00165 ccmH ko:K02198,ko:K02200,ko:K04017,ko:K04018 subunit of a heme lyase NA C2_00166 narP ko02020,map02020 ko:K07684,ko:K07685 Nitrate nitrite response regulator Two-component system : Signal transduction : Environmental Information Processing C2_00169 yejM ko:K07014 sulfuric ester hydrolase activity NA C2_00170 yejL ko:K09904 Belongs to the UPF0352 family NA C2_00171 ndpA ko:K06899 nucleoid-associated protein NA C2_00172 rplY ko03010,map03010 ko:K02897 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance Ribosome : Translation : Genetic Information Processing C2_00173 yejH ko:K19789 Type III restriction protein res subunit NA C2_00174 rsuA ko:K06178,ko:K06181,ko:K06183 5.4.99.19,5.4.99.20,5.4.99.22 Responsible for synthesis of pseudouridine from uracil- 516 in 16S ribosomal RNA NA C2_00175 bcr ko:K07552 Major facilitator Superfamily NA C2_00177 yejF ko02010,map02010 ko:K13896 Belongs to the ABC transporter superfamily ABC transporters : Membrane transport : Environmental Information Processing C2_00178 yejE ko02010,ko02024,map02010,map02024 ko:K02034,ko:K13895 ABC transporter (Permease ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_00179 yejB ko02010,ko02024,map02010,map02024 ko:K02033,ko:K13894 ABC transporter permease ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_00180 yejA ko02010,ko02024,map02010,map02024 ko:K02035,ko:K13893 microcin transport ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_00181 rtn ko02026,map02026 ko:K13244,ko:K21090 3.1.4.52 cyclic-guanylate-specific phosphodiesterase activity Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_00182 spr ko:K13694,ko:K13695,ko:K19303 3.4.17.13 A murein DD-endopeptidase with specificity for D-Ala- meso-diaminopimelic acid (mDAP) cross-links. Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion. Functionally redundant with MepM and MepH. Also has weak LD-carboxypeptidase activity on L-mDAP-D-Ala peptide bonds NA C2_00183 lpxT ko:K19803 2.7.4.29 Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P) NA C2_00184 yeiR ko:K07089 cobalamin synthesis protein, P47K NA C2_00185 mtlK ko00040,ko00051,ko01100,map00040,map00051,map01100 ko:K00009,ko:K00040,ko:K00041,ko:K00045,ko:K00854,ko:K19633 1.1.1.17,1.1.1.289,1.1.1.57,1.1.1.58,1.1.1.67,2.7.1.17 Belongs to the mannitol dehydrogenase family Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00186 efp ko:K02356 translation elongation factor activity NA C2_00187 yeiW ko:K06940 Putative zinc- or iron-chelating domain NA C2_00188 setB ko:K03291 Major facilitator Superfamily NA C2_00189 fruB ko00051,ko00561,ko01100,ko01120,ko02060,map00051,map00561,map01100,map01120,map02060 ko:K02768,ko:K02784,ko:K05881,ko:K08483,ko:K08485,ko:K11183,ko:K11189,ko:K11201 2.7.1.121,2.7.1.202,2.7.3.9 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_00190 fruK ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230 ko:K00882,ko:K16370 2.7.1.11,2.7.1.56 Belongs to the carbohydrate kinase PfkB family Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00191 fruA ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 ko:K02768,ko:K02769,ko:K02770,ko:K11202 2.7.1.202 Pts system fructose-specific Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_00192 psuK ko00030,ko00240,ko01100,ko01120,ko01200,map00030,map00240,map01100,map01120,map01200 ko:K00852,ko:K00874,ko:K16328 2.7.1.15,2.7.1.45,2.7.1.83 pseudouridine kinase activity Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_00193 psuG ko00240,map00240 ko:K16329 4.2.1.70 Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway Pyrimidine metabolism : Nucleotide metabolism : Metabolism C2_00194 yeiM ko:K03317,ko:K16324 Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family NA C2_00195 yeiL ko:K16326 Cyclic nucleotide-monophosphate binding domain NA C2_00196 rihB ko00230,ko00240,ko00760,ko01100,map00230,map00240,map00760,map01100 ko:K01239,ko:K01250,ko:K10213 3.2.2.1,3.2.2.8 Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00197 nupX ko:K03317,ko:K16324,ko:K16325 Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family NA C2_00198 yeiI ko00030,ko00240,ko01100,ko01120,ko01200,map00030,map00240,map01100,map01120,map01200 ko:K00852,ko:K00874,ko:K16328 2.7.1.15,2.7.1.45,2.7.1.83 phosphotransferase activity, alcohol group as acceptor Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_00199 nfo ko03410,map03410 ko:K01151 3.1.21.2 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin Base excision repair : Replication and repair : Genetic Information Processing C2_00202 lysP ko:K03293,ko:K11733,ko:K16235 Lysine-specific permease NA C2_00203 cirA ko02020,map02020 ko:K16089,ko:K19611 Colicin I receptor Two-component system : Signal transduction : Environmental Information Processing C2_00204 yeiG ko00680,ko01120,ko01200,map00680,map01120,map01200 ko:K01070,ko:K09795 3.1.2.12 Serine hydrolase involved in the detoxification of formaldehyde Methane metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_00205 folE ko00790,ko01100,map00790,map01100 ko:K00950,ko:K01495 2.7.6.3,3.5.4.16 GTP cyclohydrolase Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00206 yeiB ko:K07148 Protein of unknown function (DUF418) NA C2_00207 galS ko:K02529,ko:K03487 transcriptional regulator NA C2_00208 mglB ko02010,ko02030,map02010,map02030 ko:K10439,ko:K10540 Wtih MglAC is involved in the transport of beta-methylgalactoside ABC transporters : Membrane transport : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes C2_00209 mglA ko02010,map02010 ko:K10542 3.6.3.17 import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_00210 mglC ko02010,map02010 ko:K10541 the binding-protein-dependent transport system ABC transporters : Membrane transport : Environmental Information Processing C2_00211 preA ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100 ko:K02572,ko:K02573,ko:K17723 1.3.1.1 Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate. It also catalyzes the reverse reaction and the reduction of thymine to 5,6- dihydrothymine (DHT) Pyrimidine metabolism : Nucleotide metabolism : Metabolism;beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00212 preT ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100 ko:K17722 1.3.1.1 Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate. It also catalyzes the reverse reaction and the reduction of thymine to 5,6- dihydrothymine (DHT) Pyrimidine metabolism : Nucleotide metabolism : Metabolism;beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00214 sanA ko:K03748 Participates in the barrier function of the cell envelope NA C2_00215 cdd ko00240,ko00983,ko01100,map00240,map00983,map01100 ko:K01489 3.5.4.5 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00217 lrgA ko02020,map02020 ko:K05338,ko:K06518 UPF0299 membrane protein Two-component system : Signal transduction : Environmental Information Processing C2_00218 dusC ko:K05541 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines NA C2_00219 mdtQ ko:K15550 Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride NA C2_00223 pbpG ko00550,ko01100,map00550,map01100 ko:K07258,ko:K07262 3.4.16.4 Belongs to the peptidase S11 family Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00224 dld ko00620,ko01120,map00620,map01120 ko:K03777 1.1.5.12 Catalyzes the oxidation of D-lactate to pyruvate Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_00225 bglX ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 ko:K05349 3.2.1.21 Belongs to the glycosyl hydrolase 3 family Cyanoamino acid metabolism : Metabolism of other amino acids : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Phenylpropanoid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_00226 yehZ ko02010,map02010 ko:K05845 Part of an ABC transporter complex involved in low- affinity glycine betaine uptake. Binds glycine betaine with low affinity ABC transporters : Membrane transport : Environmental Information Processing C2_00227 yehY ko02010,map02010 ko:K05846 Permease protein ABC transporters : Membrane transport : Environmental Information Processing C2_00228 yehX ko02010,map02010 ko:K05847 abc transporter atp-binding protein ABC transporters : Membrane transport : Environmental Information Processing C2_00229 yehW ko02010,map02010 ko:K05846 Permease protein ABC transporters : Membrane transport : Environmental Information Processing C2_00231 mlrA ko02026,map02026 ko:K21089,ko:K21972,ko:K22491 transcriptional regulator Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_00232 yehU ko02020,map02020 ko:K02478,ko:K07704 2.7.13.3 Histidine kinase Two-component system : Signal transduction : Environmental Information Processing C2_00233 yehT ko:K02477 Member of the two-component regulatory system BtsS BtsR, which is part of a nutrient-sensing regulatory network composed of BtsS BtsR, the low-affinity pyruvate signaling system YpdA YpdB and their respective target proteins, YjiY and YhjX. Responds to depletion of nutrients, specifically serine, and the concomitant presence of extracellular pyruvate. BtsR regulates expression of yjiY by binding to its promoter region. Activation of the BtsS BtsR signaling cascade also suppresses YpdA YpdB-mediated yhjX induction NA C2_00239 yehL ko:K03924 ATPase activity NA C2_00243 metG ko00450,ko00970,map00450,map00970 ko:K01874,ko:K01890,ko:K06878 6.1.1.10,6.1.1.20 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_00244 mrp ko:K03593 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP NA C2_00247 yehC ko:K07346,ko:K07353,ko:K15540 fimbrial chaperone NA C2_00248 yehB ko05133,map05133 ko:K07347 outer membrane usher protein Pertussis : Infectious disease: bacterial : Human Diseases C2_00251 rcnA ko:K08970 Efflux system for nickel and cobalt NA C2_00252 rcnR ko:K21600 Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter NA C2_00253 thiM ko00730,ko01100,map00730,map01100 ko:K00878 2.7.1.50 Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ) Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00254 thiD ko00730,ko01100,map00730,map01100 ko:K00941 2.7.1.49,2.7.4.7 Phosphomethylpyrimidine kinase Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00255 yegX ko:K07273 lysozyme activity NA C2_00256 yegW ko:K03710,ko:K11922 Transcriptional regulator NA C2_00259 yegT ko01501,map01501 ko:K03289,ko:K03301,ko:K08218 nucleoside transporter beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases C2_00260 fbaB ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 ko:K11645 4.1.2.13 fructose-bisphosphate aldolase activity Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00261 gatY ko00052,ko01100,map00052,map01100 ko:K08302 4.1.2.40 which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6- bisphosphate (TBP). Requires Galactose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00262 gatZ ko00052,ko01100,ko02060,map00052,map01100,map02060 ko:K02775,ko:K16371,ko:K21622 5.1.3.40 that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of Galactose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_00263 gatA ko00051,ko00052,ko00053,ko01100,ko01120,ko02060,map00051,map00052,map00053,map01100,map01120,map02060 ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02798,ko:K02806,ko:K02821,ko:K08483,ko:K11189,ko:K11201,ko:K18531 2.7.1.194,2.7.1.197,2.7.1.200,2.7.1.202,2.7.3.9 Phosphoenolpyruvate-dependent sugar phosphotransferase system Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_00264 gatB ko00052,ko00053,ko01100,ko01120,ko02060,map00052,map00053,map01100,map01120,map02060 ko:K02774,ko:K02822 2.7.1.194,2.7.1.200 The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The enzyme II complex composed of GatA, GatB and GatC is involved in galactitol transport Galactose metabolism : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_00265 gatC ko00052,ko01100,ko02060,map00052,map01100,map02060 ko:K02775 system Galactitol-specific IIC component Galactose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_00266 gatD ko00040,ko00051,ko00052,ko01100,map00040,map00051,map00052,map01100 ko:K00008,ko:K00094 1.1.1.14,1.1.1.251 5-dehydrogenase Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00267 gatR ko:K02081,ko:K02436,ko:K02468 Transcriptional NA C2_00268 yegS ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 ko:K07029 2.7.1.107 the in vivo substrate is Glycerolipid metabolism : Lipid metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_00270 yegQ ko05120,map05120 ko:K08303 peptidase activity Epithelial cell signaling in Helicobacter pylori infection : Infectious disease: bacterial : Human Diseases C2_00271 ko:K19092 ParE toxin of type II toxin-antitoxin system, parDE NA C2_00272 ko:K07746 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH NA C2_00273 yegP ko:K09946 double-strand break repair NA C2_00276 mdtD ko02020,map02020 ko:K18326 Major facilitator Superfamily Two-component system : Signal transduction : Environmental Information Processing C2_00277 mdtC ko02020,map02020 ko:K03296,ko:K07788,ko:K07789 The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate Two-component system : Signal transduction : Environmental Information Processing C2_00278 mdtB ko02020,map02020 ko:K03296,ko:K07788,ko:K07789 The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate Two-component system : Signal transduction : Environmental Information Processing C2_00279 mdtA ko02020,map02020 ko:K07799 The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate Two-component system : Signal transduction : Environmental Information Processing C2_00284 yegD ko:K04046,ko:K18640 ATP binding NA C2_00285 alkA ko03410,map03410 ko:K01247,ko:K13529 3.2.2.21 Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, 3-methylguanine, 7-methylguanine, O2- methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions Base excision repair : Replication and repair : Genetic Information Processing C2_00286 yegE ko02020,ko02026,ko02030,ko04112,map02020,map02026,map02030,map04112 ko:K07636,ko:K07716,ko:K13924,ko:K21084 2.1.1.80,2.7.13.3,2.7.7.65,3.1.1.61 diguanylate cyclase activity Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Bacterial chemotaxis : Cell motility : Cellular Processes;Cell cycle - Caulobacter : Cell growth and death : Cellular Processes C2_00287 udk ko00240,ko00983,ko01100,map00240,map00983,map01100 ko:K00876 2.7.1.48 CTP salvage Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00288 dcd ko00240,ko01100,map00240,map01100 ko:K01494 3.5.4.13 Belongs to the dCTP deaminase family Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00289 asmA ko:K07289,ko:K07290 Involved in the inhibition of assembly of mutant ompF proteins. In general, could be involved in the assembly of outer membrane proteins NA C2_00290 yegH ko:K03699 flavin adenine dinucleotide binding NA C2_00291 wza ko02026,map02026 ko:K01991,ko:K02237 polysaccharide export protein Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_00292 wzb ko:K01104 3.1.3.48 low molecular weight NA C2_00293 wzc ko:K16692 Tyrosine-protein kinase NA C2_00295 wcaB ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 ko:K00640,ko:K03819 2.3.1.30 serine O-acetyltransferase activity Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_00296 wcaC ko:K00754,ko:K13684 lipopolysaccharide-1,6-galactosyltransferase activity NA C2_00297 wcaD ko:K13620 slime layer organization NA C2_00298 wcaE ko:K13683 colanic acid biosynthesis glycosyl transferase NA C2_00299 wcaF ko:K00661,ko:K03818 2.3.1.79 colanic acid biosynthesis acetyltransferase wcaF NA C2_00300 gmd ko00051,ko00520,ko01100,map00051,map00520,map01100 ko:K01711 4.2.1.47 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00301 fcl ko00051,ko00520,ko01100,ko05111,map00051,map00520,map01100,map05111 ko:K01711,ko:K02377,ko:K16554 1.1.1.271,4.2.1.47 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_00302 gmm ko:K03207,ko:K03574 3.6.1.55 Belongs to the Nudix hydrolase family NA C2_00303 wcaI ko00500,ko01100,map00500,map01100 ko:K00696,ko:K00754,ko:K03208 2.4.1.14 slime layer organization Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00304 cpsB ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 ko:K00971,ko:K16011 2.7.7.13,5.3.1.8 mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes C2_00305 manB ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 ko:K01840,ko:K15778 5.4.2.2,5.4.2.8 Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Purine metabolism : Nucleotide metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Streptomycin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA C2_00306 wcaJ ko05111,map05111 ko:K03606 Is the initiating enzyme for colanic acid (CA) synthesis. Catalyzes the transfer of the glucose-1-phosphate moiety from UDP-Glc onto the carrier lipid undecaprenyl phosphate (C55-P), forming a phosphoanhydride bond yielding to glucosyl- pyrophosphoryl-undecaprenol (Glc-PP-C55). Also possesses a weak galactose-1-P transferase activity Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_00307 wzxC ko:K03328,ko:K16694,ko:K16695 lipopolysaccharide biosynthetic process NA C2_00308 wcaK ko:K16710 slime layer organization NA C2_00309 wcaL ko:K16703 colanic acid biosynthesis glycosyl transferase NA C2_00310 wcaM ko:K16711 slime layer organization NA C2_00311 gne ko:K19997 5.1.3.26 Polysaccharide biosynthesis protein NA C2_00312 galU ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 ko:K00963 2.7.7.9 UTP:glucose-1-phosphate uridylyltransferase activity Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;NA : NA : NA C2_00314 ko00680,ko01100,ko01120,map00680,map01100,map01120 ko:K00441 1.12.98.1 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_00315 ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K02551 2.2.1.9 Polysaccharide pyruvyl transferase Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_00319 ko:K09809,ko:K19354 2.7.8.12 Glycosyltransferase like family 2 NA C2_00320 glf ko00052,ko00520,map00052,map00520 ko:K01854 5.4.99.9 Catalyzes the interconversion through a 2-keto intermediate of uridine diphosphogalactopyranose (UDP-GalP) into uridine diphosphogalactofuranose (UDP-GalF) Galactose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism C2_00321 glfT1 ko:K16649 2.4.1.287 Glycosyl Transferase NA C2_00322 gnd ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 ko:K00033 1.1.1.343,1.1.1.44 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_00323 ugd ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 ko:K00012 1.1.1.22 Belongs to the UDP-glucose GDP-mannose dehydrogenase family Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00324 wzzB ko:K05789,ko:K05790 Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules NA C2_00325 hisI ko00340,ko00740,ko00790,ko01100,ko01110,ko01230,ko02024,map00340,map00740,map00790,map01100,map01110,map01230,map02024 ko:K01496,ko:K01497,ko:K01523,ko:K01814,ko:K11755 3.5.4.19,3.5.4.25,3.6.1.31,5.3.1.16 Histidine biosynthesis bifunctional protein HisIE Histidine metabolism : Amino acid metabolism : Metabolism;Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_00326 hisF ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 ko:K01663,ko:K02500,ko:K11755 3.5.4.19,3.6.1.31 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit Histidine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00327 hisA ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 ko:K01814 5.3.1.16 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase Histidine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00328 hisH ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 ko:K02501 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR Histidine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00329 hisB ko00340,ko00350,ko00360,ko00400,ko00401,ko00540,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00540,map00960,map01100,map01110,map01130,map01230 ko:K00013,ko:K00817,ko:K01089,ko:K01693,ko:K03273 1.1.1.23,2.6.1.9,3.1.3.15,3.1.3.82,3.1.3.83,4.2.1.19 Histidine biosynthesis bifunctional protein HisB Histidine metabolism : Amino acid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Phenylalanine metabolism : Amino acid metabolism : Metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Novobiocin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Tropane, piperidine and pyridine alkaloid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00330 hisC ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 ko:K00013,ko:K00817 1.1.1.23,2.6.1.9 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily Histidine metabolism : Amino acid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Phenylalanine metabolism : Amino acid metabolism : Metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Novobiocin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Tropane, piperidine and pyridine alkaloid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00331 hisD ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 ko:K00013,ko:K15509 1.1.1.23,1.1.1.308 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine Histidine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00332 hisG ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 ko:K00765 2.4.2.17 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity Histidine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00333 yefM ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 ko:K08591,ko:K19159 2.3.1.15 Antitoxin component of a toxin-antitoxin (TA) module Glycerolipid metabolism : Lipid metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_00334 yoeB ko:K19158 Addiction module toxin, Txe YoeB NA C2_00336 yeeY ko:K10972 transcriptional regulator NA C2_00337 yeeF ko:K14052 putrescine transmembrane transporter activity NA C2_00338 yeeE ko:K07112 Inner membrane protein PRK11099 NA C2_00339 yeeD ko04122,map04122 ko:K04085,ko:K07112 Sulfurtransferase TusA Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_00340 sbcB ko03430,map03430 ko:K01141 3.1.11.1 Degrades single-stranded DNA (ssDNA) in a highly processive manner. Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage of DNA at an apurinic apyrimidinic (AP) site by either an AP endonuclease or AP lyase Mismatch repair : Replication and repair : Genetic Information Processing C2_00341 dacC ko00550,ko01100,map00550,map01100 ko:K07258 3.4.16.4 Belongs to the peptidase S11 family Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00342 sbmC ko:K07470,ko:K13652 Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell NA C2_00344 yeeX ko:K09802 Belongs to the UPF0265 family NA C2_00346 cbtA ko:K18837 inhibits FtsZ GTP-dependent polymerization and GTPase activity as well as MreB ATP-dependent polymerization. Binds to both the N- and C-terminus of FtsZ, likely blocking its polymerization. Overexpression results in inhibition of growth in liquid cultures and decrease in colony formation NA C2_00347 yeeU ko:K18838 CbeA_antitoxin, type IV, cytoskeleton bundling-enhancing factor A NA C2_00349 fabD ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 ko:K00645,ko:K15327,ko:K15329,ko:K15355,ko:K15469 2.3.1.39 Acyl transferase domain Fatty acid biosynthesis : Lipid metabolism : Metabolism;Prodigiosin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;NA : NA : NA;Fatty acid metabolism : Global and overview maps : Metabolism C2_00352 ghrA ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120 ko:K12972 1.1.1.79,1.1.1.81 Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_00353 ycdX ko:K04477 Belongs to the PHP family NA C2_00356 csgG ko:K06214 Curli production assembly transport component CsgG NA C2_00357 csgF ko:K04338 May be involved in the biogenesis of curli organelles NA C2_00358 csgE ko:K04337 May be involved in the biogenesis of curli organelles NA C2_00359 csgD ko02020,ko02026,map02020,map02026 ko:K04333,ko:K07684 necessary for transcription of the csgBAC ymdA operon. Plays a positive role in biofilm formation. May have the capability to respond to starvation and or high cell density by activating csgBA transcription. Low-level constitutive expression confers an adherent curli fimbriae-expressing phenotype, up- regulates 10 genes and down-regulates 14 others Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_00360 csgB ko02026,map02026 ko:K04335 PFAM Curlin associated repeat Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_00361 csgA ko02026,map02026 ko:K04334 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_00362 csgC ko02026,map02026 ko:K04336 Curli assembly protein Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_00365 clsC ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 ko:K00998,ko:K06131,ko:K06132 2.7.8.8 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_00366 mdoC ko:K11941 Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane NA C2_00367 mdoG ko:K03670 Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) NA C2_00368 mdoH ko:K03669 Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) NA C2_00370 msyB ko:K12147 MsyB protein NA C2_00371 mdtG ko:K05820,ko:K08161 Major facilitator Superfamily NA C2_00372 lpxL ko00540,ko01100,map00540,map01100 ko:K02517,ko:K02560,ko:K12974 2.3.1.241,2.3.1.242,2.3.1.243 Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A) Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00373 yceA ko:K07146 Belongs to the UPF0176 family NA C2_00375 yceJ ko:K12262 respiratory electron transport chain NA C2_00377 solA ko00260,ko01100,map00260,map01100 ko:K00301,ko:K02846 1.5.3.1 Catalyzes the oxidative demethylation of N-methyl-L- tryptophan Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00378 bssS ko:K12148 Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway NA C2_00379 dinI ko:K12149 Involved in SOS regulation. Inhibits RecA by preventing RecA to bind ssDNA. Can displace ssDNA from RecA NA C2_00380 pyrC ko00240,ko01100,map00240,map01100 ko:K01465 3.5.2.3 Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00382 grxB ko:K03675 in a coupled system with glutathione reductase. Does not act as hydrogen donor for ribonucleotide reductase NA C2_00383 mdtH ko:K06610,ko:K08162 Confers resistance to norfloxacin and enoxacin NA C2_00384 rimJ ko:K03790 2.3.1.128 This enzyme acetylates the N-terminal alanine of ribosomal protein S5. Plays also a role in the temperature regulation of pap pilin transcription NA C2_00385 yceH ko:K03810,ko:K09915 Belongs to the UPF0502 family NA C2_00386 mviM ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 ko:K00010,ko:K03810 1.1.1.18,1.1.1.369 oxidoreductase activity Streptomycin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Inositol phosphate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA C2_00387 murJ ko:K03980 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane NA C2_00388 flgN ko02040,map02040 ko:K02399 Flagella synthesis protein FlgN Flagellar assembly : Cell motility : Cellular Processes C2_00389 flgM ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040 ko:K02398 negative regulator of flagellin synthesis Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes C2_00390 flgA ko02040,map02040 ko:K02279,ko:K02386 Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly Flagellar assembly : Cell motility : Cellular Processes C2_00391 flgB ko02040,map02040 ko:K02387 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body Flagellar assembly : Cell motility : Cellular Processes C2_00392 flgC ko02040,map02040 ko:K02388 Belongs to the flagella basal body rod proteins family Flagellar assembly : Cell motility : Cellular Processes C2_00393 flgD ko02040,map02040 ko:K02389,ko:K02390 Required for flagellar hook formation. May act as a scaffolding protein Flagellar assembly : Cell motility : Cellular Processes C2_00394 flgE ko02040,map02040 ko:K02390 bacterial-type flagellum-dependent swarming motility Flagellar assembly : Cell motility : Cellular Processes C2_00395 flgF ko02040,map02040 ko:K02391 bacterial-type flagellum-dependent swarming motility Flagellar assembly : Cell motility : Cellular Processes C2_00396 flgG ko02040,map02040 ko:K02392 Belongs to the flagella basal body rod proteins family Flagellar assembly : Cell motility : Cellular Processes C2_00397 flgH ko02040,map02040 ko:K02393 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation Flagellar assembly : Cell motility : Cellular Processes C2_00398 flgI ko02040,map02040 ko:K02394 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation Flagellar assembly : Cell motility : Cellular Processes C2_00399 flgJ ko01503,map01503 ko:K01448,ko:K02395 3.5.1.28 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_00400 flgK ko02040,map02040 ko:K02396 flagellar hook-associated protein Flagellar assembly : Cell motility : Cellular Processes C2_00401 flgL ko02040,map02040 ko:K02397 Flagellar hook-associated protein 3 Flagellar assembly : Cell motility : Cellular Processes C2_00402 rne ko03018,map03018 ko:K08300 3.1.26.12 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs RNA degradation : Folding, sorting and degradation : Genetic Information Processing C2_00403 rluC ko:K06179 5.4.99.24 Responsible for synthesis of pseudouridine from uracil NA C2_00404 maf ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko:K00014,ko:K03215,ko:K06287 1.1.1.25,2.1.1.190 Maf-like protein Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00405 yceD ko:K07040 Plays a role in synthesis, processing and or stability of 23S rRNA NA C2_00406 rpmF ko03010,map03010 ko:K02911 Ribosomal L32p protein family Ribosome : Translation : Genetic Information Processing C2_00407 plsX ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 ko:K03621 2.3.1.15 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA Glycerolipid metabolism : Lipid metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_00408 fabH ko00061,ko01100,ko01212,map00061,map01100,map01212 ko:K00648 2.3.1.180 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids Fatty acid biosynthesis : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism C2_00409 fabD ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 ko:K00645 2.3.1.39 malonyl CoA-acyl carrier protein transacylase Fatty acid biosynthesis : Lipid metabolism : Metabolism;Prodigiosin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;NA : NA : NA;Fatty acid metabolism : Global and overview maps : Metabolism C2_00411 acpP ko:K02078 Carrier of the growing fatty acid chain in fatty acid biosynthesis NA C2_00412 fabF ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 ko:K09458 2.3.1.179 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP Fatty acid biosynthesis : Lipid metabolism : Metabolism;Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism C2_00413 pabC ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230 ko:K00826,ko:K02619 2.6.1.42,4.1.3.38 4-amino-4-deoxychorismate lyase Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00414 mltG ko:K07082 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation NA C2_00415 tmk ko00240,ko01100,map00240,map01100 ko:K00943 2.7.4.9 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00416 holB ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02341 2.7.7.7 Part of the beta sliding clamp loading complex, which hydrolyzes ATP to load the beta clamp onto primed DNA to form the DNA replication pre-initiation complex. DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The gamma complex (gamma(3),delta,delta') is thought to load beta dimers onto DNA by binding ATP which alters the complex's conformation so it can bind beta sliding clamp dimers and open them at one interface. Primed DNA is recognized, ATP is hydrolyzed releasing the gamma complex and closing the beta sliding clamp ring around the primed DNA Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing C2_00417 ycfH ko:K03424 metal-dependent hydrolase YcfH NA C2_00418 ptsG ko00010,ko00500,ko00520,ko02060,ko05111,map00010,map00500,map00520,map02060,map05111 ko:K02749,ko:K02750,ko:K02752,ko:K02753,ko:K02778,ko:K02779,ko:K02790,ko:K02791,ko:K02802,ko:K02803,ko:K02804,ko:K02818,ko:K02819,ko:K11191,ko:K11192,ko:K20116,ko:K20117,ko:K20118 2.7.1.192,2.7.1.193,2.7.1.199,2.7.1.201,2.7.1.208 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport. Also functions as a chemoreceptor monitoring the environment for changes in sugar concentration Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_00419 fhuE ko:K16088 Outer-membrane receptor for Fe(III)-coprogen, Fe(III)-ferrioxamine B and Fe(III)-rhodotrulic acid NA C2_00420 hinT ko:K02503 Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate), guanosine 5'monophosphomorpholidate (GMP-morpholidate) and tryptamine 5'guanosine monophosphate (TpGd). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha- acetyl lysine methyl ester)) generated by lysine--tRNA ligase, and lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)). Is essential for the activity of the enzyme D- alanine dehydrogenase (DadA) and is required for E.coli to grow on D-alanine as a sole carbon source. Is also required for growth at high salt concentrations NA C2_00422 lpoB ko02025,map02025 ko:K07337,ko:K21008 Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes C2_00423 thiK ko00730,ko01100,map00730,map01100 ko:K07251 2.7.1.89 Catalyzes the phosphorylation of thiamine to thiamine phosphate Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00424 nagZ ko00460,ko00500,ko00520,ko00531,ko00770,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00770,map00940,map01100,map01110,map01501 ko:K00997,ko:K01207,ko:K05349 2.7.8.7,3.2.1.21,3.2.1.52 Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides Cyanoamino acid metabolism : Metabolism of other amino acids : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Glycosaminoglycan degradation : Glycan biosynthesis and metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Phenylpropanoid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases C2_00425 ycfP ko:K07000 Belongs to the UPF0227 family NA C2_00426 ndh ko00190,map00190 ko:K03885 1.6.99.3 NADH dehydrogenase Oxidative phosphorylation : Energy metabolism : Metabolism C2_00428 ycfQ ko:K16137,ko:K19335,ko:K22041 Transcriptional regulator NA C2_00429 bhsA ko:K12151 Reduces the permeability of the outer membrane to copper NA C2_00430 ycfS ko01503,map01503 ko:K16291,ko:K19234,ko:K19235,ko:K19236 Responsible, at least in part, for anchoring of the major outer membrane lipoprotein (Lpp, also known as the Braun lipoprotein) to the peptidoglycan via a meso-diaminopimelyl-L- Lys- bond on the terminal residue of Lpp Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_00431 mfd ko03420,map03420 ko:K03723 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site Nucleotide excision repair : Replication and repair : Genetic Information Processing C2_00433 lolC ko02010,map02010 ko:K02004,ko:K09808 Part of an ATP-dependent transport system LolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA ABC transporters : Membrane transport : Environmental Information Processing C2_00434 lolD ko02010,map02010 ko:K09810 Part of the ABC transporter complex LolCDE involved in the translocation of ABC transporters : Membrane transport : Environmental Information Processing C2_00435 lolE ko02010,map02010 ko:K02004,ko:K09808 system transmembrane protein lolE ABC transporters : Membrane transport : Environmental Information Processing C2_00436 nagK ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 ko:K00847,ko:K00884 2.7.1.4,2.7.1.59 Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00437 cobB ko:K12410 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form NA C2_00438 ycfZ ko:K01387,ko:K06872 3.4.24.3 TPM domain NA C2_00440 potD ko02010,map02010 ko:K11069,ko:K11070 Required for the activity of the bacterial periplasmic transport system of putrescine ABC transporters : Membrane transport : Environmental Information Processing C2_00441 potC ko02010,map02010 ko:K11070,ko:K11074 Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine ABC transporters : Membrane transport : Environmental Information Processing C2_00442 potB ko02010,map02010 ko:K11071 Binding-protein-dependent transport system inner membrane component ABC transporters : Membrane transport : Environmental Information Processing C2_00443 potA ko02010,map02010 ko:K11072 3.6.3.31 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_00444 pepT ko:K01258 3.4.11.4 Cleaves the N-terminal amino acid of tripeptides NA C2_00445 ycfD ko:K18850 1.14.11.47 peptidyl-arginine hydroxylation NA C2_00448 purB ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 ko:K01756 4.3.2.2 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily Purine metabolism : Nucleotide metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_00449 hflD ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 ko:K01756,ko:K07153 4.3.2.2 Negative regulator of phage lambda lysogenization. Contributes to the degradation of the phage regulatory protein CII. Acts probably by holding CII on the membrane surface, away from the target promoters, but close to the FtsH protease Purine metabolism : Nucleotide metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_00450 mnmA ko04122,map04122 ko:K00566 2.8.1.13 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_00451 nudJ ko:K03574,ko:K12152 3.6.1.55 Belongs to the Nudix hydrolase family. NudJ subfamily NA C2_00452 rluE ko:K06178,ko:K06181,ko:K06183 5.4.99.19,5.4.99.20,5.4.99.22 Responsible for synthesis of pseudouridine from uracil- 2457 in 23S ribosomal RNA NA C2_00453 icd ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 ko:K00031 1.1.1.42 Isocitrate dehydrogenase Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Glutathione metabolism : Metabolism of other amino acids : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Peroxisome : Transport and catabolism : Cellular Processes C2_00455 ycgE ko02026,map02026 ko:K21089,ko:K21972,ko:K22491 Controls the expression of several small proteins that may play a role in biofilm maturation. Binds to and represses the operator of the ycgZ-ymgA-ariR-ymgC operon and also regulates ynaK. Binding is antagonized by BluF upon blue light (470 nm) irradiation. Blue light may increase the affinity of BluF for BluR, allowing it to be released from its operator Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_00456 ycgF ko:K21973 Binds to and releases the BluR repressor from its bound DNA target in a blue light-dependent (470 nm) fashion. A shift to low temperature also triggers a BluF-mediated relief of repression by BluR, suggesting BluF may serve as a thermometer. Blue light may act to increase the affinity of BluF for BluR, allowing it to be released from its operator. The protein has a reversible photocycle, and undergoes structural changes, probably in the EAL domain, in response to light NA C2_00457 ycgZ ko:K21974 Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component NA C2_00458 ariR ko:K21976 Probably a connector protein for RcsB C regulation of biofilm and acid-resistance, providing additional signal input into the two-component signaling pathway. May serve to stimulate biofilm maturation, via the Rcs phosphorelay. Regulates expression of genes involved in acid-resistance and biofilm formation, including the RcsB C two-component system. May be a non-specific DNA-binding protein that binds genes and or intergenic regions via a geometric recognition. Also confers resistance to H(2)O(2). Overexpression at 28 and 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB NA C2_00460 ycgG ko02026,map02026 ko:K13244,ko:K21090 3.1.4.52 cyclic-guanylate-specific phosphodiesterase activity Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_00463 ko05131,map05131 ko:K12678,ko:K12679 outer membrane autotransporter barrel domain protein Shigellosis : Infectious disease: bacterial : Human Diseases C2_00467 minE ko:K03608 Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell NA C2_00468 minD ko:K03609 ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings NA C2_00469 minC ko:K03610,ko:K09749 Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization NA C2_00472 ycgL ko:K09902 YcgL domain-containing protein NA C2_00473 ycgM ko00350,ko01100,ko01120,map00350,map01100,map01120 ko:K16165 3.7.1.20 metal ion binding Tyrosine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_00474 ycgN ko:K09160 Putative zinc- or iron-chelating domain NA C2_00475 hlyE ko:K11139 Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells NA C2_00476 hlyE ko:K11139 Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells NA C2_00477 umuD ko:K03503 Involved in UV protection and mutation. Poorly processive, error-prone DNA polymerase involved in translesion repair. Essential for induced (or SOS) mutagenesis. Able to replicate DNA across DNA lesions (thymine photodimers and abasic sites, called translesion synthesis) in the presence of activated RecA NA C2_00478 umuC ko:K02346,ko:K03502 2.7.7.7 efficiency is maximal in the presence of the beta sliding-clamp and clamp-loading complex of DNA polymerase III plus single-stranded binding protein (SSB). RecA and to a lesser extent the beta clamp- complex may target Pol V to replication complexes stalled at DNA template lesions NA C2_00479 dsbB ko:K03611 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein NA C2_00480 nhaB ko:K03314 Na( ) H( ) antiporter that extrudes sodium in exchange for external protons NA C2_00481 fadR ko:K03603,ko:K05799,ko:K22104 Multifunctional regulator of fatty acid metabolism NA C2_00482 spoVR ko:K06415 cellular response to DNA damage stimulus NA C2_00483 dadA ko00360,map00360 ko:K00285 1.4.5.1 Oxidative deamination of D-amino acids Phenylalanine metabolism : Amino acid metabolism : Metabolism C2_00484 alr ko00473,ko01100,ko01502,map00473,map01100,map01502 ko:K01775 5.1.1.1 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids D-Alanine metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases C2_00486 nhaP2 ko:K11105 ) H( ) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels NA C2_00487 ldcA ko:K01297 3.4.17.13 Releases the terminal D-alanine residue from the cytoplasmic tetrapeptide recycling product L-Ala-gamma-D-Glu-meso- Dap-D-Ala. To a lesser extent, can also cleave D-Ala from murein derivatives containing the tetrapeptide, i.e. MurNAc-tetrapeptide, UDP-MurNAc-tetrapeptide, GlcNAc-MurNAc-tetrapeptide, and GlcNAc- anhMurNAc-tetrapeptide. Does not act on murein sacculi or cross- linked muropeptides. The tripeptides produced by the LcdA reaction can then be reused as peptidoglycan building blocks NA C2_00488 emtA ko:K08306,ko:K08308,ko:K08309 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain NA C2_00489 ycgR ko02026,map02026 ko:K21087 Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_00492 treA ko00500,ko01100,map00500,map01100 ko:K01194,ko:K03931 3.2.1.28 Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00493 dhaM ko00051,ko00561,ko01100,ko01120,ko02060,map00051,map00561,map01100,map01120,map02060 ko:K02768,ko:K02784,ko:K05881,ko:K08483,ko:K08485,ko:K11183,ko:K11189,ko:K11201 2.7.1.121,2.7.1.202,2.7.3.9 Protein deacetylase that removes acetyl groups on specific lysine residues in target proteins. Regulates transcription by catalyzing deacetylation of 'Lys-52' and 'Lys-62' of the transcriptional repressor RutR. Is also able to deacetylate NhoA and RluC in vitro. Targets a distinct set of substrates compared to CobB Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_00494 dhaL ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622 ko:K00863,ko:K05879 2.7.1.121,2.7.1.28,2.7.1.29,4.6.1.15 ADP-binding subunit of the dihydroxyacetone kinase, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaL-ADP is converted to DhaL-ATP via a phosphoryl group transfer from DhaM and transmits it to dihydroxyacetone binds to DhaK. DhaL acts also as coactivator of the transcription activator DhaR by binding to the sensor domain of DhaR. In the presence of dihydroxyacetone, DhaL- ADP displaces DhaK and stimulates DhaR activity. In the absence of dihydroxyacetone, DhaL-ADP is converted by the PTS to DhaL-ATP, which does not bind to DhaR Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;RIG-I-like receptor signaling pathway : Immune system : Organismal Systems C2_00495 dhaK ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622 ko:K00863,ko:K05878 2.7.1.121,2.7.1.28,2.7.1.29,4.6.1.15 Dihydroxyacetone binding subunit of the dihydroxyacetone kinase, which is responsible for the phosphoenolpyruvate (PEP)- dependent phosphorylation of dihydroxyacetone via a phosphoryl group transfer from DhaL-ATP. Binds covalently dihydroxyacetone in hemiaminal linkage. DhaK acts also as corepressor of the transcription activator DhaR by binding to the sensor domain of DhaR. In the presence of dihydroxyacetone, DhaL-ADP displaces DhaK and stimulates DhaR activity. In the absence of dihydroxyacetone, DhaL-ADP is converted by the PTS to DhaL-ATP, which does not bind to DhaR Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;RIG-I-like receptor signaling pathway : Immune system : Organismal Systems C2_00496 dhaR ko:K05880,ko:K21405 PTS-dependent dihydroxyacetone kinase operon regulatory protein NA C2_00499 ychF ko:K06942 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner NA C2_00500 pth ko:K01056 3.1.1.29 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis NA C2_00502 sulP ko:K03321 Responsible for the aerobic transport of succinate from the periplasm to the cytoplasm at acidic pH. Can transport other C4-dicarboxylic acids such as aspartate and fumarate. May also play a role in the regulation of C4-dicarboxylic acid metabolism at pH 7, via regulation of expression and or activity of DctA. May act as a co-sensor of DcuS NA C2_00503 prs ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 ko:K00948 2.7.6.1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00504 ispE ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko:K00919,ko:K02528,ko:K16924 2.1.1.182,2.7.1.148 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_00505 lolB ko:K02494 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein NA C2_00506 hemA ko00860,ko01100,ko01110,ko01120,ko02040,map00860,map01100,map01110,map01120,map02040 ko:K02407,ko:K02492 1.2.1.70 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Flagellar assembly : Cell motility : Cellular Processes C2_00507 prfA ko:K02835,ko:K15034 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA NA C2_00508 prmC ko:K02493,ko:K02835,ko:K07320 2.1.1.297,2.1.1.298 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif NA C2_00511 kdsA ko00540,ko01100,map00540,map01100 ko:K01627 2.5.1.55 Belongs to the KdsA family Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00514 ko:K18862 Toxin Ldr, type I toxin-antitoxin system NA C2_00515 chaA ko:K07300 proton antiporter NA C2_00516 chaB ko:K06197 Might be a regulator of the sodium-potassium proton antiporter ChaA NA C2_00517 chaC ko:K07232 Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides NA C2_00518 ychN ko:K06039 protein hexamerization NA C2_00519 ychO ko00520,ko01100,map00520,map01100 ko:K01183 3.2.1.14 entry into host Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00520 narL ko02020,map02020 ko:K07684,ko:K07685 This protein activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate nitrite induction signal transmitted by either the NarX or NarQ proteins Two-component system : Signal transduction : Environmental Information Processing C2_00521 narX ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 ko:K07673,ko:K07674,ko:K07678 2.7.13.3 Acts as a sensor for nitrate nitrite and transduces signal of nitrate availability to the NarL protein and of both nitrate nitrite to the NarP protein. NarX probably activates NarL and NarP by phosphorylation in the presence of nitrate. NarX also plays a negative role in controlling NarL activity, probably through dephosphorylation in the absence of nitrate Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_00523 narK ko00910,map00910 ko:K02575 Catalyzes nitrate uptake, nitrite uptake and nitrite export across the cytoplasmic membrane. Functions as a nitrate nitrite exchanger, and protons are probably not co- transported with the substrate Nitrogen metabolism : Energy metabolism : Metabolism C2_00524 narG ko00910,ko01120,ko02020,map00910,map01120,map02020 ko:K00370,ko:K17050 1.7.5.1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family Nitrogen metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_00525 narH ko00910,ko01120,ko02020,map00910,map01120,map02020 ko:K00371 1.7.5.1 The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The beta chain is an electron transfer unit containing four cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit Nitrogen metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_00526 narJ ko00910,ko01120,ko02020,map00910,map01120,map02020 ko:K00370,ko:K00373,ko:K17052 1.7.5.1 Chaperone required for proper molybdenum cofactor insertion and final assembly of the membrane-bound respiratory nitrate reductase 1. Required for the insertion of the molybdenum into the apo-NarG subunit, maybe by keeping NarG in an appropriate competent-open conformation for the molybdenum cofactor insertion to occur. NarJ maintains the apoNarGH complex in a soluble state. Upon insertion of the molybdenum cofactor, NarJ seems to dissociate from the activated soluble NarGH complex, before its association with the NarI subunit on the membrane Nitrogen metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_00527 narI ko00910,ko01120,ko02020,map00910,map01120,map02020 ko:K00370,ko:K00374,ko:K02575 1.7.5.1 The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The gamma chain is a membrane-embedded heme-iron unit resembling cytochrome b, which transfers electrons from quinones to the beta subunit Nitrogen metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_00530 purU ko00630,ko00670,ko03013,map00630,map00670,map03013 ko:K00974,ko:K01433 2.7.7.72,3.5.1.10 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;RNA transport : Translation : Genetic Information Processing C2_00531 ychJ ko:K09858 Belongs to the UPF0225 family NA C2_00532 rssA ko:K07001 phosphatidylcholine metabolic process NA C2_00534 galU ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 ko:K00963 2.7.7.9 May play a role in stationary phase survival Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;NA : NA : NA C2_00535 hns ko02020,ko02024,map02020,map02024 ko:K03746,ko:K11685,ko:K20552 A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds nucleation sites in AT-rich DNA and bridges them, forming higher- order nucleoprotein complexes and condensing the chromosome. As many horizontally transferred genes are AT-rich, it plays a central role in silencing foreign genes. A subset of genes are repressed by H-NS in association with other proteins (By similarity) Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_00536 tdk ko00240,ko00983,ko01100,map00240,map00983,map01100 ko:K00857 2.7.1.21 thymidine kinase Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00537 insG ko:K07495 COG3385 FOG Transposase and inactivated derivatives NA C2_00538 insG ko:K07495 COG3385 FOG Transposase and inactivated derivatives NA C2_00539 adhE ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220 ko:K04072 1.1.1.1,1.2.1.10 This enzyme has three activities ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent reaction Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Fatty acid degradation : Lipid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Chloroalkane and chloroalkene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Naphthalene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_00540 ychE ko:K05595 Membrane NA C2_00543 oppA ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02035,ko:K15580 periplasmic oligopeptide-binding protein beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_00544 oppB ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02033,ko:K15581 probably responsible for the translocation of the substrate across the membrane beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_00545 oppC ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02034,ko:K12370,ko:K13891,ko:K15582,ko:K15586 Oligopeptide transport system permease protein OppC beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_00546 oppD ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02031,ko:K02032,ko:K02034,ko:K12371,ko:K15583,ko:K15587 3.6.3.24 Belongs to the ABC transporter superfamily beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_00547 oppF ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02032,ko:K10823,ko:K12372 Belongs to the ABC transporter superfamily beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_00548 yciU ko:K09901 Belongs to the UPF0263 family NA C2_00549 cls ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 ko:K00998,ko:K06131,ko:K06132 2.7.8.8 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_00550 kch ko:K10716 Potassium channel NA C2_00551 yciI ko:K05527,ko:K09780 YCII-related domain NA C2_00564 tonB ko:K03832 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins NA C2_00565 yciA ko01040,map01040 ko:K10806 acyl-CoA thioester hydrolase Biosynthesis of unsaturated fatty acids : Lipid metabolism : Metabolism C2_00566 ispZ ko:K06190 probably involved in intracellular septation NA C2_00568 ompW ko:K07275 outer membrane protein W NA C2_00571 yciG ko:K06884 Stress-induced protein NA C2_00572 trpA ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 ko:K01695 4.2.1.20 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00573 trpB ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 ko:K01696 4.2.1.20 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00574 trpF ko00260,ko00400,ko00790,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map00790,map01100,map01110,map01130,map01230 ko:K01609,ko:K01696,ko:K01817,ko:K13498,ko:K22100 4.1.1.48,4.2.1.160,4.2.1.20,5.3.1.24 Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00575 trpD ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 ko:K00766,ko:K01658,ko:K01664,ko:K13497 2.4.2.18,2.6.1.85,4.1.3.27 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Phenazine biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes C2_00576 trpE ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 ko:K01657 4.1.3.27 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Phenazine biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes C2_00577 trpH ko:K07053 3.1.3.97 Efficiently catalyzes the hydrolysis of the 3'-phosphate from 3',5'-bis-phosphonucleotides as well as the successive hydrolysis of 5'-phosphomononucleotides from the 5'-end of short pieces of RNA and DNA, with no specificity toward the identity of the nucleotide base. Is more efficient at hydrolyzing RNA oligonucleotides than DNA oligonucleotides. This enzyme can also hydrolyze annealed DNA duplexes, albeit at a catalytic efficiency approximately 10-fold lower than that of the corresponding single- stranded oligonucleotides NA C2_00578 yciO ko:K07566 2.7.7.87 Belongs to the SUA5 family NA C2_00579 rluB ko:K06178 5.4.99.22 Responsible for synthesis of pseudouridine from uracil- 2605 in 23S ribosomal RNA NA C2_00580 cobO ko00860,ko01100,map00860,map01100 ko:K16092,ko:K19221 2.5.1.17 Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00582 sohB ko:K04773,ko:K04774 peptidase NA C2_00584 topA ko:K03168 5.99.1.2 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone NA C2_00585 cysB ko:K13634,ko:K13635 This protein is a positive regulator of gene expression for the cysteine regulon NA C2_00589 acnA ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 ko:K01681 4.2.1.3 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00590 ribA ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024 ko:K01497 3.5.4.25 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_00591 pgpB ko00550,ko00564,ko01100,map00550,map00564,map01100 ko:K01096,ko:K19302 3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Also has undecaprenyl pyrophosphate phosphatase activity, required for the biosynthesis of the lipid carrier undecaprenyl phosphate. Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates. The pattern of activities varies according to subcellular location, PGP phosphatase activity is higher in the cytoplasmic membrane, whereas PA and LPA phosphatase activities are higher in the outer membrane. Activity is independent of a divalent cation ion and insensitive to inhibition by N- ethylmaleimide Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00592 lapA ko:K08992 Involved in the assembly of lipopolysaccharide (LPS) NA C2_00593 lapB ko:K19804 Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane NA C2_00594 pyrF ko00240,ko01100,map00240,map01100 ko:K01591 4.1.1.23 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00595 yciH ko03013,map03013 ko:K03113 cap-independent translational initiation of linear mRNA RNA transport : Translation : Genetic Information Processing C2_00596 osmB ko:K04062 Provides resistance to osmotic stress. May be important for stationary-phase survival NA C2_00599 gmr ko02024,ko02026,ko05111,map02024,map02026,map05111 ko:K14051,ko:K20965 3.1.4.52 Part of a 2 protein system that seems to be dedicated to transcription of csgD. This protein decreases csgD transcription and thus decreases expression of adhesive curli fimbriae genes csgEFG, csgBAC ymaD and adrA (yaic). Activity of this protein is antagonized by the diguanylate cyclase YdaM. In vitro has c-di-GMP phosphodiesterase activity. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_00600 rnb ko:K01147 3.1.13.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction NA C2_00602 fabI ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 ko:K00208 1.3.1.10,1.3.1.9 Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis Fatty acid biosynthesis : Lipid metabolism : Metabolism;Prodigiosin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;NA : NA : NA;Fatty acid metabolism : Global and overview maps : Metabolism C2_00603 ycjD ko:K04568 Protein of unknown function (DUF559) NA C2_00604 sapF ko01503,ko02010,map01503,map02010 ko:K19230 ATPase activity Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing C2_00605 sapD ko01503,ko02010,map01503,map02010 ko:K19229 Part of a putrescine export transport system, does not play a role in resistance to antimicrobial peptides. Stimulates K( )-uptake proteins TrkG and TrkH to import K( ), may act via ATP-binding rather than ATP hydrolysis Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing C2_00606 sapC ko01503,ko02010,map01503,map02010 ko:K19228 peptide transport system, permease Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing C2_00607 sapB ko01503,ko02010,map01503,map02010 ko:K19227 permease protein sapB Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing C2_00608 sapA ko01503,ko02010,ko02024,ko02030,map01503,map02010,map02024,map02030 ko:K02035,ko:K12368,ko:K19226 to a S.typhimurium protein implicated in antimicrobial peptide resistance, but the SapBCDF operon in E.coli is implicated in putrescine export Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Bacterial chemotaxis : Cell motility : Cellular Processes C2_00610 puuP ko:K14052 Amino Acid NA C2_00611 puuA ko00220,ko00250,ko00330,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 ko:K01915,ko:K09470 6.3.1.11,6.3.1.2 Involved in the breakdown of putrescine via the biosynthesis of gamma-L-glutamylputrescine. It is able to use several diamines, spermidine and spermine. Absolutely essential to utilize putrescine as both nitrogen and carbon sources and to decrease the toxicity of putrescine, which can lead to inhibition of cell growth and protein synthesis Arginine biosynthesis : Amino acid metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Nitrogen metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing;Necroptosis : Cell growth and death : Cellular Processes;Glutamatergic synapse : Nervous system : Organismal Systems;GABAergic synapse : Nervous system : Organismal Systems C2_00612 puuD ko00330,ko01100,map00330,map01100 ko:K07010,ko:K09473 3.5.1.94 Involved in the breakdown of putrescine via hydrolysis of the gamma-glutamyl linkage of gamma-glutamyl-gamma- aminobutyrate Arginine and proline metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00613 puuR ko:K14056 Transcriptional regulator NA C2_00614 puuC ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 ko:K00128,ko:K09472,ko:K12254 1.2.1.3,1.2.1.54,1.2.1.99 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Fatty acid degradation : Lipid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Lysine degradation : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;Histidine metabolism : Amino acid metabolism : Metabolism;Tryptophan metabolism : Amino acid metabolism : Metabolism;beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Chloroalkane and chloroalkene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Limonene and pinene degradation : Metabolism of terpenoids and polyketides : Metabolism;Insect hormone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA C2_00615 puuB ko00330,ko01100,map00330,map01100 ko:K09471 putrescine catabolic process Arginine and proline metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00616 gabT ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 ko:K00823,ko:K07250 2.6.1.19,2.6.1.22 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_00617 pspF ko:K03974,ko:K19505 psp operon transcriptional activator NA C2_00618 pspA ko:K03969 The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspA negatively regulates expression of the pspABCDE promoter and of pspG through negative regulation of the psp-specific transcriptional activator PspF. Is also required for membrane integrity, efficient translocation and maintenance of the proton motive force NA C2_00619 pspB ko:K03970 The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspB is involved in transcription regulation NA C2_00620 pspC ko:K03973 The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspC is involved in transcription regulation NA C2_00621 pspD ko:K03971 The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions NA C2_00622 pspE ko:K03972 The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspE catalyzes the sulfur- transfer reaction from thiosulfate to cyanide, to form sulfite and thiocyanate. Also able to use dithiol (dithiothreitol) as an alternate sulfur acceptor. Also possesses a very low mercaptopyruvate sulfurtransferase activity NA C2_00623 ycjM ko00500,map00500 ko:K00690 2.4.1.7 Catalyzes the reversible phosphorolysis of glucosylglycerate into alpha-D-glucose 1-phosphate (Glc1P) and D- glycerate. May be a regulator of intracellular levels of glucosylglycerate, a compatible solute that primarily protects organisms facing salt stress and very specific nutritional constraints. Cannot catalyze the phosphorolysis of sucrose Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism C2_00624 ycjN ko:K02027 Bacterial extracellular solute-binding protein NA C2_00625 ycjO ko02010,map02010 ko:K02025,ko:K02026,ko:K05814,ko:K10109,ko:K15771 transporter ABC transporters : Membrane transport : Environmental Information Processing C2_00626 ycjP ko:K02026 ABC transporter permease protein YcjP NA C2_00627 ycjP ko:K02026 ABC transporter permease protein YcjP NA C2_00631 ycjT ko:K04844,ko:K10231 2.4.1.230 carbohydrate binding NA C2_00632 pgmB ko00500,ko01100,map00500,map01100 ko:K01087,ko:K01194,ko:K01838,ko:K05342 2.4.1.64,3.1.3.12,3.2.1.28,5.4.2.6 Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), forming beta-D-glucose 1,6- (bis)phosphate (beta-G16P) as an intermediate. The beta- phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. Glucose or lactose are used in preference to maltose, which is only utilized after glucose or lactose has been exhausted. It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00633 msmK ko02010,map02010 ko:K10112 ATP-binding protein YcjV ABC transporters : Membrane transport : Environmental Information Processing C2_00634 ompG ko:K14053 Outer membrane protein G NA C2_00636 ycjX ko:K06918 ATP binding NA C2_00637 ycjF ko:K06883,ko:K08990 UPF0283 membrane protein YcjF NA C2_00638 tyrR ko:K03721 Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino acids (phenylalanine, tyrosine and tryptophan). These amino acids are suggested to act as co-effectors which bind to the TyrR protein to form an active regulatory protein. In most cases TyrR causes negative regulation, but positive effects on the tyrP gene have been observed at high phenylalanine concentrations NA C2_00639 tpx ko:K11065 1.11.1.15 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides NA C2_00640 ycjG ko:K19802 5.1.1.20 Belongs to the mandelate racemase muconate lactonizing enzyme family NA C2_00641 mpaA ko:K14054 murein tripeptide carboxypeptidase activity NA C2_00643 ko:K06889 Dienelactone hydrolase family NA C2_00644 ycjY ko:K06889 cell division NA C2_00646 mppA ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02035,ko:K15580 Periplasmic murein peptide-binding protein beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_00647 ynaI ko:K16052 Belongs to the MscS (TC 1.A.23) family NA C2_00649 uspE ko:K14055 Required for resistance to DNA-damaging agents NA C2_00650 fnr ko:K01420 Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor, O(2), is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration NA C2_00651 ogt ko:K00567,ko:K10778 2.1.1.63 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated NA C2_00652 abgT ko:K12942 transporter NA C2_00653 abgB ko:K12940,ko:K12941 Component of the p-aminobenzoyl-glutamate hydrolase multicomponent enzyme system which catalyzes the cleavage of p- aminobenzoyl-glutamate (PABA-GLU) to form p-aminobenzoate (PABA) and glutamate. AbgAB does not degrade dipeptides and the physiological role of abgABT should be clarified NA C2_00654 abgA ko:K12940,ko:K12941 Component of the p-aminobenzoyl-glutamate hydrolase multicomponent enzyme system which catalyzes the cleavage of p- aminobenzoyl-glutamate (PABA-GLU) to form p-aminobenzoate (PABA) and glutamate. AbgAB does not degrade dipeptides and the physiological role of abgABT should be clarified NA C2_00655 abgR ko:K07592,ko:K14057 transcriptional regulator NA C2_00657 ydaM ko02026,map02026 ko:K21088 2.7.7.65 Part of a 2 protein system that seems to be dedicated to regulate transcription of csgD. The CsdG protein in turn regulates expression of adhesive curli fimbriae genes csgEFG, csgBAC ymaD and adrA (yaic). Activity of this protein is antagonized by the phosphodiesterase Gmr (YciR). In vitro has weak diguanylate cyclase activity. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_00658 zntB ko:K03284,ko:K16074 Mediates efflux of zinc ions NA C2_00660 dbpA ko03018,map03018 ko:K05591,ko:K05592 3.6.4.13 DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes RNA degradation : Folding, sorting and degradation : Genetic Information Processing C2_00661 ttcA ko:K04075,ko:K14058 6.3.4.19 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system NA C2_00662 intR ko:K03733,ko:K14059 Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome (By similarity) NA C2_00664 ydaC ko:K19780 response to antibiotic NA C2_00665 recT ko:K07455 Binds to single-stranded DNA and also promotes the renaturation of complementary single-stranded DNA. Function in recombination. Has a function NA C2_00666 recE ko00230,ko00240,ko01100,ko03018,ko03030,ko03410,ko03420,ko03430,ko03440,map00230,map00240,map01100,map03018,map03030,map03410,map03420,map03430,map03440 ko:K02335,ko:K02342,ko:K03654,ko:K03722,ko:K10906 2.7.7.7,3.6.4.12 Is involved in the RecE pathway of recombination. Catalyzes the degradation of double-stranded DNA. Acts progressively in a 5' to 3' direction, releasing 5'- phosphomononucleotides. Has a strong preference for linear duplex substrate DNA and appears to be unable to initiate degradation from single-stranded breaks in DNA Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;RNA degradation : Folding, sorting and degradation : Genetic Information Processing;DNA replication : Replication and repair : Genetic Information Processing;Base excision repair : Replication and repair : Genetic Information Processing;Nucleotide excision repair : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing C2_00673 cI ko:K01356 3.4.21.88 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair NA C2_00678 betT ko:K02168 BCCT, betaine/carnitine/choline family transporter NA C2_00681 chaC ko:K07232 Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides NA C2_00687 tolA ko:K03646 Involved in the TonB-independent uptake of group A colicins (colicins A, E1, E2, E3, and K). Necessary for the colicins to reach their respective targets after initial binding to the bacteria. Also involved in the translocation of bacteriophage DNA NA C2_00688 tolA ko:K03646 TolA C-terminal NA C2_00690 rrrD ko:K01185 3.2.1.17 Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity. Exhibits lytic activity against E.coli and S.typhi cell wall substrate NA C2_00691 rzpD ko:K14744 Necessary for host cell lysis. It is believed to code for an endopeptidase that cleaves the amino-carboxyl cross-link between the diaminopimelic acid and D-alanine residues in the murein component of the bacterial cell wall (By similarity) NA C2_00692 trkH ko:K03498 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA NA C2_00696 ko:K07474 Terminase small subunit NA C2_00712 JD73_18915 ko:K01449,ko:K21471 3.5.1.28 JAB/MPN domain NA C2_00716 yeaP ko:K13069 2.7.7.65 diguanylate cyclase activity NA C2_00717 yoaF ko:K09712 Domain of unknown function (DUF333) NA C2_00719 yeaN ko:K03449 response to antibiotic NA C2_00722 yeaK ko:K03976,ko:K19055 Ser-tRNA(Ala) hydrolase activity NA C2_00723 yeaJ ko02026,map02026 ko:K18968 2.7.7.65 negative regulation of cell motility Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_00725 yhbH ko:K09786 Belongs to the UPF0229 family NA C2_00726 prkA ko:K07180 cellular response to nitrogen levels NA C2_00727 mipA ko:K07274 MltA-interacting protein NA C2_00728 yeaE ko00040,ko00051,ko00052,ko00561,ko00790,ko01100,map00040,map00051,map00052,map00561,map00790,map01100 ko:K00011 1.1.1.21 methylglyoxal catabolic process Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00729 yeaD ko00010,ko00290,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00010,map00290,map00770,map01100,map01110,map01120,map01130,map01210,map01230 ko:K01687,ko:K01792 4.2.1.9,5.1.3.15 Belongs to the glucose-6-phosphate 1-epimerase family Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00730 gapA ko00010,ko00710,ko00750,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map00750,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 ko:K00134,ko:K03472 1.2.1.12,1.2.1.72 Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;HIF-1 signaling pathway : Signal transduction : Environmental Information Processing;Alzheimer disease : Neurodegenerative disease : Human Diseases C2_00731 msrB ko:K07305 1.8.4.12 peptide-methionine (R)-S-oxide reductase activity NA C2_00732 yeaC ko:K09916 protein conserved in bacteria NA C2_00733 gutB ko00010,ko00040,ko00051,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00051,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 ko:K00001,ko:K00008 1.1.1.1,1.1.1.14 zinc ion binding Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Fatty acid degradation : Lipid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Chloroalkane and chloroalkene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Naphthalene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Retinol metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolism of xenobiotics by cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_00734 ydjK ko:K08369 transmembrane transporter activity NA C2_00735 ydjJ ko00040,ko00051,ko01100,map00040,map00051,map01100 ko:K00008 1.1.1.14 Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00737 ydjH ko00030,map00030 ko:K00852 2.7.1.15 phosphotransferase activity, alcohol group as acceptor Pentose phosphate pathway : Carbohydrate metabolism : Metabolism C2_00738 ydjG ko00640,map00640 ko:K18471 Catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It is not known if this activity has physiological significance. Cannot use NADPH as a cosubstrate. Seems to play some role in intestinal colonization Propanoate metabolism : Carbohydrate metabolism : Metabolism C2_00740 ydjE ko:K08369 Major facilitator Superfamily NA C2_00741 pncA ko00760,ko01100,map00760,map01100 ko:K08281,ko:K12132 2.7.11.1,3.5.1.19 nicotinamidase activity Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00742 ansA ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 ko:K01424 3.5.1.1 asparagine catabolic process via L-aspartate Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Cyanoamino acid metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_00743 sppA ko:K04773,ko:K04774,ko:K21511 signal peptide peptidase NA C2_00745 selD ko00450,ko01100,map00450,map01100 ko:K01008 2.7.9.3 Synthesizes selenophosphate from selenide and ATP Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00746 topB ko:K03169 5.99.1.2 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone NA C2_00749 gdhA ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 ko:K00262 1.4.1.4 Belongs to the Glu Leu Phe Val dehydrogenases family Arginine biosynthesis : Amino acid metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Nitrogen metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00751 nudG ko:K03574,ko:K08320 3.6.1.55,3.6.1.65 belongs to the nudix hydrolase family NA C2_00752 ynjF ko00564,ko01100,map00564,map01100 ko:K00995 2.7.8.5 Belongs to the CDP-alcohol phosphatidyltransferase class-I family Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00753 ynjE ko04122,map04122 ko:K21028 2.8.1.11 thiosulfate sulfurtransferase activity Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_00754 ynjD ko:K05779 ABC transporter NA C2_00755 ynjC ko02024,map02024 ko:K02053,ko:K05778 ABC transporter permease Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_00756 ynjB ko02024,map02024 ko:K02055,ko:K05777 Bacterial extracellular solute-binding protein Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_00757 ynjA ko:K07486 peroxiredoxin activity NA C2_00761 xthA ko03410,map03410 ko:K01142 3.1.11.2 Major apurinic-apyrimidinic endonuclease of E.coli. It removes the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction. It exhibits 3'-5'-exonuclease, 3'-phosphomonoesterase, 3'-repair diesterase and ribonuclease H activities Base excision repair : Replication and repair : Genetic Information Processing C2_00762 argD ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230 ko:K00821,ko:K00840 2.6.1.11,2.6.1.17,2.6.1.81 Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase Arginine biosynthesis : Amino acid metabolism : Metabolism;Lysine biosynthesis : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00763 astA ko00330,ko01100,map00330,map01100 ko:K00673,ko:K06447 1.2.1.71,2.3.1.109 Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine Arginine and proline metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00764 astD ko00330,ko01100,map00330,map01100 ko:K06447 1.2.1.71 Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate Arginine and proline metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00765 astB ko00330,ko01100,map00330,map01100 ko:K01484 3.5.3.23 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) Arginine and proline metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00766 astE ko00330,ko01100,map00330,map01100 ko:K05526 3.5.1.96 Belongs to the AspA AstE family. Succinylglutamate desuccinylase subfamily Arginine and proline metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00767 spy ko:K06006 An ATP-independent periplasmic chaperone, decreases protein aggregation and helps protein refolding. Binds substrate over a large region NA C2_00768 ves ko:K09975 Belongs to the Ves family NA C2_00769 cho ko00230,ko00240,ko01100,ko03030,ko03420,ko03430,ko03440,map00230,map00240,map01100,map03030,map03420,map03430,map03440 ko:K02342,ko:K03703,ko:K05984 2.7.7.7 When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Nucleotide excision repair : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing C2_00770 nadE ko00760,ko01100,map00760,map01100 ko:K01916 6.3.1.5 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00771 osmE ko:K04064,ko:K06186 response to osmotic stress NA C2_00772 chbB ko00500,ko02060,map00500,map02060 ko:K02760 2.7.1.196,2.7.1.205 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ChbABC PTS system is involved in the transport of the chitin disaccharide N,N'-diacetylchitobiose (GlcNAc2) Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_00773 celB ko00500,ko02060,map00500,map02060 ko:K02761 The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_00774 celC ko00500,ko02060,map00500,map02060 ko:K02759 2.7.1.196,2.7.1.205 Phosphotransferase System Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_00775 chbR ko03410,map03410 ko:K01174,ko:K03490,ko:K10778,ko:K13529,ko:K15051 2.1.1.63,3.1.31.1,3.2.2.21 Dual-function repressor activator of the chbBCARFG operon. In the absence of the inducing sugar chitobiose, together with NagC, represses the chbBCARFG operon for the uptake and metabolism of chitobiose. In association with Crp, and probably in the presence of chitobiose 6-phosphate, induces the transcription of the chbBCARFG operon Base excision repair : Replication and repair : Genetic Information Processing C2_00776 chbF ko00010,ko00500,map00010,map00500 ko:K01222 3.2.1.86 methyl beta-D-glucoside 6-phosphate glucohydrolase activity Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism C2_00777 chbG ko00500,ko02060,map00500,map02060 ko:K02759,ko:K03478 2.7.1.196,2.7.1.205,3.5.1.105 Involved in the degradation of chitin. ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer, the deacetylated form of chitobiose. Deacetylation of chitobiose-6-P and chitotriose-6-P is necessary for both the activation of the chb promoter by the regulatory protein ChbR and the hydrolysis of phosphorylated beta-glucosides by the phospho- beta-glucosidase ChbF. Catalyzes the removal of only one acetyl group from chitobiose-6-P to yield monoacetylchitobiose-6-P, the inducer of ChbR and the substrate of ChbF Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_00778 katE ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014 ko:K03781 1.11.1.6 serves to protect cells from the toxic effects of hydrogen peroxide Tryptophan metabolism : Amino acid metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;MAPK signaling pathway - yeast : Signal transduction : Environmental Information Processing;MAPK signaling pathway - plant : Signal transduction : Environmental Information Processing;FoxO signaling pathway : Signal transduction : Environmental Information Processing;Peroxisome : Transport and catabolism : Cellular Processes;Longevity regulating pathway : Aging : Organismal Systems;Longevity regulating pathway - worm : Aging : Organismal Systems;Longevity regulating pathway - multiple species : Aging : Organismal Systems;Amyotrophic lateral sclerosis : Neurodegenerative disease : Human Diseases C2_00779 cedA ko:K15722 Activates the cell division inhibited by chromosomal DNA over-replication NA C2_00782 ydjN ko:K06956 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family NA C2_00783 ydjM ko:K07038 membrane-bound metal-dependent NA C2_00784 yniC ko:K19270 3.1.3.23 this is a biologically important activity in vivo since it contributes to the elimination of this toxic compound and plays an important role in the resistance of E.coli to 2-deoxyglucose NA C2_00788 pfkB ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230 ko:K00882,ko:K16370 2.7.1.11,2.7.1.56 Belongs to the carbohydrate kinase PfkB family Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00789 ydiY ko:K07283 Protein of unknown function, DUF481 NA C2_00791 ko:K06867 Corresponds to locus_tag NA C2_00792 thrS ko00970,map00970 ko:K01868 6.1.1.3 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_00793 infC ko:K02520 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins NA C2_00794 rpmI ko03010,map03010 ko:K02916 Belongs to the bacterial ribosomal protein bL35 family Ribosome : Translation : Genetic Information Processing C2_00795 rplT ko03010,map03010 ko:K02887 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit Ribosome : Translation : Genetic Information Processing C2_00796 pheS ko00970,map00970 ko:K01889 6.1.1.20 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_00797 pheT ko00970,map00970 ko:K01890 6.1.1.20 phenylalanine-tRNA ligase activity Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_00798 himA ko:K04764 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control NA C2_00799 btuC ko02010,map02010 ko:K06073 Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane ABC transporters : Membrane transport : Environmental Information Processing C2_00800 btuE ko00480,ko00590,ko04918,map00480,map00590,map04918 ko:K00432 1.11.1.9 Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent Glutathione metabolism : Metabolism of other amino acids : Metabolism;Arachidonic acid metabolism : Lipid metabolism : Metabolism;Thyroid hormone synthesis : Endocrine system : Organismal Systems C2_00801 btuD ko02010,map02010 ko:K06074 3.6.3.33 Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_00802 nlpC ko:K13694,ko:K13695,ko:K19303 3.4.17.13 cysteine-type peptidase activity NA C2_00803 ydiV ko02026,map02026 ko:K21086 3.1.4.52 Upon overexpression acts as a novel anti-FlhC(2)FlhD(4) factor, decreasing its DNA-binding activity, able to negatively regulate expression of flagellar class II operons including FliC Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_00804 ydiU ko:K08997 Belongs to the UPF0061 (SELO) family NA C2_00806 aroH ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 ko:K01626 2.5.1.54 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_00807 ydiA ko:K09773 2.7.11.33,2.7.4.28 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation NA C2_00808 ppsA ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 ko:K01007 2.7.9.2 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_00809 fadK ko:K12507 Catalyzes the esterification, concomitant with transport, of exogenous fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Is maximally active on C6 0, C8 0 and C12 0 fatty acids, while has a low activity on C14-C18 chain length fatty acids. Is involved in the anaerobic beta-oxidative degradation of fatty acids, which allows anaerobic growth of E.coli on fatty acids as a sole carbon and energy source in the presence of nitrate or fumarate as a terminal electron acceptor. Can functionally replace FadD under anaerobic conditions NA C2_00810 ydiT ko:K03855 Could be a 3Fe-4S cluster-containing protein NA C2_00811 ydiS ko:K00313 electron transfer flavoprotein-quinone oxidoreductase ydiS NA C2_00812 ydiR ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 ko:K00248,ko:K03522 1.3.8.1 Electron transfer flavoprotein Fatty acid degradation : Lipid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism C2_00813 ydiQ ko:K03521 Electron transfer flavoprotein NA C2_00816 ydiO ko:K08297 1.3.8.13 Acyl-coa dehydrogenase NA C2_00817 ydiF ko00620,ko00627,ko00640,ko00643,ko00650,ko01100,ko01120,map00620,map00627,map00640,map00643,map00650,map01100,map01120 ko:K01026,ko:K19709 2.8.3.1,2.8.3.8 CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Aminobenzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Styrene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_00818 aroD ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko:K03785,ko:K13832 1.1.1.25,4.2.1.10 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00819 aroE ko00020,ko00190,ko00400,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko02020,map00020,map00190,map00400,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map01230,map02020 ko:K00014,ko:K00244,ko:K05887 1.1.1.25,1.1.1.282,1.3.5.4 The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Oxidative phosphorylation : Energy metabolism : Metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_00820 ydiN ko:K03762 Major Facilitator Superfamily NA C2_00821 ydiM ko:K02429,ko:K06141 transporter activity NA C2_00823 ydiK ko:K03548,ko:K11744 ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated NA C2_00825 menI ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K19222 3.1.2.28 Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl- CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA) Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_00827 sufA ko:K05997,ko:K13628 Belongs to the HesB IscA family NA C2_00828 sufB ko:K07033,ko:K09014 The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation NA C2_00829 sufC ko:K09013 Has low ATPase activity. The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation NA C2_00830 sufD ko:K07033,ko:K09015 The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation. Required for the stability of the FhuF protein NA C2_00831 sufS ko00450,ko01100,map00450,map01100 ko:K01766,ko:K11717 2.8.1.7,4.4.1.16 Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine. Selenocysteine lyase activity is however unsure in vivo Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00832 sufE ko00450,ko01100,map00450,map01100 ko:K02426,ko:K11717 2.8.1.7,4.4.1.16 Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00833 ycfS ko01503,map01503 ko:K16291,ko:K19234,ko:K19235,ko:K19236 ErfK YbiS YcfS YnhG family protein Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_00834 lpp ko:K06078 Lipoprotein leucine-zipper NA C2_00835 pyk ko00010,ko00230,ko00261,ko00450,ko00620,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00261,map00450,map00620,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 ko:K00873,ko:K00958 2.7.1.40,2.7.7.4 Pyruvate kinase Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Purine metabolism : Nucleotide metabolism : Metabolism;Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Glucagon signaling pathway : Endocrine system : Organismal Systems;Type II diabetes mellitus : Endocrine and metabolic disease : Human Diseases;Human papillomavirus infection : Infectious disease: viral : Human Diseases;Viral carcinogenesis : Cancer: overview : Human Diseases;Central carbon metabolism in cancer : Cancer: overview : Human Diseases C2_00838 ydhV ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 ko:K03738 1.2.7.5 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_00840 ydhX ko00920,ko01120,ko02020,map00920,map01120,map02020 ko:K04014,ko:K08353,ko:K08358 4 iron, 4 sulfur cluster binding Sulfur metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_00841 ydhU ko00920,ko01120,ko02020,map00920,map01120,map02020 ko:K03620,ko:K08354 Thiosulfate reductase cytochrome b subunit Sulfur metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_00847 ydhQ ko:K12132 2.7.11.1 cellular response to DNA damage stimulus NA C2_00848 mdtK ko:K03327 Multidrug efflux pump that functions probably as a Na( ) drug antiporter NA C2_00849 ribE ko00740,ko01100,ko01110,map00740,map01100,map01110 ko:K00793 2.5.1.9 Riboflavin synthase Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_00850 cfa ko:K00574,ko:K20238 2.1.1.317,2.1.1.79 Transfers a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge NA C2_00852 ydhB ko:K10972 DNA-binding transcription factor activity NA C2_00853 purR ko:K02529,ko:K03604 Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression NA C2_00855 ydhP ko:K08156,ko:K19577 Major facilitator Superfamily NA C2_00856 sodB ko03430,ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map03430,map04013,map04068,map04146,map04211,map04212,map04213,map05016 ko:K03601,ko:K04564 1.15.1.1,3.1.11.6 radicals which are normally produced within the cells and which are toxic to biological systems Mismatch repair : Replication and repair : Genetic Information Processing;MAPK signaling pathway - fly : Signal transduction : Environmental Information Processing;FoxO signaling pathway : Signal transduction : Environmental Information Processing;Peroxisome : Transport and catabolism : Cellular Processes;Longevity regulating pathway : Aging : Organismal Systems;Longevity regulating pathway - worm : Aging : Organismal Systems;Longevity regulating pathway - multiple species : Aging : Organismal Systems;Huntington disease : Neurodegenerative disease : Human Diseases C2_00857 ydhO ko00520,ko01100,map00520,map01100 ko:K01183,ko:K13694,ko:K13695,ko:K19303,ko:K21471 3.2.1.14,3.4.17.13 A murein DD-endopeptidase with specificity for D-Ala- meso-diaminopimelic acid (mDAP) cross-links. Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion. Functionally redundant with MepM and MepH. Partially suppresses an mepS disruption mutant Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00858 grxD ko:K07390 Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters NA C2_00859 lhr ko:K03724 RNA secondary structure unwinding NA C2_00860 rnt ko:K03683 Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis NA C2_00861 gloA ko00620,map00620 ko:K01759 4.4.1.5 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione Pyruvate metabolism : Carbohydrate metabolism : Metabolism C2_00862 nemA ko00633,ko01120,map00633,map01120 ko:K10680 N-ethylmaleimide reductase activity Nitrotoluene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_00863 nemR ko:K16137 Represses the transcription of the nemRA operon by binding to the nemR box NA C2_00864 ydhL ko:K06938 Protein of unknown function (DUF1289) NA C2_00866 sodC ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020 ko:K04565 1.15.1.1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems Peroxisome : Transport and catabolism : Cellular Processes;Longevity regulating pathway - multiple species : Aging : Organismal Systems;Amyotrophic lateral sclerosis : Neurodegenerative disease : Human Diseases;Huntington disease : Neurodegenerative disease : Human Diseases;Prion disease : Neurodegenerative disease : Human Diseases C2_00868 ydhJ ko:K03543,ko:K15548,ko:K15549 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family NA C2_00870 slyA ko:K06075 Transcription regulator that can specifically activate or repress expression of target genes NA C2_00871 slyB ko:K06077 Outer membrane lipoprotein slyB NA C2_00872 anmK ko00520,ko01100,map00520,map01100 ko:K07106,ko:K09001 2.7.1.170,4.2.1.126 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00874 pdxH ko00750,ko01100,ko01120,map00750,map01100,map01120 ko:K00275 1.4.3.5 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_00875 tyrS ko00970,map00970 ko:K01866 6.1.1.1 to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_00876 pdxY ko00750,ko01100,map00750,map01100 ko:K00868 2.7.1.35 Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00877 gst ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 ko:K00799 2.5.1.18 Catalyzes the conjugation of reduced glutathione (GSH) to a wide number of exogenous and endogenous hydrophobic electrophiles. Shows activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and ethacrynic acid. Also possesses thiol disulfide oxidoreductase activity, using GSH to reduce bis-(2-hydroxyethyl) disulfide (HEDS). Has a low level of glutathione-dependent peroxidase activity toward cumene hydroperoxide. Is important for defense against oxidative stress, probably via its peroxidase activity Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolism of xenobiotics by cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Platinum drug resistance : Drug resistance: antineoplastic : Human Diseases;Pathways in cancer : Cancer: overview : Human Diseases;Chemical carcinogenesis : Cancer: overview : Human Diseases;Hepatocellular carcinoma : Cancer: specific types : Human Diseases;Fluid shear stress and atherosclerosis : Cardiovascular disease : Human Diseases C2_00878 dtpA ko:K03305 Proton-dependent permease that transports di- and tripeptides NA C2_00880 nth ko03410,map03410 ko:K10773 4.2.99.18 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate Base excision repair : Replication and repair : Genetic Information Processing C2_00881 rnfE ko00540,ko01100,ko03410,map00540,map01100,map03410 ko:K02560,ko:K03613,ko:K10773 2.3.1.243,4.2.99.18 Part of a membrane complex involved in electron transport. Required to maintain the reduced state of SoxR Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Base excision repair : Replication and repair : Genetic Information Processing C2_00882 rnfG ko:K03612,ko:K03613 Part of a membrane complex involved in electron transport. Required to maintain the reduced state of SoxR NA C2_00883 rnfD ko:K00347,ko:K03614 1.6.5.8 Part of a membrane complex involved in electron transport. Required to maintain the reduced state of SoxR NA C2_00884 rnfC ko:K03615 Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily NA C2_00885 rnfB ko00680,ko01100,ko01120,map00680,map01100,map01120 ko:K00441,ko:K03616 1.12.98.1 Part of a membrane complex involved in electron transport. Required to maintain the reduced state of SoxR Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_00886 rnfA ko:K03617 Part of a membrane complex involved in electron transport. Required to maintain the reduced state of SoxR NA C2_00889 ydgJ ko00562,ko01120,map00562,map01120 ko:K16044 1.1.1.371 oxidoreductase activity Inositol phosphate metabolism : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_00890 add ko00230,ko01100,ko05340,map00230,map01100,map05340 ko:K01488 3.5.4.4 Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Primary immunodeficiency : Immune disease : Human Diseases C2_00891 malY ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 ko:K14155 4.4.1.8 maltose regulon Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_00892 malX ko00010,ko00500,ko00520,ko02060,ko05111,map00010,map00500,map00520,map02060,map05111 ko:K02755,ko:K02756,ko:K02757,ko:K02778,ko:K02779,ko:K02790,ko:K02791,ko:K02802,ko:K02803,ko:K02804,ko:K02818,ko:K02819,ko:K11191,ko:K11192,ko:K20117,ko:K20118 2.7.1.192,2.7.1.193,2.7.1.199,2.7.1.201,2.7.1.208 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in maltose transport. MalX can also recognize and transport glucose even though this sugar may not represent the natural substrate of the system Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_00893 malI ko:K02529,ko:K16136 Maltose regulon Regulatory protein malI NA C2_00895 uidR ko:K16138 HTH-type transcriptional regulator UidR NA C2_00896 uidA ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142 ko:K01195 3.2.1.31 Belongs to the glycosyl hydrolase 2 family Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Glycosaminoglycan degradation : Glycan biosynthesis and metabolism : Metabolism;Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Flavone and flavonol biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Lysosome : Transport and catabolism : Cellular Processes C2_00897 uidB ko:K03292,ko:K11104,ko:K16139 MFS/sugar transport protein NA C2_00898 uidC ko:K16140 Enhances the activity of the UidB (GusB) glucuronide transporter, on its own however it has no transport activity. Glucuronide transport does not occur in strain K12 due to a variant at position 100 of the UidB (GusB, AC P0CE44, AC P0CE45) protein NA C2_00900 manA ko00051,ko00520,ko00860,ko01100,ko01110,ko01130,map00051,map00520,map00860,map01100,map01110,map01130 ko:K01809,ko:K01840,ko:K04035 1.14.13.81,5.3.1.8,5.4.2.8 mannose-6-phosphate isomerase Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_00901 fumA ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200 ko:K01676,ko:K01677,ko:K01678,ko:K03780 4.2.1.2,4.2.1.32 Catalyzes the reversible hydration of fumarate to (S)- malate. Functions as an aerobic enzyme in the direction of malate formation as part of the citric acid cycle. Accounts for about 80 of the fumarase activity when the bacteria grow aerobically. To a lesser extent, also displays D-tartrate dehydratase activity in vitro, but is not able to convert (R)-malate, L-tartrate or meso- tartrate. Can also catalyze the isomerization of enol- to keto- oxaloacetate Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_00902 fumC ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 ko:K01679 4.2.1.2 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Cushing syndrome : Endocrine and metabolic disease : Human Diseases;Pathways in cancer : Cancer: overview : Human Diseases;Renal cell carcinoma : Cancer: specific types : Human Diseases C2_00903 tus ko:K10748 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence NA C2_00906 ydgC ko:K02442 GlpM protein NA C2_00908 ydgI ko:K03758 Arginine ornithine antiporter NA C2_00910 pntA ko00760,ko01100,map00760,map01100 ko:K00324 1.6.1.2 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00911 pntB ko00760,ko01100,map00760,map01100 ko:K00325 1.6.1.2 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00912 tqsA ko:K03548,ko:K11744 permease NA C2_00913 mdtJ ko:K11743 Catalyzes the excretion of spermidine NA C2_00914 mdtI ko:K03297,ko:K11742 Catalyzes the excretion of spermidine NA C2_00915 ydgD ko:K04775 Belongs to the peptidase S1B family NA C2_00917 ynfM ko:K08224 Major facilitator Superfamily NA C2_00919 mlc ko:K02565,ko:K15545 Transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. Regulates the expression of malT NA C2_00920 bioD ko00780,ko01100,map00780,map01100 ko:K01935 6.3.3.3 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00921 clcB ko:K03281 Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response NA C2_00923 dmsC ko00920,map00920 ko:K07308,ko:K07312 Dmso reductase anchor subunit Sulfur metabolism : Energy metabolism : Metabolism C2_00924 dmsB ko00920,map00920 ko:K07307,ko:K07311 Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds Sulfur metabolism : Energy metabolism : Metabolism C2_00925 ynfF ko00450,ko00920,map00450,map00920 ko:K07306,ko:K07309,ko:K07310 1.8.5.3,1.97.1.9 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism C2_00926 ynfE ko00450,ko00920,map00450,map00920 ko:K07306,ko:K07309,ko:K07310 1.8.5.3,1.97.1.9 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism C2_00929 speG ko00330,ko01100,ko04216,map00330,map01100,map04216 ko:K00657 2.3.1.57 Involved in the protection against polyamine toxicity by regulating their concentration. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to the primary amino groups of spermidine to yield N(1)- and N(8)-acetylspermidine Arginine and proline metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Ferroptosis : Cell growth and death : Cellular Processes C2_00931 ynfA ko:K09771 Uncharacterised BCR, YnfA/UPF0060 family NA C2_00932 rspA ko00040,ko01100,map00040,map01100 ko:K08323 4.2.1.8 Has low D-mannonate dehydratase activity (in vitro), suggesting that this is not a physiological substrate and that it has no significant role in D-mannonate degradation in vivo. Has no detectable activity with a panel of 70 other acid sugars (in vitro) Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00933 rspB ko00040,ko01100,map00040,map01100 ko:K08322 1.1.1.380 zinc ion binding Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00934 ko:K18926 Major facilitator Superfamily NA C2_00935 ko:K03733,ko:K14059 Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome (By similarity) NA C2_00937 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02342,ko:K09951,ko:K10906 2.7.7.7 3' exoribonuclease, RNase T-like Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing C2_00939 dicB ko:K22304 Division inhibition protein dicB NA C2_00942 dicA ko:K22300 helix-turn-helix domain protein NA C2_00943 ko:K22302 DNA-binding transcriptional regulator Cro NA C2_00948 hokD ko:K18919 When overexpressed kills the cells from the inside by interfering with a vital function in the cell membrane NA C2_00952 cspA ko:K03704 Cold shock NA C2_00955 rrrQ ko:K01185 3.2.1.17 Corresponds to locus_tag NA C2_00957 cspA ko:K03704 Binds to and stimulates the transcription of the CCAAT- containing, cold-shock-inducible promoters of the H-NS and GyrA proteins. Binds also to the inverted repeat 5'-ATTGG-3' NA C2_00980 kamA ko00310,map00310 ko:K01843,ko:K19810 5.4.3.2 With EpmA is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'. EpmB appears to act before EpmA. Displays lysine 2,3-aminomutase activity, producing (R)-beta-lysine from (S)-alpha-lysine (L-lysine). Cannot use (S)-ornithine or (R)- alpha-lysine as a substrate Lysine degradation : Amino acid metabolism : Metabolism C2_00981 efp ko:K02356 Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation NA C2_00982 ecnA ko:K16347,ko:K16348 Entericidin EcnA/B family NA C2_00983 ecnB ko:K16347,ko:K16348 Entericidin EcnA/B family NA C2_00984 sugE ko:K11741 Quaternary ammonium compound efflux pump. Confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations NA C2_00985 blc ko:K03098,ko:K07071 Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids NA C2_00986 ampC ko01501,ko02020,map01501,map02020 ko:K01467,ko:K19100,ko:K19215 3.5.2.6 beta-lactamase beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing C2_00987 frdD ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 ko:K00247 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Oxidative phosphorylation : Energy metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_00988 frdC ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 ko:K00246 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Oxidative phosphorylation : Energy metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_00989 frdB ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 ko:K00240,ko:K00245 1.3.5.1,1.3.5.4 the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Oxidative phosphorylation : Energy metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_00990 frdA ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134 ko:K00239,ko:K00244 1.3.5.1,1.3.5.4 fumarate reductase, flavoprotein subunit Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Oxidative phosphorylation : Energy metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing;Legionellosis : Infectious disease: bacterial : Human Diseases C2_00991 epmA ko:K04568 With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Catalyzes the ATP-dependent activation of (R)- beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon- amino group of EF-P 'Lys-34' NA C2_00992 yjeM ko02024,map02024 ko:K20265 transmembrane transporter activity Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_00993 yjeP ko05110,map05110 ko:K01421,ko:K02004,ko:K05802,ko:K10953,ko:K12684,ko:K22051 Mechanosensitive channel that protects cells against hypoosmotic stress when highly overexpressed. Gates spontaneously in response to increased membrane tension Vibrio cholerae infection : Infectious disease: bacterial : Human Diseases C2_00994 psd ko00564,ko01100,ko01110,map00564,map01100,map01110 ko:K01613 4.1.1.65 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_00995 rsgA ko00730,ko01100,map00730,map01100 ko:K06949 3.1.3.100 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_00996 orn ko03008,map03008 ko:K13288 3'-to-5' exoribonuclease specific for small oligoribonucleotides Ribosome biogenesis in eukaryotes : Translation : Genetic Information Processing C2_01000 queG ko:K18979 1.17.99.6 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) NA C2_01001 nnrD ko:K17758,ko:K17759 4.2.1.136,5.1.99.6 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration NA C2_01002 yjeE ko:K06925 ATPase or kinase NA C2_01003 amiB ko01503,map01503 ko:K01448 3.5.1.28 N-acetylmuramoyl-L-alanine amidase Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_01004 mutL ko03430,map03430 ko:K03572 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of Mismatch repair : Replication and repair : Genetic Information Processing C2_01005 miaA ko00908,ko01100,ko01110,map00908,map01100,map01110 ko:K00791 2.5.1.75 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) Zeatin biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_01006 hfq ko02024,ko03018,ko05111,map02024,map03018,map05111 ko:K03666 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs Quorum sensing : Cellular community - prokaryotes : Cellular Processes;RNA degradation : Folding, sorting and degradation : Genetic Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_01007 hflX ko:K03665 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis NA C2_01008 hflK ko:K04088 HflC and HflK could encode or regulate a protease NA C2_01009 hflC ko:K04087 HflC and HflK help govern the stability of phage lambda cII protein, and thereby control the lysogenization frequency of phage lambda. HflKC inhibits the SecY-degrading activity of FtsH, possibly helping quality control of integral membrane proteins NA C2_01010 yjeT ko:K09937 Uncharacterized protein conserved in bacteria (DUF2065) NA C2_01011 purA ko00230,ko00250,ko01100,map00230,map00250,map01100 ko:K01939 6.3.4.4 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP Purine metabolism : Nucleotide metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01012 nsrR ko05132,map05132 ko:K13771 Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity Salmonella infection : Infectious disease: bacterial : Human Diseases C2_01013 rnr ko03018,map03018 ko:K12573 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs RNA degradation : Folding, sorting and degradation : Genetic Information Processing C2_01014 rlmB ko:K00556,ko:K03214,ko:K03218,ko:K22132 2.1.1.185,2.1.1.34 Specifically methylates the ribose of guanosine 2251 in 23S rRNA NA C2_01015 yjfI ko03440,map03440 ko:K04066,ko:K09980 Uncharacterized protein conserved in bacteria (DUF2170) Homologous recombination : Replication and repair : Genetic Information Processing C2_01016 yjfJ ko:K03969 identical protein binding NA C2_01018 yjfL ko:K08989 Domain of Unknown Function (DUF350) NA C2_01020 yjfC ko00480,ko01100,map00480,map01100 ko:K01460 3.5.1.78,6.3.1.8 Glutathionylspermidine synthase preATP-grasp Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01021 aidB ko:K09456 Part of the adaptive DNA-repair response to alkylating agents. Could prevent alkylation damage by protecting DNA and destroying alkylating agents that have yet to reach their DNA target. Binds to double-stranded DNA with a preference for a DNA region that includes its own promoter. Shows weak isovaleryl-CoA dehydrogenase activity in vitro NA C2_01023 bsmA ko:K09914 response to hydrogen peroxide NA C2_01024 yjfP ko:K06889 short-chain carboxylesterase activity NA C2_01025 ulaR ko:K03477 Represses ulaG and the ulaABCDEF operon NA C2_01026 ulaG ko00053,ko01100,ko01120,map00053,map01100,map01120 ko:K03476 Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01027 ulaA ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060 ko:K02822,ko:K03475 2.7.1.194 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_01028 ulaB ko00052,ko00053,ko01100,ko01120,ko02060,map00052,map00053,map01100,map01120,map02060 ko:K02774,ko:K02822,ko:K03475 2.7.1.194,2.7.1.200 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport Galactose metabolism : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_01029 ulaC ko00051,ko00052,ko00053,ko01100,ko01120,ko02060,map00051,map00052,map00053,map01100,map01120,map02060 ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02798,ko:K02806,ko:K02821,ko:K08483,ko:K11189,ko:K11198,ko:K11199,ko:K11200,ko:K11201,ko:K18531 2.7.1.194,2.7.1.195,2.7.1.197,2.7.1.200,2.7.1.202,2.7.3.9 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_01030 ulaD ko00030,ko00040,ko00053,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00040,map00053,map00680,map01100,map01120,map01200,map01230 ko:K03078,ko:K08093 4.1.1.85,4.1.2.43 Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01031 ulaE ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120 ko:K03079 5.1.3.22 Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate. Is involved in the anaerobic L-ascorbate utilization Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01032 ulaF ko00040,ko00051,ko00053,ko01100,ko01120,map00040,map00051,map00053,map01100,map01120 ko:K01628,ko:K01629,ko:K03077,ko:K22130 4.1.1.104,4.1.2.17,4.1.2.19,5.1.3.4 Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01034 rpsF ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,ko03010,map00260,map00290,map01100,map01110,map01130,map01200,map01230,map03010 ko:K01754,ko:K02990 4.3.1.19 Binds together with S18 to 16S ribosomal RNA Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Ribosome : Translation : Genetic Information Processing C2_01035 priB ko03440,map03440 ko:K02686 Binds single-stranded DNA at the primosome assembly site (PAS). During primosome assembly it facilitates the complex formation between PriA and DnaT Homologous recombination : Replication and repair : Genetic Information Processing C2_01036 rpsR ko03010,map03010 ko:K02963 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit Ribosome : Translation : Genetic Information Processing C2_01037 rplI ko03010,map03010 ko:K02939 Binds to the 23S rRNA Ribosome : Translation : Genetic Information Processing C2_01039 ytfA ko:K09017 Bacterial regulatory proteins, tetR family NA C2_01040 ytfB ko:K07268,ko:K07269 Opacity-associated protein A N-terminal motif NA C2_01041 fklB ko:K03773 5.2.1.8 peptidyl-prolyl cis-trans isomerase NA C2_01042 cycA ko:K03293,ko:K11737 Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine NA C2_01043 ytfE ko:K07322 Di-iron-containing protein involved in the repair of iron-sulfur clusters NA C2_01047 cpdB ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 ko:K01119,ko:K08693 3.1.3.5,3.1.3.6,3.1.4.16 Belongs to the 5'-nucleotidase family Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_01048 cysQ ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 ko:K01082 3.1.3.7 Belongs to the inositol monophosphatase superfamily. CysQ family Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA C2_01050 ytfJ ko:K07109 Bacterial protein of unknown function (YtfJ_HI0045) NA C2_01052 ytfL ko:K03699 inner membrane protein YtfL NA C2_01053 msrA ko:K07304 1.8.4.11 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine NA C2_01054 ytfM ko:K07278 Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane NA C2_01055 ytfN ko:K09800 Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane. In reconstituted TAM this subunit (Ag43, AC P39180) is not necessary for substrate penetration in the outer membrane. Substrate binding to TamA moves its POTRA domains about 30 Angstroms into the periplasm, which would deform either the outer membrane or TamB and may provide force to reset TAM NA C2_01057 chpS ko:K07172,ko:K18842 Antitoxin component of a type II toxin-antitoxin (TA) system. May be involved in the regulation of cell growth. It acts as a suppressor of the endoribonuclease (inhibitory function) of ChpB protein. Both ChpS and ChpB probably bind to the promoter region of the chpS-chpB operon to autoregulate their synthesis NA C2_01058 chpB ko:K07171,ko:K18841 Toxic component of a toxin-antitoxin (TA) module NA C2_01059 ppa ko00190,map00190 ko:K01507 3.6.1.1 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions Oxidative phosphorylation : Energy metabolism : Metabolism C2_01060 ytfQ ko:K02058 galactose binding NA C2_01061 ytfR ko:K02056 3.6.3.17 ABC transporter, ATP-binding protein NA C2_01062 ytfT ko:K02057 Belongs to the binding-protein-dependent transport system permease family NA C2_01063 yjfF ko:K02057 ABC transporter permease protein YjfF NA C2_01064 fbp ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 ko:K03841 3.1.3.11 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;AMPK signaling pathway : Signal transduction : Environmental Information Processing;Insulin signaling pathway : Endocrine system : Organismal Systems C2_01065 murC ko00471,ko00473,ko00550,ko01100,ko01502,map00471,map00473,map00550,map01100,map01502 ko:K01921,ko:K01924,ko:K02558 6.3.2.4,6.3.2.45,6.3.2.8 Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate D-Glutamine and D-glutamate metabolism : Metabolism of other amino acids : Metabolism;D-Alanine metabolism : Metabolism of other amino acids : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases C2_01066 yjgA ko:K09889 UPF0307 protein YjgA NA C2_01067 pmbA ko:K03592 Metalloprotease involved in CcdA degradation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA) NA C2_01068 cybC ko:K15536 Soluble cytochrome b562 NA C2_01069 relB ko:K07473,ko:K18918 Antitoxin component of a type II toxin-antitoxin (TA) system. Counteracts the effect of cognate toxin RelE via direct protein-protein interaction, preventing RelE from entering the ribosome A site and thus inhibiting its endoribonuclease activity. An autorepressor of relBE operon transcription. 2 RelB dimers bind to 2 operator sequences NA C2_01070 relE ko:K06218 silverDB NA C2_01071 nrdG ko:K04068 1.97.1.4 Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine NA C2_01072 nrdD ko00230,ko00240,ko01100,map00230,map00240,map01100 ko:K21636 1.1.98.6 anaerobic ribonucleoside-triphosphate reductase Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01073 treC ko00500,map00500 ko:K01226 3.2.1.93 Hydrolyzes trehalose-6-phosphate to glucose and glucose 6-phosphate. Can also very effectively hydrolyzes p-nitrophenyl- alpha-D-glucopyranoside, but it does not recognize trehalose, sucrose, maltose, isomaltose, or maltodextrins Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism C2_01074 treB ko00010,ko00500,ko00520,ko02060,ko05111,map00010,map00500,map00520,map02060,map05111 ko:K02749,ko:K02750,ko:K02752,ko:K02753,ko:K02778,ko:K02779,ko:K02790,ko:K02791,ko:K02802,ko:K02803,ko:K02804,ko:K02817,ko:K02818,ko:K02819,ko:K11191,ko:K11192 2.7.1.192,2.7.1.193,2.7.1.199,2.7.1.201,2.7.1.208 PTS system, trehalose-specific Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_01075 treR ko:K03485 repressor NA C2_01076 mgtA ko02010,map02010 ko:K01531,ko:K16905 3.6.3.2 Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily ABC transporters : Membrane transport : Environmental Information Processing C2_01077 ridA ko:K09022 3.5.99.10 Accelerates the release of ammonia from reactive enamine imine intermediates of the PLP-dependent threonine dehydratase (IlvA) in the low water environment of the cell. It catalyzes the deamination of enamine imine intermediates to yield 2-ketobutyrate and ammonia. It is required for the detoxification of reactive intermediates of IlvA due to their highly nucleophilic abilities. Involved in the isoleucine biosynthesis (By similarity) NA C2_01078 pyrI ko00240,ko00250,ko01100,map00240,map00250,map01100 ko:K00608,ko:K00610 2.1.3.2 Involved in allosteric regulation of aspartate carbamoyltransferase Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01079 pyrB ko00240,ko00250,ko01100,map00240,map00250,map01100 ko:K00609 2.1.3.2 Belongs to the ATCase OTCase family Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01082 yjgJ ko:K16137,ko:K19335,ko:K22041 tetR family NA C2_01083 tabA ko00052,ko00511,ko01100,map00052,map00511,map01100 ko:K12112,ko:K19334 Toxin-antitoxin biofilm protein TabA Galactose metabolism : Carbohydrate metabolism : Metabolism;Other glycan degradation : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01085 argF ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 ko:K00611 2.1.3.3 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline Arginine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01086 rraB ko:K09893 Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome NA C2_01087 yjgM ko:K03828 transferase activity, transferring acyl groups NA C2_01089 valS ko00970,map00970 ko:K01873 6.1.1.9 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_01090 holC ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02339 2.7.7.7 Part of the beta sliding clamp loading complex, which hydrolyzes ATP to load the beta clamp onto primed DNA to form the DNA replication pre-initiation complex. DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing C2_01091 pepA ko00480,ko01100,map00480,map01100 ko:K01255,ko:K07751 3.4.11.1,3.4.11.23 involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01092 lptF ko02010,map02010 ko:K07091,ko:K11720 Permease ABC transporters : Membrane transport : Environmental Information Processing C2_01093 lptG ko02010,map02010 ko:K11720 Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane ABC transporters : Membrane transport : Environmental Information Processing C2_01094 yjgR ko:K06915,ko:K19172 Type IV secretion-system coupling protein DNA-binding domain NA C2_01095 yjgR ko:K06915,ko:K19172 Type IV secretion-system coupling protein DNA-binding domain NA C2_01096 gntR ko:K06145,ko:K06146 Idn operon regulator. May repress gntKU and gntT genes when growing on L-idonate NA C2_01097 gntT ko:K03299,ko:K06155,ko:K06157,ko:K13629,ko:K16321 gluconate transporter NA C2_01099 idnD ko:K00098 1.1.1.264 L-idonate 5-dehydrogenase NA C2_01100 idnK ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 ko:K00851 2.7.1.12 gluconokinase activity Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_01101 yjgB ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 ko:K12957,ko:K13953,ko:K13979 1.1.1.1 Catalyzes the reduction of a wide range of aldehydes including aliphatic fatty aldehydes (C4-C16), into their corresponding alcohols. Has a strong preference for NADPH over NADH as the electron donor. Cannot use glyceraldehyde or a ketone as substrate. Is a relevant source of NADPH-dependent aldehyde reductase activity in E.coli. The in vivo functions of Ahr has yet to be determined Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Fatty acid degradation : Lipid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Chloroalkane and chloroalkene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Naphthalene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Retinol metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolism of xenobiotics by cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_01105 ko:K07459 AAA ATPase domain NA C2_01109 ko:K07733 Prophage CP4-57 regulatory protein (AlpA) NA C2_01113 ko:K06919 D5 N terminal like NA C2_01115 ko:K07454 HNH endonuclease NA C2_01116 nanS ko:K22111 Probably catalyzes the hydrolysis of the 9-O-acetyl group of 9-O-acetyl-N-acetylneuraminate (Neu5,9Ac2). Is required for growth of E.coli on Neu5,9Ac2, an alternative sialic acid commonly found in mammalian host mucosal sites, in particular in the human intestine NA C2_01117 nanM ko:K17948 5.1.3.24 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses NA C2_01118 lptD ko:K04744,ko:K22110 Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria NA C2_01120 fimB ko:K07357 FimB is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimB switches fimA on NA C2_01121 fimE ko:K04763,ko:K07357,ko:K07358 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off NA C2_01122 fimA ko05133,map05133 ko:K07345,ko:K07352 Fimbrial protein Pertussis : Infectious disease: bacterial : Human Diseases C2_01123 fimI ko:K07351 pilus assembly NA C2_01124 fimC ko:K07346,ko:K07353,ko:K15540 Required for the biogenesis of type 1 fimbriae. Binds and interact with FimH NA C2_01125 fimD ko05133,map05133 ko:K07347 Outer membrane usher protein fimD Pertussis : Infectious disease: bacterial : Human Diseases C2_01126 fimF ko:K07348 Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Involved in the integration of FimH in the fimbriae NA C2_01127 fimG ko:K07349 Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Involved in the integration of FimH in the fimbriae NA C2_01128 fimH ko:K07350 Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed NA C2_01130 gntP ko:K03299,ko:K06155,ko:K16321 High-affinity gluconate transporter with fairly broad specificity, including low affinity for glucuronate, several disaccharides, and some hexoses, but not glucose NA C2_01131 uxuA ko00040,ko01100,map00040,map01100 ko:K01686 4.2.1.8 Catalyzes the dehydration of D-mannonate Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01132 uxuB ko00040,ko00051,ko01100,map00040,map00051,map01100 ko:K00009,ko:K00040,ko:K00041,ko:K00045,ko:K00854,ko:K19633 1.1.1.17,1.1.1.289,1.1.1.57,1.1.1.58,1.1.1.67,2.7.1.17 Belongs to the mannitol dehydrogenase family Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01133 uxuR ko:K05799,ko:K13637,ko:K19775 Uxu operon transcriptional regulator NA C2_01135 iraD ko:K11897,ko:K21637 Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway NA C2_01136 yjiE ko:K21645 Protects cells from HOCl (hypochlorite) stress but not peroxide or diamide stress. Decreases the intracellular load of reactive oxygen species by up-regulating genes involved in methionine and cysteine biosynthesis and down-regulating Fur- regulated genes involved in iron acquisition. Has also been suggested to down-regulate expression of the flagellar regulon, decreasing motility, but this activity was not confirmed in a second study NA C2_01137 iadA ko:K01305 Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation NA C2_01140 kptA ko:K07559 Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase NA C2_01141 lppY ko05100,map05100 ko:K13735 cell adhesion Bacterial invasion of epithelial cells : Infectious disease: bacterial : Human Diseases C2_01149 mdtM ko:K08160 Confers resistance to acriflavine, chloramphenicol, norfloxacin, ethidium bromide and TPP NA C2_01154 ko:K06877 dEAD DEAH box helicase NA C2_01155 mcrC ko:K19147 DNA restriction-modification system NA C2_01156 mcrB ko:K07452 also binds to GTP. Isoform 33 kDa is less active than isoform 51 kDa and may play a role in regulating the activity of isoform 51 kDa by competing with it in DNA and protein binding abilities NA C2_01157 symE ko:K19048 Involved in the degradation and recycling of damaged RNA. It is itself a target for degradation by the ATP-dependent protease Lon NA C2_01158 ko:K01154 3.1.21.3 Type I restriction modification DNA specificity domain NA C2_01159 hsdM ko:K03427 2.1.1.72 The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated. The EcoKI enzyme recognizes 5'-AACN(6)GTGC-3' NA C2_01160 hsdR ko:K01153 3.1.21.3 The EcoKI enzyme recognizes 5'-AACN(6)GTGC-3'. Subunit R is required for both nuclease and ATPase activities, but not for modification NA C2_01161 mrr ko:K07448 Involved in the acceptance of foreign DNA which is modified. Restricts both adenine- and cytosine-methylated DNA NA C2_01164 cstA ko:K06200 Part of a nutrient-sensing regulatory network composed of the two-component regulatory systems BtsS BtsR and YpdA YpdB, and their respective target proteins, YjiY and YhjX NA C2_01165 tsr ko02020,ko02030,map02020,map02030 ko:K03406,ko:K05874,ko:K05875,ko:K05876,ko:K05877 Methyl-accepting chemotaxis protein Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes C2_01168 yjjN ko00010,ko00040,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 ko:K00001,ko:K00041 1.1.1.1,1.1.1.58 Catalyzes the oxidation of L-galactonate to D- tagaturonate. Required for growth on L-galactonate as the sole carbon source. In vitro, can also use L-gulonate Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fatty acid degradation : Lipid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Chloroalkane and chloroalkene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Naphthalene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Retinol metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolism of xenobiotics by cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_01169 mdoB ko01100,map01100 ko:K01002 2.7.8.20 Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones Metabolic pathways : Global and overview maps : Metabolism C2_01171 dnaC ko:K02315,ko:K10762 This protein is required for chromosomal replication. It forms, in concert with DnaB protein and other prepriming proteins DnaT, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' NA C2_01172 dnaT ko03440,map03440 ko:K02317 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' Homologous recombination : Replication and repair : Genetic Information Processing C2_01175 yjjQ ko02020,ko02024,ko02026,map02020,map02024,map02026 ko:K07781 response to methylglyoxal Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_01176 bglJ ko02020,ko02024,ko02026,map02020,map02024,map02026 ko:K07781 Transcriptional activator protein BglJ Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_01177 fhuF ko:K13255 ferric iron reductase NA C2_01182 rsmC ko:K00564,ko:K11391 2.1.1.172,2.1.1.174 Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle NA C2_01183 holD ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02344 2.7.7.7 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing C2_01184 rimI ko:K01409,ko:K03789,ko:K14742 2.3.1.128,2.3.1.234 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 NA C2_01185 yjjG ko00230,ko00240,ko00361,ko00625,ko00740,ko00760,ko01100,ko01110,ko01120,map00230,map00240,map00361,map00625,map00740,map00760,map01100,map01110,map01120 ko:K01560,ko:K07025,ko:K08723,ko:K20862 3.1.3.102,3.1.3.104,3.1.3.5,3.8.1.2 Nucleotidase that shows high phosphatase activity toward non-canonical pyrimidine nucleotides and three canonical nucleoside 5'-monophosphates (UMP, dUMP, and dTMP), and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6- phosphogluconate. Appears to function as a house-cleaning nucleotidase in vivo, since the general nucleotidase activity of YjjG allows it to protect cells against non-canonical pyrimidine derivatives such as 5-fluoro-2'-deoxyuridine, 5-fluorouridine, 5- fluoroorotate, 5-fluorouracil, and 5-aza-2'-deoxycytidine, and prevents the incorporation of potentially mutagenic nucleotides into DNA. Its dUMP phosphatase activity that catalyzes the hydrolysis of dUMP to deoxyuridine is necessary for thymine utilization via the thymine salvage pathway. Is strictly specific to substrates with 5'-phosphates and shows no activity against nucleoside 2'- or 3'-monophosphates Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Chlorocyclohexane and chlorobenzene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Chloroalkane and chloroalkene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01186 prfC ko:K02837 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP NA C2_01187 osmY ko:K04065 hyperosmotic response NA C2_01190 yjjV ko:K03424 endodeoxyribonuclease activity, producing 5'-phosphomonoesters NA C2_01191 yjjW ko:K04069 1.97.1.4 4 iron, 4 sulfur cluster binding NA C2_01193 deoC ko00030,map00030 ko:K01619 4.1.2.4 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate Pentose phosphate pathway : Carbohydrate metabolism : Metabolism C2_01194 deoA ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 ko:K00756,ko:K00758 2.4.2.2,2.4.2.4 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Bladder cancer : Cancer: specific types : Human Diseases C2_01195 deoB ko00030,ko00230,map00030,map00230 ko:K01839 5.4.2.7 Phosphotransfer between the C1 and C5 carbon atoms of pentose Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Purine metabolism : Nucleotide metabolism : Metabolism C2_01196 deoD ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110 ko:K00772,ko:K03784 2.4.2.1,2.4.2.28 Purine nucleoside phosphorylase Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_01198 lplA ko00785,ko01100,map00785,map01100 ko:K03800 6.3.1.20 Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes Lipoic acid metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01199 lplA ko00500,ko00785,ko01100,ko02020,ko02025,map00500,map00785,map01100,map02020,map02025 ko:K00697,ko:K03800,ko:K07186,ko:K20973 2.4.1.15,2.4.1.347,2.7.13.3,6.3.1.20 Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Lipoic acid metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes C2_01200 serB ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 ko:K01079 3.1.3.3 Catalyzes the dephosphorylation of phosphoserine (P- Ser) Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01201 radA ko:K04485 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function NA C2_01202 nadR ko00760,ko01100,map00760,map01100 ko:K06211 2.7.1.22,2.7.7.1 This enzyme has three activities DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase within the cell, the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity catalyzes the transfer of the AMP moiety of ATP to nicotinamide ribonucleotide to form NAD( ). The NMN adenylyltransferase domain also functions as the NAD and ATP sensor Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01203 yjjK ko:K06020 3.6.3.25 A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P site) into the translation elongation cycle by using a mechanism sensitive to the ATP ADP ratio. Binds to the 70S ribosome E site where it modulates the state of the translating ribosome during subunit translocation NA C2_01204 slt ko:K08309 Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N- acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and or cell division NA C2_01205 trpR ko:K03720 This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region NA C2_01207 gpmB ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 ko:K15634 5.4.2.12 Belongs to the phosphoglycerate mutase family. GpmB subfamily Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01208 rob ko:K05804,ko:K13653 Binds to the right arm of the replication origin oriC of the chromosome. Rob binding may influence the formation of the nucleoprotein structure, required for oriC function in the initiation of replication NA C2_01209 creA ko:K05805 CreA protein NA C2_01212 creD ko:K06143 Inner membrane protein CreD NA C2_01214 trmJ ko:K02533,ko:K15396 2.1.1.200 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA NA C2_01215 thrA ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 ko:K00003,ko:K00928,ko:K12524,ko:K12525 1.1.1.3,2.7.2.4 homoserine dehydrogenase I Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Lysine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01216 thrB ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 ko:K00872 2.7.1.39 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01217 thrC ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 ko:K01733 4.2.3.1 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. To a lesser extent, is able to slowly catalyze the deamination of L-threonine into alpha-ketobutyrate and that of L- serine and 3-chloroalanine into pyruvate. Is also able to rapidly convert vinylglycine to threonine, which proves that the pyridoxal p-quinonoid of vinylglycine is an intermediate in the TS reaction Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01221 pgaB ko02026,map02026 ko:K11931,ko:K21478 Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl- D-glucosamine (PGA), a biofilm adhesin polysaccharide. N- deacetylation promotes PGA export through the PgaA porin Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_01222 pgaC ko02026,map02026 ko:K11936 N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N- acetylglucosamine to produce the linear homopolymer poly-beta-1,6- N-acetyl-D-glucosamine (PGA), a biofilm adhesin polysaccharide Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_01223 pgaD ko02026,map02026 ko:K11937 PgaD-like protein Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_01224 phoH ko:K06217 Phosphate starvation-inducible protein NA C2_01226 efeB ko:K16301 Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact NA C2_01227 efeO ko:K07224 Involved in Fe(2 ) uptake. Could be an iron-binding and or electron-transfer component NA C2_01228 efeU ko:K07243 iron ion transmembrane transporter activity NA C2_01229 putP ko:K11928 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family NA C2_01230 putA ko00071,ko00250,ko00280,ko00330,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00250,map00280,map00330,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 ko:K00249,ko:K00294,ko:K13821 1.2.1.88,1.3.8.7,1.5.5.2 Oxidizes proline to glutamate for use as a carbon and nitrogen source Fatty acid degradation : Lipid metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism;PPAR signaling pathway : Endocrine system : Organismal Systems C2_01231 rutR ko:K09017 transcriptional regulator NA C2_01232 rutA ko00240,ko01100,map00240,map01100 ko:K09018 1.14.99.46 Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01233 rutB ko00240,ko01100,map00240,map01100 ko:K09020 3.5.1.110 In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01234 rutC ko00240,ko01100,map00240,map01100 ko:K09021,ko:K09022 3.5.99.10 May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01235 rutD ko00240,ko01100,map00240,map01100 ko:K09023 May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01236 rutE ko00240,ko01100,map00240,map01100 ko:K09019 May reduce toxic product malonic semialdehyde to 3- hydroxypropionic acid, which is excreted Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01237 rutF ko00240,ko00350,ko00740,ko01100,ko01120,ko01220,map00240,map00350,map00740,map01100,map01120,map01220 ko:K00484,ko:K09024 1.5.1.36 Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_01238 rutG ko:K02824,ko:K03458,ko:K09016,ko:K16345,ko:K16346 permease NA C2_01239 ymdF ko:K06884 Stress-induced bacterial acidophilic repeat motif NA C2_01240 wrbA ko00130,ko01110,map00130,map01110 ko:K03809 1.6.5.2 Belongs to the WrbA family Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_01242 agp ko00010,ko01120,map00010,map01120 ko:K01085 3.1.3.10 glucose-1-phosphatase Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01245 cbpA ko:K03686,ko:K04082,ko:K05516 displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock. Lacks autonomous chaperone activity NA C2_01246 cbpM ko:K18997 Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ NA C2_01247 torD ko02020,map02020 ko:K03533 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor Two-component system : Signal transduction : Environmental Information Processing C2_01248 torA ko00780,ko00920,ko01100,ko02020,map00780,map00920,map01100,map02020 ko:K07306,ko:K07811,ko:K07812,ko:K08351 1.7.2.3,1.8.5.3 an anaerobic reaction coupled to energy-yielding reactions Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_01249 torC ko02020,map02020 ko:K02569,ko:K03532,ko:K07821 Part of the anaerobic respiratory chain of trimethylamine-N-oxide reductase TorA. Acts by transferring electrons from the membranous menaquinones to TorA. This transfer probably involves an electron transfer pathway from menaquinones to the N-terminal domain of TorC, then from the N-terminus to the C-terminus, and finally to TorA. TorC apocytochrome negatively autoregulates the torCAD operon probably by inhibiting the TorS kinase activity Two-component system : Signal transduction : Environmental Information Processing C2_01251 torT ko:K11930 inducer it probably interacts with TorS and allows it to play a role in the induction of the torCAD operon for trimethylamine N-oxide reductase NA C2_01252 torS ko02020,ko02030,map02020,map02030 ko:K03407,ko:K07647,ko:K14978 2.7.13.3 PhoQ Sensor Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes C2_01255 cspG ko:K03704 nucleic acid-templated transcription NA C2_01259 wbfB ko:K07277 extracellular polysaccharide metabolic process NA C2_01260 comEA ko02026,map02026 ko:K01991,ko:K02237 polysaccharide export protein Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_01261 etp ko:K01104 3.1.3.48 low molecular weight NA C2_01262 wzc ko:K16692 Tyrosine-protein kinase NA C2_01263 appA ko00010,ko00562,ko00740,ko01100,ko01120,map00010,map00562,map00740,map01100,map01120 ko:K01085,ko:K01093 3.1.3.10,3.1.3.2,3.1.3.26 myo-inositol hexakisphosphate dephosphorylation Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Inositol phosphate metabolism : Carbohydrate metabolism : Metabolism;Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01265 cydB ko00190,ko01100,ko02020,map00190,map01100,map02020 ko:K00426 1.10.3.14 oxidase, subunit Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_01266 cydA ko00190,ko01100,ko02020,map00190,map01100,map02020 ko:K00425 1.10.3.14 oxidase, subunit Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_01267 hyaF ko05132,map05132 ko:K03618,ko:K12264 Hydrogenase-1 operon protein hyaF Salmonella infection : Infectious disease: bacterial : Human Diseases C2_01268 senC ko:K03619,ko:K07152 Hydrogenase-1 operon protein HyaE NA C2_01269 hyaD ko:K03605,ko:K08315 3.4.23.51 Protease involved in the C-terminal processing of HyaB, the large subunit of hydrogenase 1 NA C2_01270 cybH ko02020,map02020 ko:K03620 Ni Fe-hydrogenase 1 B-type cytochrome subunit Two-component system : Signal transduction : Environmental Information Processing C2_01271 hyaB ko00633,ko01120,map00633,map01120 ko:K06281 1.12.99.6 Belongs to the NiFe NiFeSe hydrogenase large subunit family Nitrotoluene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01272 hyaA ko00633,ko01120,map00633,map01120 ko:K06282 1.12.99.6 This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth Nitrotoluene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01274 yccA ko:K06890,ko:K19416 Belongs to the BI1 family NA C2_01275 tusE ko04122,map04122 ko:K11179 Part of a sulfur-relay system Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_01276 acyP ko00620,ko00627,ko01120,map00620,map00627,map01120 ko:K01512 3.6.1.7 acylphosphatase activity Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Aminobenzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01277 rlmI ko:K06969 2.1.1.191 Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA NA C2_01278 hspQ ko:K11940 Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress NA C2_01279 yccU ko00270,ko01100,map00270,map01100 ko:K01740,ko:K06929 2.5.1.49 cofactor binding Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01280 yccT ko:K09909 Uncharacterized protein conserved in bacteria (DUF2057) NA C2_01281 mgsA ko00640,ko01120,map00640,map01120 ko:K01734 4.2.3.3 methylglyoxal synthase activity Propanoate metabolism : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01282 helD ko:K03658 3.6.4.12 Helicase IV catalyzes the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP NA C2_01285 sxy ko:K07343 Induces low levels of natural DNA uptake by inducing transcription of the competence genes (the CRP-S regulon) required for DNA transformation. Induction of the CRP-S regulon also requires Sxy-activated promoter (CRP-S), cAMP receptor protein (CRP) and cAMP. Induces CRP-S site-containing genes which are involved in genome maintenance and transcription or encoding transposases and toxin-antitoxin pairs NA C2_01286 sulA ko:K13053,ko:K14160 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division NA C2_01287 ompA ko:K03286,ko:K03640 Belongs to the ompA family NA C2_01288 matP ko:K09911 Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain NA C2_01289 ycbZ ko:K04770 Belongs to the peptidase S16 family NA C2_01290 fabA ko00061,ko01100,ko01212,map00061,map01100,map01212 ko:K01716 4.2.1.59,5.3.3.14 Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length Fatty acid biosynthesis : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism C2_01291 rmf ko:K03812 During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) NA C2_01292 ymbA ko:K09857 protein conserved in bacteria NA C2_01293 pqiB ko02010,map02010 ko:K02067,ko:K06192 Paraquat-inducible protein B ABC transporters : Membrane transport : Environmental Information Processing C2_01294 pqiA ko:K03808 paraquat-inducible protein A NA C2_01295 uup ko:K15738 ABC transporter, ATP-binding protein NA C2_01296 rlmL ko:K00571,ko:K06969,ko:K07444,ko:K12297 2.1.1.173,2.1.1.191,2.1.1.264,2.1.1.72 Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA NA C2_01297 ycbX ko00520,map00520 ko:K00523,ko:K04755,ko:K07140,ko:K08952,ko:K08953,ko:K08954 1.17.1.1 Mosc domain protein beta barrel domain protein Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism C2_01298 zapC ko:K18657 Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ NA C2_01299 pyrD ko00240,ko01100,map00240,map01100 ko:K00254,ko:K02823,ko:K17828 1.3.1.14,1.3.5.2 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01300 ycbF ko:K07346,ko:K07353,ko:K15540 chaperone NA C2_01304 ycbS ko05133,map05133 ko:K07347,ko:K07354 Usher protein Pertussis : Infectious disease: bacterial : Human Diseases C2_01305 elfD ko:K07346,ko:K07353,ko:K15540 Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae NA C2_01306 elfA ko05133,map05133 ko:K07345,ko:K07351 Fimbrial Pertussis : Infectious disease: bacterial : Human Diseases C2_01307 ssuE ko00740,ko00920,ko01100,map00740,map00920,map01100 ko:K00299 1.5.1.38 Catalyzes an NADPH-dependent reduction of FMN, but is also able to reduce FAD or riboflavin Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01308 ssuA ko00920,ko02010,map00920,map02010 ko:K02051,ko:K15553 aliphatic sulfonates Sulfur metabolism : Energy metabolism : Metabolism;ABC transporters : Membrane transport : Environmental Information Processing C2_01309 ssuD ko00920,map00920 ko:K04091 1.14.14.5 Belongs to the SsuD family Sulfur metabolism : Energy metabolism : Metabolism C2_01310 ssuC ko00920,ko02010,map00920,map02010 ko:K04091,ko:K15554 1.14.14.5 aliphatic sulfonates transport permease protein ssuC Sulfur metabolism : Energy metabolism : Metabolism;ABC transporters : Membrane transport : Environmental Information Processing C2_01311 ssuB ko00920,ko02010,map00920,map02010 ko:K02049,ko:K15555 Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system Sulfur metabolism : Energy metabolism : Metabolism;ABC transporters : Membrane transport : Environmental Information Processing C2_01312 pepN ko00480,ko01100,map00480,map01100 ko:K01256 3.4.11.2 Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01313 pncB ko00760,ko01100,map00760,map01100 ko:K00763 6.3.4.21 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01314 asnS ko00970,map00970 ko:K01893 6.1.1.22 Asparaginyl-tRNA synthetase Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_01315 ompF ko01501,ko02020,map01501,map02020 ko:K09476 Belongs to the Gram-negative porin family beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing C2_01316 aspC ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 ko:K00813,ko:K00832 2.6.1.1,2.6.1.57 L-aspartate:2-oxoglutarate aminotransferase activity Arginine biosynthesis : Amino acid metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Phenylalanine metabolism : Amino acid metabolism : Metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Novobiocin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Isoquinoline alkaloid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Tropane, piperidine and pyridine alkaloid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01317 ycbL ko00620,map00620 ko:K01069 3.1.2.6 COG0491 Zn-dependent hydrolases, including glyoxylases Pyruvate metabolism : Carbohydrate metabolism : Metabolism C2_01318 ycbK ko:K02395 Bacterial protein of unknown function (DUF882) NA C2_01319 ycbB ko:K21470 cysteine-type carboxypeptidase activity NA C2_01320 mukB ko00130,ko01110,map00130,map01110 ko:K03632,ko:K18286 3.5.4.40 Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_01321 mukE ko02025,map02025 ko:K03804,ko:K21006 Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes C2_01322 mukF ko:K03633 Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity NA C2_01323 cmoM ko:K06219,ko:K20444 Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs NA C2_01326 kdsB ko00540,ko01100,map00540,map01100 ko:K00979 2.7.7.38 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01327 ycaR ko00540,ko01100,map00540,map01100 ko:K00912,ko:K09791 2.7.1.130 Belongs to the UPF0434 family Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01328 ycaQ ko:K09927 protein conserved in bacteria NA C2_01329 lpxK ko00540,ko01100,map00540,map01100 ko:K00912 2.7.1.130 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01330 msbA ko02010,map02010 ko:K02021,ko:K06147,ko:K11085 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation ABC transporters : Membrane transport : Environmental Information Processing C2_01331 ycaI ko:K02238 establishment of competence for transformation NA C2_01332 himD ko:K05788 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control NA C2_01333 rpsA ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 ko:K02945,ko:K03527 1.17.7.4 acts as an RNA chaperone to unfold structured mRNA on the ribosome but is not essential for mRNAs with strong SDs and little 5'-UTR structure, thus it may help fine-tune which mRNAs that are translated. Unwinds dsRNA by binding to transiently formed ssRNA regions Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Ribosome : Translation : Genetic Information Processing C2_01334 cmk ko00240,ko00400,ko00410,ko00740,ko00770,ko00900,ko01100,ko01110,ko01130,ko01230,ko03010,map00240,map00400,map00410,map00740,map00770,map00900,map01100,map01110,map01130,map01230,map03010 ko:K00800,ko:K00945,ko:K02945,ko:K03527,ko:K03977,ko:K11753,ko:K13799 1.17.7.4,2.5.1.19,2.7.1.26,2.7.4.25,2.7.7.2,6.3.2.1 Belongs to the cytidylate kinase family. Type 1 subfamily Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism;Ribosome : Translation : Genetic Information Processing C2_01335 ycaL ko:K07387 metalloprotease NA C2_01336 aroA ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko:K00800 2.5.1.19 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01337 serC ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 ko:K00831 2.6.1.52 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01339 ycaO ko:K09136 ATP diphosphatase activity NA C2_01340 focA ko:K02598,ko:K03459,ko:K06212,ko:K21990,ko:K21993 Involved in the bidirectional transport of formate NA C2_01341 pflB ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 ko:K00656 2.3.1.54 formate C-acetyltransferase activity Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01342 pflA ko:K04069 1.97.1.4 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine NA C2_01343 ycaK ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418 ko:K00355,ko:K03923,ko:K11746,ko:K11748 1.6.5.2 NAD(P)H dehydrogenase (quinone) Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Pathways in cancer : Cancer: overview : Human Diseases;Hepatocellular carcinoma : Cancer: specific types : Human Diseases;Fluid shear stress and atherosclerosis : Cardiovascular disease : Human Diseases C2_01345 ycaM ko02024,map02024 ko:K20265 transmembrane transporter activity Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_01346 ycaD ko:K08219 MFS-type transporter YcaD NA C2_01348 dmsC ko00920,map00920 ko:K07308,ko:K07312 Dimethyl sulfoxide reductase Sulfur metabolism : Energy metabolism : Metabolism C2_01349 dmsB ko00920,map00920 ko:K07307,ko:K07311 Anaerobic dimethyl sulfoxide reductase chain B Sulfur metabolism : Energy metabolism : Metabolism C2_01350 dmsA ko00450,ko00920,map00450,map00920 ko:K07306,ko:K07309,ko:K07310 1.8.5.3,1.97.1.9 Dimethyl sulfoxide reductase Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism C2_01351 serS ko00970,map00970 ko:K01875 6.1.1.11 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_01352 rarA ko:K07478 DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes NA C2_01353 lolA ko:K03634 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) NA C2_01354 ftsK ko02010,map02010 ko:K02011,ko:K02012,ko:K03466 COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins ABC transporters : Membrane transport : Environmental Information Processing C2_01355 lrp ko:K03719,ko:K05800 lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes NA C2_01356 trxB ko00450,ko04621,ko05418,map00450,map04621,map05418 ko:K00384,ko:K03671 1.8.1.9 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family Selenocompound metabolism : Metabolism of other amino acids : Metabolism;NOD-like receptor signaling pathway : Immune system : Organismal Systems;Fluid shear stress and atherosclerosis : Cardiovascular disease : Human Diseases C2_01357 cydD ko02010,map02010 ko:K16013 ATP-binding ABC transporters : Membrane transport : Environmental Information Processing C2_01358 cydC ko02010,map02010 ko:K16012 ATP-binding ABC transporters : Membrane transport : Environmental Information Processing C2_01359 aat ko:K00684 2.3.2.6 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine NA C2_01360 infA ko:K02518 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex NA C2_01363 ko:K03733,ko:K14059 Phage integrase family NA C2_01371 clpA ko:K03694 ATP-dependent specificity component of the ClpAP protease. It directs the protease to specific substrates. It has unfoldase activity. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins NA C2_01372 clpS ko:K06891 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation NA C2_01373 cspD ko:K03704 Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single- stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells NA C2_01374 macB ko02010,map02010 ko:K02003,ko:K02004,ko:K05685 Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation ABC transporters : Membrane transport : Environmental Information Processing C2_01375 macA ko:K02005,ko:K13888 Part of the tripartite efflux system MacAB-TolC. MacA stimulates the ATPase activity of MacB by promoting the closed ATP-bound state of MacB, increases the capacity of MacB to bind macrolides such as erythromycin, and provides a physical link between MacB and TolC NA C2_01376 ybjX ko:K09824 protein conserved in bacteria NA C2_01377 ybjD ko:K07459 ATP-dependent endonuclease of the OLD family NA C2_01378 aqpZ ko:K02440,ko:K06188 Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity NA C2_01380 hcp ko00910,map00910 ko:K05601 1.7.99.1 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O Nitrogen metabolism : Energy metabolism : Metabolism C2_01381 hcr ko:K11933 NADH oxidoreductase NA C2_01382 poxB ko00620,ko01100,map00620,map01100 ko:K00156,ko:K00158 1.2.3.3,1.2.5.1 Belongs to the TPP enzyme family Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01383 ltaE ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 ko:K01620 4.1.2.48 Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01385 ybjS ko00521,ko00523,ko01130,map00521,map00523,map01130 ko:K00067,ko:K01790 1.1.1.133,5.1.3.13 coenzyme binding Streptomycin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Polyketide sugar unit biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;NA : NA : NA C2_01386 amiD ko:K03806,ko:K11066 3.5.1.28 N-acetyl-anhydromuramoyl-L-alanine amidase activity NA C2_01389 artP ko02010,map02010 ko:K10000 Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_01390 artI ko02010,map02010 ko:K09996,ko:K09997 Belongs to the bacterial solute-binding protein 3 family ABC transporters : Membrane transport : Environmental Information Processing C2_01391 artQ ko02010,map02010 ko:K02029,ko:K09999 arginine transporter permease subunit ArtQ ABC transporters : Membrane transport : Environmental Information Processing C2_01392 artM ko02010,map02010 ko:K02029,ko:K09998 Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane ABC transporters : Membrane transport : Environmental Information Processing C2_01393 artJ ko02010,map02010 ko:K09996,ko:K09997 belongs to the bacterial solute-binding protein 3 family ABC transporters : Membrane transport : Environmental Information Processing C2_01394 rumB ko:K03212,ko:K03215 2.1.1.189,2.1.1.190 Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA NA C2_01396 potI ko02010,map02010 ko:K11070,ko:K11074 Required for the activity of the bacterial periplasmic transport system of putrescine ABC transporters : Membrane transport : Environmental Information Processing C2_01397 potH ko02010,map02010 ko:K11075 ABC-type spermidine putrescine transport system, permease component I ABC transporters : Membrane transport : Environmental Information Processing C2_01398 potG ko02010,map02010 ko:K11076 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_01399 potF ko02010,map02010 ko:K11073 Required for the activity of the bacterial periplasmic transport system of putrescine ABC transporters : Membrane transport : Environmental Information Processing C2_01401 rimK ko00250,ko00680,ko01100,ko01120,map00250,map00680,map01100,map01120 ko:K05844,ko:K14940,ko:K18310 6.3.1.17,6.3.2.32,6.3.2.41 Is an L-glutamate ligase that catalyzes the ATP- dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein S6 (RpsF). Is also able to catalyze the synthesis of poly-alpha-glutamate in vitro, via ATP hydrolysis from unprotected glutamate as substrate. The number of glutamate residues added to either RpsF or to poly-alpha-glutamate changes with pH Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01402 nfsA ko00633,ko00740,ko01100,ko01120,map00633,map00740,map01100,map01120 ko:K10678,ko:K19285,ko:K19286 1.5.1.38,1.5.1.39 Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. Major oxygen-insensitive nitroreductase in E.coli Nitrotoluene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01404 grxA ko00230,ko00240,ko01100,map00230,map00240,map01100 ko:K00526,ko:K03674,ko:K03676 1.17.4.1 Glutaredoxin Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01406 ybjL ko:K03281,ko:K07085 potassium ion transport NA C2_01408 ybjJ ko:K02429,ko:K06141 transmembrane transport NA C2_01409 ybjI ko00740,ko01100,ko01110,map00740,map01100,map01110 ko:K07757,ko:K20861 3.1.3.102,3.1.3.104,3.1.3.23 Catalyzes the dephosphorylation of 5-amino-6-(5-phospho- D-ribitylamino)uracil, and thus could be involved in the riboflavin biosynthesis pathway. Is also able to dephosphorylate flavin mononucleotide (FMN), erythrose 4-phosphate and other phosphoric acid esters Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_01411 cmr ko:K08160 Major facilitator Superfamily NA C2_01412 ybjG ko00550,map00550 ko:K19302 3.6.1.27 Overexpression leads to increased undecaprenyl diphosphatase activity and to increased resistance to bacitracin. May have a preferred substrate other than undecaprenyl diphosphate in vivo Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism C2_01413 deoR ko:K11534 transcriptional NA C2_01414 dacC ko00550,ko01100,map00550,map01100 ko:K07258 3.4.16.4 Belongs to the peptidase S11 family Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01415 yliJ ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 ko:K00799 2.5.1.18 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolism of xenobiotics by cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Platinum drug resistance : Drug resistance: antineoplastic : Human Diseases;Pathways in cancer : Cancer: overview : Human Diseases;Chemical carcinogenesis : Cancer: overview : Human Diseases;Hepatocellular carcinoma : Cancer: specific types : Human Diseases;Fluid shear stress and atherosclerosis : Cardiovascular disease : Human Diseases C2_01416 yliI ko:K21430 Can oxidize glucose to gluconolactone. Can also utilize D-arabinose, L- arabinose and 2-deoxy-glucose. Has higher activity towards oligomeric sugars, such as maltose, maltotriose or cellobiose. It may function to input sugar-derived electrons into the respiratory network NA C2_01417 bssR ko:K19688 Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway NA C2_01418 rimO ko:K14441 2.8.4.4 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 NA C2_01420 yliE ko05111,map05111 ko:K20964 3.1.4.52 Overexpression reduces biofilm formation. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_01421 gsiD ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02034,ko:K12370,ko:K13891,ko:K15582,ko:K15586 Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_01422 gsiC ko02010,map02010 ko:K13890 Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane ABC transporters : Membrane transport : Environmental Information Processing C2_01423 gsiB ko02010,map02010 ko:K13889 Extracellular solute-binding protein, family 5 ABC transporters : Membrane transport : Environmental Information Processing C2_01424 gsiA ko02010,ko02024,map02010,map02024 ko:K02031,ko:K02032,ko:K13892 Part of the ABC transporter complex GsiABCD involved in glutathione import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_01425 iaaA ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 ko:K01424,ko:K13051 3.4.19.5,3.5.1.1 Degrades proteins damaged by L-isoaspartyl residue formation (also known as beta-Asp residues). Degrades L- isoaspartyl-containing di- and maybe also tripeptides. Also has L- asparaginase activity, although this may not be its principal function Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Cyanoamino acid metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_01426 moeA ko00790,ko01100,map00790,map01100 ko:K03750 2.10.1.1 Molybdopterin Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01427 moeB ko00730,ko01100,ko04122,map00730,map01100,map04122 ko:K03148,ko:K21029 2.7.7.73,2.7.7.80 molybdopterin-synthase adenylyltransferase activity Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_01428 tal ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 ko:K00616,ko:K08313,ko:K08314 2.2.1.2 Catalyzes the reversible formation of fructose 6- phosphate from dihydroxyacetone and D-glyceraldehyde 3-phosphate via an aldolization reaction Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01429 ybiY ko:K04069 1.97.1.4 Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine NA C2_01430 ybiW ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 ko:K00656 2.3.1.54 formate C-acetyltransferase activity Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01431 supH ko00740,ko01100,ko01110,map00740,map01100,map01110 ko:K07757,ko:K20861 3.1.3.102,3.1.3.104,3.1.3.23 Catalyzes the hydrolysis of sugar phosphate to sugar and inorganic phosphate. Has a wide substrate specificity catalyzing the hydrolysis of ribose-5-phosphate, glucose-6-phosphate, fructose-1-phosphate, acetyl-phosphate, glycerol-1-phosphate, glycerol-2-phosphate, 2-deoxy-glucose-6-phosphate, mannose-6- phosphate and fructose-6-phosphate. Appears to have a low level of phosphotransferase activity using monophosphates as the phosphate donor Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_01434 yeeU ko:K18838 CbeA_antitoxin, type IV, cytoskeleton bundling-enhancing factor A NA C2_01435 dsdC ko:K13636 Transcriptional NA C2_01436 dsdX ko:K03299,ko:K06155,ko:K06157,ko:K13629 A D-serine-specific transporter, may function as a H( ) symporter NA C2_01437 dsdA ko00260,map00260 ko:K01753 4.3.1.18 D-serine dehydratase Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism C2_01438 emrY ko02020,map02020 ko:K03446,ko:K07786 multidrug resistance Two-component system : Signal transduction : Environmental Information Processing C2_01439 emrA ko02020,map02020 ko:K03543,ko:K07797 Multidrug resistance protein Two-component system : Signal transduction : Environmental Information Processing C2_01440 evgA ko02020,ko02024,ko02025,ko02026,ko05111,ko05133,map02020,map02024,map02025,map02026,map05111,map05133 ko:K02282,ko:K07686,ko:K07687,ko:K07688,ko:K07689,ko:K07690,ko:K13246,ko:K20264 3.1.4.52 response regulator Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes;Pertussis : Infectious disease: bacterial : Human Diseases C2_01441 evgS ko02020,ko02026,ko05133,map02020,map02026,map05133 ko:K02486,ko:K07677,ko:K07679 2.7.13.3 PhoQ Sensor Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Pertussis : Infectious disease: bacterial : Human Diseases C2_01442 yfdE ko:K07749,ko:K18702 2.8.3.16,2.8.3.19 Involved in the catabolism of oxalate and in the adapatation to low pH. ACOCT serves to prime the oxalate-induced acid tolerance response (ATR) cycle by producing substrate for oxalyl-CoA decarboxylase (OXC) and formyl-coenzyme A transferase (FCOCT). Catalyzes the reversible conversion of acetyl-CoA and oxalate to oxalyl-CoA and acetate. It can also use formyl-CoA and oxalate to produce oxalyl-CoA and formate with significantly reduced specific activity NA C2_01443 yfdV ko:K07088 transmembrane transport NA C2_01444 oxc ko00630,ko01100,map00630,map01100 ko:K01577 4.1.1.8 Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the decarboxylation of oxalyl-CoA to yield carbon dioxide and formyl-CoA Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01445 frc ko:K07749,ko:K18702 2.8.3.16,2.8.3.19 acyl-CoA transferases carnitine dehydratase NA C2_01449 lpxL ko00540,ko01100,map00540,map01100 ko:K02517,ko:K02560,ko:K12974 2.3.1.241,2.3.1.242,2.3.1.243 Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(palmitoleoyl)-lipid IV(A) Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01450 yfdZ ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 ko:K10206,ko:K14261 2.6.1.83 Aminotransferase Lysine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01451 ypdA ko02020,map02020 ko:K02478,ko:K07704 2.7.13.3 Member of the two-component regulatory system YpdA YpdB, which is part of a nutrient-sensing regulatory network composed of YpdA YpdB, the high-affinity pyruvate signaling system BtsS BtsR and their respective target proteins, YhjX and YjiY. YpdA activates YpdB by phosphorylation in response to high concentrations of extracellular pyruvate. Activation of the YpdA YpdB signaling cascade also promotes BtsS BtsR-mediated yjiY expression Two-component system : Signal transduction : Environmental Information Processing C2_01452 ypdB ko02020,map02020 ko:K02477,ko:K07705 Member of the two-component regulatory system YpdA YpdB, which is part of a nutrient-sensing regulatory network composed of YpdA YpdB, the high-affinity pyruvate signaling system BtsS BtsR and their respective target proteins, YhjX and YjiY. YpdB regulates expression of yhjX by binding to its promoter region. Activation of the YpdA YpdB signaling cascade also promotes BtsS BtsR-mediated yjiY expression Two-component system : Signal transduction : Environmental Information Processing C2_01454 fryA ko00051,ko00052,ko00053,ko00561,ko01100,ko01120,ko02060,map00051,map00052,map00053,map00561,map01100,map01120,map02060 ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02784,ko:K02806,ko:K02821,ko:K05881,ko:K08483,ko:K08485,ko:K11183,ko:K11184,ko:K11189,ko:K11198,ko:K11199,ko:K11200,ko:K11201 2.7.1.121,2.7.1.194,2.7.1.195,2.7.1.200,2.7.1.202,2.7.3.9 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_01455 ypdE ko:K18530,ko:K20609 Has a broad aminopeptidase activity on non-blocked peptides by progressively cleaving amino acids off the peptide substrate. Aminopeptidase activity stops at the residue before the first proline in the peptide. Cannot cleave when proline is the first N-terminal residue NA C2_01456 pepP ko:K01262,ko:K01271,ko:K08326 3.4.11.9,3.4.13.9 Hydrolyzes the N-terminal methionine when the next amino acid is alanine, proline or serine. The substrate preference for methionyl aminopeptidase activity is Pro Ala Ser. Also able to hydrolyze the Xaa-Pro peptide bond when the first amino acid is alanine, asparagine or methionine NA C2_01457 fryC ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 ko:K02768,ko:K02769,ko:K02770,ko:K11198,ko:K11199,ko:K11200,ko:K11203 2.7.1.195,2.7.1.202 The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_01458 fryB ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 ko:K02768,ko:K02769,ko:K02770,ko:K11202,ko:K11203 2.7.1.202 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FryABC PTS system is involved in fructose transport Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_01459 glk ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 ko:K00845 2.7.1.2 Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Streptomycin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Neomycin, kanamycin and gentamicin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_01460 yfeO ko:K03281 ion-transport protein YfeO NA C2_01462 mntH ko:K03322 H( )-stimulated, divalent metal cation uptake system NA C2_01463 nupC ko:K03317,ko:K11535 Transports nucleosides with a high affinity except guanosine and deoxyguanosine. Driven by a proton motive force NA C2_01469 gltX ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 ko:K01885,ko:K09698 6.1.1.17,6.1.1.24 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01476 yfeH ko:K14347 symporter activity NA C2_01477 ypeB ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02342,ko:K09954,ko:K10857 2.7.7.7 Putative quorum-sensing-regulated virulence factor Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing C2_01478 ligA ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 ko:K01972 6.5.1.2 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA DNA replication : Replication and repair : Genetic Information Processing;Base excision repair : Replication and repair : Genetic Information Processing;Nucleotide excision repair : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing C2_01479 zipA ko:K03528 Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of NA C2_01480 cysZ ko:K06203 High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway NA C2_01481 cysK ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 ko:K01738 2.5.1.47 stimulation does not require O-acetylserine sulfhydrylase activity. CdiA is the toxic component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion (experiments done in strains BW25113 and X90, both K12 derivatives). This protein is not required for CDI of strain EC93, whose toxin may function by forming inner cell membrane pores Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01482 ptsH ko00051,ko00561,ko01100,ko01120,ko02060,map00051,map00561,map01100,map01120,map02060 ko:K02768,ko:K02784,ko:K05881,ko:K08485,ko:K11183,ko:K11189 2.7.1.121,2.7.1.202 PTS HPr component phosphorylation site Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_01483 ptsI ko00561,ko02060,map00561,map02060 ko:K05881,ko:K08483,ko:K11189,ko:K11201 2.7.1.121,2.7.3.9 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) Glycerolipid metabolism : Lipid metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_01484 crr ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 ko:K02755,ko:K02756,ko:K02757,ko:K02777 pts system Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_01485 pdxK ko00750,ko01100,map00750,map01100 ko:K00868 2.7.1.35 Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01487 cysM ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 ko:K01738,ko:K12339 2.5.1.47 Belongs to the cysteine synthase cystathionine beta- synthase family Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01488 cysA ko00920,ko02010,map00920,map02010 ko:K02017,ko:K02045,ko:K10112 3.6.3.25,3.6.3.29 Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system Sulfur metabolism : Energy metabolism : Metabolism;ABC transporters : Membrane transport : Environmental Information Processing C2_01489 cysW ko00920,ko02010,map00920,map02010 ko:K02046,ko:K02047 Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate thiosulfate import. Probably responsible for the translocation of the substrate across the membrane Sulfur metabolism : Energy metabolism : Metabolism;ABC transporters : Membrane transport : Environmental Information Processing C2_01490 cysT ko00920,ko02010,map00920,map02010 ko:K02018,ko:K02046 Sulfate transport system permease protein CysT Sulfur metabolism : Energy metabolism : Metabolism;ABC transporters : Membrane transport : Environmental Information Processing C2_01491 cysP ko00920,ko02010,map00920,map02010 ko:K02048 Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate thiosulfate import. This protein specifically binds thiosulfate and is involved in its transmembrane transport Sulfur metabolism : Energy metabolism : Metabolism;ABC transporters : Membrane transport : Environmental Information Processing C2_01493 murR ko:K15835,ko:K19337 Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator NA C2_01494 murQ ko00520,ko01100,map00520,map01100 ko:K07106 4.2.1.126 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01495 murP ko00010,ko00500,ko00520,ko02060,ko05111,map00010,map00500,map00520,map02060,map05111 ko:K02749,ko:K02752,ko:K02753,ko:K02755,ko:K02756,ko:K02757,ko:K02778,ko:K02779,ko:K02790,ko:K02791,ko:K02802,ko:K02803,ko:K02804,ko:K02818,ko:K02819,ko:K11191,ko:K11192 2.7.1.192,2.7.1.193,2.7.1.199,2.7.1.201,2.7.1.208 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_01496 yfeW ko00550,map00550 ko:K21469 3.4.16.4 COG1680 Beta-lactamase class C and other penicillin binding proteins Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism C2_01497 yfeX ko:K07223 peroxidase activity NA C2_01500 ypeA ko:K03826 transferase activity, transferring acyl groups other than amino-acyl groups NA C2_01501 amiA ko01503,map01503 ko:K01448 3.5.1.28 N-acetylmuramoyl-L-alanine amidase amiA Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_01502 hemF ko00860,ko01100,ko01110,map00860,map01100,map01110 ko:K00228 1.3.3.3 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_01503 eutR ko:K04033 Activates the transcription of the eut operon. Also positively regulates its own transcription. Probably binds ethanolamine and vitamin B12 as effectors (By similarity) NA C2_01504 eutK ko:K04025 Ethanolamine utilization protein EutK NA C2_01505 eutL ko:K04026 Carboxysome structural protein involved in ethanolamine utilization NA C2_01506 eutC ko00564,ko01100,map00564,map01100 ko:K03736 4.3.1.7 Belongs to the EutC family Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01507 eutB ko00564,ko01100,ko02010,map00564,map01100,map02010 ko:K03735,ko:K16785 4.3.1.7 ethanolamine ammonia-lyase activity Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;ABC transporters : Membrane transport : Environmental Information Processing C2_01508 eutA ko00564,ko01100,map00564,map01100 ko:K04019 ethanolamine utilization protein Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01509 eutH ko:K04023 ethanolamine utilization protein NA C2_01510 eutG ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130 ko:K04022 Ethanolamine utilization protein eutG Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA C2_01511 eutJ ko:K04024 Ethanolamine utilization NA C2_01512 eutE ko00620,ko00640,ko01100,ko01120,map00620,map00640,map01100,map01120 ko:K04021,ko:K13922 1.2.1.87 Ethanolamine utilization protein EutE Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01513 eutN ko:K04028 May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place NA C2_01514 eutM ko:K04027,ko:K04028 May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place NA C2_01515 pta ko00430,ko00620,ko00640,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00710,map00720,map01100,map01120,map01200 ko:K00029,ko:K00625,ko:K04020,ko:K13788 1.1.1.40,2.3.1.8 phosphate acetyltransferase activity Taurine and hypotaurine metabolism : Metabolism of other amino acids : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_01516 eutT ko00860,ko01100,map00860,map01100 ko:K04032 2.5.1.17 Ethanolamine utilization cobalamin adenosyltransferase Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01517 eutQ ko00564,ko01100,map00564,map01100 ko:K04019,ko:K04030 ethanolamine metabolic process Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01518 eutP ko:K04029 ethanolamine metabolic process NA C2_01519 eutS ko:K04031 May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place NA C2_01520 maeB ko00430,ko00620,ko00640,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02020,map00430,map00620,map00640,map00680,map00710,map00720,map01100,map01120,map01200,map02020 ko:K00027,ko:K00029,ko:K00625,ko:K04020,ko:K13788 1.1.1.38,1.1.1.40,2.3.1.8 malate dehydrogenase (decarboxylating) (NADP+) activity Taurine and hypotaurine metabolism : Metabolism of other amino acids : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_01521 tal ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 ko:K00616,ko:K08313,ko:K08314 2.2.1.2 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01522 tkt ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 ko:K00615 2.2.1.1 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Biosynthesis of ansamycins : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01524 nudK ko00230,map00230 ko:K01515,ko:K12945 3.6.1.13 GDP-mannose pyrophosphatase NudK Purine metabolism : Nucleotide metabolism : Metabolism C2_01525 gltD ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 ko:K00266,ko:K05796,ko:K12136,ko:K15827 1.4.1.13,1.4.1.14 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Nitrogen metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01526 narQ ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 ko:K07673,ko:K07674,ko:K07678 2.7.13.3 Acts as a sensor for nitrate nitrite and transduces signal of nitrate nitrite availability to the NarL NarP proteins. NarQ probably activates NarL and NarP by phosphorylation. NarQ probably negatively regulates the NarL protein by dephosphorylation Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_01527 acrD ko01501,ko01503,ko02020,map01501,map01503,map02020 ko:K03296,ko:K18138,ko:K18324 efflux pump beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing C2_01528 yffB ko:K00537,ko:K16509 1.20.4.1 Belongs to the ArsC family NA C2_01529 dapE ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 ko:K01439 3.5.1.18 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls Lysine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01531 ypfH ko:K06999 carboxylic ester hydrolase activity NA C2_01532 tmcA ko00330,ko01100,ko04216,map00330,map01100,map04216 ko:K00657,ko:K06957 2.3.1.193,2.3.1.57 Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) Arginine and proline metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Ferroptosis : Cell growth and death : Cellular Processes C2_01533 ypfJ ko:K07054 Putative neutral zinc metallopeptidase NA C2_01534 vapC ko:K18828 PIN domain NA C2_01535 mvpT ko:K18829 Antidote-toxin recognition MazE, bacterial antitoxin NA C2_01536 purC ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 ko:K01587,ko:K01756,ko:K01923 4.1.1.21,4.3.2.2,6.3.2.6 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Purine metabolism : Nucleotide metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_01537 bamC ko:K07287 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane NA C2_01538 dapA ko00261,ko00300,ko00760,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map00760,map01100,map01110,map01120,map01130,map01230 ko:K01714,ko:K03517 2.5.1.72,4.3.3.7 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Lysine biosynthesis : Amino acid metabolism : Metabolism;Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01539 gcvR ko02026,map02026 ko:K03567 Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how GcvR acts as a repressor. It does not seem to bind DNA. It could interact with GcvA and suppress its activatory activity Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_01540 bcp ko:K03564 1.11.1.15 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events NA C2_01541 hyfA ko:K05796,ko:K12136,ko:K15827 Formate hydrogenlyase NA C2_01542 hyfB ko:K12137,ko:K15828 Formate hydrogenlyase, subunit NA C2_01543 hyfB ko:K12137,ko:K15828 Formate hydrogenlyase, subunit NA C2_01544 hyfC ko:K12138,ko:K12139,ko:K15829 oxidoreductase activity NA C2_01545 hyfD ko:K12139 hydrogenase 4 NA C2_01546 hyfD ko:K12139 hydrogenase 4 NA C2_01547 hyfD ko:K12139 hydrogenase 4 NA C2_01548 hyfE ko:K12140 Hydrogenase-4 component E NA C2_01549 hyfE ko:K12140 Hydrogenase-4 component E NA C2_01550 hyfF ko:K12141 PFAM NADH Ubiquinone plastoquinone NA C2_01551 hyfG ko:K12142,ko:K15830 nickel cation binding NA C2_01552 hyfH ko:K12143,ko:K15831 electron transfer protein for hydrogenase NA C2_01553 hyfI ko:K12144 NADH ubiquinone oxidoreductase, 20 NA C2_01554 hyfJ ko:K12145,ko:K15834 formate hydrogenlyase maturation NA C2_01555 fhlA ko02020,ko05132,map02020,map05132 ko:K02584,ko:K12146,ko:K12266,ko:K15836 Formate hydrogen-lyase transcriptional activator Two-component system : Signal transduction : Environmental Information Processing;Salmonella infection : Infectious disease: bacterial : Human Diseases C2_01556 focA ko:K02598,ko:K03459,ko:K06212,ko:K21990,ko:K21993 formate transporter NA C2_01557 perM ko:K03548,ko:K11744 transporter activity NA C2_01559 arsC ko:K00537 1.20.4.1 oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor NA C2_01560 hda ko02020,ko04112,map02020,map04112 ko:K02313,ko:K10763 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA Two-component system : Signal transduction : Environmental Information Processing;Cell cycle - Caulobacter : Cell growth and death : Cellular Processes C2_01561 uraA ko:K02824,ko:K09016,ko:K16345,ko:K16346 permease NA C2_01562 upp ko00240,ko01100,map00240,map01100 ko:K00761 2.4.2.9 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01563 purM ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 ko:K01933,ko:K11788 6.3.3.1,6.3.4.13 Phosphoribosylformylglycinamidine cyclo-ligase Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_01564 purN ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 ko:K11175 2.1.2.2 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate Purine metabolism : Nucleotide metabolism : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_01565 ppk ko00190,ko03018,map00190,map03018 ko:K00937 2.7.4.1 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) Oxidative phosphorylation : Energy metabolism : Metabolism;RNA degradation : Folding, sorting and degradation : Genetic Information Processing C2_01566 ppx ko00230,map00230 ko:K01524 3.6.1.11,3.6.1.40 Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain Purine metabolism : Nucleotide metabolism : Metabolism C2_01570 yfgH ko:K06077 Glycine zipper NA C2_01572 guaA ko00230,ko00983,ko01100,map00230,map00983,map01100 ko:K01951 6.3.5.2 Catalyzes the synthesis of GMP from XMP Purine metabolism : Nucleotide metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01573 guaB ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 ko:K00088 1.1.1.205 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth Purine metabolism : Nucleotide metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_01574 xseA ko03430,map03430 ko:K03601 3.1.11.6 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides Mismatch repair : Replication and repair : Genetic Information Processing C2_01576 der ko:K03977 GTPase that plays an essential role in the late steps of ribosome biogenesis NA C2_01577 bamB ko:K17713 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane NA C2_01579 hisS ko00970,map00970 ko:K01892 6.1.1.21 histidyl-tRNA aminoacylation Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_01580 ispG ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko:K03526 1.17.7.1,1.17.7.3 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_01581 rodZ ko:K15539 Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis NA C2_01582 rlmN ko:K06941 2.1.1.192 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs NA C2_01583 ndk ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 ko:K00940 2.7.4.6 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;MAPK signaling pathway - plant : Signal transduction : Environmental Information Processing C2_01584 pbpC ko00550,map00550 ko:K05367 2.4.1.129 penicillin-binding protein 1C Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism C2_01585 yfhM ko:K06894 peptidase regulator activity NA C2_01586 sseA ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 ko:K01011 2.8.1.1,2.8.1.2 Its participation in detoxification of cyanide may be small. May be involved in the enhancement of serine sensitivity Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_01588 pepB ko00480,ko01100,map00480,map01100 ko:K01255,ko:K07751 3.4.11.1,3.4.11.23 Probably plays an important role in intracellular peptide degradation Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01590 fdx ko:K04755 that it has a role as a cellular electron transfer protein. Involved in the in vivo assembly of the Fe-S clusters in a wide variety of iron- sulfur proteins NA C2_01591 hscA ko03018,ko04212,ko05152,map03018,map04212,map05152 ko:K04043,ko:K04044 Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU RNA degradation : Folding, sorting and degradation : Genetic Information Processing;Longevity regulating pathway - worm : Aging : Organismal Systems;Tuberculosis : Infectious disease: bacterial : Human Diseases C2_01592 hscB ko:K04082,ko:K05801 Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA NA C2_01593 iscA ko:K05997,ko:K13628 Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of 2Fe2S cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA TrxB NA C2_01594 iscU ko:K04488 It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters NA C2_01595 iscS ko00730,ko01100,ko04122,map00730,map01100,map04122 ko:K04487 2.8.1.7 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_01596 iscR ko00730,ko01100,ko04122,map00730,map01100,map04122 ko:K04487,ko:K13643 2.8.1.7 Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_01597 trmJ ko00760,ko00970,ko01100,map00760,map00970,map01100 ko:K01883,ko:K02533,ko:K08281,ko:K15396 2.1.1.200,3.5.1.19,6.1.1.16 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing;Metabolic pathways : Global and overview maps : Metabolism C2_01598 suhB ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 ko:K01092 3.1.3.25 inositol metabolic process Streptomycin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Inositol phosphate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Phosphatidylinositol signaling system : Signal transduction : Environmental Information Processing C2_01599 yfhR ko:K06889 Prolyl oligopeptidase family NA C2_01601 hcaT ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 ko:K00286,ko:K05820,ko:K08161 1.5.1.2 Major facilitator Superfamily Arginine and proline metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01602 hcaR ko:K05817 transcriptional activator of NA C2_01603 hcaE ko00360,ko01120,ko01220,map00360,map01120,map01220 ko:K05708 1.14.12.19 Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively Phenylalanine metabolism : Amino acid metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_01604 hcaF ko00360,ko01120,ko01220,map00360,map01120,map01220 ko:K05709 1.14.12.19 Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively Phenylalanine metabolism : Amino acid metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_01605 hcaC ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220 ko:K00363,ko:K05710 1.7.1.15 Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP- dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively. This protein seems to be a 2Fe-2S ferredoxin Phenylalanine metabolism : Amino acid metabolism : Metabolism;Nitrogen metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_01607 hcaD ko00071,ko00360,ko00910,ko01120,ko01220,ko05132,map00071,map00360,map00910,map01120,map01220,map05132 ko:K00362,ko:K00529,ko:K12265 1.18.1.3,1.7.1.15 pyridine nucleotide-disulphide oxidoreductase Fatty acid degradation : Lipid metabolism : Metabolism;Phenylalanine metabolism : Amino acid metabolism : Metabolism;Nitrogen metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism;Salmonella infection : Infectious disease: bacterial : Human Diseases C2_01608 yphA ko:K15977 SURF4 family NA C2_01609 yphB ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 ko:K01785 5.1.3.3 aldose 1-epimerase activity Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA C2_01610 yphC ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 ko:K13953 1.1.1.1 zinc ion binding Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Fatty acid degradation : Lipid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Chloroalkane and chloroalkene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Naphthalene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Retinol metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolism of xenobiotics by cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_01611 yphD ko02010,map02010 ko:K02057,ko:K10440 the binding-protein-dependent transport system ABC transporters : Membrane transport : Environmental Information Processing C2_01612 yphE ko02010,map02010 ko:K02056,ko:K10441 3.6.3.17 ABC transporter, ATP-binding protein ABC transporters : Membrane transport : Environmental Information Processing C2_01613 yphF ko02010,ko02030,map02010,map02030 ko:K02058,ko:K10439 ABC transporter ABC transporters : Membrane transport : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes C2_01615 yphH ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 ko:K00845 2.7.1.2 ROK family Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Streptomycin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Neomycin, kanamycin and gentamicin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_01616 glyA ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 ko:K00600 2.1.2.1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Cyanoamino acid metabolism : Metabolism of other amino acids : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Antifolate resistance : Drug resistance: antineoplastic : Human Diseases C2_01617 hmp ko05132,map05132 ko:K05916 1.14.12.17 Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress Salmonella infection : Infectious disease: bacterial : Human Diseases C2_01618 glnB ko02020,map02020 ko:K04751,ko:K04752 Nitrogen regulatory protein P-II Two-component system : Signal transduction : Environmental Information Processing C2_01619 yfhA ko02020,ko02024,map02020,map02024 ko:K07715 Member of the two-component regulatory system GlrR GlrK that up-regulates transcription of the glmY sRNA when cells enter the stationary growth phase. Regulates glmY transcription by binding to three conserved sites in the purL-glmY intergenic region Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_01620 yfhG ko01501,ko01503,ko02020,map01501,map01503,map02020 ko:K02487,ko:K18138 YfhG lipoprotein beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing C2_01622 purL ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 ko:K01952 6.3.5.3 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_01623 mltF ko:K18691 Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella NA C2_01624 tadA ko00230,ko00240,ko00330,ko00361,ko00625,ko01100,ko01120,map00230,map00240,map00330,map00361,map00625,map01100,map01120 ko:K01297,ko:K01485,ko:K01487,ko:K01563,ko:K11991 3.4.17.13,3.5.4.1,3.5.4.3,3.5.4.33,3.8.1.5 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;Chlorocyclohexane and chlorobenzene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Chloroalkane and chloroalkene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01625 yfhB ko00564,map00564 ko:K18697 3.1.3.27 phosphatidylglycerophosphatase activity Glycerophospholipid metabolism : Lipid metabolism : Metabolism C2_01626 yfhH ko:K15835,ko:K19337 Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator NA C2_01627 yfhL ko:K03522,ko:K05337 4 iron, 4 sulfur cluster binding NA C2_01628 acpS ko00520,ko00531,ko00770,ko01100,ko01501,map00520,map00531,map00770,map01100,map01501 ko:K00997,ko:K01207 2.7.8.7,3.2.1.52 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Glycosaminoglycan degradation : Glycan biosynthesis and metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases C2_01629 pdxJ ko00750,ko01100,map00750,map01100 ko:K03474 2.6.99.2 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01630 recO ko00750,ko01100,ko03440,map00750,map01100,map03440 ko:K03474,ko:K03584 2.6.99.2 Involved in DNA repair and RecF pathway recombination Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Homologous recombination : Replication and repair : Genetic Information Processing C2_01631 era ko:K03595 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism NA C2_01632 rnc ko03008,ko05205,map03008,map05205 ko:K03685 3.1.26.3 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism Ribosome biogenesis in eukaryotes : Translation : Genetic Information Processing;Proteoglycans in cancer : Cancer: overview : Human Diseases C2_01633 lepB ko02024,ko03060,map02024,map03060 ko:K03100 3.4.21.89 Belongs to the peptidase S26 family Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing C2_01634 lepA ko05134,map05134 ko:K03596 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner Legionellosis : Infectious disease: bacterial : Human Diseases C2_01635 rseC ko:K03803 Sigma-E factor regulatory protein RseC NA C2_01636 rseB ko:K03598 Negatively modulates the activity of sigma-E (RpoE) by stabilizing RseA under non-stress conditions. Although not essential for association of sigma-E with Rsea it increases their affinity 2- to 3-fold. When bound to RseA it prevents proteolysis by DegS, which is probably relieved by lipopolysaccharide binding (LPS) NA C2_01637 rseA ko:K03597 An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E NA C2_01638 rpoE ko:K03088 Sigma factors are initiation factors that promote the attachment of RNA polymerase (RNAP) to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma-E controls the envelope stress response, responding to periplasmic protein stress, increased levels of periplasmic lipopolysaccharide (LPS) as well as heat shock and oxidative stress NA C2_01639 nadB ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020 ko:K00244,ko:K00278 1.3.5.4,1.4.3.16 Catalyzes the oxidation of L-aspartate to iminoaspartate Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Oxidative phosphorylation : Energy metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_01640 yfiC ko:K00571,ko:K15460 2.1.1.223,2.1.1.72 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) NA C2_01641 srmB ko03018,map03018 ko:K05590,ko:K11927 3.6.4.13 DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity RNA degradation : Folding, sorting and degradation : Genetic Information Processing C2_01642 cutF ko01503,map01503 ko:K06079 Copper homeostasis Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_01643 yaeJ ko:K15034 Rescues stalled ribosomes. Can hydrolyze peptidyl-tRNA on ribosomes stalled by both non-stop mRNAs and mRNAs that contain rare codon clusters or ribosomes stalled in the middle of mRNA. First identified as a complementary ribosome rescue system when the stalled ribosome cannot be rescued by the SsrA(tmRNA)-SmpB quality control system or the alternative ribosome-rescue factor A (arfA) NA C2_01646 rof ko:K19000 Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination NA C2_01647 tilS ko:K04075,ko:K14058 6.3.4.19 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine NA C2_01648 yaeR ko:K08234 metal ion binding NA C2_01649 ldcC ko00310,ko00330,ko00480,ko00960,ko01100,ko01110,ko01130,map00310,map00330,map00480,map00960,map01100,map01110,map01130 ko:K01581,ko:K01582,ko:K01584,ko:K01585 4.1.1.17,4.1.1.18,4.1.1.19 lysine decarboxylase Lysine degradation : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;Glutathione metabolism : Metabolism of other amino acids : Metabolism;Tropane, piperidine and pyridine alkaloid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_01650 accA ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 ko:K01962,ko:K01963 2.1.3.15,6.4.1.2 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA Fatty acid biosynthesis : Lipid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism C2_01651 dnaE ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02337 2.7.7.7 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing C2_01652 rnhB ko03030,map03030 ko:K03470 3.1.26.4 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids DNA replication : Replication and repair : Genetic Information Processing C2_01653 lpxB ko00540,ko01100,map00540,map01100 ko:K00748 2.4.1.182 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01654 lpxA ko00540,ko01100,ko01503,map00540,map01100,map01503 ko:K00677 2.3.1.129 involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_01655 fabZ ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 ko:K02372 4.2.1.59 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs Fatty acid biosynthesis : Lipid metabolism : Metabolism;Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism C2_01656 lpxD ko00540,ko01100,map00540,map01100 ko:K02536 2.3.1.191 Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01657 skp ko:K06142 Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm NA C2_01658 bamA ko:K07277 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery NA C2_01659 rseP ko01503,ko02020,ko02024,ko04112,map01503,map02020,map02024,map04112 ko:K04771,ko:K11749 3.4.21.107 A site-2 regulated intramembrane protease (S2P) that cleaves the peptide bond between 'Ala-108' and 'Cys-109' in the transmembrane region of RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. Acts on DegS-cleaved RseA to release the cytoplasmic domain of RseA Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Cell cycle - Caulobacter : Cell growth and death : Cellular Processes C2_01660 cdsA ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 ko:K00981 2.7.7.41 Belongs to the CDS family Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Phosphatidylinositol signaling system : Signal transduction : Environmental Information Processing C2_01662 uppS ko00900,ko01110,map00900,map01110 ko:K00806 2.5.1.31 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_01663 dxr ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko:K00099 1.1.1.267 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_01664 frr ko:K02838 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another NA C2_01665 pyrH ko00240,ko01100,map00240,map01100 ko:K09903 2.7.4.22 Catalyzes the reversible phosphorylation of UMP to UDP Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01666 tsf ko:K02357 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome NA C2_01667 rpsB ko03010,map03010 ko:K02967 ribosomal protein Ribosome : Translation : Genetic Information Processing C2_01668 map ko:K01265 3.4.11.18 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed NA C2_01669 glnD ko02020,map02020 ko:K00990 2.7.7.59 in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen Two-component system : Signal transduction : Environmental Information Processing C2_01670 dapD ko00300,ko01100,ko01110,ko01120,ko01230,map00300,map01100,map01110,map01120,map01230 ko:K00674,ko:K05822 2.3.1.117,2.3.1.89 Belongs to the transferase hexapeptide repeat family Lysine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01672 cdaR ko:K02647 diacid regulator NA C2_01673 degP ko01503,ko02020,map01503,map02020 ko:K04771,ko:K04772,ko:K08070 1.3.1.74,3.4.21.107 DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. Degrades transiently denatured and unfolded or misfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins. Its proteolytic activity is essential for the survival of cells at elevated temperatures. It can degrade IciA, Ada, casein, globin and PapA. DegP shares specificity with DegQ. DegP is also involved in the biogenesis of partially folded outer-membrane proteins (OMP) Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing C2_01674 dgt ko00230,map00230 ko:K01129 3.1.5.1 dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs Purine metabolism : Nucleotide metabolism : Metabolism C2_01675 mtnN ko00270,ko01100,ko01230,map00270,map01100,map01230 ko:K01243 3.2.2.9 Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01676 btuF ko02010,map02010 ko:K02016,ko:K06858 Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC ABC transporters : Membrane transport : Environmental Information Processing C2_01678 erpA ko:K13628,ko:K15724 Probably involved in the insertion of Fe-S clusters into apoproteins in vivo including IspG and or IspH. Essential for growth under aerobic conditions and for anaerobic respiration but not for fermentation. In vitro it binds Fe-S clusters and transfers them to apo-IspG, which is involved in quinone biosynthesis among many other cell components. Experiments indicate that it is probably also involved in the insertion of other Fe-S clusters than IspG IspH NA C2_01679 clcA ko:K03281 proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response NA C2_01680 hemL ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 ko:K01845 5.4.3.8 glutamate-1-semialdehyde 2,1-aminomutase activity Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01681 fhuB ko02010,map02010 ko:K02015 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily ABC transporters : Membrane transport : Environmental Information Processing C2_01682 fhuD ko02010,map02010 ko:K02016 Part of the ABC transporter complex FhuCDB involved in iron(3 )-hydroxamate import. Binds the iron(3 )-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3 )-hydroxamate siderophores such as ferrichrome, gallichrome, desferrioxamine, coprogen, aerobactin, shizokinen, rhodotorulic acid and the antibiotic albomycin ABC transporters : Membrane transport : Environmental Information Processing C2_01683 fhuC ko02010,map02010 ko:K02013 3.6.3.34 Part of the ABC transporter complex FhuCDB involved in iron(3 )-hydroxamate import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_01684 fhuA ko:K02014 Involved in the uptake of iron in complex with ferrichrome, an hydroxamate-type siderophore. Binds and transports ferrichrome-iron across the outer membrane. In addition to its role in ferrichrome-iron transport, transports the antibiotic albomycin, which is a structural analog of ferrichrome, and acts as a receptor for colicin M, microcin J25 and bacteriophages T1, T5, phi80 and UC-1. The energy source, which is required for all FhuA functions except infection by phage T5, is provided by the inner membrane TonB system NA C2_01685 mrcB ko00550,map00550 ko:K05365 2.4.1.129,3.4.16.4 Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism C2_01686 hrpB ko:K03579 3.6.4.13 ATP-dependent helicase activity NA C2_01687 ligT ko00760,map00760 ko:K01975,ko:K03743 3.1.4.58,3.5.1.42 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism C2_01688 sfsA ko:K06206 Binds to DNA non-specifically. Could be a regulatory factor involved in maltose metabolism NA C2_01689 dksA ko02026,map02026 ko:K06204 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_01690 gluQ ko:K01894 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon NA C2_01691 pcnB ko03013,ko03018,map03013,map03018 ko:K00970,ko:K00974 2.7.7.19,2.7.7.72 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control RNA transport : Translation : Genetic Information Processing;RNA degradation : Folding, sorting and degradation : Genetic Information Processing C2_01692 folK ko00790,ko01100,map00790,map01100 ko:K00950,ko:K13940 2.7.6.3,4.1.2.25 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01694 ecpD ko:K07346,ko:K07353,ko:K15540 Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches NA C2_01695 htrE ko05133,map05133 ko:K07347 outer membrane usher protein Pertussis : Infectious disease: bacterial : Human Diseases C2_01696 yadM ko05133,map05133 ko:K07345 Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches Pertussis : Infectious disease: bacterial : Human Diseases C2_01699 yadC ko:K07350 Fimbrial protein NA C2_01700 panB ko00770,ko01100,ko01110,map00770,map01100,map01110 ko:K00606 2.1.2.11 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_01701 panC ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 ko:K01918 6.3.2.1 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_01703 panD ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 ko:K01579 4.1.1.11 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_01704 yadE ko00520,ko01100,map00520,map01100 ko:K01452 3.5.1.41 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01705 yadI ko00052,ko02060,map00052,map02060 ko:K02744 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane Galactose metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_01706 yadH ko:K01992 Transport Permease Protein NA C2_01707 yadG ko02010,map02010 ko:K01990,ko:K09695 ABC transporter, ATP-binding protein ABC transporters : Membrane transport : Environmental Information Processing C2_01708 can ko00910,map00910 ko:K01673 4.2.1.1 Reversible hydration of carbon dioxide Nitrogen metabolism : Energy metabolism : Metabolism C2_01709 hpt ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 ko:K00760 2.4.2.8 Belongs to the purine pyrimidine phosphoribosyltransferase family Purine metabolism : Nucleotide metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_01710 gcd ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 ko:K00117 1.1.5.2 Glucose dehydrogenase Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_01711 cueO ko:K04753,ko:K14588 Probably involved in periplasmic detoxification of copper by oxidizing Cu( ) to Cu(2 ) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm NA C2_01713 speE ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 ko:K00797 2.5.1.16 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01714 speD ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 ko:K00797,ko:K01611 2.5.1.16,4.1.1.50 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01715 yacL ko:K09910 Belongs to the UPF0231 family NA C2_01716 acnB ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 ko:K01682 4.2.1.3,4.2.1.99 Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Also catalyzes the hydration of 2-methyl-cis- aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnB functions as a RNA-binding regulatory protein. During oxidative stress inactive AcnB apo-enzyme without iron sulfur clusters binds the acnB mRNA 3' UTRs (untranslated regions), stabilizes acnB mRNA and increases AcnB synthesis, thus mediating a post-transcriptional positive autoregulatory switch. AcnB also decreases the stability of the sodA transcript Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01718 lpdA ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 ko:K00382 1.8.1.4 Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_01719 aceF ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 ko:K00627 2.3.1.12 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_01720 aceE ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 ko:K00163 1.2.4.1 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_01721 pdhR ko:K05799 Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd NA C2_01722 aroP ko:K03293,ko:K11732,ko:K11734 Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) NA C2_01723 ampE ko00860,ko01100,map00860,map01100 ko:K02227,ko:K03807 6.3.1.10 regulatory protein AmpE Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01724 ampD ko:K03806,ko:K11066 3.5.1.28 Involved in both cell wall peptidoglycans recycling and beta-lactamase induction. Specifically cleaves the amide bond between the lactyl group of N-acetylmuramic acid and the alpha- amino group of the L-alanine in degradation products containing an anhydro N-acetylmuramyl moiety (By similarity) NA C2_01725 nadC ko00760,ko01100,map00760,map01100 ko:K00767 2.4.2.19 Belongs to the NadC ModD family Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01726 ppdD ko02020,map02020 ko:K02650,ko:K02682 Prokaryotic N-terminal methylation motif Two-component system : Signal transduction : Environmental Information Processing C2_01727 hofB ko03070,ko05111,map03070,map05111 ko:K02454,ko:K02504,ko:K02652 ATP binding Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_01728 hofC ko03070,ko05111,map03070,map05111 ko:K02455,ko:K02505,ko:K02653 protein transport across the cell outer membrane Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_01729 guaC ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 ko:K00088,ko:K00364 1.1.1.205,1.7.1.7 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides Purine metabolism : Nucleotide metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_01730 coaE ko00770,ko01100,map00770,map01100 ko:K00859 2.7.1.24 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01731 zapD ko:K18778 Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity NA C2_01732 yacG ko00770,ko01100,map00770,map01100 ko:K00859,ko:K09862 2.7.1.24 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01733 mutT ko:K03574,ko:K08320 3.6.1.55,3.6.1.65 Belongs to the Nudix hydrolase family NA C2_01734 secA ko02024,ko03060,ko03070,map02024,map03060,map03070 ko:K03070 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_01735 secM ko03060,ko03070,map03060,map03070 ko:K13301 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_01736 lpxC ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212 ko:K02535,ko:K16363 3.5.1.108,4.2.1.59 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis Fatty acid biosynthesis : Lipid metabolism : Metabolism;Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism C2_01737 ftsZ ko04112,map04112 ko:K03531 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity Cell cycle - Caulobacter : Cell growth and death : Cellular Processes C2_01738 ftsA ko04112,map04112 ko:K03590 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring Cell cycle - Caulobacter : Cell growth and death : Cellular Processes C2_01739 ftsQ ko00473,ko00550,ko01100,ko01502,ko04112,map00473,map00550,map01100,map01502,map04112 ko:K01921,ko:K03589 6.3.2.4 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly D-Alanine metabolism : Metabolism of other amino acids : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases;Cell cycle - Caulobacter : Cell growth and death : Cellular Processes C2_01740 ddl ko00473,ko00520,ko00550,ko01100,ko01502,map00473,map00520,map00550,map01100,map01502 ko:K00075,ko:K01921 1.3.1.98,6.3.2.4 Belongs to the D-alanine--D-alanine ligase family D-Alanine metabolism : Metabolism of other amino acids : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases C2_01741 murC ko00471,ko00550,ko01100,map00471,map00550,map01100 ko:K01924,ko:K02558 6.3.2.45,6.3.2.8 Belongs to the MurCDEF family D-Glutamine and D-glutamate metabolism : Metabolism of other amino acids : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01742 murG ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 ko:K02563 2.4.1.227 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases;Cell cycle - Caulobacter : Cell growth and death : Cellular Processes C2_01743 ftsW ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 ko:K02563,ko:K03588 2.4.1.227 Peptidoglycan polymerase that is essential for cell division Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases;Cell cycle - Caulobacter : Cell growth and death : Cellular Processes C2_01744 murD ko00471,ko00550,ko01100,map00471,map00550,map01100 ko:K01925 6.3.2.9 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) D-Glutamine and D-glutamate metabolism : Metabolism of other amino acids : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01745 mraY ko00550,ko01100,ko01502,map00550,map01100,map01502 ko:K01000 2.7.8.13 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases C2_01746 murF ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 ko:K01929 6.3.2.10 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein Lysine biosynthesis : Amino acid metabolism : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases C2_01747 murE ko00300,ko00550,ko01501,map00300,map00550,map01501 ko:K01928,ko:K03587,ko:K15792 3.4.16.4,6.3.2.10,6.3.2.13 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan Lysine biosynthesis : Amino acid metabolism : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases C2_01748 ftsI ko00550,ko01100,ko01501,map00550,map01100,map01501 ko:K03587,ko:K08384,ko:K08724,ko:K12552,ko:K12556 3.4.16.4 of the peptidoglycan cell wall at the division septum Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases C2_01749 ftsL ko:K03586 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic NA C2_01750 rsmH ko:K03438 2.1.1.199 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA NA C2_01751 mraZ ko:K03925 Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster NA C2_01752 fruR ko00052,ko00500,ko01100,map00052,map00500,map01100 ko:K01193,ko:K02529,ko:K03435 3.2.1.26 Global transcriptional regulator, which plays an important role in the regulation of carbon metabolism Galactose metabolism : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01753 ilvH ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 ko:K01653 2.2.1.6 acetolactate synthase Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01754 ilvI ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 ko:K01652 2.2.1.6 acetolactate synthase activity Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01755 leuO ko:K05798 uxaCA, sdaCB and yjiY. H-NS repression of the bgl operon, leading to the ability to metabolize some beta-glucosides. It also directly activates the bgl operon. Activation is H-NS and BglJ-RcsB independent NA C2_01756 leuA ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 ko:K01649 2.3.3.13 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01757 leuB ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 ko:K00052 1.1.1.85 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01758 leuC ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 ko:K01703 4.2.1.33,4.2.1.35 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Glucosinolate biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01759 leuD ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 ko:K01704 4.2.1.33,4.2.1.35 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01760 setA ko:K03291 Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport IPTG, lactose and glucose. Has broad substrate specificity, with preferences for glucosides or galactosides with alkyl or aryl substituents NA C2_01762 sgrR ko:K11925 Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain NA C2_01763 tbpA ko02010,map02010 ko:K02064 thiamine ABC transporter ABC transporters : Membrane transport : Environmental Information Processing C2_01764 thiP ko02010,map02010 ko:K02063 with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell ABC transporters : Membrane transport : Environmental Information Processing C2_01765 thiQ ko02010,map02010 ko:K02062 Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_01766 yabI ko00550,map00550 ko:K03975,ko:K19302 3.6.1.27 membrane-associated protein Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism C2_01767 araC ko02020,map02020 ko:K02099,ko:K07720 This protein controls the expression of at least six genes that are involved in the transport and catabolism of L- arabinose. It regulates initiation of transcription of the araBAD operon and it also controls its own synthesis. The L-arabinose operon displays both positive and negative regulation through AraC Two-component system : Signal transduction : Environmental Information Processing C2_01768 araB ko00040,ko01100,map00040,map01100 ko:K00853 2.7.1.16 Belongs to the ribulokinase family Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01769 araA ko00040,ko01100,map00040,map01100 ko:K01804 5.3.1.4 Catalyzes the conversion of L-arabinose to L-ribulose Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01770 araD ko00040,ko00051,ko00053,ko01100,ko01120,map00040,map00051,map00053,map01100,map01120 ko:K01628,ko:K01629,ko:K03077,ko:K22130 4.1.1.104,4.1.2.17,4.1.2.19,5.1.3.4 Belongs to the aldolase class II family. AraD FucA subfamily Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01771 polB ko:K02336 2.7.7.7 DNA polymerase NA C2_01772 rapA ko:K03580 Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair NA C2_01773 rluA ko:K06177 5.4.99.28,5.4.99.29 Responsible for synthesis of pseudouridine from uracil NA C2_01774 djlA ko:K05801 Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host NA C2_01775 lptD ko:K04744,ko:K22110 Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane NA C2_01776 surA ko:K03769,ko:K03771 5.2.1.8 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation NA C2_01777 pdxA ko00750,ko01100,map00750,map01100 ko:K00097,ko:K22024 1.1.1.262,1.1.1.408,1.1.1.409 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01778 ksgA ko:K02528 2.1.1.182 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits NA C2_01779 apaG ko:K06195 ApaG domain NA C2_01780 apaH ko00230,map00230 ko:K01525 3.6.1.41 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP Purine metabolism : Nucleotide metabolism : Metabolism C2_01781 folA ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 ko:K00287 1.5.1.3 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Antifolate resistance : Drug resistance: antineoplastic : Human Diseases C2_01782 kefC ko:K03455,ko:K11745,ko:K11747 Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K( ) H( ) antiport NA C2_01783 kefF ko:K03923,ko:K11746,ko:K11748 Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefC. Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC NA C2_01784 yaaU ko:K08368 response to oxidative stress NA C2_01785 fixX ko:K03855 Could be a 3Fe-4S cluster-containing protein NA C2_01786 fixC ko:K00313 Could be part of an electron transfer system required for anaerobic carnitine reduction NA C2_01787 fixB ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 ko:K00248,ko:K03522 1.3.8.1 Required for anaerobic carnitine reduction. May bring reductant to CaiA Fatty acid degradation : Lipid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism C2_01788 fixA ko:K03521 Required for anaerobic carnitine reduction. May bring reductant to CaiA NA C2_01789 caiT ko:K05245 Catalyzes the exchange of L-carnitine for gamma- butyrobetaine and related betaines NA C2_01790 caiA ko:K08297 1.3.8.13 Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA NA C2_01791 caiB ko:K08298 2.8.3.21 Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl- CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl- CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA NA C2_01792 caiC ko:K02182 6.2.1.48 Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle NA C2_01793 caiD ko:K08299 4.2.1.149 Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA NA C2_01794 caiE ko:K02617,ko:K08279 Overproduction of CaiE stimulates the activity of CaiB and CaiD NA C2_01795 caiF ko:K08277 CaiF/GrlA transcriptional regulator NA C2_01797 carB ko00240,ko00250,ko01100,map00240,map00250,map01100 ko:K01955 6.3.5.5 Carbamoyl-phosphate synthetase ammonia chain Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01798 carA ko00240,ko00250,ko01100,map00240,map00250,map01100 ko:K01956 6.3.5.5 Carbamoyl-phosphate synthetase glutamine chain Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01799 dapB ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 ko:K00215,ko:K03546 1.17.1.8 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Lysine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01800 rihC ko00230,ko00240,ko00760,ko01100,map00230,map00240,map00760,map01100 ko:K01239,ko:K01250,ko:K10213,ko:K12700 3.2.2.1,3.2.2.8 Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01801 ispH ko00240,ko00900,ko01100,ko01110,ko01130,ko03010,map00240,map00900,map01100,map01110,map01130,map03010 ko:K00945,ko:K02945,ko:K03527 1.17.7.4,2.7.4.25 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Ribosome : Translation : Genetic Information Processing C2_01802 fkpB ko:K03774,ko:K03775 5.2.1.8 with 'Suc-Ala-Xaa-Pro-Phe-4-nitroanilide' where Xaa is the amino acid tested, was found to be Phe Leu Ile Lys Ala Trp His Gln NA C2_01803 lspA ko03060,map03060 ko:K03101 3.4.23.36 This protein specifically catalyzes the removal of signal peptides from prolipoproteins Protein export : Folding, sorting and degradation : Genetic Information Processing C2_01804 ileS ko00970,map00970 ko:K01870 6.1.1.5 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_01805 ribF ko00740,ko01100,ko01110,map00740,map01100,map01110 ko:K11753 2.7.1.26,2.7.7.2 Belongs to the ribF family Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_01806 rpsT ko03010,map03010 ko:K02968 Binds directly to 16S ribosomal RNA Ribosome : Translation : Genetic Information Processing C2_01809 yehB ko05133,map05133 ko:K07347 outer membrane usher protein Pertussis : Infectious disease: bacterial : Human Diseases C2_01810 yehB ko05133,map05133 ko:K07347 outer membrane usher protein Pertussis : Infectious disease: bacterial : Human Diseases C2_01812 nhaR ko:K03717 regulatory protein NA C2_01813 nhaA ko:K03313 Na( ) H( ) antiporter that extrudes sodium in exchange for external protons NA C2_01814 ko:K18919,ko:K18920,ko:K18921 PFAM Hok gef cell toxic protein NA C2_01815 dnaJ ko:K03686 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins NA C2_01816 dnaK ko03018,ko04212,ko05152,map03018,map04212,map05152 ko:K04043 Heat shock 70 kDa protein RNA degradation : Folding, sorting and degradation : Genetic Information Processing;Longevity regulating pathway - worm : Aging : Organismal Systems;Tuberculosis : Infectious disease: bacterial : Human Diseases C2_01819 yaaH ko:K07034 Uptake of acetate and succinate. Transport is energetically dependent on the protonmotive force NA C2_01820 mog ko00790,ko01100,ko04122,map00790,map01100,map04122 ko:K03635,ko:K03638,ko:K03831 2.7.7.75,2.8.1.12 Catalyzes the adenylation of molybdopterin as part of the biosynthesis of the molybdenum-cofactor Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_01821 tal ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 ko:K00616,ko:K08313 2.2.1.2 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01822 yaaJ ko:K03310 alanine:sodium symporter activity NA C2_01823 yaaA ko:K09861 Belongs to the UPF0246 family NA C2_01824 yggR ko:K02669 ATP binding NA C2_01825 yggS ko:K06997 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis NA C2_01826 yggT ko:K02221 YGGT family NA C2_01827 yggU ko:K09131 Belongs to the UPF0235 family NA C2_01828 rdgB ko00230,ko00471,ko01100,map00230,map00471,map01100 ko:K01776,ko:K02428 3.6.1.66,5.1.1.3 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions Purine metabolism : Nucleotide metabolism : Metabolism;D-Glutamine and D-glutamate metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01831 ko02020,map02020 ko:K11689 TRAP-type C4-dicarboxylate transport system small permease component Two-component system : Signal transduction : Environmental Information Processing C2_01834 ansB ko00220,ko00250,ko00460,ko00471,ko01100,ko01110,ko02020,map00220,map00250,map00460,map00471,map01100,map01110,map02020 ko:K01424,ko:K05597 3.5.1.1,3.5.1.38 Belongs to the asparaginase 1 family Arginine biosynthesis : Amino acid metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Cyanoamino acid metabolism : Metabolism of other amino acids : Metabolism;D-Glutamine and D-glutamate metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_01836 yggL ko:K09923 Protein with unknown function (DUF469) NA C2_01837 trmB ko00540,ko01100,map00540,map01100 ko:K02493,ko:K02527,ko:K03439 2.1.1.297,2.1.1.33,2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01838 mutY ko03410,map03410 ko:K03575 A G-specific adenine glycosylase Base excision repair : Replication and repair : Genetic Information Processing C2_01840 mltC ko:K08306,ko:K08308,ko:K08309 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division NA C2_01841 nupG ko01501,map01501 ko:K03289,ko:K03301,ko:K08218,ko:K11537 Broad-specificity transporter of purine and pyrimidine nucleosides. Driven by a proton motive force beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases C2_01842 speC ko00310,ko00330,ko00480,ko00960,ko01100,ko01110,ko01130,map00310,map00330,map00480,map00960,map01100,map01110,map01130 ko:K01581,ko:K01582,ko:K01584,ko:K01585 4.1.1.17,4.1.1.18,4.1.1.19 putrescine biosynthetic process from ornithine Lysine degradation : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;Glutathione metabolism : Metabolism of other amino acids : Metabolism;Tropane, piperidine and pyridine alkaloid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_01843 yqgA ko:K07150 Protein of unknown function (DUF554) NA C2_01845 gspM ko03070,ko05111,map03070,map05111 ko:K02462 involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_01846 gspL ko03070,ko05111,map03070,map05111 ko:K02461 involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_01847 gspK ko03070,ko05111,map03070,map05111 ko:K02460 Type II secretion system Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_01848 gspJ ko03070,ko05111,map03070,map05111 ko:K02459,ko:K02680 Type II secretion system (T2SS), protein J Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_01849 gspI ko03070,ko05111,map03070,map05111 ko:K02456,ko:K02457,ko:K02458,ko:K02679 Type II secretion system (T2SS), protein I Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_01850 gspH ko02020,ko03070,ko05111,map02020,map03070,map05111 ko:K02456,ko:K02457,ko:K02458,ko:K02650,ko:K02679 Type II transport protein GspH Two-component system : Signal transduction : Environmental Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_01851 gspG ko03070,ko05111,map03070,map05111 ko:K02246,ko:K02456,ko:K02457,ko:K02458,ko:K02679 General secretion pathway protein Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_01852 gspF ko03070,ko05111,map03070,map05111 ko:K02455,ko:K02505,ko:K02653 General secretion pathway Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_01853 gspE ko03070,ko05111,map03070,map05111 ko:K02454 Type II/IV secretion system protein Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_01854 gspD ko03070,ko05111,map03070,map05111 ko:K02453,ko:K03219 General secretion pathway protein Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_01855 gspC ko03070,ko05111,map03070,map05111 ko:K02452 Type II secretion system protein C Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_01857 pppA ko03070,map03070 ko:K02464,ko:K02654 3.4.23.43 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue Bacterial secretion system : Membrane transport : Environmental Information Processing C2_01858 acfD ko02024,ko03060,ko03070,ko05111,map02024,map03060,map03070,map05111 ko:K02004,ko:K10939,ko:K12257,ko:K14393 N-terminal domain of M60-like peptidases Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_01859 glcA ko:K00427,ko:K02550,ko:K03303 Glycolate permease glcA NA C2_01860 glcB ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 ko:K01638 2.3.3.9 Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_01861 glcG ko:K11477 Haem-degrading NA C2_01862 glcF ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 ko:K11473 glycolate dehydrogenase activity Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA C2_01863 glcE ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 ko:K11472 glycolate dehydrogenase activity Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA C2_01864 glcD ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130 ko:K00102,ko:K00104 1.1.2.4,1.1.3.15 Glycolate oxidase subunit Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA C2_01865 glcC ko:K05799,ko:K11474 Activator for the glycolate oxidation locus NA C2_01867 JD73_00810 ko:K00666 AMP-binding enzyme NA C2_01868 JD73_00815 ko00052,ko00520,ko01100,map00052,map00520,map01100 ko:K01784 5.1.3.2 NmrA-like family Galactose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01869 AKN40_0794 ko:K02078,ko:K14661 acyl carrier protein NA C2_01870 bioF ko00260,ko00600,ko00780,ko01100,ko04071,ko04138,map00260,map00600,map00780,map01100,map04071,map04138 ko:K00639,ko:K00652,ko:K00654 2.3.1.29,2.3.1.47,2.3.1.50 Aminotransferase class-V Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Sphingolipid metabolism : Lipid metabolism : Metabolism;Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sphingolipid signaling pathway : Signal transduction : Environmental Information Processing;Autophagy - yeast : Transport and catabolism : Cellular Processes C2_01871 lptG ko02010,map02010 ko:K11720 Predicted permease YjgP/YjgQ family ABC transporters : Membrane transport : Environmental Information Processing C2_01872 JD73_00835 ko02010,map02010 ko:K07091,ko:K11720 Predicted permease YjgP/YjgQ family ABC transporters : Membrane transport : Environmental Information Processing C2_01873 ytfJ ko:K07109 Bacterial protein of unknown function (YtfJ_HI0045) NA C2_01876 tmk ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 ko:K00560,ko:K00943 2.1.1.45,2.7.4.9 ATP binding Pyrimidine metabolism : Nucleotide metabolism : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Antifolate resistance : Drug resistance: antineoplastic : Human Diseases C2_01877 tmk ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 ko:K00560,ko:K00943 2.1.1.45,2.7.4.9 ATP binding Pyrimidine metabolism : Nucleotide metabolism : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Antifolate resistance : Drug resistance: antineoplastic : Human Diseases C2_01878 tmk ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 ko:K00560,ko:K00943 2.1.1.45,2.7.4.9 ATP binding Pyrimidine metabolism : Nucleotide metabolism : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Antifolate resistance : Drug resistance: antineoplastic : Human Diseases C2_01879 pitA ko:K03306,ko:K16322 phosphate transporter NA C2_01880 gsp ko00480,ko01100,map00480,map01100 ko:K01460 3.5.1.78,6.3.1.8 Glutathionylspermidine synthase Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01881 yghU ko:K11209 the actual physiological substrates are not known. Also displays a modest GSH-dependent peroxidase activity toward several organic hydroperoxides, such as cumene hydroperoxide and linoleic acid 13(S)-hydroperoxide, but does not reduce H(2)O(2) or tert- butyl hydroperoxide at appreciable rates. Exhibits little or no GSH transferase activity with most typical electrophilic substrates, and has no detectable transferase activity toward 1- chloro-2,4-dinitrobenzene (CDNB) with glutathionylspermidine (GspSH) as the nucleophilic substrate NA C2_01882 hybG ko:K04653 May have a specific role in the maturation of the large subunits of HYD1 and HYD2 NA C2_01883 hypA ko:K04651 Probably plays a role in a hydrogenase nickel cofactor insertion step NA C2_01884 hybE ko:K03618 preprotein binding NA C2_01885 hybD ko:K03605 Hydrogenase expression formation protein NA C2_01886 hybC ko00633,ko01120,map00633,map01120 ko:K06281 1.12.99.6 Belongs to the NiFe NiFeSe hydrogenase large subunit family Nitrotoluene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01888 hybA ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 ko:K00124 Participates in the periplasmic electron-transferring activity of hydrogenase 2 during its catalytic turnover Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_01889 hybO ko00633,ko01120,map00633,map01120 ko:K06282,ko:K18008 1.12.2.1,1.12.99.6 This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake Nitrotoluene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01891 yghX ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 ko:K01061 3.1.1.45 X-Pro dipeptidyl-peptidase (S15 family) Chlorocyclohexane and chlorobenzene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Fluorobenzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Toluene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA C2_01892 yghZ ko:K19265 reductase NA C2_01893 yqhA ko:K03535 Uncharacterized protein family, UPF0114 NA C2_01895 exbD ko:K03559,ko:K03560 Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates NA C2_01896 exbB ko01120,map01120 ko:K03561,ko:K03562 Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01897 metC ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 ko:K01739,ko:K01760,ko:K01761 2.5.1.48,4.4.1.11,4.4.1.8 cystathionine beta-lyase Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01900 yqhD ko00640,ko00650,ko01120,map00640,map00650,map01120 ko:K00100,ko:K08325,ko:K19955 alcohol dehydrogenase [NAD(P)+] activity Propanoate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01901 dkgA ko:K06221 1.1.1.346 Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG) NA C2_01904 lpp ko:K06078 Lipoprotein leucine-zipper NA C2_01906 ftsP ko:K04753,ko:K14588 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress NA C2_01907 plsC ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 ko:K00655,ko:K07003,ko:K15781 2.3.1.51,3.1.3.3 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family Glycerolipid metabolism : Lipid metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_01908 parC ko:K02469,ko:K02621 5.99.1.3 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule NA C2_01910 ygiV ko:K07471,ko:K13652 transcriptional regulator NA C2_01913 qseC ko01502,ko01503,ko02020,ko02024,map01502,map01503,map02020,map02024 ko:K07643,ko:K07645,ko:K07653,ko:K18351 2.7.13.3 Member of a two-component regulatory system QseB QseC. Activates the flagella regulon by activating transcription of FlhDC. May activate QseB by phosphorylation Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_01915 mdaB ko:K03923,ko:K11746,ko:K11748 Modulator of drug activity B NA C2_01917 parE ko:K02470,ko:K02622 5.99.1.3 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule NA C2_01918 yqiA ko:K07000 Displays esterase activity toward palmitoyl-CoA and pNP- butyrate NA C2_01919 cpdA ko00230,ko00670,ko01100,ko01110,ko01130,ko02025,map00230,map00670,map01100,map01110,map01130,map02025 ko:K03651,ko:K11175 2.1.2.2,3.1.4.53 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes Purine metabolism : Nucleotide metabolism : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes C2_01920 yqiB ko:K09920 Protein of unknown function (DUF1249) NA C2_01921 nudF ko00230,map00230 ko:K01515,ko:K12945 3.6.1.13 Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process Purine metabolism : Nucleotide metabolism : Metabolism C2_01922 tolC ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 ko:K12340 Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing;Plant-pathogen interaction : Environmental adaptation : Organismal Systems;Pertussis : Infectious disease: bacterial : Human Diseases C2_01924 ygiC ko00480,ko01100,map00480,map01100 ko:K01460 3.5.1.78,6.3.1.8 May be a ligase forming an amide bond. Shows ATPase activity Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01925 ygiD ko00362,ko00624,ko00627,ko00965,ko01120,map00362,map00624,map00627,map00965,map01120 ko:K04100,ko:K15777 1.13.11.8 In vitro, opens the cyclic ring of dihydroxy- phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. The physiological substrate is Benzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Polycyclic aromatic hydrocarbon degradation : Xenobiotics biodegradation and metabolism : Metabolism;Aminobenzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Betalain biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01926 zupT ko:K07238 Mediates zinc uptake. May also transport other divalent cations NA C2_01928 ribB ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 ko:K02858,ko:K14652 3.5.4.25,4.1.99.12 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_01929 yqiC ko:K09806 protein conserved in bacteria NA C2_01930 ygiL ko05133,map05133 ko:K07345 cell adhesion Pertussis : Infectious disease: bacterial : Human Diseases C2_01932 yqiH ko:K07353,ko:K15540 chaperone NA C2_01936 yqiK ko04910,map04910 ko:K07192 Flotillin Insulin signaling pathway : Endocrine system : Organismal Systems C2_01937 hldE ko00540,ko01100,map00540,map01100 ko:K03272,ko:K21344 2.7.1.167,2.7.7.70 belongs to the carbohydrate kinase PfkB family Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01938 glnE ko:K00982 2.7.7.42,2.7.7.89 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell NA C2_01939 ygiF ko:K18446 3.6.1.25 Involved in the hydrolysis of the beta-gamma- phosphoanhydride linkage of triphosphate-containing substrates (inorganic or nucleoside-linked). Catalyzes the hydrolysis of inorganic triphosphate (PPPi), which could be cytotoxic because of its high affinity for calcium ion, thereby interfering with calcium signaling. It also hydrolyzes slowly thiamine triphosphate (ThTP). YgiF is a specific PPPase, but it contributes only marginally to the total PPPase activity in E.coli, where the main enzyme responsible for hydrolysis of PPPi is inorganic pyrophosphatase (PPase) NA C2_01940 ygiM ko:K07184 Bacterial SH3 domain NA C2_01941 cca ko03013,ko03018,map03013,map03018 ko:K00970,ko:K00974 2.7.7.19,2.7.7.72 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases RNA transport : Translation : Genetic Information Processing;RNA degradation : Folding, sorting and degradation : Genetic Information Processing C2_01942 uppP ko00550,map00550 ko:K06153 3.6.1.27 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism C2_01943 folB ko00790,ko01100,map00790,map01100 ko:K01633,ko:K07589 1.13.11.81,4.1.2.25,5.1.99.7,5.1.99.8 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01944 plsY ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 ko:K08591 2.3.1.15 Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl-PO(4) Glycerolipid metabolism : Lipid metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_01945 ttdR ko:K16135,ko:K21742 Positive regulator required for L-tartrate-dependent anaerobic growth on glycerol. Induces expression of the ttdA-ttdB- ygjE operon NA C2_01946 ttdA ko00630,map00630 ko:K03779 4.2.1.32 L( )-tartrate dehydratase subunit alpha Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism C2_01947 ttdB ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200 ko:K01676,ko:K01678,ko:K03780 4.2.1.2,4.2.1.32 )-tartrate dehydratase Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_01948 ttdT ko02020,map02020 ko:K03319,ko:K09477,ko:K11106 Catalyzes the uptake of tartrate in exchange for intracellular succinate. Essential for anaerobic L-tartrate fermentation Two-component system : Signal transduction : Environmental Information Processing C2_01949 tsaD ko02024,ko03060,ko03070,map02024,map03060,map03070 ko:K01409,ko:K03070 2.3.1.234 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_01950 rpsU ko03010,map03010 ko:K02970 Belongs to the bacterial ribosomal protein bS21 family Ribosome : Translation : Genetic Information Processing C2_01951 dnaG ko03030,map03030 ko:K02316 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication DNA replication : Replication and repair : Genetic Information Processing C2_01952 rpoD ko:K03086 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth NA C2_01953 mug ko00670,ko01100,ko03410,map00670,map01100,map03410 ko:K01934,ko:K03649 3.2.2.28,6.3.3.2 Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Base excision repair : Replication and repair : Genetic Information Processing C2_01955 yqjH ko:K07229 1.16.1.9 ferric-chelate reductase (NADPH) activity NA C2_01957 aer ko02020,ko02030,map02020,map02030 ko:K03776 Signal transducer for aerotaxis. The aerotactic response is the accumulation of cells around air bubbles. The nature of the sensory stimulus detected by this protein is the proton motive force or cellular redox state. It uses a FAD prosthetic group as a redox sensor to monitor oxygen levels Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes C2_01958 patA ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230 ko:K00821,ko:K05830,ko:K09251 2.6.1.11,2.6.1.17,2.6.1.82 Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithine Arginine biosynthesis : Amino acid metabolism : Metabolism;Lysine biosynthesis : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01959 ygjH ko00450,ko00970,map00450,map00970 ko:K01874,ko:K01890,ko:K06878 6.1.1.10,6.1.1.20 tRNA aminoacylation for protein translation Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_01960 ebgR ko:K02529,ko:K12113 Transcriptional regulator EbgR NA C2_01961 ebgA ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 ko:K01190,ko:K12111 3.2.1.23 lactose catabolic process Galactose metabolism : Carbohydrate metabolism : Metabolism;Other glycan degradation : Glycan biosynthesis and metabolism : Metabolism;Sphingolipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01962 ebgC ko00052,ko00511,ko01100,map00052,map00511,map01100 ko:K12112,ko:K19334 Required for full activity of the EbgA enzyme. Exact function not known Galactose metabolism : Carbohydrate metabolism : Metabolism;Other glycan degradation : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01963 ygjI ko02024,map02024 ko:K20265 transmembrane transporter activity Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_01965 ygjK ko00500,ko01100,map00500,map01100 ko:K01194,ko:K03931 3.2.1.28 Glucoside hydrolase that cleaves the alpha-1,3- glucosidic linkage in nigerose. Has very low activity towards maltooligosaccharides, soluble starch, nigerotriose, kojibiose and trehalose Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01966 fadH ko:K00219 1.3.1.34 Functions as an auxiliary enzyme in the beta-oxidation of unsaturated fatty acids with double bonds at even carbon positions. Catalyzes the NADPH-dependent reduction of the C4-C5 double bond of the acyl chain of 2,4-dienoyl-CoA to yield 2-trans- enoyl-CoA. Acts on both isomers, 2-trans,4-cis- and 2-trans,4-trans-decadienoyl-CoA, with almost equal efficiency. Is not active with NADH instead of NADPH. Does not show cis- trans isomerase activity NA C2_01967 higA ko:K18831 transcriptional regulator NA C2_01968 rlmG ko:K00564,ko:K11391 2.1.1.172,2.1.1.174 Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA NA C2_01969 ygjP ko:K07043 Specifically catalyzes the hydrolysis of UTP to UMP and diphosphate in vitro, albeit at apparently slow rate. Shows no activity towards ATP, GTP, CTP, dTTP and ITP as substrates NA C2_01970 ygjQ ko:K03748 DUF218 domain NA C2_01971 ygjR ko00562,ko01120,map00562,map01120 ko:K22230 oxidoreductase activity Inositol phosphate metabolism : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_01972 alx ko:K05794 Has been proposed to be a redox modulator NA C2_01973 sstT ko:K07862 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) NA C2_01975 uxaA ko00040,ko01100,map00040,map01100 ko:K01685 4.2.1.7 altronate dehydratase activity Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01976 uxaC ko00040,ko01100,map00040,map01100 ko:K01812 5.3.1.12 glucuronate isomerase Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_01977 exuT ko:K08191 Hexuronate transporter NA C2_01979 cblC ko05133,map05133 ko:K07347,ko:K21966 E-set like domain Pertussis : Infectious disease: bacterial : Human Diseases C2_01982 exuR ko:K05799,ko:K13637,ko:K19775 Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the ExuT, UxaCA and UxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers NA C2_01986 yqjD ko:K05594,ko:K07184 ribosome binding NA C2_01989 yqjF ko:K15977 DoxX NA C2_01990 yqjG ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 ko:K00799,ko:K07393 1.8.5.7,2.5.1.18 Glutathione S-Transferase Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolism of xenobiotics by cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Platinum drug resistance : Drug resistance: antineoplastic : Human Diseases;Pathways in cancer : Cancer: overview : Human Diseases;Chemical carcinogenesis : Cancer: overview : Human Diseases;Hepatocellular carcinoma : Cancer: specific types : Human Diseases;Fluid shear stress and atherosclerosis : Cardiovascular disease : Human Diseases C2_01994 yhaK ko:K06911 Belongs to the pirin family NA C2_01997 yhaO ko:K03834,ko:K03835,ko:K03836,ko:K03837,ko:K03838 Plays a role in L-cysteine detoxification. May transport both D- and L-serine (By similarity) NA C2_01998 sdaA ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 ko:K01752 4.3.1.17 L-serine ammonia-lyase activity Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_01999 tdcF ko:K09022 3.5.99.10 May be a post-translational regulator that controls the metabolic fate of L-threonine or the potentially toxic intermediate 2-ketobutyrate NA C2_02000 pflB ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 ko:K00656 2.3.1.54 formate acetyltransferase Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_02001 ackA ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 ko:K00925,ko:K00932 2.7.2.1,2.7.2.15 Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP Taurine and hypotaurine metabolism : Metabolism of other amino acids : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_02002 tdcC ko:K03834,ko:K03835,ko:K03836,ko:K03837,ko:K03838 Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) NA C2_02003 tdcB ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 ko:K01751,ko:K01754 4.3.1.15,4.3.1.19 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02004 tdcA ko:K07592,ko:K14057 Transcriptional regulator NA C2_02010 leuE ko:K11250 efflux protein NA C2_02011 dmlR ko:K16135,ko:K21742 transcriptional regulator NA C2_02012 dmlA ko00630,ko00650,map00630,map00650 ko:K07246 1.1.1.83,1.1.1.93,4.1.1.73 Catalyzes the NAD( )-dependent oxidative decarboxylation of D-malate into pyruvate. Is essential for aerobic growth on D- malate as the sole carbon source. But is not required for anaerobic D-malate utilization, although DmlA is expressed and active in those conditions. Appears to be not able to use L- tartrate as a substrate for dehydrogenation instead of D-malate Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism C2_02013 yeaV ko:K03451 nitrogen compound transport NA C2_02014 yeaV ko:K03451 nitrogen compound transport NA C2_02015 yeaW ko:K22443 1.14.13.239 Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family. CntA subfamily NA C2_02016 yeaW ko:K22443 1.14.13.239 Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family. CntA subfamily NA C2_02017 yeaX ko:K22343,ko:K22444 1.14.13.238,1.14.13.239 Converts carnitine to trimethylamine and malic semialdehyde. Can also use gamma-butyrobetaine, choline and betaine as substrates NA C2_02018 rnd ko:K03684 3.1.13.5 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides NA C2_02019 fadD ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 ko:K01897 6.2.1.3 Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids Fatty acid biosynthesis : Lipid metabolism : Metabolism;Fatty acid degradation : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;PPAR signaling pathway : Endocrine system : Organismal Systems;Peroxisome : Transport and catabolism : Cellular Processes;Ferroptosis : Cell growth and death : Cellular Processes;Thermogenesis : Environmental adaptation : Organismal Systems;Adipocytokine signaling pathway : Endocrine system : Organismal Systems C2_02020 yeaY ko:K07285 Outer membrane lipoprotein Slp family NA C2_02021 yeaZ ko:K01409,ko:K14742 2.3.1.234 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaE. TsaB seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD. In fact, can act as a protease that specifically degrades TsaD in vitro NA C2_02022 dinG ko:K03722 3.6.4.12 postreplication repair NA C2_02025 yoaH ko:K09917 Belongs to the UPF0181 family NA C2_02026 pabB ko00790,map00790 ko:K01665,ko:K13950 2.6.1.85 Part of a heterodimeric complex that catalyzes the two- step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabB, in the absence of PabA, can catalyze the formation of ADC in the presence of exogenous ammonia Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism C2_02028 sdaA ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 ko:K01752 4.3.1.17 L-serine dehydratase 1 Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02029 yoaD ko02026,map02026 ko:K13244,ko:K21090 3.1.4.52 overexpression inhibits cell aggregation in strains able to produce adhesive curli fimbriae. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_02030 yoaE ko:K03699 UPF0053 inner membrane protein YoaE NA C2_02032 manX ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 ko:K02793,ko:K02794,ko:K02812,ko:K02813 2.7.1.191,2.7.1.206 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport. Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_02033 manY ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 ko:K02795,ko:K02796,ko:K02814 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport. Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_02034 manZ ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060 ko:K02747,ko:K02796,ko:K02815,ko:K10986 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport. Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_02038 rrmA ko:K00563 2.1.1.187 Methyl-transferase NA C2_02039 cspC ko:K03704 Cold shock NA C2_02042 kdgR ko:K19333 Transcriptional regulator NA C2_02043 yebQ ko:K08169 Major facilitator Superfamily NA C2_02044 htpX ko:K03799 Heat shock protein HtpX NA C2_02045 prc ko:K03797 3.4.21.102 Belongs to the peptidase S41A family NA C2_02046 proQ ko:K03607 RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities NA C2_02047 yebR ko00270,map00270 ko:K08968 1.8.4.14 L-methionine-(R)-S-oxide reductase activity Cysteine and methionine metabolism : Amino acid metabolism : Metabolism C2_02048 yebS ko:K03808 response to heat NA C2_02049 yebT ko:K06192 intermembrane lipid transfer NA C2_02050 rsmF ko:K03500,ko:K11392,ko:K22446 2.1.1.176,2.1.1.178 Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA NA C2_02053 pphA ko:K07313 3.1.3.16 Plays a key role in signaling protein misfolding via the CpxR CPXA transducing system. It also modulates the phosphorylated status of many phosphoproteins in E.coli, some of which acting as major chaperones. Has been shown, in vitro, to act on Ser, Thr and Tyr-phosphorylated substrates NA C2_02055 yebZ ko:K07245 copper ion transport NA C2_02056 yobA ko:K07156 Resistance protein NA C2_02057 holE ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02345 2.7.7.7 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing C2_02058 yobB ko00760,ko01100,map00760,map01100 ko:K01950 6.3.5.1 nitrogen compound metabolic process Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02059 exoX ko03430,map03430 ko:K10857 Capable of degrading both single-strand and double- strand DNA with 3' to 5' polarity. Has higher affinity for ssDNA ends than for dsDNA Mismatch repair : Replication and repair : Genetic Information Processing C2_02060 ptrB ko05142,ko05143,map05142,map05143 ko:K01354 3.4.21.83 oligopeptidase activity Chagas disease : Infectious disease: parasitic : Human Diseases;African trypanosomiasis : Infectious disease: parasitic : Human Diseases C2_02065 yebG ko:K09918 response to X-ray NA C2_02066 purT ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 ko:K08289 2.1.2.2 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate Purine metabolism : Nucleotide metabolism : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_02067 eda ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200 ko:K01625 4.1.2.14,4.1.3.42 Involved in the degradation of glucose via the Entner- Doudoroff pathway. Catalyzes the reversible, stereospecific retro- aldol cleavage of 2-Keto-3-deoxy-6-phosphogluconate (KDPG) to pyruvate and D-glyceraldehyde-3-phosphate. In the synthetic direction, it catalyzes the addition of pyruvate to electrophilic aldehydes with si-facial selectivity. It accepts some nucleophiles other than pyruvate, including 2-oxobutanoate, phenylpyruvate, and fluorobutanoate. It has a preference for the S-configuration at C2 of the electrophile Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_02068 edd ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 ko:K01690 4.2.1.12 Belongs to the IlvD Edd family Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_02069 zwf ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 ko:K00036 1.1.1.363,1.1.1.49 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Central carbon metabolism in cancer : Cancer: overview : Human Diseases C2_02071 hexR ko:K15835,ko:K19337 transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding NA C2_02072 pyk ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 ko:K00873 2.7.1.40 Belongs to the pyruvate kinase family Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Purine metabolism : Nucleotide metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Glucagon signaling pathway : Endocrine system : Organismal Systems;Type II diabetes mellitus : Endocrine and metabolic disease : Human Diseases;Human papillomavirus infection : Infectious disease: viral : Human Diseases;Viral carcinogenesis : Cancer: overview : Human Diseases;Central carbon metabolism in cancer : Cancer: overview : Human Diseases C2_02073 lpxM ko00540,ko01100,map00540,map01100 ko:K02517,ko:K02560,ko:K12974 2.3.1.241,2.3.1.242,2.3.1.243 Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)-lipid A Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02074 yebA ko:K19304,ko:K21472 A murein DD-endopeptidase with specificity for D-Ala- meso-diaminopimelic acid (mDAP) cross-links. Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion. Functionally redundant with MepM and MepH NA C2_02075 znuA ko02010,map02010 ko:K09815 ABC-type Zn2 transport system, periplasmic component surface adhesin ABC transporters : Membrane transport : Environmental Information Processing C2_02076 znuC ko02010,map02010 ko:K02074,ko:K09817 Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_02077 znuB ko02010,map02010 ko:K02075,ko:K09816 High-affinity zinc uptake system membrane protein ZnuB ABC transporters : Membrane transport : Environmental Information Processing C2_02078 ruvB ko03440,map03440 ko:K03551 3.6.4.12 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing Homologous recombination : Replication and repair : Genetic Information Processing C2_02079 ruvA ko03440,map03440 ko:K03550 3.6.4.12 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB Homologous recombination : Replication and repair : Genetic Information Processing C2_02081 ruvC ko03440,map03440 ko:K01159 3.1.22.4 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group Homologous recombination : Replication and repair : Genetic Information Processing C2_02083 nudB ko00230,ko00785,ko00790,ko01100,map00230,map00785,map00790,map01100 ko:K01515,ko:K03574,ko:K03801,ko:K08310 2.3.1.181,3.6.1.13,3.6.1.55,3.6.1.67 Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP Purine metabolism : Nucleotide metabolism : Metabolism;Lipoic acid metabolism : Metabolism of cofactors and vitamins : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02084 aspS ko00970,map00970 ko:K01876 6.1.1.12 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_02087 yecN ko:K07136 MAPEG family NA C2_02088 cmoA ko:K15256 Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM) NA C2_02089 cmoB ko:K15257 Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs NA C2_02090 torZ ko00780,ko00920,ko01100,ko02020,map00780,map00920,map01100,map02020 ko:K07306,ko:K07811,ko:K07812,ko:K08351 1.7.2.3,1.8.5.3 an anaerobic reaction coupled to energy-yielding reactions. Can also reduce other N- and S-oxide compounds such as 4-methylmorpholine-N-oxide and biotin sulfoxide (BSO), but with a lower catalytic efficiency Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_02091 torY ko02020,map02020 ko:K02569,ko:K03532,ko:K07821 Part of the anaerobic respiratory chain of trimethylamine-N-oxide reductase TorZ. Required for electron transfer to the TorZ terminal enzyme Two-component system : Signal transduction : Environmental Information Processing C2_02092 cutC ko:K06201 Participates in the control of copper homeostasis NA C2_02093 yecM ko:K09907 YecM protein NA C2_02094 argS ko00970,map00970 ko:K01887 6.1.1.19 arginyl-tRNA aminoacylation Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_02096 flhE ko:K03516 Flagellar protein flhE NA C2_02097 flhA ko02040,map02040 ko:K02400 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin Flagellar assembly : Cell motility : Cellular Processes C2_02098 flhB ko02020,ko02030,ko02040,ko03070,map02020,map02030,map02040,map03070 ko:K02401,ko:K02556,ko:K03229,ko:K04061,ko:K13820 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_02099 cheZ ko02030,map02030 ko:K03414 Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) Bacterial chemotaxis : Cell motility : Cellular Processes C2_02101 cheB ko02020,ko02030,map02020,map02030 ko:K03412 3.1.1.61,3.5.1.44 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes C2_02102 cheR ko02020,ko02030,map02020,map02030 ko:K00575 2.1.1.80 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes C2_02103 tap ko02020,ko02030,map02020,map02030 ko:K03406,ko:K05874,ko:K05875,ko:K05876,ko:K05877 Methyl-accepting chemotaxis protein Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes C2_02104 tar ko02020,ko02030,map02020,map02030 ko:K03406,ko:K05874,ko:K05875 Methyl-accepting chemotaxis protein II Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes C2_02105 cheW ko02020,ko02030,map02020,map02030 ko:K03408 Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. It physically bridges CheA to the MCPs (methyl-accepting chemotaxis proteins) to allow regulated phosphotransfer to CheY and CheB Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes C2_02106 cheA ko02020,ko02025,ko02030,map02020,map02025,map02030 ko:K02487,ko:K03407,ko:K06596 2.7.13.3 Chemotaxis protein cheA Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Bacterial chemotaxis : Cell motility : Cellular Processes C2_02107 motB ko02030,ko02040,map02030,map02040 ko:K02557 MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Probably a linker that fastens the torque- generating machinery to the cell wall. Overexpression of this protein with MotA improves motility in a yhjH disruption, (a c-di- GMP phosphodiesterase) suggesting there is an interaction (direct or indirect) between the c-di-GMP-binding flagellar brake protein YcgR and the flagellar stator Bacterial chemotaxis : Cell motility : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes C2_02108 motA ko02020,ko02030,ko02040,map02020,map02030,map02040 ko:K02556 transmembrane proton channel. Overexpression of MotA, with or without MotB, restores motility in a yhjH disruption, (a c-di-GMP phosphodiesterase) suggesting there is an interaction (direct or indirect) between the c-di-GMP-binding flagellar brake protein YcgR and the flagellar stator Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes C2_02109 flhC ko02020,ko02024,ko02026,ko02040,map02020,map02024,map02026,map02040 ko:K02402 Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes C2_02110 flhD ko02020,ko02024,ko02026,ko02040,map02020,map02024,map02026,map02040 ko:K02403 Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes C2_02111 uspC ko:K06149,ko:K14064,ko:K14065 Required for resistance to DNA-damaging agents NA C2_02112 otsA ko00500,ko01100,map00500,map01100 ko:K00697 2.4.1.15,2.4.1.347 Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02113 otsB ko00500,ko01100,map00500,map01100 ko:K00697,ko:K01087,ko:K16055 2.4.1.15,2.4.1.347,3.1.3.12 Removes the phosphate from trehalose 6-phosphate to produce free trehalose Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02114 araH ko02010,map02010 ko:K10538,ko:K17214 Belongs to the binding-protein-dependent transport system permease family ABC transporters : Membrane transport : Environmental Information Processing C2_02115 araG ko02010,map02010 ko:K10539 3.6.3.17 Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_02116 araF ko02010,map02010 ko:K10537 L-arabinose-binding periplasmic protein ABC transporters : Membrane transport : Environmental Information Processing C2_02117 ftnA ko:K02217,ko:K02255 1.16.3.2 Iron-storage protein NA C2_02120 ftnA ko:K02217,ko:K02255 1.16.3.2 Iron-storage protein NA C2_02122 tyrP ko:K03834,ko:K03835,ko:K03836,ko:K03837,ko:K03838 Tyrosine-specific transport protein NA C2_02123 yecA ko:K07039 Belongs to the UPF0149 family NA C2_02127 pgsA ko00564,ko01100,map00564,map01100 ko:K00995,ko:K08744 2.7.8.41,2.7.8.5 This protein catalyzes the committed step to the synthesis of the acidic phospholipids Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02128 uvrC ko03420,map03420 ko:K03703 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision Nucleotide excision repair : Replication and repair : Genetic Information Processing C2_02129 uvrY ko02020,ko02024,ko02025,ko02026,ko05111,ko05133,map02020,map02024,map02025,map02026,map05111,map05133 ko:K02282,ko:K07686,ko:K07687,ko:K07688,ko:K07689,ko:K07690,ko:K20264 Member of the two-component regulatory system UvrY BarA involved in the regulation of carbon metabolism via the CsrA CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the effects of CsrA on csrB RNA by BarA-dependent and BarA-independent mechanisms Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes;Pertussis : Infectious disease: bacterial : Human Diseases C2_02131 sdiA ko02020,ko02024,ko02026,map02020,map02024,map02026 ko:K07782,ko:K15852,ko:K19666 Activates cell division by specifically increasing transcription from one of the two promoters that lie immediately upstream of the ftsQAZ gene cluster. Activates ydiV expression in response to extracellular autoinducer AI-1 (Vibrio fischeri autoinducer oxoC6) Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_02132 yecC ko02010,map02010 ko:K02028,ko:K10010 3.6.3.21 Part of the ABC transporter complex FliY-YecC-YecS involved in L-cystine transport. The system can probably also transport L-cysteine, and it mediates accumulation of the toxic compounds L-selenaproline (SCA) and L-selenocystine (SeCys). Probably responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_02133 yecS ko02010,map02010 ko:K10009 amino acid ABC transporter ABC transporters : Membrane transport : Environmental Information Processing C2_02134 dcyD ko00270,map00270 ko:K05396 4.4.1.15 Catalyzes the alpha,beta-elimination reaction of D- cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine Cysteine and methionine metabolism : Amino acid metabolism : Metabolism C2_02135 fliY ko02010,map02010 ko:K02424 Ligated ion channel L-glutamate- and glycine-binding site ABC transporters : Membrane transport : Environmental Information Processing C2_02136 fliZ ko02026,map02026 ko:K02425 During the post-exponential growth phase transiently interferes with RpoS (sigma S) activity without affecting expression of RpoS itself. It is probably not an anti-sigma factor as its overexpression is detrimental in rapidly growing cells where there is almost no sigma S factor. There is a strong overlap between Crl-activated genes and FliZ-down-regulated genes. FliZ acts as a timing device for expression of the genes for the adhesive curli fimbriae by indirectly decreasing expression of the curli regulator CsgD Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_02137 fliA ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 ko:K02405 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_02138 fliC ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 ko:K02406 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella Two-component system : Signal transduction : Environmental Information Processing;Flagellar assembly : Cell motility : Cellular Processes;NOD-like receptor signaling pathway : Immune system : Organismal Systems;Plant-pathogen interaction : Environmental adaptation : Organismal Systems;Salmonella infection : Infectious disease: bacterial : Human Diseases;Legionellosis : Infectious disease: bacterial : Human Diseases C2_02139 fliD ko02040,map02040 ko:K02407 morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end Flagellar assembly : Cell motility : Cellular Processes C2_02140 fliS ko02040,map02040 ko:K02422 bacterial-type flagellum assembly Flagellar assembly : Cell motility : Cellular Processes C2_02141 fliT ko02040,map02040 ko:K02423 it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus Flagellar assembly : Cell motility : Cellular Processes C2_02142 amyA ko00500,ko01100,ko04973,map00500,map01100,map04973 ko:K01176 3.2.1.1 alpha-amylase activity Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Carbohydrate digestion and absorption : Digestive system : Organismal Systems C2_02144 yedE ko:K07112 Sulphur transport NA C2_02147 yedL ko:K03829 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases NA C2_02148 ko:K07126,ko:K09973 COG4886 Leucine-rich repeat (LRR) protein NA C2_02149 fliE ko02040,map02040 ko:K02408 Flagellar hook-basal body complex protein FliE Flagellar assembly : Cell motility : Cellular Processes C2_02150 fliF ko02040,map02040 ko:K02409 The M ring may be actively involved in energy transduction Flagellar assembly : Cell motility : Cellular Processes C2_02151 fliG ko02030,ko02040,map02030,map02040 ko:K02410 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation Bacterial chemotaxis : Cell motility : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes C2_02152 fliH ko02040,map02040 ko:K02411 Flagellar assembly protein fliH Flagellar assembly : Cell motility : Cellular Processes C2_02153 fliI ko02040,map02040 ko:K02412 3.6.3.14 catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage Flagellar assembly : Cell motility : Cellular Processes C2_02154 fliJ ko02040,map02040 ko:K02413 Flagellar protein that affects chemotactic events Flagellar assembly : Cell motility : Cellular Processes C2_02155 fliK ko02040,map02040 ko:K02414 Flagellar hook-length control protein Flagellar assembly : Cell motility : Cellular Processes C2_02156 fliL ko:K02415 Controls the rotational direction of flagella during chemotaxis NA C2_02157 fliM ko02030,ko02040,map02030,map02040 ko:K02416 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation Bacterial chemotaxis : Cell motility : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes C2_02158 fliN ko02030,ko02040,map02030,map02040 ko:K02417 FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation Bacterial chemotaxis : Cell motility : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes C2_02159 fliO ko02040,map02040 ko:K02418 bacterial-type flagellum organization Flagellar assembly : Cell motility : Cellular Processes C2_02160 fliP ko02040,ko03070,map02040,map03070 ko:K02419,ko:K03226 Plays a role in the flagellum-specific transport system Flagellar assembly : Cell motility : Cellular Processes;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_02161 fliQ ko02040,map02040 ko:K02420 Flagellar biosynthetic protein FliQ Flagellar assembly : Cell motility : Cellular Processes C2_02162 fliR ko02040,map02040 ko:K02421 Role in flagellar biosynthesis Flagellar assembly : Cell motility : Cellular Processes C2_02163 rcsA ko02020,ko02024,ko02026,map02020,map02024,map02026 ko:K07688,ko:K07781 Component of the Rcs signaling system, which controls transcription of numerous genes. Binds to DNA to regulate expression of genes Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_02166 yedP ko00051,ko00260,ko00561,ko00630,ko01100,ko01110,ko01130,ko01200,map00051,map00260,map00561,map00630,map01100,map01110,map01130,map01200 ko:K07026,ko:K15918 2.7.1.31,3.1.3.70 glycoside biosynthetic process Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_02167 yedQ ko02026,map02026 ko:K21085 2.7.7.65 in the regulation of cellulose production Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_02169 yedI ko:K09781 Protein of unknown function (DUF808) NA C2_02171 vsr ko:K07458 May nick specific sequences that contain T G mispairs resulting from m5C-deamination NA C2_02172 dcm ko00270,ko01100,ko05206,map00270,map01100,map05206 ko:K00558 2.1.1.37 This methylase recognizes the double-stranded sequence CCWGG, causes specific methylation on C-2 on both strands Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;MicroRNAs in cancer : Cancer: overview : Human Diseases C2_02173 yedJ ko:K06950 Metal dependent phosphohydrolases with conserved 'HD' motif. NA C2_02178 hchA ko00030,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00620,map00710,map01100,map01110,map01120,map01130,map01200,map01230 ko:K01807,ko:K03152,ko:K05520,ko:K05523 3.5.1.124,4.2.1.130,5.3.1.6 Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of Schiff bases and advanced glycation endproducts (AGE). Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. Plays an important role in protecting cells from carbonyl stress Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02181 hiuH ko00230,ko01100,ko01120,map00230,map01100,map01120 ko:K07127,ko:K13485 3.5.2.17,4.1.1.97 Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_02182 msrP ko:K07147 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide NA C2_02183 msrQ ko:K17247 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain NA C2_02184 adcA ko02010,map02010 ko:K09815 May function as a periplasmic zinc chaperone or mediate direct transport of zinc from the periplasm to the cytoplasm under zinc-limited conditions. Binds zinc with high affinity, and can also bind cadmium, mercury or nickel. Preferentially binds Zn(2 ) over Cd(2 ). Contains one high affinity metal binding site, and can bind additional metal ions at other sites ABC transporters : Membrane transport : Environmental Information Processing C2_02185 yodB ko:K12262 respiratory electron transport chain NA C2_02187 mtfA ko:K09933 Involved in the regulation of ptsG expression by binding and inactivating Mlc NA C2_02190 lppY ko05100,map05100 ko:K13735 cell adhesion Bacterial invasion of epithelial cells : Infectious disease: bacterial : Human Diseases C2_02192 shiA ko:K03761,ko:K03762,ko:K08172,ko:K08173 Shikimate transporter NA C2_02193 amn ko00230,map00230 ko:K01241 3.2.2.4 Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations Purine metabolism : Nucleotide metabolism : Metabolism C2_02196 yeeO ko:K03327 A transporter able to export peptides and flavins. When overexpressed allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth. Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide, overproduction of this protein increases its export. When overexpressed increases secretion of FMN and FAD but not riboflavin NA C2_02198 cbl ko:K13634,ko:K13635 Transcriptional regulator NA C2_02199 nac ko:K19338 Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity) NA C2_02201 erfK ko01503,map01503 ko:K16291,ko:K19234,ko:K19235,ko:K19236 Responsible, at least in part, for anchoring of the major outer membrane lipoprotein (Lpp, also known as the Braun lipoprotein) to the peptidoglycan via a meso-diaminopimelyl-L- Lys- bond on the terminal residue of Lpp Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_02202 cobT ko00860,ko01100,ko01120,map00860,map01100,map01120 ko:K00768,ko:K02224 2.4.2.21,6.3.5.11,6.3.5.9 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_02203 cobS ko00860,ko01100,map00860,map01100 ko:K02233 2.7.8.26 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02204 cobU ko00860,ko01100,map00860,map01100 ko:K02231,ko:K02232 2.7.1.156,2.7.7.62,6.3.5.10 Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02205 insC ko:K07483 transposase activity NA C2_02206 ko:K07483,ko:K07497 COG2801 Transposase and inactivated derivatives NA C2_02207 dexB ko00052,ko00500,ko00511,ko01100,map00052,map00500,map00511,map01100 ko:K00690,ko:K01187,ko:K01206,ko:K01215,ko:K01226,ko:K17624 2.4.1.7,3.2.1.20,3.2.1.51,3.2.1.70,3.2.1.93,3.2.1.97 Alpha amylase, catalytic domain Galactose metabolism : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Other glycan degradation : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02208 csiD ko:K15737 May be involved in the control of utilization of gamma- aminobutyric acid NA C2_02209 lhgO ko:K15736 L-2-hydroxyglutarate oxidase LhgO NA C2_02210 gabD ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 ko:K00135 1.2.1.16,1.2.1.20,1.2.1.79 Belongs to the aldehyde dehydrogenase family Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Lysine degradation : Amino acid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_02211 gabT ko00250,ko00280,ko00310,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00310,map00410,map00640,map00650,map01100,map01120 ko:K00823,ko:K07250,ko:K14268 2.6.1.19,2.6.1.22,2.6.1.48 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Lysine degradation : Amino acid metabolism : Metabolism;beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_02212 gabP ko:K11735 4-amino butyrate transport carrier NA C2_02213 csiR ko:K15735 Modulates expression of csiD and lhgO in a temporal manner during entry into stationary phase or during the first few hours of carbon starvation NA C2_02214 ygaU ko:K21687,ko:K21688,ko:K21689,ko:K21690,ko:K21691 response to potassium ion NA C2_02218 stpA ko02020,ko02024,map02020,map02024 ko:K03746,ko:K11685,ko:K20552 Hha and Cnu (YdgT) increases the number of genes DNA bound by H-NS StpA and may also modulate the oligomerization of the H-NS StpA-complex. Repression can be inhibited by dominant-negative mutants of StpA or H-NS Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_02221 ygaM ko:K05594,ko:K07184 ribosome binding NA C2_02222 nrdH ko:K06191 Electron transport system for the ribonucleotide reductase system NrdEF NA C2_02223 nrdI ko:K03647 Probably involved in ribonucleotide reductase function NA C2_02224 nrdE ko00230,ko00240,ko01100,map00230,map00240,map01100 ko:K00525 1.17.4.1 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02225 nrdF ko00230,ko00240,ko01100,map00230,map00240,map01100 ko:K00526 1.17.4.1 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02226 proV ko02010,map02010 ko:K02000 3.6.3.32 glycine, betaine ABC transporters : Membrane transport : Environmental Information Processing C2_02227 proW ko02010,map02010 ko:K02001,ko:K02002 glycine betaine ABC transporters : Membrane transport : Environmental Information Processing C2_02228 proX ko02010,map02010 ko:K02001,ko:K02002 Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake. Binds glycine betaine and proline betaine with high affinity ABC transporters : Membrane transport : Environmental Information Processing C2_02232 mprA ko:K03712,ko:K15974 Negative regulator of the multidrug operon emrAB NA C2_02233 emrA ko02020,map02020 ko:K03543,ko:K07797 Multidrug resistance protein Two-component system : Signal transduction : Environmental Information Processing C2_02234 emrB ko:K03446 Major facilitator Superfamily NA C2_02235 luxS ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111 ko:K07173 4.4.1.21 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_02236 gshA ko00270,ko00480,ko01100,map00270,map00480,map01100 ko:K01919 6.3.2.2 Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02244 csrA ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 ko:K03563 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_02245 alaS ko00970,map00970 ko:K01872 6.1.1.7 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_02246 recX ko00561,ko01100,map00561,map01100 ko:K03565,ko:K19002 2.4.1.337 Modulates RecA activity through direct physical interaction. Can inhibit both RecA recombinase and coprotease activities. May have a regulatory role during the SOS response. Inhibits DNA strand exchange in vitro Glycerolipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02247 recA ko03440,map03440 ko:K03553 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage Homologous recombination : Replication and repair : Genetic Information Processing C2_02248 ygaD ko00760,map00760 ko:K03742,ko:K03743 3.5.1.42 Belongs to the CinA family Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism C2_02249 mltB ko:K08305 Lytic murein transglycosylase B NA C2_02250 srlA ko00051,ko02060,map00051,map02060 ko:K02783 PTS system glucitol sorbitol-specific Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_02251 srlE ko00051,ko02060,map00051,map02060 ko:K02782,ko:K02783 2.7.1.198 PTS system glucitol sorbitol-specific Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_02252 srlB ko00051,ko02060,map00051,map02060 ko:K02781 2.7.1.198 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of SrlA, SrlB and SrlE is involved in glucitol sorbitol transport. It can also use D- mannitol Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_02254 gutM ko:K02466 Glucitol operon activator NA C2_02255 srlR ko:K02081,ko:K02468 phosphoenolpyruvate-dependent sugar phosphotransferase system NA C2_02256 gutQ ko00540,ko01100,map00540,map01100 ko:K02467,ko:K06041 5.3.1.13 It is also able of sustaining the biosynthetic pathway of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs) Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02257 norR ko02020,ko05132,map02020,map05132 ko:K02584,ko:K12146,ko:K12266,ko:K15836 Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54 Two-component system : Signal transduction : Environmental Information Processing;Salmonella infection : Infectious disease: bacterial : Human Diseases C2_02258 norV ko05132,map05132 ko:K03618,ko:K12264,ko:K22405 1.6.3.4 uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center Salmonella infection : Infectious disease: bacterial : Human Diseases C2_02259 norW ko00071,ko00360,ko00910,ko01120,ko01220,ko05132,map00071,map00360,map00910,map01120,map01220,map05132 ko:K00362,ko:K00529,ko:K12265 1.18.1.3,1.7.1.15 One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase Fatty acid degradation : Lipid metabolism : Metabolism;Phenylalanine metabolism : Amino acid metabolism : Metabolism;Nitrogen metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism;Salmonella infection : Infectious disease: bacterial : Human Diseases C2_02260 hypF ko:K04656 Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide NA C2_02261 hydN ko:K05796,ko:K12136,ko:K15827 electron transport from formate to hydrogen NA C2_02262 ascG ko:K02529,ko:K03487 Repressor of the asc operon. The cryptic operon is activated by the insertion of IS186 into the ascG gene NA C2_02263 ascF ko00010,ko00500,ko00520,ko02060,ko05111,map00010,map00500,map00520,map02060,map05111 ko:K02749,ko:K02752,ko:K02753,ko:K02755,ko:K02756,ko:K02757,ko:K02778,ko:K02779,ko:K02790,ko:K02791,ko:K02802,ko:K02803,ko:K02804,ko:K02818,ko:K02819,ko:K11191,ko:K11192 2.7.1.192,2.7.1.193,2.7.1.199,2.7.1.201,2.7.1.208 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in arbutin, cellobiose, and salicin transport Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_02264 ascB ko00010,ko00500,map00010,map00500 ko:K01223 3.2.1.86 Catalyzes the hydrolysis of phosphorylated beta- glucosides into glucose-6-phosphate (G-6-P) and aglycone. It has a high affinity for phosphorylated aromatic beta-glucosides (p- nitrophenyl-beta-glucoside, phenyl beta-glucoside, arbutin and phosphorylated salicin), and a low affinity for phosphorylated beta-methyl-glucoside Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism C2_02265 ygjM ko:K18831 transcriptional regulator NA C2_02266 higB ko:K19166 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase. mRNA interferases play a role in bacterial persistence to antibiotics NA C2_02268 hycI ko00680,ko01100,ko01120,map00680,map01100,map01120 ko:K00442,ko:K03605,ko:K08315 3.4.23.51 Protease involved in the C-terminal processing of HycE, the large subunit of hydrogenase 3 Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_02269 hycH ko:K12145,ko:K15834 formate hydrogenlyase maturation NA C2_02270 hycG ko:K12144,ko:K15832 Formate hydrogenlyase NA C2_02271 hycF ko:K12143,ko:K15831 electron transfer protein for hydrogenase NA C2_02272 hycE ko:K12142,ko:K15830 nickel cation binding NA C2_02273 hycD ko:K12138,ko:K15829 oxidoreductase activity NA C2_02274 hycC ko:K12137,ko:K15828 Formate hydrogenlyase, subunit NA C2_02275 hycB ko:K05796,ko:K12136,ko:K15827 electron transfer protein for hydrogenase NA C2_02276 hycA ko:K15833 Regulatory protein for the formate hydrogenlyase system. Could act by directly interacting with FhlA or by preventing the binding of FhlA to the upstream activatory sequence NA C2_02277 hypA ko:K04651 Probably plays a role in a hydrogenase nickel cofactor insertion step NA C2_02278 hypB ko:K04652 Required for the maturation of the three NiFe hydrogenases. Exhibits a low intrinsic GTPase activity. The GTP hydrolysis catalyzed by HypB is an integral process in the incorporation of nickel into hydrogenases NA C2_02279 hypC ko:K04653 Is required for the formation of all three hydrogenase isoenzymes. May bind to the precursor form of the large subunit of dehydrogenases to keep them in a conformation accessible for metal incorporation NA C2_02280 hypD ko:K04654 Belongs to the HypD family NA C2_02281 hypE ko:K04655 formation protein hypE NA C2_02282 fhlA ko02020,ko05132,map02020,map05132 ko:K02584,ko:K12146,ko:K12266,ko:K15836 Formate hydrogen-lyase transcriptional activator Two-component system : Signal transduction : Environmental Information Processing;Salmonella infection : Infectious disease: bacterial : Human Diseases C2_02285 mutS ko03430,map03430 ko:K03555 that it carries out the mismatch recognition step. This protein has a weak ATPase activity Mismatch repair : Replication and repair : Genetic Information Processing C2_02286 pphA ko:K07313,ko:K07314 3.1.3.16 phosphatase 2 NA C2_02287 lacR ko:K02081,ko:K02530,ko:K03436 Transcriptional regulator NA C2_02288 ygbJ ko:K08319 1.1.1.411 Catalyzes oxidation of L-threonate to 2-oxo-tetronate. Can use either NAD( ) or NADP( ) as cosubstrate, with a preference for NAD( ) NA C2_02289 ygbK ko:K21948 2.7.1.217 kinase activity NA C2_02290 ygbL ko00040,ko00051,ko00053,ko01100,ko01120,map00040,map00051,map00053,map01100,map01120 ko:K01628,ko:K01629,ko:K03077,ko:K22130 4.1.1.104,4.1.2.17,4.1.2.19,5.1.3.4 Belongs to the aldolase class II family. AraD FucA subfamily Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_02291 ygbM ko00630,ko01100,map00630,map01100 ko:K01816,ko:K22131 5.3.1.22,5.3.1.35 isomerase activity Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02292 ygbN ko:K03299 gluconate transmembrane transporter activity NA C2_02293 bsdD ko00627,ko01120,ko01220,map00627,map01120,map01220 ko:K21759 4.1.1.61 4-hydroxybenzoate decarboxylase Aminobenzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_02294 yclC ko00627,ko01120,ko01220,map00627,map01120,map01220 ko:K01612 4.1.1.61 Decarboxylase involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions. It is able to catalyze the reversible decarboxylation of 4-hydroxybenzoate and vanillate Aminobenzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_02295 ubiX ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 ko:K03186 2.5.1.129 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Aminobenzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Phenylpropanoid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_02296 ubiX ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 ko:K03186 2.5.1.129 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for phenolic acid decarboxylase C Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Aminobenzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Phenylpropanoid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_02297 hosA ko:K06075,ko:K22489 Transcriptional regulator NA C2_02298 rpoS ko02026,ko05111,map02026,map05111 ko:K03087 Sigma-70 factor, region 1.2 Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_02299 nlpD ko:K06194,ko:K12943 autolysis NA C2_02300 pcm ko:K00573 2.1.1.77 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins NA C2_02301 surE ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 ko:K03787 3.1.3.5 Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'- monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain- length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_02302 truD ko:K06176 5.4.99.27 Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs NA C2_02303 ispF ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko:K00554,ko:K00991,ko:K01770,ko:K12506 2.1.1.228,2.7.7.60,4.6.1.12 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_02304 ispD ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko:K00991 2.7.7.60 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_02305 ftsB ko:K05589 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic NA C2_02307 cysC ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 ko:K00860 2.7.1.25 Catalyzes the synthesis of activated sulfate Purine metabolism : Nucleotide metabolism : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_02308 cysN ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 ko:K00955,ko:K00956 2.7.1.25,2.7.7.4 Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily Purine metabolism : Nucleotide metabolism : Metabolism;Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA C2_02309 cysD ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 ko:K00390,ko:K00957 1.8.4.10,1.8.4.8,2.7.7.4 sulfate adenylyltransferase), subunit 2 Purine metabolism : Nucleotide metabolism : Metabolism;Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA C2_02310 iap ko:K09612 Catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3 NA C2_02311 cas3 ko:K07012,ko:K19123 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 plus Cascade participate in CRISPR interference, the third stage of CRISPR immunity NA C2_02312 hokE ko:K18922 Hok/gef family NA C2_02313 cysH ko00920,ko01100,ko01120,map00920,map01100,map01120 ko:K00390 1.8.4.10,1.8.4.8 Reduction of activated sulfate into sulfite Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_02314 cysI ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120 ko:K00366,ko:K00381,ko:K00392 1.7.7.1,1.8.1.2,1.8.7.1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate Nitrogen metabolism : Energy metabolism : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_02315 cysJ ko00920,ko01100,ko01120,map00920,map01100,map01120 ko:K00380 1.8.1.2 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_02316 queD ko00790,ko01100,map00790,map01100 ko:K01737 4.1.2.50,4.2.3.12 Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02318 queE ko00790,ko01100,map00790,map01100 ko:K04068,ko:K10026 1.97.1.4,4.3.99.3 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02320 ygcG ko:K06872 TPM domain NA C2_02321 eno ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 ko:K01689 4.2.1.11 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;RNA degradation : Folding, sorting and degradation : Genetic Information Processing;HIF-1 signaling pathway : Signal transduction : Environmental Information Processing C2_02322 pyrG ko00240,ko01100,map00240,map01100 ko:K01937 6.3.4.2 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02323 mazG ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100 ko:K02428,ko:K02499,ko:K04765 3.6.1.66,3.6.1.9 mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp produced by RelA under amino acid starvation, thus protecting the cell from the toxicity of MazF. Reduction of (p)ppGpp can be achieved by direct degradation of (p)ppGpp or by degradation of NTPs, which are substrates for (p)ppGpp synthesis by RelA Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02324 chpA ko:K07171 Transcriptional modulator of MazE toxin, MazF NA C2_02325 chpR ko:K07172,ko:K18829,ko:K18842 Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to the MazF endoribonuclease toxin and neutralizes its endoribonuclease activity. Is considered to be an 'addiction' molecule as the cell dies in its absence. Toxicity results when the levels of MazE decrease in the cell, leading to mRNA degradation. This effect can be rescued by expression of MazE, but after 6 hours in rich medium the overexpression of MazF leads to programmed cell death. Cell growth and viability are not affected when MazF and MazE are coexpressed. Both MazE and MazE-MazF bind to the promoter region of the mazE- mazF operon to inhibit their own transcription. There are 3 operators to which MazE binds. MazE has higher affinity for promoter DNA in the presence of MazF NA C2_02326 relA ko00230,map00230 ko:K00951,ko:K01139 2.7.6.5,3.1.7.2 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance Purine metabolism : Nucleotide metabolism : Metabolism C2_02327 rlmD ko:K03215 2.1.1.190 Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA NA C2_02328 barA ko01501,ko02020,ko02025,ko02026,ko02030,ko05111,map01501,map02020,map02025,map02026,map02030,map05111 ko:K03407,ko:K07647,ko:K07673,ko:K07674,ko:K07678,ko:K18143,ko:K20973,ko:K20974 2.7.13.3 PhoQ Sensor beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Bacterial chemotaxis : Cell motility : Cellular Processes;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_02329 gudD ko00053,ko01100,map00053,map01100 ko:K01706,ko:K13918 4.2.1.40 Catalyzes the dehydration of glucarate to 5-keto-4- deoxy-D-glucarate (5-kdGluc). Also acts on L-idarate Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02330 gudD ko00053,ko01100,map00053,map01100 ko:K01706,ko:K13918 4.2.1.40 Does not seem to have an in-vivo activity on glucarate or idarate. Its real substrate is Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02331 gudP ko:K03535,ko:K08194,ko:K12299 glucarate transporter NA C2_02332 yqcA ko:K06205 FMN binding NA C2_02333 truC ko:K06175 5.4.99.26 Pseudouridine synthase NA C2_02334 yqcC ko00521,ko00523,ko01130,map00521,map00523,map01130 ko:K01790,ko:K03806,ko:K06175 3.5.1.28,5.1.3.13,5.4.99.26 single-species biofilm formation Streptomycin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Polyketide sugar unit biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;NA : NA : NA C2_02335 syd ko:K15723 Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function NA C2_02336 queF ko00790,ko01100,map00790,map01100 ko:K06879,ko:K09457 1.7.1.13 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02337 ygdH ko00230,ko00240,map00230,map00240 ko:K06966 3.2.2.10 Catalyzes the hydrolysis of the N-glycosidic bond of diverse pyrimidine and purine nucleotide 5'-monophosphates, to form ribose 5-phosphate and the corresponding free base. Can use AMP, GMP, IMP, CMP, dTMP and UMP as substrates. Cannot catalyze the reverse reactions Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism C2_02338 sdaC ko:K03834,ko:K03835,ko:K03836,ko:K03837,ko:K03838 Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity NA C2_02339 sdaB ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 ko:K01752 4.3.1.17 L-serine dehydratase Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02340 xni ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 ko:K01146,ko:K02335 2.7.7.7 activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Base excision repair : Replication and repair : Genetic Information Processing;Nucleotide excision repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing C2_02341 fucO ko00010,ko00071,ko00350,ko00625,ko00626,ko00630,ko00640,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00010,map00071,map00350,map00625,map00626,map00630,map00640,map00680,map01100,map01110,map01120,map01130,map01200,map01220 ko:K00048,ko:K13954,ko:K17067 1.1.1.1,1.1.1.77,1.1.99.37,1.2.98.1 glycol catabolic process Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Fatty acid degradation : Lipid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Chloroalkane and chloroalkene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Naphthalene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_02342 fucA ko00040,ko00051,ko00053,ko01100,ko01120,map00040,map00051,map00053,map01100,map01120 ko:K01628,ko:K03077 4.1.2.17,5.1.3.4 Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_02343 fucP ko:K02429,ko:K06141 Mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-galactose and D-arabinose, but at reduced rates compared with L-fucose. Is not able to transport L-rhamnose and L-arabinose NA C2_02344 fucI ko00051,ko01120,map00051,map01120 ko:K01818 5.3.1.25,5.3.1.3 Converts the aldose L-fucose into the corresponding ketose L-fuculose Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_02345 fucK ko00040,ko00051,ko00053,ko01100,ko01120,ko02024,map00040,map00051,map00053,map01100,map01120,map02024 ko:K00848,ko:K00854,ko:K00879,ko:K00880,ko:K11216 2.7.1.17,2.7.1.189,2.7.1.5,2.7.1.51,2.7.1.53 Catalyzes the phosphorylation of L-fuculose Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_02346 fucU ko:K02431 5.1.3.29 Involved in the anomeric conversion of L-fucose NA C2_02347 fucR ko:K02430,ko:K02444 transcriptional regulator NA C2_02348 rlmM ko:K06968 2.1.1.186 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily NA C2_02350 gcvA ko02026,map02026 ko:K03566 Regulatory protein for the glycine cleavage system operon (gcv). Mediates activation of gcv by glycine and repression by purines. GcvA is negatively autoregulated. Binds to three sites upstream of the gcv promoter Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_02352 csdA ko00450,ko01100,map00450,map01100 ko:K01766,ko:K11717 2.8.1.7,4.4.1.16 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine, and transiently retains the released sulfur atom on a cysteine residue, in the form of a persulfide. Can also desulfinate L-cysteine sulfinate, which is the best substrate of the enzyme. Functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate. Seems to participate in Fe S biogenesis by recruiting the SufBCD- SufE proteins. Transfers sulfur to CsdE that increases the cysteine desulfurase activity of CsdA. Can also transfer sulfur directly to TcdA CsdL in vitro. Appears to support the function of TcdA in the generation of cyclic threonylcarbamoyladenosine at position 37 (ct(6)A37) in tRNAs that read codons beginning with adenine Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02353 csdE ko00450,ko01100,map00450,map01100 ko:K02426,ko:K07125,ko:K11717 2.8.1.7,4.4.1.16 Stimulates the cysteine desulfurase activity of CsdA. Contains a cysteine residue (Cys-61) that acts to accept sulfur liberated via the desulfurase activity of CsdA. May be able to transfer sulfur to TcdA CsdL. Seems to support the function of TcdA in the generation of cyclic threonylcarbamoyladenosine at position 37 (ct(6)A37) in tRNAs that read codons beginning with adenine. Does not appear to participate in Fe S biogenesis Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02354 ygdL ko00730,ko01100,ko04122,map00730,map01100,map04122 ko:K03148,ko:K21029,ko:K22132 2.7.7.73,2.7.7.80 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_02355 mltA ko:K08304 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division NA C2_02359 amiC ko01503,map01503 ko:K01448 3.5.1.28 Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_02360 argA ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 ko:K00619,ko:K00930,ko:K14682 2.3.1.1,2.7.2.8 Belongs to the acetyltransferase family. ArgA subfamily Arginine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02361 recD ko03440,map03440 ko:K03581 3.1.11.5 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD Homologous recombination : Replication and repair : Genetic Information Processing C2_02362 recB ko03440,map03440 ko:K03582,ko:K16898 3.1.11.5,3.6.4.12 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA Homologous recombination : Replication and repair : Genetic Information Processing C2_02363 ptrA ko05010,map05010 ko:K01407,ko:K01408 3.4.24.55,3.4.24.56 Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin Alzheimer disease : Neurodegenerative disease : Human Diseases C2_02364 recC ko03440,map03440 ko:K03583 3.1.11.5 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity Homologous recombination : Replication and repair : Genetic Information Processing C2_02365 ppdC ko03070,ko05111,map03070,map05111 ko:K02458,ko:K02671,ko:K02681 Type II secretion prepilin peptidase dependent protein C Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_02367 ppdB ko03070,ko05111,map03070,map05111 ko:K02459,ko:K02672,ko:K02680 Prepilin peptidase dependent protein B Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_02368 ppdA ko03070,ko05111,map03070,map05111 ko:K02456,ko:K02457,ko:K02458,ko:K02679 Prokaryotic N-terminal methylation motif Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_02369 thyA ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 ko:K00560 2.1.1.45 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis Pyrimidine metabolism : Nucleotide metabolism : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Antifolate resistance : Drug resistance: antineoplastic : Human Diseases C2_02370 lgt ko:K03438,ko:K13292 2.1.1.199 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins NA C2_02371 ptsP ko02060,map02060 ko:K08483,ko:K08484 2.7.3.9 Component of the phosphoenolpyruvate-dependent nitrogen- metabolic phosphotransferase system (nitrogen-metabolic PTS), that seems to be involved in regulating nitrogen metabolism. Enzyme I- Ntr transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (NPr). Could function in the transcriptional regulation of sigma-54 dependent operons in conjunction with the NPr (PtsO) and EIIA-Ntr (PtsN) proteins. Enzyme I-Ntr is specific for NPr Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_02372 nudH ko03018,map03018 ko:K08311 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage RNA degradation : Folding, sorting and degradation : Genetic Information Processing C2_02374 mutH ko03430,map03430 ko:K03573 Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair Mismatch repair : Replication and repair : Genetic Information Processing C2_02378 lplT ko00071,ko00564,map00071,map00564 ko:K05939,ko:K08227 2.3.1.40,6.2.1.20 Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell Fatty acid degradation : Lipid metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism C2_02381 lysA ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 ko:K01586,ko:K12526 2.7.2.4,4.1.1.20 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Lysine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02383 ygeA ko00250,ko01054,map00250,map01054 ko:K01779 5.1.1.13 Belongs to the aspartate glutamate racemases family Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Nonribosomal peptide structures : Metabolism of terpenoids and polyketides : Metabolism C2_02384 araE ko:K02100,ko:K08137,ko:K08138 Major facilitator Superfamily NA C2_02386 kduI ko00040,map00040 ko:K01815 5.3.1.17 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism C2_02387 yqeF ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 ko:K00626 2.3.1.9 Belongs to the thiolase family Fatty acid degradation : Lipid metabolism : Metabolism;Synthesis and degradation of ketone bodies : Lipid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Lysine degradation : Amino acid metabolism : Metabolism;Benzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Tryptophan metabolism : Amino acid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_02388 yqeG ko:K03834,ko:K03835,ko:K03836,ko:K03837,ko:K03838 Inner membrane transport protein YqeG NA C2_02389 yieP ko:K19776 DNA-binding transcription factor activity NA C2_02391 rbsR ko:K02529,ko:K03604 Transcriptional repressor for the ribose rbsDACBK operon. RbsR binds to a region of perfect dyad symmetry spanning the rbs operon transcriptional start site. The affinity for the rbs operator is reduced by addition of ribose, consistent with ribose being the inducer of the operon NA C2_02392 rbsK ko00030,map00030 ko:K00852 2.7.1.15 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway Pentose phosphate pathway : Carbohydrate metabolism : Metabolism C2_02393 rbsB ko02010,ko02030,map02010,map02030 ko:K02058,ko:K10439 Part of the ABC transporter complex RbsABC involved in ribose import. Binds ribose. Also serves as the primary chemoreceptor for chemotaxis ABC transporters : Membrane transport : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes C2_02394 rbsC ko02010,map02010 ko:K03549,ko:K10440 Part of the ABC transporter complex RbsABC involved in ribose import. Probably responsible for the translocation of the substrate across the membrane ABC transporters : Membrane transport : Environmental Information Processing C2_02395 rbsA ko02010,map02010 ko:K10441,ko:K10542 3.6.3.17 Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_02396 rbsD ko02010,map02010 ko:K06726 5.4.99.62 Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose ABC transporters : Membrane transport : Environmental Information Processing C2_02397 kup ko:K03549 Responsible for the low-affinity transport of potassium into the cell, with the NA C2_02398 ravA ko:K03924 Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone NA C2_02400 asnA ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230 ko:K01914 6.3.1.1 aspartate--ammonia ligase Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Cyanoamino acid metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02401 asnC ko:K03718 and repressor of the expression of gidA at a post-transcriptional level NA C2_02402 mioC ko:K06205 electron transporter required for biotin synthase activity NA C2_02403 gidA ko:K03495 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 NA C2_02404 rsmG ko:K03501 2.1.1.170 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA NA C2_02405 atpI ko:K02116 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation NA C2_02406 atpB ko00190,ko00195,ko01100,map00190,map00195,map01100 ko:K02108 it plays a direct role in the translocation of protons across the membrane Oxidative phosphorylation : Energy metabolism : Metabolism;Photosynthesis : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02407 atpE ko00190,ko00195,ko01100,map00190,map00195,map01100 ko:K02110 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation Oxidative phosphorylation : Energy metabolism : Metabolism;Photosynthesis : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02408 atpF ko00190,ko00195,ko01100,map00190,map00195,map01100 ko:K02109 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation Oxidative phosphorylation : Energy metabolism : Metabolism;Photosynthesis : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02409 atpH ko00190,ko00195,ko01100,map00190,map00195,map01100 ko:K02113 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation Oxidative phosphorylation : Energy metabolism : Metabolism;Photosynthesis : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02410 atpA ko00190,ko00195,ko01100,map00190,map00195,map01100 ko:K02111 3.6.3.14 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit Oxidative phosphorylation : Energy metabolism : Metabolism;Photosynthesis : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02411 atpG ko00190,ko00195,ko01100,map00190,map00195,map01100 ko:K02115 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex Oxidative phosphorylation : Energy metabolism : Metabolism;Photosynthesis : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02412 atpD ko00190,ko00195,ko01100,map00190,map00195,map01100 ko:K02112 3.6.3.14 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits Oxidative phosphorylation : Energy metabolism : Metabolism;Photosynthesis : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02413 atpC ko00190,ko00195,ko01100,map00190,map00195,map01100 ko:K02114 Produces ATP from ADP in the presence of a proton gradient across the membrane Oxidative phosphorylation : Energy metabolism : Metabolism;Photosynthesis : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02414 glmU ko00520,ko01100,ko01130,map00520,map01100,map01130 ko:K04042 2.3.1.157,2.7.7.23 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;NA : NA : NA C2_02415 glmS ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 ko:K00820 2.6.1.16 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;NA : NA : NA;Insulin resistance : Endocrine and metabolic disease : Human Diseases C2_02416 lpfA ko05133,map05133 ko:K07345 Fimbrial protein Pertussis : Infectious disease: bacterial : Human Diseases C2_02417 ko:K07346 chaperone NA C2_02418 ko05133,map05133 ko:K07347,ko:K07354 Usher protein Pertussis : Infectious disease: bacterial : Human Diseases C2_02420 pstS ko02010,ko02020,ko05152,map02010,map02020,map05152 ko:K02040 Part of the ABC transporter complex PstSACB involved in phosphate import ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing;Tuberculosis : Infectious disease: bacterial : Human Diseases C2_02421 pstC ko02010,map02010 ko:K02037,ko:K02038 probably responsible for the translocation of the substrate across the membrane ABC transporters : Membrane transport : Environmental Information Processing C2_02422 pstA ko02010,map02010 ko:K02037,ko:K02038 Phosphate transport system permease protein PstA ABC transporters : Membrane transport : Environmental Information Processing C2_02423 pstB ko02010,map02010 ko:K02036 3.6.3.27 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_02424 phoU ko:K02039 Part of the phosphate (Pho) regulon, which plays a key role in phosphate homeostasis. PhoU is essential for the repression of the Pho regulon at high phosphate conditions NA C2_02425 bglG ko:K02538,ko:K03488 Mediates the positive regulation of the beta-glucoside (bgl) operon by functioning as a transcriptional antiterminator. This is an RNA-binding protein that recognizes a specific sequence located just upstream of two termination sites within the operon NA C2_02426 bglF ko00010,ko00500,ko00520,ko02060,ko05111,map00010,map00500,map00520,map02060,map05111 ko:K02749,ko:K02750,ko:K02752,ko:K02753,ko:K02755,ko:K02756,ko:K02757,ko:K02778,ko:K02779,ko:K02790,ko:K02791,ko:K02802,ko:K02803,ko:K02804,ko:K02818,ko:K02819,ko:K11191,ko:K11192 2.7.1.192,2.7.1.193,2.7.1.199,2.7.1.201,2.7.1.208 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in beta-glucoside transport Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_02427 bglB ko00010,ko00500,map00010,map00500 ko:K01223 3.2.1.86 Catalyzes the hydrolysis of phosphorylated beta- glucosides into glucose-6-phosphate (G-6-P) and aglycone. It has a high affinity for phosphorylated aromatic beta-glucosides (p- nitrophenyl-beta-glucoside, phenyl beta-glucoside, arbutin and phosphorylated salicin), and a low affinity for phosphorylated beta-methyl-glucoside Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism C2_02428 bglH ko:K02024,ko:K10124 PFAM porin LamB type NA C2_02429 yieL ko:K07214 Belongs to the glycosyl hydrolase 13 family NA C2_02430 yieL ko:K07214 Belongs to the glycosyl hydrolase 13 family NA C2_02431 nagB ko00030,ko00052,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00052,map00520,map01100,map01110,map01120,map01130,map01200 ko:K01057,ko:K02080,ko:K02564 3.1.1.31,3.5.99.6 glucosamine-6-phosphate deaminase activity Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_02432 cbrC ko:K09925 bacteriocin immunity NA C2_02435 yieG ko:K06901 Belongs to the xanthine uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily NA C2_02436 yieF ko:K19784 Can also reduce toxic chromate to insoluble and less toxic Cr(3 ). Catalyzes the transfer of three electrons to Cr(6 ) producing Cr(3 ) and one electron to molecular oxygen without producing the toxic Cr(5 ) species and only producing a minimal amount of reactive oxygen species (ROS). Chromate reduction protects the cell against chromate toxicity, but is likely a secondary activity NA C2_02437 yieE ko00770,map00770 ko:K00997,ko:K06133 2.7.8.7 Phosphopantetheinyl transferase Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism C2_02439 mdtL ko:K07552,ko:K08163,ko:K18552 Major facilitator Superfamily NA C2_02440 tnaB ko:K03834,ko:K03835,ko:K03836,ko:K03837,ko:K03838 Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically NA C2_02441 tnaA ko00380,map00380 ko:K01667 4.1.99.1 Belongs to the beta-eliminating lyase family Tryptophan metabolism : Amino acid metabolism : Metabolism C2_02442 mnmE ko:K03650 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 NA C2_02443 yidC ko02024,ko03060,ko03070,map02024,map03060,map03070 ko:K03217 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_02444 rnpA ko:K03536,ko:K08998 3.1.26.5 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme NA C2_02445 rpmH ko03010,map03010 ko:K02914 Belongs to the bacterial ribosomal protein bL34 family Ribosome : Translation : Genetic Information Processing C2_02446 dnaA ko02020,ko04112,map02020,map04112 ko:K02313 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids Two-component system : Signal transduction : Environmental Information Processing;Cell cycle - Caulobacter : Cell growth and death : Cellular Processes C2_02447 dnaN ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02338 2.7.7.7 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing C2_02448 recF ko03440,map03440 ko:K03629 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP Homologous recombination : Replication and repair : Genetic Information Processing C2_02449 gyrB ko:K02470 5.99.1.3 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner NA C2_02453 dgoR ko:K19776 transcriptional NA C2_02454 dgoK ko00052,ko01100,map00052,map01100 ko:K00883 2.7.1.58 2-keto-3-deoxy-galactonokinase Galactose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02455 dgoA ko00030,ko00052,ko00630,ko01100,ko01120,ko01200,map00030,map00052,map00630,map01100,map01120,map01200 ko:K01625,ko:K01631 4.1.2.14,4.1.2.21,4.1.3.42 Involved in the degradation of galactose via the DeLey- Doudoroff pathway. Catalyzes the reversible, stereospecific retro- aldol cleavage of 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) to pyruvate and D-glyceraldehyde-3-phosphate. In the synthetic direction, it catalyzes the addition of pyruvate to electrophilic aldehydes with re-facial selectivity. It can use a limited number of aldehyde substrates, including D-glyceraldehyde-3-phosphate (natural substrate), D-glyceraldehyde, glycolaldehyde, 2- pyridinecarboxaldehyde, D-ribose, D-erythrose and D-threose. It efficiently catalyzes aldol addition only using pyruvate as the nucleophilic component and accepts both stereochemical configurations at C2 of the electrophile Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_02456 dgoD ko00052,ko01100,ko01120,map00052,map01100,map01120 ko:K01684 4.2.1.6 Catalyzes the dehydration of D-galactonate to 2-keto-3- deoxy-D-galactonate Galactose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_02457 dgoT ko:K03535,ko:K08194,ko:K12299 Intake of galactonate into the cell NA C2_02461 ibpA ko04141,map04141 ko:K04080,ko:K04081,ko:K13993 Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent Protein processing in endoplasmic reticulum : Folding, sorting and degradation : Genetic Information Processing C2_02462 ibpB ko04141,map04141 ko:K04080,ko:K04081,ko:K13993 Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent Protein processing in endoplasmic reticulum : Folding, sorting and degradation : Genetic Information Processing C2_02463 yidE ko:K03281,ko:K07085 potassium ion transport NA C2_02464 yidP ko:K03482,ko:K03710,ko:K11922 transcriptional regulator NA C2_02465 glvC ko00010,ko00500,ko00520,ko02060,ko05111,map00010,map00500,map00520,map02060,map05111 ko:K02749,ko:K02750,ko:K02752,ko:K02753,ko:K02778,ko:K02779,ko:K02790,ko:K02791,ko:K02802,ko:K02803,ko:K02804,ko:K02818,ko:K02819,ko:K11191,ko:K11192 2.7.1.192,2.7.1.193,2.7.1.199,2.7.1.201,2.7.1.208 Phosphotransferase system, EIIC Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_02466 aglB ko00010,ko00052,ko00500,ko00561,ko00600,ko00603,map00010,map00052,map00500,map00561,map00600,map00603 ko:K01222,ko:K01232,ko:K07406 3.2.1.122,3.2.1.22,3.2.1.86 Family 4 glycosyl hydrolase Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Sphingolipid metabolism : Lipid metabolism : Metabolism;Glycosphingolipid biosynthesis - globo and isoglobo series : Glycan biosynthesis and metabolism : Metabolism C2_02467 aglB ko00010,ko00052,ko00500,ko00561,ko00600,ko00603,map00010,map00052,map00500,map00561,map00600,map00603 ko:K01222,ko:K01232,ko:K07406 3.2.1.122,3.2.1.22,3.2.1.86 Family 4 glycosyl hydrolase Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Sphingolipid metabolism : Lipid metabolism : Metabolism;Glycosphingolipid biosynthesis - globo and isoglobo series : Glycan biosynthesis and metabolism : Metabolism C2_02469 yidK ko:K03307 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family NA C2_02470 yidJ ko:K01138 sulfuric ester hydrolase activity NA C2_02472 yidH ko:K00389 response to oxidative stress NA C2_02474 yidF ko:K06871 radical SAM NA C2_02475 emrD ko:K08154 Major facilitator Superfamily NA C2_02478 ilvB ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 ko:K01652 2.2.1.6 acetolactate synthase Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02479 ilvN ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 ko:K01653 2.2.1.6 acetolactate synthase Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02480 uhpA ko02020,ko02024,ko02025,ko02026,ko05111,ko05133,map02020,map02024,map02025,map02026,map05111,map05133 ko:K02282,ko:K07686,ko:K07687,ko:K07688,ko:K07689,ko:K07690,ko:K20264 Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. Activates the transcription of the uhpT gene. Acts by binding specifically to the uhpT promoter region Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes;Pertussis : Infectious disease: bacterial : Human Diseases C2_02481 uhpB ko02020,ko02024,map02020,map02024 ko:K07675,ko:K14988,ko:K20263 2.7.13.3 Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpB functions as a membrane-associated protein kinase that autophosphorylates in response to interaction with UhpC, and subsequently transfers its phosphate group to the response regulator UhpA. Can also dephosphorylate UhpA Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_02482 uhpC ko02020,map02020 ko:K02445,ko:K07783 Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC senses external glucose-6-phosphate and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB Two-component system : Signal transduction : Environmental Information Processing C2_02483 uhpT ko02020,map02020 ko:K02445,ko:K07784 Mediates the exchange of external hexose 6-phosphate and internal inorganic phosphate. Can transport glucose-6-phosphate, fructose-6-phosphate and mannose-6-phosphate. Also catalyzes the neutral exchange of internal and external phosphate Two-component system : Signal transduction : Environmental Information Processing C2_02484 ade ko00230,ko01100,map00230,map01100 ko:K01486 3.5.4.2 adenine deaminase Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02485 yieG ko:K06901 permease NA C2_02487 nepI ko:K03445 Major facilitator Superfamily NA C2_02489 metQ ko02010,map02010 ko:K02072,ko:K02073 NLPA lipoprotein ABC transporters : Membrane transport : Environmental Information Processing C2_02491 setB ko:K03291 sugar efflux transporter NA C2_02494 yicJ ko:K03292,ko:K11104,ko:K16139,ko:K16248 sodium ion transport NA C2_02495 yicI ko:K01811 3.2.1.177 Belongs to the glycosyl hydrolase 31 family NA C2_02496 yicH ko:K07289 AsmA family NA C2_02497 xanP ko:K02824,ko:K03458,ko:K09016,ko:K16345,ko:K16346 Specific, proton motive force-dependent high-affinity transporter for xanthine NA C2_02498 gltS ko:K03312 Catalyzes the sodium-dependent transport of glutamate NA C2_02500 recG ko03440,map03440 ko:K03655 3.6.4.12 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) Homologous recombination : Replication and repair : Genetic Information Processing C2_02501 trmH ko:K00556,ko:K03214,ko:K03218,ko:K03437,ko:K15333 2.1.1.185,2.1.1.34 Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA NA C2_02502 spoT ko00230,map00230 ko:K00951,ko:K01139 2.7.6.5,3.1.7.2 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance Purine metabolism : Nucleotide metabolism : Metabolism C2_02503 rpoZ ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 ko:K03060 2.7.7.6 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;RNA polymerase : Transcription : Genetic Information Processing C2_02504 gmk ko00230,ko00240,ko01100,map00230,map00240,map01100 ko:K00942,ko:K01591 2.7.4.8,4.1.1.23 Essential for recycling GMP and indirectly, cGMP Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02505 ligB ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 ko:K01972 6.5.1.2 catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction DNA replication : Replication and repair : Genetic Information Processing;Base excision repair : Replication and repair : Genetic Information Processing;Nucleotide excision repair : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing C2_02507 dinD ko:K07741,ko:K14623 DNA-damage-inducible protein d NA C2_02509 rph ko00230,map00230 ko:K00989,ko:K02428 2.7.7.56,3.6.1.66 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates Purine metabolism : Nucleotide metabolism : Metabolism C2_02510 pyrE ko00240,ko01100,map00240,map01100 ko:K00762 2.4.2.10 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02511 slmA ko:K05501 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions NA C2_02512 dut ko00240,ko00770,ko00983,ko01100,map00240,map00770,map00983,map01100 ko:K01520,ko:K13038 3.6.1.23,4.1.1.36,6.3.2.5 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02513 coaBC ko00770,ko01100,map00770,map01100 ko:K01598,ko:K13038 4.1.1.36,6.3.2.5 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02514 radC ko:K03630 Belongs to the UPF0758 family. YicR subfamily NA C2_02515 rpmB ko03010,map03010 ko:K02902 Belongs to the bacterial ribosomal protein bL28 family Ribosome : Translation : Genetic Information Processing C2_02516 rpmG ko03010,map03010 ko:K02913 there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc Ribosome : Translation : Genetic Information Processing C2_02517 fpg ko03410,map03410 ko:K10563 3.2.2.23,4.2.99.18 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates Base excision repair : Replication and repair : Genetic Information Processing C2_02518 coaD ko00770,ko01100,map00770,map01100 ko:K00954 2.7.7.3 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02519 kdtA ko00540,ko01100,map00540,map01100 ko:K02527 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of two 3-deoxy-D-manno-octulosonate (Kdo) residues from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide- 1,4'-bisphosphate precursor of lipid A Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02520 rfaQ ko00540,ko01100,map00540,map01100 ko:K02849 heptosyltransferase Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02521 rfaG ko00540,ko01100,map00540,map01100 ko:K02844 Lipopolysaccharide core biosynthesis protein RfaG Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02523 rfaJ ko00540,ko01100,map00540,map01100 ko:K03275,ko:K03278,ko:K03279 2.4.1.44,2.4.1.58 lipopolysaccharide glucosyltransferase II activity Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02524 waaB ko00540,ko01100,map00540,map01100 ko:K02840 Adds a galactose goup to a glucose group of LPS Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02525 rfaI ko00540,ko01100,map00540,map01100 ko:K03275,ko:K03276,ko:K03278 2.4.1.44 lipopolysaccharide glucosyltransferase II activity Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02526 rfaJ ko00540,ko01100,map00540,map01100 ko:K03275,ko:K03276,ko:K03278,ko:K03279 2.4.1.44,2.4.1.58 Lipopolysaccharide 1,2-glucosyltransferase Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02527 rfaY ko00540,ko01100,map00540,map01100 ko:K02850 Catalyzes the phosphorylation of heptose(II) of the outer membrane lipopolysaccharide core Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02528 rfaZ ko00540,map00540 ko:K12981 lipopolysaccharide core region biosynthetic process Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism C2_02529 waaU ko00540,ko01100,map00540,map01100 ko:K03277 Adds the terminal N-acetyl-D-glucosamine group on the glucose(II) group of LPS Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02530 rfaL ko00540,ko01100,map00540,map01100 ko:K02847 O-antigen ligase Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02531 rfaC ko00540,ko01100,map00540,map01100 ko:K02841 lipopolysaccharide Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02532 rfaF ko00540,ko01100,map00540,map01100 ko:K02843 heptosyltransferase Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02533 hldD ko00540,ko01100,map00540,map01100 ko:K03274 5.1.3.20 Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02534 kbl ko00260,ko00780,ko01100,map00260,map00780,map01100 ko:K00639,ko:K00652 2.3.1.29,2.3.1.47 Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02535 tdh ko00260,map00260 ko:K00060 1.1.1.103 Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism C2_02536 yibD ko:K19354 glucuronosyltransferase activity NA C2_02537 yibQ ko:K09798 carbohydrate metabolic process NA C2_02538 envC ko:K06194,ko:K12943,ko:K21471 Activator of the cell wall hydrolases AmiA and AmiB. Required for septal murein cleavage and daughter cell separation during cell division. In vitro, exhibits weak endoproteolytic activity on beta-casein NA C2_02539 gpmI ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 ko:K15633 5.4.2.12 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02540 yibN ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 ko:K01011 2.8.1.1,2.8.1.2 Rhodanese-like domain Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_02541 grxC ko:K03674,ko:K03676 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins NA C2_02542 secB ko02024,ko03060,ko03070,map02024,map03060,map03070 ko:K03071 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_02543 gpsA ko00564,ko01110,map00564,map01110 ko:K00057 1.1.1.94 Glycerol-3-phosphate dehydrogenase Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_02544 cysE ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 ko:K00640 2.3.1.30 Belongs to the transferase hexapeptide repeat family Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_02545 trmL ko:K03216 2.1.1.207 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide NA C2_02546 lldD ko00620,ko01100,map00620,map01100 ko:K00101 1.1.2.3 Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02547 lldR ko:K14348 Represses the lctPRD operon NA C2_02548 lldP ko:K00427,ko:K02550,ko:K03303 Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force NA C2_02549 ko:K21449 Mediates aggregation, biofilm formation and adhesion to a range of extracellular matrix (ECM) proteins, such as fibronectin, fibrinogen, laminin and collagen types I, II, III, and V. Mediates adhesion to NA C2_02551 yibL ko:K14762 Protein of unknown function (DUF2810) NA C2_02553 mtlR ko:K02562 Involved in the repression of the expression of the mannitol mtlADR operon. Does not bind the operator promoter regulatory region of this operon. Therefore, seems to belong to a new class of transcription factors in bacteria that may regulate gene expression indirectly, perhaps as a part of a larger transcriptional complex NA C2_02554 mtlD ko00051,map00051 ko:K00009 1.1.1.17 Mannitol-1-Phosphate 5-Dehydrogenase Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism C2_02555 mtlA ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 ko:K02768,ko:K02769,ko:K02770,ko:K02798,ko:K02799,ko:K02800 2.7.1.197,2.7.1.202 PTS system mannitol-specific Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_02557 yibH ko:K03543,ko:K15548,ko:K15549 membrane NA C2_02558 yibG ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110 ko:K01058,ko:K07126 3.1.1.32,3.1.1.4 COG0790 FOG TPR repeat, SEL1 subfamily Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Ether lipid metabolism : Lipid metabolism : Metabolism;Arachidonic acid metabolism : Lipid metabolism : Metabolism;Linoleic acid metabolism : Lipid metabolism : Metabolism;alpha-Linolenic acid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_02561 yhdZ ko02010,ko02020,map02010,map02020 ko:K02028,ko:K09972,ko:K10004 3.6.3.21 amino-acid ABC transporter ATP-binding protein YhdZ ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing C2_02562 yhdY ko02010,map02010 ko:K02029,ko:K09971 amino acid ABC transporter ABC transporters : Membrane transport : Environmental Information Processing C2_02563 yhdX ko02010,map02010 ko:K09970 amino-acid ABC transporter permease protein YhdX ABC transporters : Membrane transport : Environmental Information Processing C2_02564 aapJ ko02010,map02010 ko:K09969 amino-acid ABC ABC transporters : Membrane transport : Environmental Information Processing C2_02567 acrF ko01501,ko01503,map01501,map01503 ko:K18138,ko:K18142,ko:K18899 efflux transmembrane transporter activity beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_02568 acrE ko01501,ko01503,map01501,map01503 ko:K03585,ko:K18141,ko:K18898 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_02569 ttgR ko:K03577,ko:K18140 acrEF envCD operon repressor NA C2_02571 yhdJ ko:K00571,ko:K07319 2.1.1.72 Belongs to the N(4) N(6)-methyltransferase family NA C2_02572 fis ko02020,ko05111,map02020,map05111 ko:K03557,ko:K07712 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_02573 dusB ko:K05539,ko:K05540 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines NA C2_02574 prmA ko:K02687 Methylates ribosomal protein L11 NA C2_02575 panF ko:K03307,ko:K14392 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family NA C2_02577 scrK ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 ko:K00847 2.7.1.4 PFAM PfkB domain protein Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02579 kbaY ko00052,ko01100,map00052,map01100 ko:K08302 4.1.2.40 which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6- bisphosphate (TBP). Requires Galactose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02580 rbsB ko02010,ko02030,map02010,map02030 ko:K10439 Periplasmic binding protein domain ABC transporters : Membrane transport : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes C2_02581 rbsA ko02010,map02010 ko:K10441,ko:K17215 3.6.3.17 Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_02582 ko02010,map02010 ko:K10440 Belongs to the binding-protein-dependent transport system permease family ABC transporters : Membrane transport : Environmental Information Processing C2_02583 scrK ko00051,ko00052,ko00500,ko00520,ko01100,map00051,map00052,map00500,map00520,map01100 ko:K00847,ko:K21621 2.7.1.101,2.7.1.4 Belongs to the carbohydrate kinase PfkB family Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02585 accC ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 ko:K01961 6.3.4.14,6.4.1.2 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA Fatty acid biosynthesis : Lipid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism C2_02586 accB ko00010,ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00010,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 ko:K00627,ko:K02160 2.3.1.12 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Fatty acid biosynthesis : Lipid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism C2_02588 yhdH ko00640,ko01100,map00640,map01100 ko:K19745 acryloyl-CoA reductase (NADP+) activity Propanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02589 csrD ko:K18765 Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di- GMP, despite its domain composition. Positively modulates motility gene expression, is also required for curli expression NA C2_02590 mreB ko:K03569 rod shape-determining protein MreB NA C2_02591 mreC ko:K03570 shape-determining protein MreC NA C2_02592 mreD ko:K03571 Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins NA C2_02593 maf ko:K03215,ko:K06287 2.1.1.190 UTP diphosphatase activity NA C2_02594 rng ko:K08301 Involved in the processing of the 5'-end of 16S rRNA. Could be involved in chromosome segregation and cell division. It may be one of the components of the cytoplasmic axial filaments bundles or merely regulate the formation of this structure NA C2_02596 tldD ko:K03568 'responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase NA C2_02597 aaeR ko:K21698 Activates transcription of the aaeXAB operon NA C2_02598 aaeX ko:K21695 Protein of unknown function (DUF1656) NA C2_02599 aaeA ko:K03543,ko:K15548,ko:K15549 P-hydroxybenzoic acid efflux pump subunit AaeA NA C2_02600 aaeB ko:K03468 Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell NA C2_02601 yhcO ko:K03623 Barstar (barnase inhibitor) NA C2_02603 argR ko:K03402 Regulates arginine biosynthesis genes NA C2_02604 mdh ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 ko:K00024 1.1.1.37 Catalyzes the reversible oxidation of malate to oxaloacetate Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_02605 degS ko01503,ko02020,map01503,map02020 ko:K04691,ko:K04771,ko:K04772 3.4.21.107 Belongs to the peptidase S1C family Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing C2_02606 degQ ko01503,ko02020,map01503,map02020 ko:K04771,ko:K04772,ko:K08070 1.3.1.74,3.4.21.107 DegQ could degrade transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions. DegQ is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for a beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable to be cleaved, thereby preventing non-specific proteolysis of folded proteins. DegQ can substitute for the periplasmic protease DegP Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing C2_02607 yhcB ko:K09908 oxidoreductase activity NA C2_02608 zapE ko:K06916 Reduces the stability of FtsZ polymers in the presence of ATP NA C2_02609 rplM ko03010,map03010 ko:K02871 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly Ribosome : Translation : Genetic Information Processing C2_02610 rpsI ko03010,map03010 ko:K02996 Belongs to the universal ribosomal protein uS9 family Ribosome : Translation : Genetic Information Processing C2_02611 sspA ko:K03599 Forms an equimolar complex with the RNA polymerase holoenzyme (RNAP) but not with the core enzyme NA C2_02612 sspB ko:K03600,ko:K09985 the ssrA degradation tag (AANDENYALAA) is added trans-translationally to proteins that are stalled on the ribosome, freeing the ribosome and targeting stalled peptides for degradation. SspB activates the ATPase activity of ClpX. Seems to act in concert with SspA in the regulation of several proteins during exponential and stationary-phase growth NA C2_02613 dcuD ko:K03326 Responsible for the transport of C4-dicarboxylates during anaerobic growth NA C2_02614 nanR ko:K22104 Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids NA C2_02615 nanA ko00261,ko00300,ko00520,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map00520,map01100,map01110,map01120,map01130,map01230 ko:K01639,ko:K01714 4.1.3.3,4.3.3.7 Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Lysine biosynthesis : Amino acid metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02616 nanT ko:K03290,ko:K08178 Major facilitator Superfamily NA C2_02617 nanE ko00520,ko01100,map00520,map01100 ko:K01788,ko:K13967 2.7.1.60,5.1.3.9 Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02618 nanK ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 ko:K00845,ko:K00885,ko:K13967 2.7.1.2,2.7.1.60,5.1.3.9 Belongs to the ROK (NagC XylR) family. NanK subfamily Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Streptomycin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Neomycin, kanamycin and gentamicin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_02619 yhcH ko00052,ko00511,ko01100,map00052,map00511,map01100 ko:K12112,ko:K19334 cellular response to DNA damage stimulus Galactose metabolism : Carbohydrate metabolism : Metabolism;Other glycan degradation : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02621 gltD ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 ko:K00266 1.4.1.13,1.4.1.14 glutamate synthase Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Nitrogen metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02622 gltB ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 ko:K00265,ko:K00284 1.4.1.13,1.4.1.14,1.4.7.1 glutamate synthase Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Nitrogen metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02623 yhcC ko:K07139 4 iron, 4 sulfur cluster binding NA C2_02624 arcB ko02020,ko02026,map02020,map02026 ko:K07648 2.7.13.3 Histidine kinase Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_02626 mtgA ko00550,map00550 ko:K03814,ko:K05365 2.4.1.129,3.4.16.4 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism C2_02628 ptsO ko00051,ko00561,ko01100,ko01120,ko02060,map00051,map00561,map01100,map01120,map02060 ko:K02768,ko:K02784,ko:K05881,ko:K08483,ko:K08485,ko:K11183,ko:K11189,ko:K11201 2.7.1.121,2.7.1.202,2.7.3.9 Phosphotransferase System Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_02629 rapZ ko:K06958 Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS NA C2_02630 ptsN ko00051,ko00052,ko00053,ko01100,ko01120,ko02060,map00051,map00052,map00053,map01100,map01120,map02060 ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02806,ko:K02821,ko:K08483,ko:K11189,ko:K11198,ko:K11199,ko:K11200,ko:K11201 2.7.1.194,2.7.1.195,2.7.1.200,2.7.1.202,2.7.3.9 PTS IIA-like nitrogen-regulatory protein PtsN Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_02631 hpf ko:K05808,ko:K05809 During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes NA C2_02632 rpoN ko02020,ko05111,map02020,map05111 ko:K03092 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_02633 lptB ko02010,map02010 ko:K01990,ko:K06861 Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_02634 lptA ko:K09774 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm NA C2_02635 lptC ko02010,ko02020,ko05152,map02010,map02020,map05152 ko:K02040,ko:K11719 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing;Tuberculosis : Infectious disease: bacterial : Human Diseases C2_02636 kdsC ko00540,ko01100,map00540,map01100 ko:K03270 3.1.3.45 Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02637 kdsD ko00540,ko01100,map00540,map01100 ko:K02467,ko:K06041 5.3.1.13 Involved in the biosynthesis of 3-deoxy-D-manno- octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs) Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02638 yrbG ko:K07301 calcium:cation antiporter activity NA C2_02639 mlaF ko02010,map02010 ko:K02065 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_02640 mlaE ko02010,map02010 ko:K02066 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane ABC transporters : Membrane transport : Environmental Information Processing C2_02641 mlaD ko02010,map02010 ko:K02067 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane ABC transporters : Membrane transport : Environmental Information Processing C2_02642 mlaC ko02010,map02010 ko:K07323 ABC-type transport system involved in resistance to organic solvents auxiliary component ABC transporters : Membrane transport : Environmental Information Processing C2_02643 mlaB ko02010,map02010 ko:K02066,ko:K04749,ko:K07122 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane ABC transporters : Membrane transport : Environmental Information Processing C2_02644 yrbA ko:K07390 Belongs to the BolA IbaG family NA C2_02645 murA ko00520,ko00550,ko01100,map00520,map00550,map01100 ko:K00790 2.5.1.7 Belongs to the EPSP synthase family. MurA subfamily Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02646 sfsB ko:K07724 This protein is involved in positive regulation of the metabolism of sugars NA C2_02647 ispB ko00900,ko01110,map00900,map01110 ko:K00805,ko:K02523 2.5.1.30,2.5.1.90 Polyprenyl synthetase Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_02648 rplU ko03010,map03010 ko:K02888 This protein binds to 23S rRNA in the presence of protein L20 Ribosome : Translation : Genetic Information Processing C2_02649 rpmA ko03010,map03010 ko:K02899 Ribosomal L27 protein Ribosome : Translation : Genetic Information Processing C2_02651 obg ko:K03979 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control NA C2_02652 dacB ko00550,map00550 ko:K07259 3.4.16.4 D-alanyl-D-alanine carboxypeptidase Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism C2_02653 greA ko:K03624 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides NA C2_02654 yhbY ko:K07574 preribosome binding NA C2_02655 ftsJ ko:K02427 2.1.1.166 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit NA C2_02656 ftsH ko:K03798 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins NA C2_02657 folP ko00790,ko01100,map00790,map01100 ko:K00796 2.5.1.15 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02658 glmM ko00520,ko01100,ko01130,map00520,map01100,map01130 ko:K03431 5.4.2.10 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;NA : NA : NA C2_02659 secG ko02024,ko03060,ko03070,map02024,map03060,map03070 ko:K03075 Preprotein translocase band 1 subunit Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_02661 yhbX ko00540,ko01503,map00540,map01503 ko:K03760,ko:K12975,ko:K19353 2.7.8.42,2.7.8.43 sulfuric ester hydrolase activity Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_02662 argG ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 ko:K01940 6.3.4.5 Belongs to the argininosuccinate synthase family. Type Arginine biosynthesis : Amino acid metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism;Fluid shear stress and atherosclerosis : Cardiovascular disease : Human Diseases C2_02664 rimP ko:K09748 Required for maturation of 30S ribosomal subunits NA C2_02665 nusA ko:K02600 Participates in both transcription termination and antitermination NA C2_02666 infB ko:K02519 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex NA C2_02667 rbfA ko:K02834 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA NA C2_02668 truB ko:K03177 5.4.99.25 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs NA C2_02669 rpsO ko03010,map03010 ko:K02956 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome Ribosome : Translation : Genetic Information Processing C2_02670 pnp ko00230,ko00240,ko03018,map00230,map00240,map03018 ko:K00962 2.7.7.8 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;RNA degradation : Folding, sorting and degradation : Genetic Information Processing C2_02671 nlpI ko:K05803 May be involved in cell division. May play a role in bacterial septation or regulation of cell wall degradation during cell division NA C2_02672 deaD ko03018,map03018 ko:K05591,ko:K05592 3.6.4.13 DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation RNA degradation : Folding, sorting and degradation : Genetic Information Processing C2_02673 mtr ko:K03834,ko:K03835,ko:K03836,ko:K03837,ko:K03838 Tryptophan-specific transport protein NA C2_02676 yhbU ko05120,map05120 ko:K08303 peptidase activity Epithelial cell signaling in Helicobacter pylori infection : Infectious disease: bacterial : Human Diseases C2_02677 yhbT ko05120,map05120 ko:K08303 SCP-2 sterol transfer family Epithelial cell signaling in Helicobacter pylori infection : Infectious disease: bacterial : Human Diseases C2_02678 yhbS ko:K03824 transferase activity, transferring acyl groups NA C2_02679 yhbQ ko:K07461 Belongs to the UPF0213 family NA C2_02680 yhbP ko:K09979 Belongs to the UPF0306 family NA C2_02681 yfkM ko00620,ko01120,map00620,map01120 ko:K03152,ko:K05520,ko:K05523 3.5.1.124,4.2.1.130 Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Is able to repair glycated serum albumin, collagen, glyceraldehyde-3-phosphate dehydrogenase, and fructose biphosphate aldolase. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage. Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. In vitro, prevents acrylamide formation in asparagine glyoxal and asparagine sugar mixtures at 55 degrees Celsius, likely by degrading asparagine glyoxal Maillard adducts formed at high temperatures. Also displays an apparent glyoxalase activity that in fact reflects its deglycase activity. Is a general stress protein Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_02683 yraQ ko:K07089 permease NA C2_02685 gmhA ko00540,ko00770,ko01100,map00540,map00770,map01100 ko:K03271,ko:K03272,ko:K03525,ko:K12961 2.7.1.167,2.7.1.33,2.7.7.70,5.3.1.28 Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02686 yraN ko:K07460 Belongs to the UPF0102 family NA C2_02687 lpoA ko:K07121 Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) NA C2_02688 rsmI ko:K07056 2.1.1.198 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA NA C2_02690 yraJ ko05133,map05133 ko:K07347,ko:K07354 Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim operon. Probably involved in the export and assembly of fimbrial subunits across the outer membrane Pertussis : Infectious disease: bacterial : Human Diseases C2_02691 yraI ko:K07346,ko:K07353,ko:K15540 Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim operon NA C2_02692 yraH ko05133,map05133 ko:K07345 Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim operon Pertussis : Infectious disease: bacterial : Human Diseases C2_02693 nagB ko00030,ko00052,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00052,map00520,map01100,map01110,map01120,map01130,map01200 ko:K01057,ko:K02080,ko:K02564 3.1.1.31,3.5.99.6 glucosamine-6-phosphate deaminase Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_02694 agaD ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060 ko:K02747,ko:K02796,ko:K02815,ko:K10986 The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_02695 agaC ko00052,ko02060,map00052,map02060 ko:K10985 PTS system N-acetylgalactosamine-specific Galactose metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_02696 agaB ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060 ko:K02745,ko:K02794,ko:K10984 2.7.1.191 IIB component Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_02697 kbaY ko00052,ko01100,map00052,map01100 ko:K08302 4.1.2.40 which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6- bisphosphate (TBP). Requires Galactose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02698 agaS ko:K02082 Catalyzes the isomerization-deamination of galactosamine 6-phosphate to form tagatofuranose 6-phosphate and ammonium ion NA C2_02699 agaA ko00052,map00052 ko:K02079 3.5.1.25 Belongs to the metallo-dependent hydrolases superfamily. NagA family Galactose metabolism : Carbohydrate metabolism : Metabolism C2_02700 agaF ko00052,ko02060,map00052,map02060 ko:K02744 PTS system fructose IIA component Galactose metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_02701 agaD ko00030,ko00051,ko00052,ko00520,ko01100,ko01120,ko02060,map00030,map00051,map00052,map00520,map01100,map01120,map02060 ko:K02747,ko:K02796,ko:K02815,ko:K10986,ko:K17467 PTS system mannose/fructose/sorbose family IID component Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_02702 agaC ko00052,ko02060,map00052,map02060 ko:K02746 PTS system sorbose-specific iic component Galactose metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_02703 agaV ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060 ko:K02745,ko:K02794 2.7.1.191 pts system Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_02704 kbaZ ko00052,ko01100,map00052,map01100 ko:K16371,ko:K21622 5.1.3.40 that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of Galactose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02705 agaR ko:K02081,ko:K02436,ko:K02468 repressor for the aga operon for N-acetyl galactosamine transport and metabolism NA C2_02706 yhaV ko:K19155 acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression NA C2_02707 sohA ko:K19156 Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to the YhaV toxin and neutralizes its ribonuclease activity. Also acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression NA C2_02708 garD ko00040,ko00053,ko01100,map00040,map00053,map01100 ko:K01685,ko:K01708 4.2.1.42,4.2.1.7 Catalyzes the dehydration of galactarate to form 5- dehydro-4-deoxy-D-glucarate Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02709 garP ko:K03535,ko:K12299 galactarate transporter NA C2_02710 garL ko00051,ko00053,ko00350,ko01120,map00051,map00053,map00350,map01120 ko:K01630,ko:K02510,ko:K12660 4.1.2.20,4.1.2.52,4.1.2.53 Catalyzes the reversible retro-aldol cleavage of both 5- keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_02711 garR ko00630,ko01100,map00630,map01100 ko:K00042 1.1.1.60 Catalyzes the reduction of tatronate semialdehyde to D- glycerate Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02712 glxK ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130 ko:K00865 2.7.1.165 Belongs to the glycerate kinase type-1 family Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA C2_02713 yjaB ko:K03827 transferase activity, transferring acyl groups NA C2_02714 metAS ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 ko:K00651 2.3.1.46 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02715 aceB ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 ko:K01638 2.3.3.9 Belongs to the malate synthase family Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_02716 aceA ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 ko:K01637 4.1.3.1 Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_02717 aceK ko:K00906 2.7.11.5 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation NA C2_02718 arpA ko:K06867 Corresponds to locus_tag NA C2_02719 arpA ko:K06867 Corresponds to locus_tag NA C2_02720 iclR ko:K10973,ko:K13641 Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyruvate enhances promoter binding by stabilizing the tetrameric form NA C2_02721 metH ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 ko:K00548 2.1.1.13 Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02722 yjbB ko:K03324 Na Pi-Cotransporter NA C2_02723 pepE ko:K05995 3.4.13.21 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids NA C2_02724 rluF ko:K06178,ko:K06182,ko:K06183 5.4.99.19,5.4.99.21,5.4.99.22 Catalyzes the synthesis of pseudouridine from uracil- 2604 in 23S ribosomal RNA NA C2_02727 ycgL ko:K07074 nucleotidyltransferase NA C2_02728 bepH ko:K04095,ko:K16214 2.7.1.176 zeta toxin NA C2_02729 lysC ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 ko:K00928,ko:K12524,ko:K12525,ko:K12526 1.1.1.3,2.7.2.4,4.1.1.20 Belongs to the aspartokinase family Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Lysine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02730 pgi ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 ko:K01810 5.3.1.9 Belongs to the GPI family Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_02734 yjbH ko:K07277 extracellular polysaccharide metabolic process NA C2_02735 psiE ko:K13256 Protein PsiE homolog NA C2_02736 xylE ko:K02100,ko:K08137,ko:K08138 Major facilitator Superfamily NA C2_02737 malG ko02010,map02010 ko:K10110,ko:K15772 probably responsible for the translocation of the substrate across the membrane ABC transporters : Membrane transport : Environmental Information Processing C2_02738 malF ko02010,map02010 ko:K02025,ko:K05814,ko:K10109,ko:K15771 probably responsible for the translocation of the substrate across the membrane ABC transporters : Membrane transport : Environmental Information Processing C2_02739 malE ko02010,ko02030,map02010,map02030 ko:K10108 Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides ABC transporters : Membrane transport : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes C2_02741 malK ko02010,map02010 ko:K10111 Part of the ABC transporter complex MalEFGK involved in maltose maltodextrin import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_02742 lamB ko:K02024,ko:K10124 Involved in the transport of maltose and maltodextrins NA C2_02743 malM ko:K05775 Maltose operon periplasmic NA C2_02747 ubiC ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K03181 4.1.3.40 Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_02748 ubiA ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K03179 2.5.1.39 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_02749 plsB ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 ko:K00631 2.3.1.15 Belongs to the GPAT DAPAT family Glycerolipid metabolism : Lipid metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_02750 dgkA ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231 ko:K00901 2.7.1.107 Recycling of diacylglycerol produced during the turnover of membrane phospholipid Glycerolipid metabolism : Lipid metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Phosphatidylinositol signaling system : Signal transduction : Environmental Information Processing;Phospholipase D signaling pathway : Signal transduction : Environmental Information Processing;Choline metabolism in cancer : Cancer: overview : Human Diseases C2_02751 lexA ko:K01356 3.4.21.88 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair NA C2_02752 dinF ko:K03327 COG0534 Na -driven multidrug efflux pump NA C2_02754 zur ko02024,map02024 ko:K02076,ko:K03711,ko:K09823 belongs to the Fur family Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_02756 dusA ko:K05539,ko:K05540 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs NA C2_02758 qor ko:K00344 1.6.5.5 Quinone oxidoreductase NA C2_02759 dnaB ko03030,ko04112,map03030,map04112 ko:K02314 3.6.4.12 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins DNA replication : Replication and repair : Genetic Information Processing;Cell cycle - Caulobacter : Cell growth and death : Cellular Processes C2_02760 alr ko00473,ko01100,ko01502,map00473,map01100,map01502 ko:K01775 5.1.1.1 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids D-Alanine metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases C2_02761 tyrB ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 ko:K00813,ko:K00832 2.6.1.1,2.6.1.57 Broad-specificity enzyme that catalyzes the transamination of 2-ketoisocaproate, p-hydroxyphenylpyruvate, and phenylpyruvate to yield leucine, tyrosine, and phenylalanine, respectively. In vitro, is able to catalyze the conversion of beta-methyl phenylpyruvate to the nonproteinogenic amino acid (2S,3S)-beta-methyl-phenylalanine, a building block of the antibiotic mannopeptimycin produced by Streptomyces hygroscopicus NRRL3085 Arginine biosynthesis : Amino acid metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Phenylalanine metabolism : Amino acid metabolism : Metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Novobiocin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Isoquinoline alkaloid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Tropane, piperidine and pyridine alkaloid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02763 aphA ko00740,ko01100,map00740,map01100 ko:K03788 3.1.3.2 Belongs to the class B bacterial acid phosphatase family Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02766 uvrA ko03420,map03420 ko:K03701 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate Nucleotide excision repair : Replication and repair : Genetic Information Processing C2_02767 ssb ko03030,ko03430,ko03440,map03030,map03430,map03440 ko:K03111 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing C2_02769 yjcC ko02026,map02026 ko:K21090 3.1.4.52 May function as a c-di-GMP phosphodiesterase. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria. Overexpression reduces biofilm formation Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_02770 soxS ko:K05804,ko:K13631 Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters NA C2_02771 soxR ko:K13639 Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress. Upon reduction of 2Fe-2S cluster, SoxR reversibly loses its transcriptional activity, but retains its DNA binding affinity NA C2_02772 yjcD ko:K06901 High-affinity transporter for guanine and hypoxanthine NA C2_02773 yjcE ko:K03316 sodium ion import across plasma membrane NA C2_02775 actP ko:K14393 Cation acetate symporter ActP NA C2_02777 acsA ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 ko:K01895 6.2.1.1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl- adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_02778 nrfA ko00910,ko01120,ko05132,map00910,map01120,map05132 ko:K03385 1.7.2.2 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process Nitrogen metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Salmonella infection : Infectious disease: bacterial : Human Diseases C2_02779 nrfB ko:K04013 Plays a role in nitrite reduction NA C2_02780 nrfC ko00920,ko01120,ko02020,map00920,map01120,map02020 ko:K04014,ko:K08358 Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes Sulfur metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_02781 nrfD ko:K04015,ko:K16294 Polysulphide reductase, NrfD NA C2_02782 ccmF ko:K02198,ko:K04016 Cytochrome c-type biogenesis protein NA C2_02783 ccmH ko:K02198,ko:K02200,ko:K04016,ko:K04017,ko:K04018 subunit of a heme lyase NA C2_02784 nrfG ko:K02200,ko:K04018 Formate-dependent nitrite reductase complex NA C2_02785 gltP ko02020,map02020 ko:K03309,ko:K11102,ko:K11103 Catalyzes the proton-dependent transport of glutamate and aspartate Two-component system : Signal transduction : Environmental Information Processing C2_02786 yjcO ko:K07126 enzyme activator activity NA C2_02787 fdhF ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200 ko:K00123,ko:K05299,ko:K22015 1.17.1.10,1.17.1.9,1.17.99.7 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_02788 fdhF ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200 ko:K00123,ko:K05299,ko:K22015 1.17.1.10,1.17.1.9,1.17.99.7 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_02789 mdtP ko:K15550 RND efflux system, outer membrane lipoprotein NA C2_02790 mdtO ko:K15547 Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride NA C2_02791 mdtN ko:K03543,ko:K15548,ko:K15549 Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride NA C2_02794 rpiB ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 ko:K01808 5.3.1.6 isomerase B Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02796 phnP ko00440,map00440 ko:K06167 3.1.4.55 Carbon-phosphorus lyase complex accessory protein Phosphonate and phosphinate metabolism : Metabolism of other amino acids : Metabolism C2_02797 phnO ko00440,map00440 ko:K09994 Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role Phosphonate and phosphinate metabolism : Metabolism of other amino acids : Metabolism C2_02798 phnN ko00030,map00030 ko:K05774 2.7.4.23 Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) Pentose phosphate pathway : Carbohydrate metabolism : Metabolism C2_02799 phnM ko00440,map00440 ko:K06162 3.6.1.63 phosphonate metabolism protein PhnM Phosphonate and phosphinate metabolism : Metabolism of other amino acids : Metabolism C2_02800 phnL ko00440,map00440 ko:K05780 2.7.8.37 phosphonate C-P lyase system protein PhnL Phosphonate and phosphinate metabolism : Metabolism of other amino acids : Metabolism C2_02801 phnK ko00440,map00440 ko:K05781,ko:K06163 4.7.1.1 phosphonate C-P lyase system protein PhnK Phosphonate and phosphinate metabolism : Metabolism of other amino acids : Metabolism C2_02802 phnJ ko00440,map00440 ko:K06163 4.7.1.1 Catalyzes the breakage of the C-P bond in alpha-D-ribose 1-methylphosphonate 5-phosphate (PRPn) forming alpha-D-ribose Phosphonate and phosphinate metabolism : Metabolism of other amino acids : Metabolism C2_02803 phnI ko00440,map00440 ko:K06164 2.7.8.37 Phosphonate Phosphonate and phosphinate metabolism : Metabolism of other amino acids : Metabolism C2_02804 phnH ko00440,map00440 ko:K06165 2.7.8.37 Together with PhnG, PhnI and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate Phosphonate and phosphinate metabolism : Metabolism of other amino acids : Metabolism C2_02805 phnG ko00440,map00440 ko:K06166 2.7.8.37 Phosphonate C-P lyase system protein PhnG Phosphonate and phosphinate metabolism : Metabolism of other amino acids : Metabolism C2_02806 phnF ko:K02043,ko:K03710 Transcriptional regulator NA C2_02807 phnE ko00440,ko02010,map00440,map02010 ko:K02042,ko:K06162 3.6.1.63 Phosphonate ABC transporter Phosphonate and phosphinate metabolism : Metabolism of other amino acids : Metabolism;ABC transporters : Membrane transport : Environmental Information Processing C2_02808 phnD ko02010,map02010 ko:K02044 Phosphonate ABC transporter ABC transporters : Membrane transport : Environmental Information Processing C2_02809 phnC ko02010,map02010 ko:K02041 3.6.3.28 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_02810 phnB ko:K04750 3-demethylubiquinone-9 3-methyltransferase NA C2_02811 phnA ko01120,map01120 ko:K06193 PhnA Zinc-Ribbon Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_02814 proP ko:K03761,ko:K03762,ko:K08172,ko:K08173 Proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response NA C2_02816 basS ko01502,ko01503,ko02020,ko02024,map01502,map01503,map02020,map02024 ko:K07643,ko:K07645,ko:K07653,ko:K18351 2.7.13.3 Sensor protein basS Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_02818 eptA ko00540,ko01503,map00540,map01503 ko:K03760,ko:K12975,ko:K19353 2.7.8.42,2.7.8.43 Catalyzes the addition of a phosphoethanolamine moiety to the lipid A. The phosphoethanolamine modification is required for resistance to polymyxin (By similarity) Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_02819 adiC ko:K03294,ko:K03756,ko:K03757,ko:K03759 Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach NA C2_02820 adiY ko:K03755,ko:K11920,ko:K21905,ko:K21906 regulatory protein NA C2_02821 adiA ko00310,ko00330,ko00480,ko00960,ko01100,ko01110,ko01130,map00310,map00330,map00480,map00960,map01100,map01110,map01130 ko:K01581,ko:K01582,ko:K01584,ko:K01585 4.1.1.17,4.1.1.18,4.1.1.19 Biodegradative arginine decarboxylase Lysine degradation : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;Glutathione metabolism : Metabolism of other amino acids : Metabolism;Tropane, piperidine and pyridine alkaloid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_02822 melR ko03410,map03410 ko:K01174,ko:K03490,ko:K10778,ko:K13529,ko:K15051 2.1.1.63,3.1.31.1,3.2.2.21 Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site Base excision repair : Replication and repair : Genetic Information Processing C2_02823 melA ko00010,ko00052,ko00500,ko00561,ko00600,ko00603,map00010,map00052,map00500,map00561,map00600,map00603 ko:K01222,ko:K01232,ko:K07406 3.2.1.122,3.2.1.22,3.2.1.86 melibiose metabolic process Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Sphingolipid metabolism : Lipid metabolism : Metabolism;Glycosphingolipid biosynthesis - globo and isoglobo series : Glycan biosynthesis and metabolism : Metabolism C2_02824 melB ko:K03292,ko:K11104,ko:K16139 Responsible for melibiose and other galactoside transport. It is capable of using hydrogen, sodium, and lithium cations as coupling cations for cotransport, depending on the particular sugar transported (symport system) NA C2_02825 yjdF ko:K08984 Predicted membrane protein (DUF2238) NA C2_02826 fumB ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200 ko:K01676,ko:K01677,ko:K01678,ko:K03780 4.2.1.2,4.2.1.32 Catalyzes the reversible hydration of fumarate to (S)- malate Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_02827 dcuB ko02020,map02020 ko:K07791,ko:K07792 Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane Two-component system : Signal transduction : Environmental Information Processing C2_02828 dcuR ko02020,map02020 ko:K02475,ko:K07702,ko:K07703,ko:K11615 Member of the two-component regulatory system DcuR DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD Two-component system : Signal transduction : Environmental Information Processing C2_02829 dcuS ko02020,map02020 ko:K02476,ko:K07700,ko:K07701,ko:K11614 2.7.13.3 Member of the two-component regulatory system DcuR DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD Two-component system : Signal transduction : Environmental Information Processing C2_02830 yjdI ko:K07397,ko:K22405 1.6.3.4 Divergent 4Fe-4S mono-cluster NA C2_02831 yjdJ ko:K06975 GCN5-related N-acetyl-transferase NA C2_02833 lysS ko00970,map00970 ko:K04567 6.1.1.6 Belongs to the class-II aminoacyl-tRNA synthetase family Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_02834 yjdL ko:K03305 Proton-dependent permease that transports di- and tripeptides. Shows significantly higher specificity towards dipeptides than tripeptides. Has a preference for dipeptides with a C-terminal Lys residue. Can bind Ala-Lys, Lys-Ala, Ala-Ala. Can also transport alanine and trialanine NA C2_02835 cadA ko00310,ko00330,ko00480,ko00960,ko01100,ko01110,ko01130,map00310,map00330,map00480,map00960,map01100,map01110,map01130 ko:K01581,ko:K01582,ko:K01584,ko:K01585 4.1.1.17,4.1.1.18,4.1.1.19 lysine decarboxylase Lysine degradation : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;Glutathione metabolism : Metabolism of other amino acids : Metabolism;Tropane, piperidine and pyridine alkaloid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_02836 cadB ko:K03294,ko:K03756,ko:K03757,ko:K03759 cadaverine lysine antiporter NA C2_02837 cadC ko:K03765 transcriptional activator NA C2_02840 dsbD ko:K04084 1.8.1.8 Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps NA C2_02841 cutA ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 ko:K01733,ko:K03926 4.2.3.1 Involved in resistance toward heavy metals Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02842 dcuA ko02020,map02020 ko:K07791,ko:K07792 Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane Two-component system : Signal transduction : Environmental Information Processing C2_02843 aspA ko00250,ko01100,map00250,map01100 ko:K01744 4.3.1.1 Aspartate ammonia-lyase Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02844 fxsA ko:K07113 Suppressor of F exclusion of phage T7 NA C2_02845 yjeH ko:K16263 L-methionine secondary active transmembrane transporter activity NA C2_02846 groS ko:K04078 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter NA C2_02847 groL ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 ko:K04077 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions RNA degradation : Folding, sorting and degradation : Genetic Information Processing;Longevity regulating pathway - worm : Aging : Organismal Systems;Type I diabetes mellitus : Endocrine and metabolic disease : Human Diseases;Legionellosis : Infectious disease: bacterial : Human Diseases;Tuberculosis : Infectious disease: bacterial : Human Diseases C2_02849 nikR ko:K07722 Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel NA C2_02850 nikE ko02010,ko02024,map02010,map02024 ko:K02032,ko:K10824 3.6.3.24 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_02851 nikD ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02031,ko:K02032,ko:K12371,ko:K15583,ko:K15586,ko:K15587 3.6.3.24 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_02852 nikC ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02034,ko:K12370,ko:K13891,ko:K15582,ko:K15586,ko:K15587 3.6.3.24 Nickel transport system permease protein nikC beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_02853 nikB ko02010,map02010 ko:K15585 Nickel transport system permease protein NikB ABC transporters : Membrane transport : Environmental Information Processing C2_02854 nikA ko02010,map02010 ko:K15584 periplasmic ABC transporters : Membrane transport : Environmental Information Processing C2_02855 sfp ko00770,map00770 ko:K00997,ko:K06133 2.7.8.7 May be involved in an alternative pathway for phosphopantetheinyl transfer and holo-ACP synthesis in E.coli. The native apo-protein substrate is Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism C2_02856 yhhT ko:K03548,ko:K11744 transporter activity NA C2_02859 yhhQ ko:K09125 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage NA C2_02860 tusA ko04122,map04122 ko:K04085 Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_02861 zntA ko:K01534 3.6.3.3,3.6.3.5 Confers resistance to zinc, cadmium and lead. Couples the hydrolysis of ATP with the export of zinc, cadmium or lead, with highest activity when the metals are present as metal-thiolate complexes. Can also bind nickel, copper, cobalt and mercury NA C2_02864 yhhL ko:K08993 Protein of unknown function (DUF1145) NA C2_02865 rsmD ko:K08316 2.1.1.171 Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle NA C2_02866 ftsY ko02024,ko03060,ko03070,map02024,map03060,map03070 ko:K03110 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_02867 ftsE ko02010,map02010 ko:K09811,ko:K09812 Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring ABC transporters : Membrane transport : Environmental Information Processing C2_02868 ftsX ko02010,map02010 ko:K09811,ko:K09812 Part of the ABC transporter FtsEX involved in cellular division ABC transporters : Membrane transport : Environmental Information Processing C2_02869 rpoH ko:K03089 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes NA C2_02870 livJ ko02010,ko02024,map02010,map02024 ko:K01999 This protein is a component of the leucine, isoleucine, valine, (threonine) transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_02872 Z012_05445 ko:K15520 2.3.1.189 Acetyltransferase (GNAT) domain NA C2_02874 livK ko02010,ko02024,map02010,map02024 ko:K01999 This protein is a component of the leucine-specific transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids in E.coli ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_02875 livH ko02010,ko02024,map02010,map02024 ko:K01997 Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_02876 livM ko02010,ko02024,map02010,map02024 ko:K01995,ko:K01998 the binding-protein-dependent transport system ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_02877 livG ko02010,ko02024,map02010,map02024 ko:K01995,ko:K01998 High-affinity branched-chain amino acid transport ATP-binding protein livG ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_02878 livF ko02010,ko02024,map02010,map02024 ko:K01996 High-affinity branched-chain amino acid transport ATP-binding protein ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_02879 ugpB ko02010,map02010 ko:K02027,ko:K05813 Sn-glycerol-3-phosphate and glycerophosphoryl diester- binding protein interacts with the binding protein-dependent transport system UgpACE ABC transporters : Membrane transport : Environmental Information Processing C2_02880 ugpA ko02010,map02010 ko:K05814,ko:K10109,ko:K15771 probably responsible for the translocation of the substrate across the membrane ABC transporters : Membrane transport : Environmental Information Processing C2_02881 ugpE ko02010,map02010 ko:K05815 probably responsible for the translocation of the substrate across the membrane ABC transporters : Membrane transport : Environmental Information Processing C2_02882 ugpC ko02010,map02010 ko:K05816,ko:K10112 3.6.3.20 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_02883 ugpQ ko00564,map00564 ko:K01126 3.1.4.46 glycerophosphoryl diester phosphodiesterase Glycerophospholipid metabolism : Lipid metabolism : Metabolism C2_02885 ggt ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 ko:K00681 2.3.2.2,3.4.19.13 it may function in amino acid uptake salvage, or possibly in peptidoglycan linkage. Catalyzes the hydrolysis and transpeptidation of many gamma-glutamyl compounds (including some D-gamma-glutamyl substrates), with a preference for basic and aromatic amino acids as acceptors. The KM values for gamma-glutamyl acceptors are so high that it has been proposed transpeptidation is not the physiological role in E.coli Taurine and hypotaurine metabolism : Metabolism of other amino acids : Metabolism;Cyanoamino acid metabolism : Metabolism of other amino acids : Metabolism;Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02889 yhhZ ko:K06887 Type VI secretion system effector, Hcp NA C2_02890 yhhY ko00670,ko00970,map00670,map00970 ko:K00604,ko:K03825 2.1.2.9 Catalyzes the N-acetylation of L-phenylalanine and L- methionine using acetyl-CoA as acetyl donor in vitro. Cannot accept L-tyrosine as substrate and propionyl-CoA, succinyl-CoA or (S)-methylmalonyl-CoA as acyl donors. Is also able to acetylate and thus detoxify several nonhydrolyzable aminoacyl adenylates, but not the processed form of the peptide- nucleotide antibiotic microcin C (McC). When overproduced, provides complete resistance to leucyl sulfamoyl adenylate (LSA) and partial resistance to alanyl sulfamoyl adenylate (ASA) and phenylalanyl sulfamoyl adenylate (FSA). Therefore, may protect bacteria from various toxic aminoacyl nucleotides, either exogenous or those generated inside the cell during normal metabolism One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_02891 yhhX ko00562,ko01120,map00562,map01120 ko:K16044 1.1.1.371 oxidoreductase activity Inositol phosphate metabolism : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_02892 yhhW ko:K06911 however, may provide a mechanism that would avoid inhibition of key cellular proteins, such as DNA gyrase, by quercetin NA C2_02893 gntR ko:K06145 Negative regulator for the gluconate utilization system GNT-I, the gntUKR operon NA C2_02894 gntK ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 ko:K00851 2.7.1.12 gluconokinase activity Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_02895 gntU ko:K03299,ko:K06156 Low-affinity gluconate NA C2_02896 yhgN ko:K05595 MarC family integral membrane protein NA C2_02897 asd ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 ko:K00133 1.2.1.11 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Lysine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02898 glgB ko00500,ko01100,ko01110,map00500,map01100,map01110 ko:K00700,ko:K17734 2.4.1.18 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_02899 glgX ko00500,ko01100,ko01110,map00500,map01100,map01110 ko:K01214,ko:K02438 3.2.1.196,3.2.1.68 Removes maltotriose and maltotetraose chains that are attached by 1,6-alpha-linkage to the limit dextrin main chain, generating a debranched limit dextrin Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_02900 glgC ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 ko:K00975 2.7.7.27 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_02901 glgA ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 ko:K00703 2.4.1.21 Synthesizes alpha-1,4-glucan chains using ADP-glucose Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_02902 glgP ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 ko:K00688 2.4.1.1 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Necroptosis : Cell growth and death : Cellular Processes;Insulin signaling pathway : Endocrine system : Organismal Systems;Glucagon signaling pathway : Endocrine system : Organismal Systems;Insulin resistance : Endocrine and metabolic disease : Human Diseases C2_02903 sphX ko02010,ko02020,ko05152,map02010,map02020,map05152 ko:K02040 Part of the ABC transporter complex PstSACB involved in phosphate import ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing;Tuberculosis : Infectious disease: bacterial : Human Diseases C2_02907 glpD ko00564,ko01110,map00564,map01110 ko:K00111 1.1.5.3 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_02908 glpE ko00920,ko01110,ko01120,map00920,map01110,map01120 ko:K02439,ko:K07390 2.8.1.1 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide Sulfur metabolism : Energy metabolism : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_02909 glpG ko:K02441 Rhomboid-type serine protease that catalyzes intramembrane proteolysis NA C2_02910 glpR ko:K02444 transcriptional regulator NA C2_02911 rtcR ko:K14414 Transcriptional regulatory protein RtcR NA C2_02912 rtcB ko:K14415 6.5.1.3 RNA ligase that mediates the joining of broken tRNA-like stem-loop structures in case of tRNA damage. Probably participates to tRNA restriction-repair by ligating broken tRNA-like stem-loop structures with 2',3'-cyclic phosphate and 5'-OH ends to form a splice junction with a 2'-OH, 3',5'-phosphodiester, a step that requires GTP. Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'-PO4 (or cyclic-PO4) and 5'-OH ends that cannot be sealed by classical DNA ligases NA C2_02913 rtcA ko:K01974 6.5.1.4 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP NA C2_02914 malT ko:K03556 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box) 5'-GGA TG GA-3' NA C2_02915 malP ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 ko:K00688 2.4.1.1 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Necroptosis : Cell growth and death : Cellular Processes;Insulin signaling pathway : Endocrine system : Organismal Systems;Glucagon signaling pathway : Endocrine system : Organismal Systems;Insulin resistance : Endocrine and metabolic disease : Human Diseases C2_02916 malQ ko00500,ko01100,map00500,map01100 ko:K00705 2.4.1.25 beta-maltose 4-alpha-glucanotransferase activity Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02917 gntT ko:K03299,ko:K06155,ko:K06157,ko:K13629,ko:K16321 gluconate transporter NA C2_02918 nfuA ko:K07400,ko:K13628,ko:K19168 Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins NA C2_02919 comF ko03018,map03018 ko:K03654 3.6.4.12 DNA utilization protein RNA degradation : Folding, sorting and degradation : Genetic Information Processing C2_02920 bioH ko00780,ko01100,map00780,map01100 ko:K02169,ko:K02170 2.1.1.197,3.1.1.85 The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_02922 feoC ko:K07490 May function as a transcriptional regulator that controls feoABC expression NA C2_02923 feoB ko:K04759 Transporter of a GTP-driven Fe(2 ) uptake system NA C2_02924 feoA ko:K04758 Ferrous iron transport protein A NA C2_02925 yhgF ko:K06959 response to ionizing radiation NA C2_02926 greB ko:K04760 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length NA C2_02929 ko:K07726 Helix-turn-helix domain NA C2_02931 pckA ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 ko:K01610 4.1.1.49 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_02932 yhgE ko:K13652 Domain of unknown function (DUF4153) NA C2_02933 hslO ko:K04083 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress NA C2_02934 hslR ko:K04762 Belongs to the HSP15 family NA C2_02935 yrfG ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 ko:K20881 3.1.3.5 GMP 5'-nucleotidase activity Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_02937 nudE ko00230,map00230 ko:K08312 ADP compounds hydrolase nudE Purine metabolism : Nucleotide metabolism : Metabolism C2_02938 mrcA ko00550,ko01100,ko01501,map00550,map01100,map01501 ko:K05366 2.4.1.129,3.4.16.4 penicillin-binding protein 1A Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases C2_02939 hofM ko03070,ko05111,map03070,map05111 ko:K02461,ko:K02662,ko:K02663,ko:K12288 carbon utilization Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_02940 hofN ko:K02662,ko:K02663,ko:K12279,ko:K12289 carbon utilization NA C2_02941 hofO ko:K12290 carbon utilization NA C2_02942 hofP ko:K12291 carbon utilization NA C2_02943 pilQ ko:K02507,ko:K02666 Required for the use of extracellular DNA as a nutrient. Could be the porin responsible for transport of DNA across the outer membrane NA C2_02944 aroK ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko:K00891,ko:K13829 2.7.1.71,4.2.3.4 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02945 aroB ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko:K01735,ko:K13829 2.7.1.71,4.2.3.4 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02946 damX ko:K03112 Cell division protein DamX NA C2_02947 dam ko03430,map03430 ko:K06223 2.1.1.72 Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication Mismatch repair : Replication and repair : Genetic Information Processing C2_02948 rpe ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 ko:K01783 5.1.3.1 Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02949 gph ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 ko:K01091 3.1.3.18 Phosphoglycolate phosphatase Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_02950 trpS ko00970,map00970 ko:K01867 6.1.1.2 Belongs to the class-I aminoacyl-tRNA synthetase family Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_02951 yhfZ ko:K03710 YhfZ C-terminal domain NA C2_02955 php ko:K07048 Its real enzymatic activity is not yet known. It was tested for general esterase, aminopeptidase, sulfatase, phosphatase, carbonic anhydrase, phosphodiesterase, and phosphotriesterase activities with the following substrates p- nitrophenyl acetate, L-alanine nitroanilide, p-nitrophenyl sulfate, bis(p-nitrophenyl) phosphate, paraoxon, and p-nitrophenyl phosphate. No enzymatic activity was detected with any of these non-specific substrates NA C2_02958 yhfS ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 ko:K01739 2.5.1.48 O-acetylhomoserine aminocarboxypropyltransferase activity Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02959 frlR ko:K02529,ko:K10711 May regulate the transcription of the frlABCDR operon, involved in the utilization of fructoselysine and psicoselysine NA C2_02960 frlD ko:K10710 2.7.1.218 Catalyzes the ATP-dependent phosphorylation of fructoselysine to fructoselysine 6-phosphate. Functions in a fructoselysine degradation pathway that allows E.coli to grow on fructoselysine or psicoselysine. To a much lesser extenst, is also able to phosphorylate psicoselysine NA C2_02961 frlC ko:K10709 Catalyzes the reversible interconversion of fructoselysine with its C-3 epimer, psicoselysine. Allows E.coli to utilize psicoselysine for growth. Does not act on psicose or fructoselysine 6-phosphate NA C2_02962 frlB ko:K10708 Catalyzes the reversible conversion of fructoselysine 6- phosphate to glucose 6-phosphate and lysine. Functions in a fructoselysine degradation pathway that allows E.coli to grow on fructoselysine or psicoselysine NA C2_02963 frlA ko:K03294,ko:K19540 Is likely involved in the transport of fructoselysine and psicoselysine to the cytoplasm, where they are degraded NA C2_02965 cysG ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 ko:K02302,ko:K02303,ko:K02304,ko:K03795,ko:K13541,ko:K13542 1.3.1.76,2.1.1.107,2.1.1.131,3.7.1.12,4.2.1.75,4.99.1.3,4.99.1.4 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_02966 nirC ko:K02598,ko:K03459,ko:K06212,ko:K21990,ko:K21993 Catalyzes nitrite uptake and nitrite export across the cytoplasmic membrane. Is up to 10-fold more active than NarK or NarU in nitrite uptake for subsequent reduction in the cytoplasm by the NirB NirD nitrite reductase NA C2_02967 nirD ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220 ko:K00362,ko:K00363,ko:K05710 1.7.1.15 Rieske-like [2Fe-2S] domain Phenylalanine metabolism : Amino acid metabolism : Metabolism;Nitrogen metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_02968 nirB ko00910,ko01120,map00910,map01120 ko:K00362 1.7.1.15 Belongs to the nitrite and sulfite reductase 4Fe-4S domain family Nitrogen metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_02969 tsgA ko:K02429,ko:K06141 response to selenite ion NA C2_02970 ppiA ko01503,ko04217,map01503,map04217 ko:K03767,ko:K03768 5.2.1.8 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Necroptosis : Cell growth and death : Cellular Processes C2_02972 fic ko:K04095 adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (By similarity). Involved in cell filamentation induced by cyclic AMP. May have some role in cell division NA C2_02973 pabA ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 ko:K01658,ko:K01664,ko:K13497 2.4.2.18,2.6.1.85,4.1.3.27 Part of a heterodimeric complex that catalyzes the two- step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Phenazine biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes C2_02974 argD ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230 ko:K00821,ko:K00840 2.6.1.11,2.6.1.17,2.6.1.81 Involved in both the arginine and lysine biosynthetic pathways Arginine biosynthesis : Amino acid metabolism : Metabolism;Lysine biosynthesis : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_02976 crp ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 ko:K10914 class I promoters have a single CRP-binding site upstream of the RNA polymerase (RNAP)- binding site, whereas in class II promoters the single CRP- and RNAP-binding site overlap, CRP making multiple contacts with RNAP. Class III promoters require multiple activator molecules, including at least one CRP dimer. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA (about 87 degrees), bringing upstream promoter elements into contact with RNAP. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. High levels of active CRP are detrimental to growth. Plays a major role in carbon catabolite repression (CCR). CCR involves cAMP, adenylate cyclase (cyaA), CRP and the EIIA-Glc component of the PTS (crr). In the presence of glucose EIIA-Glc is dephosphorylated, and does not activate adenylate cyclase, leading to reduced cAMP and thus decreased CRP activity. Also plays a role in many other processes (see PubMed 22573269) Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_02977 yhfA ko:K07397 OsmC-like protein NA C2_02978 prkB ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200 ko:K00855 2.7.1.19 Phosphoribulokinase Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_02979 yheU ko:K07019,ko:K09898 Belongs to the UPF0270 family NA C2_02980 yheT ko:K07019 poly(3-hydroxybutyrate) depolymerase activity NA C2_02981 yheS ko:K06158 ABC transporter, ATP-binding protein NA C2_02982 kefG ko:K03923,ko:K11746,ko:K11748 Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB NA C2_02983 kefB ko:K03455,ko:K11745,ko:K11747 Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K( ) H( ) antiport NA C2_02984 yheV ko:K07070 Probable metal-binding protein (DUF2387) NA C2_02985 slyD ko:K03774,ko:K03775 5.2.1.8 Folding helper with both chaperone and peptidyl-prolyl cis-trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. PPIases catalyze the cis-trans isomerization of Xaa-Pro bonds of peptides, which accelerates slow steps of protein folding and thus shortens the lifetime of intermediates. Both strategies lower the concentration of intermediates and increase the productivity and yield of the folding reaction. SlyD could be involved in Tat-dependent translocation, by binding to the Tat-type signal of folded proteins NA C2_02986 slyX ko:K03745 Belongs to the SlyX family NA C2_02987 fkpA ko:K03772 5.2.1.8 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides NA C2_02989 tusD ko04122,map04122 ko:K07235 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_02990 tusC ko04122,map04122 ko:K07236 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_02991 tusB ko04122,map04122 ko:K07237 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_02992 rpsL ko03010,map03010 ko:K02950 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit Ribosome : Translation : Genetic Information Processing C2_02993 rpsG ko03010,map03010 ko:K02992 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center Ribosome : Translation : Genetic Information Processing C2_02994 fusA ko:K02355 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome NA C2_02998 frmR ko:K21600 Repressor of the frmRAB operon NA C2_02999 adhC ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 ko:K00121 1.1.1.1,1.1.1.284 Has high formaldehyde dehydrogenase activity in the presence of glutathione and catalyzes the oxidation of normal alcohols in a reaction that is not GSH-dependent Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Fatty acid degradation : Lipid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Chloroalkane and chloroalkene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Naphthalene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Retinol metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolism of xenobiotics by cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism;Chemical carcinogenesis : Cancer: overview : Human Diseases C2_03000 fghA ko00680,ko01120,ko01200,map00680,map01120,map01200 ko:K01070,ko:K09795 3.1.2.12 Serine hydrolase involved in the detoxification of formaldehyde Methane metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_03001 yaiL ko:K09912 Uncharacterized protein conserved in bacteria (DUF2058) NA C2_03002 mhpT ko:K05819,ko:K08195 Uptake of 3-(3-hydroxyphenyl)propionate (3HPP) across the cytoplasmic membrane. Transport is driven by the proton motive force. Does not transport benzoate, 3-hydroxybenzoate or gentisate NA C2_03003 mhpE ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220 ko:K01666 4.1.3.39 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of Phenylalanine metabolism : Amino acid metabolism : Metabolism;Benzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Dioxin degradation : Xenobiotics biodegradation and metabolism : Metabolism;Xylene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_03004 mhpF ko00360,ko00362,ko00620,ko00621,ko00622,ko00650,ko01100,ko01120,ko01220,map00360,map00362,map00620,map00621,map00622,map00650,map01100,map01120,map01220 ko:K04073 1.2.1.10 Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of Phenylalanine metabolism : Amino acid metabolism : Metabolism;Benzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Dioxin degradation : Xenobiotics biodegradation and metabolism : Metabolism;Xylene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_03005 mhpD ko00350,ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00350,map00360,map00362,map00621,map00622,map01100,map01120,map01220 ko:K02509,ko:K02554 4.2.1.80 Catalyzes the conversion of 2-hydroxypentadienoic acid (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid Tyrosine metabolism : Amino acid metabolism : Metabolism;Phenylalanine metabolism : Amino acid metabolism : Metabolism;Benzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Dioxin degradation : Xenobiotics biodegradation and metabolism : Metabolism;Xylene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_03006 mhpC ko00360,ko00621,ko00984,ko01100,ko01120,ko01220,map00360,map00621,map00984,map01100,map01120,map01220 ko:K05714,ko:K10222,ko:K16050 3.7.1.14,3.7.1.17,3.7.1.8 Catalyzes the cleavage of the C5-C6 bond of 2-hydroxy-6- oxononadienedioate and 2-hydroxy-6-oxononatrienedioate, a dienol ring fission product of the bacterial meta-cleavage pathway for degradation of phenylpropionic acid Phenylalanine metabolism : Amino acid metabolism : Metabolism;Dioxin degradation : Xenobiotics biodegradation and metabolism : Metabolism;Steroid degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_03007 mhpB ko00360,ko01120,ko01220,map00360,map01120,map01220 ko:K05713 1.13.11.16 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively Phenylalanine metabolism : Amino acid metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_03008 mhpA ko00360,ko01120,ko01220,map00360,map01120,map01220 ko:K05712 1.14.13.127 Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3- hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI) Phenylalanine metabolism : Amino acid metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_03009 mhpR ko:K02624,ko:K05818 Activator of the mhpABCDFE operon coding for components of the 3-hydroxyphenylpropionate degradation pathway NA C2_03010 lacI ko:K02529 lacI family NA C2_03011 lacZ ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 ko:K01190,ko:K12111 3.2.1.23 Belongs to the glycosyl hydrolase 2 family Galactose metabolism : Carbohydrate metabolism : Metabolism;Other glycan degradation : Glycan biosynthesis and metabolism : Metabolism;Sphingolipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03012 lacY ko:K02532 Responsible for transport of beta-galactosides into the cell, with the concomitant import of a proton (symport system). Can transport lactose, melibiose, lactulose or the analog methyl- 1-thio-beta,D-galactopyranoside (TMG), but not sucrose or fructose. The substrate specificity is directed toward the galactopyranosyl moiety of the substrate NA C2_03013 cynX ko:K03449 transporter NA C2_03014 cynS ko00910,map00910 ko:K01725 4.2.1.104 Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide Nitrogen metabolism : Energy metabolism : Metabolism C2_03015 cynT ko00910,map00910 ko:K01673 4.2.1.1 Reversible hydration of carbon dioxide. Carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (CynS) diffuses out of the cell faster than it would be hydrated to bicarbonate, so the apparent function of this enzyme is to catalyze the hydration of carbon dioxide and thus prevent depletion of cellular bicarbonate Nitrogen metabolism : Energy metabolism : Metabolism C2_03016 cynR ko:K11921 Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region NA C2_03017 codA ko00240,ko00330,ko01100,map00240,map00330,map01100 ko:K01485 3.5.4.1 Catalyzes the hydrolytic deamination of cytosine to uracil. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis. Is also able to catalyze deamination of isoguanine, a mutagenic oxidation product of adenine in DNA, and of isocytosine. To a lesser extent, also catalyzes the conversion of 5- fluorocytosine (5FC) to 5-fluorouracil (5FU) Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03018 codB ko:K10974 Required for cytosine transport into the cell NA C2_03019 prpE ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 ko:K01895,ko:K01908 6.2.1.1,6.2.1.17 Catalyzes the synthesis of propionyl-CoA from propionate and CoA. Also converts acetate to acetyl-CoA but with a lower specific activity (By similarity) Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_03020 prpD ko00640,map00640 ko:K01720 4.2.1.79 Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the stereospecific dehydration of (2S,3S)-2- methylcitrate (2-MC) to yield the cis isomer of 2-methyl- aconitate Propanoate metabolism : Carbohydrate metabolism : Metabolism C2_03021 prpC ko00020,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01210,map01230 ko:K01647,ko:K01659 2.3.3.1,2.3.3.5 Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield (2S,3S)-2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl- CoA to yield citrate but with a lower specificity Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03022 prpB ko00640,map00640 ko:K03417 4.1.3.30 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate Propanoate metabolism : Carbohydrate metabolism : Metabolism C2_03023 prpR ko:K02688 propionate catabolism operon regulatory protein NA C2_03025 yahN ko:K03329 amino acid transmembrane transporter activity NA C2_03028 yahK ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 ko:K12957,ko:K13953,ko:K13979 1.1.1.1 Catalyzes the reduction of a wide range of aldehydes into their corresponding alcohols. Has a strong preference for NADPH over NADH as the electron donor. Cannot use a ketone as substrate. Is a major source of NADPH-dependent aldehyde reductase activity in E.coli. The in vivo functions of YahK has yet to be determined Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Fatty acid degradation : Lipid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Chloroalkane and chloroalkene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Naphthalene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Retinol metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolism of xenobiotics by cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_03029 ko:K02057 Branched-chain amino acid transport system / permease component NA C2_03030 ko:K02057 Branched-chain amino acid transport system / permease component NA C2_03031 ko:K02056 3.6.3.17 ABC transporter NA C2_03032 lsrB_2 ko02010,map02010 ko:K02058,ko:K10559 Periplasmic binding protein domain ABC transporters : Membrane transport : Environmental Information Processing C2_03033 ko:K05995,ko:K06888 3.4.13.21 ASCH NA C2_03035 yahI ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 ko:K00926 2.7.2.2 Belongs to the carbamate kinase family Arginine biosynthesis : Amino acid metabolism : Metabolism;Purine metabolism : Nucleotide metabolism : Metabolism;Nitrogen metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_03037 sucD ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 ko:K01902,ko:K02381 6.2.1.5 cofactor binding Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_03039 yahD ko:K06867 response to radiation NA C2_03041 yahB ko:K10972 DNA-binding transcription factor activity NA C2_03042 yahA ko02026,map02026 ko:K13244,ko:K21090 3.1.4.52 Hydrolyzes c-di-GMP (cyclic bis(3'-5') dimeric GMP) to 5'-pGpG, known as PDE-A activity. PDE-B activity, that is hydrolysis of 5'-pGpG to GMP, proceeds only very slowly Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_03043 ko:K07279,ko:K12678 Autotransporter beta-domain NA C2_03044 betT ko:K02168 Belongs to the BCCT transporter (TC 2.A.15) family NA C2_03045 betI ko:K02167 Repressor involved in choline regulation of the bet genes NA C2_03046 betB ko00260,ko01100,map00260,map01100 ko:K00130 1.2.1.8 belongs to the aldehyde dehydrogenase family Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03047 betA ko00260,ko01100,map00260,map01100 ko:K00108 1.1.99.1 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03049 lutC ko:K00782 LUD domain NA C2_03050 lutB ko:K18929 lactate oxidation NA C2_03051 lutA ko:K18928 Fe-S oxidoreductase NA C2_03052 ykgD ko:K18991,ko:K21746 Involved in reactive chlorine species (RCS) stress resistance. Upregulates, in response to hypochlorous acid (HOCl), the expression of three genes essential for survival of RCS stress (rclA, rclB and rclC) and its own expression NA C2_03053 merA ko00480,ko04918,map00480,map04918 ko:K00383,ko:K00520,ko:K21739 1.16.1.1,1.8.1.7 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family Glutathione metabolism : Metabolism of other amino acids : Metabolism;Thyroid hormone synthesis : Endocrine system : Organismal Systems C2_03054 ykgB ko:K21741 response to hypochlorite NA C2_03055 ykgA ko:K05804,ko:K13653 Bacterial transcription activator, effector binding domain NA C2_03056 eaeH ko05100,map05100 ko:K13735 cell adhesion Bacterial invasion of epithelial cells : Infectious disease: bacterial : Human Diseases C2_03058 rpmE2 ko03010,map03010 ko:K02909 50S ribosomal protein L31 type B Ribosome : Translation : Genetic Information Processing C2_03059 rpmJ ko03010,map03010 ko:K02919 Belongs to the bacterial ribosomal protein bL36 family Ribosome : Translation : Genetic Information Processing C2_03060 matA ko:K08087,ko:K21907,ko:K21963 Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition NA C2_03061 matB ko:K21964 Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition. Major subunit of the fimbria NA C2_03062 ecpB ko:K21965 Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition (By similarity) NA C2_03063 ecpC ko:K21966 Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition (By similarity) NA C2_03064 yagW ko:K21967 Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition. Tip pilus adhesin, which is required for assembly of EcpA into fibers (By similarity) NA C2_03065 ecpE ko:K21968 Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition (By similarity) NA C2_03066 yagU ko:K08996 response to acidic pH NA C2_03067 yagT ko00230,ko00450,ko01100,ko01120,map00230,map00450,map01100,map01120 ko:K07302,ko:K12528,ko:K13480,ko:K13483 1.3.99.16 Iron-sulfur subunit of the xanthine dehydrogenase complex Purine metabolism : Nucleotide metabolism : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03068 yagS ko00230,ko01100,ko01120,map00230,map01100,map01120 ko:K11178 1.17.1.4 xanthine dehydrogenase activity Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03069 yagR ko00230,ko01100,ko01120,map00230,map01100,map01120 ko:K11177 1.17.1.4 xanthine dehydrogenase activity Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03070 yagQ ko:K07402 molybdopterin cofactor binding NA C2_03072 ko:K07454 HNH endonuclease NA C2_03073 ko:K15773 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome NA C2_03084 proA ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 ko:K00147 1.2.1.41 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate Arginine and proline metabolism : Amino acid metabolism : Metabolism;Carbapenem biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03085 proB ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 ko:K00931 2.7.2.11 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate Arginine and proline metabolism : Amino acid metabolism : Metabolism;Carbapenem biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03086 phoE ko:K11929 Belongs to the Gram-negative porin family NA C2_03087 crl ko:K11926 Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 NA C2_03088 frsA ko:K11750 Belongs to the UPF0255 family NA C2_03089 gpt ko00230,ko01100,ko01110,map00230,map01100,map01110 ko:K00769,ko:K07101 2.4.2.22 Acts on guanine, xanthine and to a lesser extent hypoxanthine Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_03090 pepD ko00480,ko01100,map00480,map01100 ko:K01270 Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipeptide amides and formyl amino acids are hydrolyzed. Also shows cysteinylglycinase activity, which is sufficient for E.coli to utilize cysteinylglycine as a cysteine source Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03091 prfH ko:K02839 RF-1 domain NA C2_03092 rtcB ko01501,map01501 ko:K14415,ko:K18148 6.5.1.3 tRNA-splicing ligase RtcB beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases C2_03093 yafP ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 ko:K01814,ko:K03830,ko:K07146 5.3.1.16 acetyltransferase Histidine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03094 dinB ko:K02346,ko:K03502 2.7.7.7 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII NA C2_03095 motB ko02030,ko02040,map02030,map02040 ko:K02557 OmpA family Bacterial chemotaxis : Cell motility : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes C2_03096 flhA ko02040,map02040 ko:K02400 FHIPEP family Flagellar assembly : Cell motility : Cellular Processes C2_03099 yafL ko00520,ko01100,map00520,map01100 ko:K01183,ko:K13694,ko:K13695,ko:K19303,ko:K21471 3.2.1.14,3.4.17.13 cysteine-type peptidase activity Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03100 dinJ ko:K07473 Antitoxin component of a type II toxin-antitoxin (TA) system. A labile antitoxin that counteracts the effect of cognate toxin YafQ. YafQ and DinJ together bind their own promoter, and repress its expression. There are 2 operators with imperfect inverted repeats (IR) in the dinJ promoter, YafQ-(DinJ)2-YafQ only binds to the first (most upstream) of them to repress transcription NA C2_03101 yafQ ko:K19157 Toxic component of a type II toxin-antitoxin (TA) system. A sequence-specific mRNA endoribonuclease that inhibits translation elongation and induces bacterial stasis. Cleavage occurs between the second and third residue of the Lys codon followed by a G or A (5'AAA(G A)3'), is reading-frame dependent and occurs within the 5' end of most mRNAs. Ribosome-binding confers the sequence specificity and reading frame-dependence. When overexpressed in liquid media YafQ partially inhibits protein synthesis, with a reduction in growth rate and colony growth rate. This effect is counteracted by coexpression with cognate antitoxin DinJ. YafQ and DinJ together bind their own promoter, and repress its expression NA C2_03104 gmhA ko00540,ko01100,map00540,map01100 ko:K03271,ko:K12961 5.3.1.28 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03105 fadE ko00071,ko01100,ko01212,map00071,map01100,map01212 ko:K06445 Catalyzes the dehydrogenation of acyl-coenzymes A (acyl- CoAs) to 2-enoyl-CoAs, the first step of the beta-oxidation cycle of fatty acid degradation. Is required for Fatty acid degradation : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism C2_03107 yafV ko00250,map00250 ko:K11206,ko:K13566 3.5.1.3 Hydrolyzes alpha-ketoglutaramate (a-KGM) to alpha- ketoglutarate (alpha-KG) and ammonia, has weak activity on L- glutamine, almost no activity on deaminated glutathione (dGSH) and none on glutathione (By similarity). May function as a metabolite repair enzyme (By similarity) Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism C2_03109 iprA ko:K21828 Involved in oxidative stress resistance NA C2_03110 ampH ko:K18988 3.4.16.4 Hydrolyzes the cross-linked dimers tetrapentapeptide (D45) and tetratetrapeptide (D44). Removes the terminal D-alanine from muropeptides and disaccharide pentapeptide M5 with a C- terminal D-Ala-D-Ala dipeptide. Associated with recycling and remodeling of peptidoglycan (PG) NA C2_03112 sbmA ko:K17938 Uptake of antimicrobial peptides. Required for the transport of microcin B17 (MccB17), microcin 25 (Mcc25) and proline-rich antimicrobial peptides into the cell NA C2_03116 ddl ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 ko:K01921 6.3.2.4 Cell wall formation D-Alanine metabolism : Metabolism of other amino acids : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases C2_03118 phoA ko00521,ko00730,ko00790,ko01100,ko01130,ko02020,map00521,map00730,map00790,map01100,map01130,map02020 ko:K01077,ko:K04342 3.1.3.1,3.1.3.39 Belongs to the alkaline phosphatase family Streptomycin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;NA : NA : NA;Two-component system : Signal transduction : Environmental Information Processing C2_03120 adrA ko02026,map02026 ko:K18968 2.7.7.65 diguanylate cyclase. The last member of a cascade of expressed proteins, its expression requires YdaM. AdrA production induces biosynthesis of cellulose in some E.coli isolates, but not in K12 strains. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_03121 proC ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 ko:K00286 1.5.1.2 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline Arginine and proline metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03122 yaiI ko:K09768 Belongs to the UPF0178 family NA C2_03123 aroK ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko:K00891,ko:K13829,ko:K15546 2.7.1.71,4.2.3.4 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03125 aroM ko:K14591 AroM protein NA C2_03126 ppnP ko00230,ko00240,map00230,map00240 ko:K09913 2.4.2.1,2.4.2.2 Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism C2_03127 rdgC ko:K03554 May be involved in recombination NA C2_03128 mak ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 ko:K00847,ko:K00884 2.7.1.4,2.7.1.59 Catalyzes the phosphorylation of fructose to fructose-6- P. Has also low level glucokinase activity in vitro. Is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03129 araJ ko:K08156,ko:K19577 Major facilitator Superfamily NA C2_03130 sbcC ko:K03546 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity NA C2_03131 sbcD ko:K03547 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity NA C2_03133 phoR ko02020,map02020 ko:K02484,ko:K07636 2.7.13.3 Histidine kinase Two-component system : Signal transduction : Environmental Information Processing C2_03134 brnQ ko:K03311 Component of the transport system for branched-chain amino acids NA C2_03135 proY ko:K03293,ko:K11736 Permease that is involved in the transport across the cytoplasmic membrane of proline NA C2_03136 malZ ko00052,ko00500,ko01100,map00052,map00500,map01100 ko:K01187 3.2.1.20 May play a role in regulating the intracellular level of maltotriose. Cleaves glucose from the reducing end of maltotriose and longer maltodextrins with a chain length of up to 7 glucose units Galactose metabolism : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03137 acpH ko00770,map00770 ko:K08682 3.1.4.14 Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism C2_03138 queA ko:K00773,ko:K07568 2.4.2.29,2.4.99.17 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) NA C2_03139 tgt ko:K00773 2.4.2.29 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) NA C2_03140 yajC ko02024,ko03060,ko03070,map02024,map03060,map03070 ko:K03210 The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_03141 secD ko03060,ko03070,map03060,map03070 ko:K03072 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_03142 secF ko02024,ko03060,ko03070,map02024,map03060,map03070 ko:K03072,ko:K03074,ko:K12257 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_03143 yajD ko00240,ko00670,ko01100,map00240,map00670,map01100 ko:K03465 2.1.1.148 endonuclease activity Pyrimidine metabolism : Nucleotide metabolism : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03144 tsx ko:K05517 Nucleoside-specific channel-forming protein Tsx NA C2_03145 yajI ko:K06078 Protein of unknown function (DUF3251) NA C2_03146 nrdR ko:K07738 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes NA C2_03147 ribD ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 ko:K11752 1.1.1.193,3.5.4.26 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_03148 ribH ko00740,ko01100,ko01110,map00740,map01100,map01110 ko:K00794 2.5.1.78 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_03149 nusB ko:K03625 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons NA C2_03150 thiL ko00730,ko01100,map00730,map01100 ko:K00946 2.7.4.16 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03151 pgpA ko00564,ko01100,map00564,map01100 ko:K01095 3.1.3.27 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03152 yajO ko:K05882 1.1.1.91 thiamine metabolic process NA C2_03153 dxs ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 ko:K01662 2.2.1.7 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_03154 ispA ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko:K00795,ko:K02523,ko:K13789 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 Belongs to the FPP GGPP synthase family Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_03155 xseB ko03430,map03430 ko:K03602 3.1.11.6 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides Mismatch repair : Replication and repair : Genetic Information Processing C2_03156 thiI ko00730,ko01100,ko04122,map00730,map01100,map04122 ko:K03151 2.8.1.4 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_03157 thiJ ko00620,ko01120,ko05012,map00620,map01120,map05012 ko:K03152,ko:K05520,ko:K05523,ko:K05687,ko:K12132 2.7.11.1,3.5.1.124,4.2.1.130 Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Is able to repair glycated serum albumin, collagen, glyceraldehyde-3-phosphate dehydrogenase, and fructose biphosphate aldolase. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of Schiff bases and advanced glycation endproducts (AGE) that cause irreversible damage. Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. However, is less efficient than Hsp31 and YhbO, suggesting that YajL might be preferentially dedicated to protein repair. Displays a covalent chaperone activity with sulfenylated thiol proteins by forming mixed disulfides with members of the thiol proteome, and preferentially with sulfenylated cellular proteins, upon oxidative stress Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Parkinson disease : Neurodegenerative disease : Human Diseases C2_03158 panE ko00770,ko01100,ko01110,map00770,map01100,map01110 ko:K00077 1.1.1.169 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_03159 yajQ ko:K09767 UPF0234 protein YajQ NA C2_03161 ko:K07126 Sel1-like repeats. NA C2_03164 cyoE ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 ko:K02257 2.5.1.141 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group Oxidative phosphorylation : Energy metabolism : Metabolism;Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Thermogenesis : Environmental adaptation : Organismal Systems C2_03165 cyoD ko00190,ko01100,map00190,map01100 ko:K02300 cytochrome o ubiquinol oxidase Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03166 cyoC ko00190,ko01100,map00190,map01100 ko:K02299 oxidase subunit Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03167 cyoB ko00190,ko01100,map00190,map01100 ko:K02274,ko:K02298,ko:K02827 1.10.3.10,1.10.3.12,1.9.3.1 Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons electron Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03168 cyoA ko00190,ko01100,map00190,map01100 ko:K02297,ko:K02826 1.10.3.10,1.10.3.12 Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons electron Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03169 ampG ko01501,map01501 ko:K08218,ko:K08223 Major facilitator superfamily beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases C2_03170 yajG ko:K07286 Uncharacterized lipoprotein NA C2_03171 bolA ko:K05527,ko:K22066 Transcriptional regulator that plays an important role in general stress response. Has many effects on cell morphology, cell growth and cell division. Acts by regulating the transcription of many genes, including dacA (PBP-5), dacC (PBP-6), ampC and mreB. Probably involved in the coordination of genes that adapt the cell physiology in order to enhance cell adaptation and survival under stress conditions. Essential for normal cell morphology in stationary phase and under conditions of starvation. Also regulates a complex network of genes encoding proteins related to biofilm development, and negatively modulates flagellar biosynthesis and swimming capacity. Could be a motile adhesive transcriptional switch, specifically involved in the transition between the planktonic and the attachment stage of biofilm formation. Overexpression produces round cell shape, impairs cell growth rate and induces biofilm development NA C2_03172 tig ko:K03545 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase NA C2_03173 clpP ko04112,ko04212,map04112,map04212 ko:K01358 3.4.21.92 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins Cell cycle - Caulobacter : Cell growth and death : Cellular Processes;Longevity regulating pathway - worm : Aging : Organismal Systems C2_03174 clpX ko04112,map04112 ko:K03544 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP Cell cycle - Caulobacter : Cell growth and death : Cellular Processes C2_03175 lon ko04112,map04112 ko:K01338 3.4.21.53 Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner Cell cycle - Caulobacter : Cell growth and death : Cellular Processes C2_03176 hupB ko:K03530 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions NA C2_03177 ppiD ko:K01802,ko:K03769,ko:K03770 5.2.1.8 PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins NA C2_03178 ybaV ko03013,map03013 ko:K00784,ko:K02237 3.1.26.11 Competence protein ComEA RNA transport : Translation : Genetic Information Processing C2_03179 tesC ko:K07107,ko:K12500 acyl-CoA hydrolase activity NA C2_03180 queC ko00790,ko01100,map00790,map01100 ko:K06920 6.3.4.20 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03182 cof ko:K11938 Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) NA C2_03183 ybaO ko:K03719,ko:K05800 Plays a role in L-cysteine detoxification. Binds to the dlsT(yhaO)-yhaM operon promoter in the presence but not absence of L-cysteine NA C2_03184 mdlA ko02010,map02010 ko:K06148,ko:K18889 ATP-binding ABC transporters : Membrane transport : Environmental Information Processing C2_03185 mdlB ko02010,map02010 ko:K06147,ko:K18890 xenobiotic transmembrane transporting ATPase activity ABC transporters : Membrane transport : Environmental Information Processing C2_03186 glnK ko02020,map02020 ko:K04751,ko:K04752 Nitrogen regulatory protein P-II Two-component system : Signal transduction : Environmental Information Processing C2_03187 amtB ko:K03320 transporter NA C2_03188 tesB ko01040,map01040 ko:K10805 acyl-CoA thioesterase II Biosynthesis of unsaturated fatty acids : Lipid metabolism : Metabolism C2_03189 ybaY ko:K09914 Type III secretion system lipoprotein chaperone (YscW) NA C2_03190 ybaZ ko:K00567,ko:K07443 2.1.1.63 Involved in DNA damage recognition. Binds DNA containing O(6)-methylguanine and larger O(6)-alkylguanine adducts, and to double-stranded DNA that contains an AP (apurinic apyrimidinic) site. Binds to the damaged base and flips the base out of the DNA duplex into an extrahelical conformation, which allows processing by repair proteins. Works in partnership with the nucleotide excision repair (NER) pathway to enhance the repair of the O(6)-alkylguanine adducts larger than the methyl adduct. Also prevents methyl-directed mismatch repair (MMR)-mediated attack of the O(6)-alkylguanine T mispairs for the larger alkyl groups NA C2_03192 ylaB ko02026,map02026 ko:K21090 3.1.4.52 May function as a c-di-GMP phosphodiesterase. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria (By similarity) Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_03194 maa ko:K00633,ko:K00661 2.3.1.18,2.3.1.79 Maltose O-acetyltransferase NA C2_03195 hha ko:K05839 Hha and Cnu (YdgT) increase the number of genes DNA bound by H-NS StpA and may also modulate the oligomerization of the H-NS StpA-complex. Binds DNA and influences DNA topology in response to environmental stimuli NA C2_03196 tomB ko:K19162 Attenuates Hha toxicity and regulates biofilm formation. Binds to various coding and intergenic regions of genomic DNA NA C2_03197 acrB ko01501,ko01503,map01501,map01503 ko:K18138,ko:K18142,ko:K18899 efflux pump beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_03198 acrA ko01501,ko01503,map01501,map01503 ko:K03585,ko:K18141,ko:K18898 AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_03199 acrR ko:K03577 transcriptional regulator NA C2_03200 kefA ko02010,map02010 ko:K05802,ko:K06994,ko:K15771,ko:K22051 mechanosensitive ion channel ABC transporters : Membrane transport : Environmental Information Processing C2_03202 priC ko03440,map03440 ko:K04067 Primosomal replication protein N' Homologous recombination : Replication and repair : Genetic Information Processing C2_03203 ybaN ko:K09790 membrane NA C2_03204 apt ko00230,ko01100,map00230,map01100 ko:K00759 2.4.2.7 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03205 dnaX ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02343 2.7.7.7 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing C2_03206 ybaB ko03440,map03440 ko:K06187,ko:K09747 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection Homologous recombination : Replication and repair : Genetic Information Processing C2_03207 recR ko03440,map03440 ko:K06187 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO Homologous recombination : Replication and repair : Genetic Information Processing C2_03208 htpG ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 ko:K04079 Molecular chaperone. Has ATPase activity Protein processing in endoplasmic reticulum : Folding, sorting and degradation : Genetic Information Processing;PI3K-Akt signaling pathway : Signal transduction : Environmental Information Processing;Necroptosis : Cell growth and death : Cellular Processes;Antigen processing and presentation : Immune system : Organismal Systems;NOD-like receptor signaling pathway : Immune system : Organismal Systems;Plant-pathogen interaction : Environmental adaptation : Organismal Systems;IL-17 signaling pathway : Immune system : Organismal Systems;Th17 cell differentiation : Immune system : Organismal Systems;Progesterone-mediated oocyte maturation : Endocrine system : Organismal Systems;Estrogen signaling pathway : Endocrine system : Organismal Systems;Pathways in cancer : Cancer: overview : Human Diseases;Prostate cancer : Cancer: specific types : Human Diseases;Fluid shear stress and atherosclerosis : Cardiovascular disease : Human Diseases C2_03209 adk ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 ko:K00939 2.7.4.3 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism Purine metabolism : Nucleotide metabolism : Metabolism;Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_03210 hemH ko00860,ko01100,ko01110,map00860,map01100,map01110 ko:K01772 4.99.1.1,4.99.1.9 Catalyzes the ferrous insertion into protoporphyrin IX Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_03211 aes ko:K01066 Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons). Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin), but not trioleylglycerol (triolein) or cholesterol oleate. Negatively regulates MalT activity by antagonizing maltotriose binding. Inhibits MelA galactosidase activity NA C2_03212 gsk ko00230,ko00562,ko01100,ko01120,map00230,map00562,map01100,map01120 ko:K00856,ko:K00892,ko:K03338 2.7.1.20,2.7.1.73,2.7.1.92 inosine kinase activity Purine metabolism : Nucleotide metabolism : Metabolism;Inositol phosphate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03213 ybaL ko:K03455 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family NA C2_03214 fsr ko:K08223 Fosmidomycin resistance protein NA C2_03215 ushA ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 ko:K11751 3.1.3.5,3.6.1.45 Belongs to the 5'-nucleotidase family Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_03216 ybaK ko:K03976,ko:K19055 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily NA C2_03217 ybaP ko:K09973 TraB family NA C2_03218 ybaQ ko:K21498 addiction module antidote protein, HigA family NA C2_03221 nlpD ko:K06194,ko:K12943 autolysis NA C2_03222 xdhA ko00230,ko00450,ko01100,ko01120,map00230,map00450,map01100,map01120 ko:K00087,ko:K12528 1.17.1.4 Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) Purine metabolism : Nucleotide metabolism : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03223 xdhB ko00230,ko01100,ko01120,map00230,map01100,map01120 ko:K13479 1.17.1.4 Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03224 xdhC ko00230,ko00450,ko01100,ko01120,map00230,map00450,map01100,map01120 ko:K03518,ko:K07302,ko:K12528,ko:K13480,ko:K13483 1.2.5.3,1.3.99.16 Xanthine dehydrogenase iron-sulfur-binding subunit Purine metabolism : Nucleotide metabolism : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03226 ygeW ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 ko:K00611 2.1.3.3 carbamoyltransferase YgeW Arginine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03227 ygeX ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 ko:K01751,ko:K01754 4.3.1.15,4.3.1.19 Catalyzes the alpha,beta-elimination reaction of both L- and D-alpha,beta-diaminopropionate (DAP) to form pyruvate and ammonia Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03229 hyuA ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100 ko:K01464 3.5.2.2 Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'-position. Has no activity on dihydropyrimidines. The physiological function is Pyrimidine metabolism : Nucleotide metabolism : Metabolism;beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03230 arcC ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 ko:K00926 2.7.2.2 Belongs to the carbamate kinase family Arginine biosynthesis : Amino acid metabolism : Metabolism;Purine metabolism : Nucleotide metabolism : Metabolism;Nitrogen metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_03231 yqeB ko:K07402 XdhC and CoxI family NA C2_03232 murE ko00300,ko00550,map00300,map00550 ko:K01928,ko:K15792 6.3.2.10,6.3.2.13 ATP binding Lysine biosynthesis : Amino acid metabolism : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism C2_03233 mocA ko00760,ko00790,ko01120,map00760,map00790,map01120 ko:K07141,ko:K19190 1.1.1.328,2.7.7.76 Transfers a CMP moiety from CTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin cytosine dinucleotide (Mo-MCD) cofactor. Is specific for CTP Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03234 ygfK ko00450,map00450 ko:K12527 1.97.1.9 Could be an iron-sulfur flavoprotein with NADPH O(2) oxidoreductase activity Selenocompound metabolism : Metabolism of other amino acids : Metabolism C2_03236 ygfM ko00230,ko00450,ko01100,ko01120,map00230,map00450,map01100,map01120 ko:K00087,ko:K03519,ko:K12529 1.17.1.4,1.2.5.3 flavin adenine dinucleotide binding Purine metabolism : Nucleotide metabolism : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03237 xdhD ko00230,ko00450,ko01100,ko01120,map00230,map00450,map01100,map01120 ko:K00087,ko:K07302,ko:K12528,ko:K13480,ko:K13483 1.17.1.4,1.3.99.16 however deletion results in increased adenine sensitivity, suggesting that this protein contributes to the conversion of adenine to guanine nucleotides during purine salvage Purine metabolism : Nucleotide metabolism : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03238 pbuX ko:K02824,ko:K03458,ko:K09016,ko:K16345,ko:K16346 Specific, proton motive force-dependent high-affinity transporter for xanthine NA C2_03239 guaD ko00230,ko01100,map00230,map01100 ko:K01487 3.5.4.3 guanine catabolic process Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03240 pbuG ko:K06901 guanine transport NA C2_03241 ygfS ko:K05796,ko:K12136,ko:K15827 4 iron, 4 sulfur cluster binding NA C2_03242 gltD ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 ko:K00266,ko:K05796,ko:K12136,ko:K15827 1.4.1.13,1.4.1.14 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Nitrogen metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03243 ygfU ko:K02824,ko:K09016,ko:K16345,ko:K16346 Proton-dependent high-capacity transporter for uric acid. Shows also a low capacity for transport of xanthine at 37 degrees Celsius but not at 25 degrees Celsius NA C2_03245 idi ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko:K01823 5.3.3.2 Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_03246 lysS ko00970,map00970 ko:K04567 6.1.1.6 Belongs to the class-II aminoacyl-tRNA synthetase family Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_03247 prfB ko:K02836 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA NA C2_03248 recJ ko03410,ko03430,ko03440,map03410,map03430,map03440 ko:K07462 single-stranded-DNA-specific exonuclease RecJ Base excision repair : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing C2_03249 dsbC ko:K03805,ko:K03981 5.3.4.1 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process NA C2_03250 xerD ko:K04763 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerC binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids NA C2_03251 fldB ko:K03839,ko:K03840 Low-potential electron donor to a number of redox enzymes NA C2_03252 ygfX ko:K19168 inner membrane protein. Has been shown not to be a toxin, no effects on growth are seen in LB or minimal medium up to 6 or 21 hours (respectively) after induction of expression. Interacts with cytoskeletal proteins FtsZ and MreB NA C2_03253 sdhE ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 ko:K00240,ko:K09159 1.3.5.1,1.3.5.4 Flavinator of succinate dehydrogenase Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Oxidative phosphorylation : Energy metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_03254 ygfZ ko:K06980,ko:K22073 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication NA C2_03255 yqfA ko:K11068 UPF0073 inner membrane protein YqfA NA C2_03256 yqfB ko:K09900 Belongs to the UPF0267 family NA C2_03257 bglA ko00010,ko00500,map00010,map00500 ko:K01223 3.2.1.86 Belongs to the glycosyl hydrolase 1 family Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism C2_03259 gcvP ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 ko:K00281,ko:K00282 1.4.4.2 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_03260 gcvH ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 ko:K02437 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_03261 gcvT ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 ko:K00605 2.1.2.10 The glycine cleavage system catalyzes the degradation of glycine Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_03262 visC ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K03184,ko:K03185,ko:K18800 FAD-dependent monooxygenase required for the aerobic hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy- phenol, the first hydroxylation step in coenzyme Q (ubiquinone) biosynthesis Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_03263 ubiH ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K03184,ko:K03185,ko:K18800 2-octaprenyl-6-methoxyphenol hydroxylase Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_03264 pepP ko:K01262 3.4.11.9 metalloexopeptidase activity NA C2_03265 ygfB ko:K09895 Belongs to the UPF0149 family NA C2_03266 zapA ko:K09888 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division NA C2_03267 fthC ko00670,ko01100,map00670,map01100 ko:K01934 6.3.3.2 Involved in the removal of 5-formyltetrahydrofolate. In vitro, it is a potent inhibitor of various folate-dependent enzymes in the C1 metabolism network and in vivo it might function as a folate storage. 5-formyltetrahydrofolate is also used as an antifolate rescue agent in cancer chemotherapy. Catalyzes the irreversible ATP-dependent transformation of 5- formyltetrahydrofolate (5-CHO-THF) to form 5,10- methenyltetrahydrofolate (5,10-CH THF). The reverse reaction is catalyzed by the serine hydroxymethyltransferase GlyA (SHMT) One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03268 serA ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 ko:K00058 1.1.1.399,1.1.1.95 Catalyzes the reversible oxidation of 3-phospho-D- glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03269 rpiA ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 ko:K01807 5.3.1.6 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03271 argP ko:K05596 Controls the transcription of genes involved in arginine and lysine metabolism NA C2_03272 scpA ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 ko:K01847,ko:K01848 5.4.99.2 Methylmalonyl-CoA mutase Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_03273 argK ko:K07588 Binds and hydrolyzes GTP. Likely functions as a G-protein chaperone that assists AdoCbl cofactor delivery to the methylmalonyl-CoA mutase (MCM) ScpA and reactivation of the enzyme during catalysis NA C2_03274 scpB ko00640,map00640 ko:K11264 4.1.1.41 Belongs to the enoyl-CoA hydratase isomerase family Propanoate metabolism : Carbohydrate metabolism : Metabolism C2_03275 cat1 ko00020,ko00620,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00640,map00650,map01100,map01110,map01120,map01130,map01200 ko:K01067,ko:K18118,ko:K22214 2.8.3.18,3.1.2.1 Catalyzes the transfer of coenzyme A from propionyl-CoA to succinate. Could be part of a pathway that converts succinate to propionate Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_03277 yggE ko:K09807 cellular response to heat NA C2_03278 argO ko:K06895 Involved in the export of arginine. Important to control the intracellular level of arginine and the correct balance between arginine and lysine NA C2_03279 mscS ko:K03442 Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage NA C2_03280 fbaA ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 ko:K01624 4.1.2.13 Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03281 pgk ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 ko:K00927,ko:K01803 2.7.2.3,5.3.1.1 Belongs to the phosphoglycerate kinase family Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Inositol phosphate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03282 epd ko00010,ko00710,ko00750,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map00750,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 ko:K00134,ko:K03472 1.2.1.12,1.2.1.72 Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;HIF-1 signaling pathway : Signal transduction : Environmental Information Processing;Alzheimer disease : Neurodegenerative disease : Human Diseases C2_03283 ko:K06934 Domain of unknown function (DUF296) NA C2_03284 ko:K16923,ko:K18967 2.7.7.65 phosphorelay sensor kinase activity NA C2_03285 ecfT ko02010,map02010 ko:K02008,ko:K16783,ko:K16785 Psort location CytoplasmicMembrane, score ABC transporters : Membrane transport : Environmental Information Processing C2_03286 ko02010,map02010 ko:K02006,ko:K16784,ko:K16785,ko:K16786,ko:K16787,ko:K21397 ABC transporter ABC transporters : Membrane transport : Environmental Information Processing C2_03287 cysA ko00920,ko02010,map00920,map02010 ko:K02017,ko:K02045,ko:K10112,ko:K16787 3.6.3.25,3.6.3.29 ATPases associated with a variety of cellular activities Sulfur metabolism : Energy metabolism : Metabolism;ABC transporters : Membrane transport : Environmental Information Processing C2_03288 yggC ko:K02173 kinase activity NA C2_03290 glpX ko00010,ko00030,ko00051,ko00680,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 ko:K00615,ko:K02446,ko:K11532 2.2.1.1,3.1.3.11,3.1.3.37 Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. Also displays a low activity toward glucose 1,6-bisphosphate, and no activity against ribulose 1,5- bisphosphate, fructose 2,6-bisphosphate, or fructose 1-phosphate Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Biosynthesis of ansamycins : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03291 yggP ko00051,map00051 ko:K19956 oxidoreductase activity Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism C2_03292 cmtA ko00051,ko02060,map00051,map02060 ko:K02799,ko:K02800 2.7.1.197 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_03293 cmtB ko00051,ko00052,ko00053,ko01100,ko01120,ko02060,map00051,map00052,map00053,map01100,map01120,map02060 ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02798,ko:K02806,ko:K02821,ko:K08483,ko:K11189,ko:K11201,ko:K18531 2.7.1.194,2.7.1.197,2.7.1.200,2.7.1.202,2.7.3.9 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_03294 tkt ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 ko:K00615 2.2.1.1 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Biosynthesis of ansamycins : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03295 yggG ko:K07387 Metalloprotease that cleaves substrates preferentially between Phe-Phe residues. Plays a role in response to some stress conditions. Seems to regulate the expression of speB NA C2_03296 ko00030,ko01100,ko01120,map00030,map01100,map01120 ko:K17463 4.1.2.14 Pfam:DUF1341 Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03297 selA ko00030,ko00450,ko00970,ko01120,map00030,map00450,map00970,map01120 ko:K01042,ko:K17468 2.9.1.1,4.3.1.29 L-seryl-tRNA selenium transferase Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03298 ko00030,ko00051,ko00520,ko01100,ko01120,ko02060,map00030,map00051,map00520,map01100,map01120,map02060 ko:K02796,ko:K17467,ko:K19509 PTS system mannose/fructose/sorbose family IID component Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_03299 ko00030,ko01120,ko02060,map00030,map01120,map02060 ko:K17466 PTS system sorbose-specific iic component Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_03300 ko00030,ko01120,ko02060,map00030,map01120,map02060 ko:K17465 2.7.1.203 PTS system sorbose subfamily IIB component Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_03301 ko00030,ko01120,ko02060,map00030,map01120,map02060 ko:K17464 2.7.1.203 PTS system fructose IIA component Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_03302 ko:K03974,ko:K17473 PRD domain NA C2_03303 speB ko00330,ko01100,ko02010,map00330,map01100,map02010 ko:K01480,ko:K12541 3.5.3.11 Catalyzes the formation of putrescine from agmatine Arginine and proline metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;ABC transporters : Membrane transport : Environmental Information Processing C2_03305 speA ko00330,ko01100,map00330,map01100 ko:K01585 4.1.1.19 Catalyzes the biosynthesis of agmatine from arginine Arginine and proline metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03307 metK ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 ko:K00789 2.5.1.6 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03308 galP ko:K02100,ko:K08137 Major facilitator Superfamily NA C2_03309 sprT ko:K02742 Belongs to the SprT family NA C2_03310 endA ko:K01150 3.1.21.1 deoxyribonuclease I activity NA C2_03311 rsmE ko:K09761 2.1.1.193 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit NA C2_03312 gshB ko00270,ko00480,ko01100,map00270,map00480,map01100 ko:K01919,ko:K01920,ko:K05844 6.3.2.2,6.3.2.3 glutathione synthase activity Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03313 yqgE ko:K07735 Belongs to the UPF0301 (AlgH) family NA C2_03314 yqgF ko:K07447 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA NA C2_03315 cusS ko02020,map02020 ko:K07644 2.7.13.3 Member of the two-component regulatory system CusS CusR. Copper ion sensor. Could also be a silver ion sensor. Activates CusR by phosphorylation Two-component system : Signal transduction : Environmental Information Processing C2_03317 cusC ko01501,ko02020,ko02024,map01501,map02020,map02024 ko:K07796,ko:K18139 Forms pores that allow passive diffusion of cations across the outer membrane. Part of a cation efflux system that mediates resistance to copper and silver beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_03318 cusF ko02020,map02020 ko:K07810 Part of a cation efflux system that mediates resistance to copper and silver. Binds one copper per polypeptide Two-component system : Signal transduction : Environmental Information Processing C2_03319 cusB ko02020,map02020 ko:K07798 Part of a cation efflux system that mediates resistance to copper and silver Two-component system : Signal transduction : Environmental Information Processing C2_03320 cusA ko02020,map02020 ko:K07787 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family Two-component system : Signal transduction : Environmental Information Processing C2_03321 pheP ko:K03293,ko:K11732,ko:K11734 Permease that is involved in the transport across the cytoplasmic membrane of phenylalanine NA C2_03322 ybdG ko:K16053 Mechanosensitive Ion channel NA C2_03323 nfnB ko00633,ko01120,map00633,map01120 ko:K10679 1.5.1.34 Oxygen-insensitive NAD(P)H nitroreductase Nitrotoluene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03326 ybdK ko:K06048 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity NA C2_03327 hokE ko:K18922 Hok/gef family NA C2_03328 hokE ko:K18922 Hok/gef family NA C2_03329 entD ko01053,ko01110,ko01130,map01053,map01110,map01130 ko:K02362 6.3.2.14 Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2 ) atoms. Plays an essential role in the assembly of the enterobactin by catalyzing the transfer of the 4'- phosphopantetheine (Ppant) moiety from coenzyme A to the apo- domains of both EntB (ArCP domain) and EntF (PCP domain) to yield their holo-forms which make them competent for the activation of 2,3-dihydroxybenzoate (DHB) and L-serine, respectively Biosynthesis of siderophore group nonribosomal peptides : Metabolism of terpenoids and polyketides : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_03330 fepA ko02020,map02020 ko:K16089,ko:K19611 This protein is involved in the initial step of iron uptake by binding ferrienterobactin (Fe-ENT), an iron chelatin siderophore that allows E.coli to extract iron from the environment. FepA also acts as a receptor for colicins B and D Two-component system : Signal transduction : Environmental Information Processing C2_03331 fes ko:K07214 esterase NA C2_03332 ybdZ ko00261,ko01130,map00261,map01130 ko:K05375,ko:K07214 Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. Plays a role in the catalytic function of EntF. It is required for adenylation of amino acids in non-ribosomal peptide biosynthesis Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;NA : NA : NA C2_03333 entF ko01053,ko01110,ko01130,map01053,map01110,map01130 ko:K02364 6.3.2.14 Activates the carboxylate group of L-serine via ATP- dependent PPi exchange reactions to the aminoacyladenylate, preparing that molecule for the final stages of enterobactin synthesis. Holo-EntF acts as the catalyst for the formation of the three amide and three ester bonds present in the cyclic (2,3- dihydroxybenzoyl)serine trimer enterobactin, using seryladenylate and acyl-holo-EntB (acylated with 2,3-dihydroxybenzoate by EntE) Biosynthesis of siderophore group nonribosomal peptides : Metabolism of terpenoids and polyketides : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_03334 fepE ko:K05789,ko:K05790 Ferric enterobactin transport protein FepE NA C2_03335 fepC ko02010,map02010 ko:K02013 3.6.3.34 Probably responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_03336 fepG ko02010,map02010 ko:K02015 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily ABC transporters : Membrane transport : Environmental Information Processing C2_03337 fepD ko02010,map02010 ko:K02015 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily ABC transporters : Membrane transport : Environmental Information Processing C2_03338 entS ko:K08225 Exports the siderophore enterobactin out of the cell NA C2_03339 fepB ko02010,map02010 ko:K02016 part of the binding-protein- dependent transport system for uptake of ferrienterobactin ABC transporters : Membrane transport : Environmental Information Processing C2_03340 entC ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130 ko:K02361,ko:K02552 5.4.4.2 Involved in the biosynthesis of the siderophore enterobactin (macrocyclic trimeric lactone of N-(2,3- dihydroxybenzoyl)-serine). Catalyzes the reversible conversion of chorismate to isochorismate Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Biosynthesis of siderophore group nonribosomal peptides : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_03341 entE ko01053,ko01110,ko01130,map01053,map01110,map01130 ko:K02363 2.7.7.58,6.3.2.14 Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2 ) atoms. EntE proccesses via a two-step adenylation- ligation reaction (bi-uni-uni-bi ping-pong mechanism). First, it catalyzes the activation of the carboxylate group of 2,3- dihydroxy-benzoate (DHB), via a reversible ATP-dependent pyrophosphate exchange reactions to yield the acyladenylate intermediate 2,3-dihydroxybenzoyl-AMP. It can also transfer AMP to salicylate, 2,4-dihydroxybenzoate, gentisate and 2,3,4- trihydroxybenzoate. In the second step, DHB is transferred from 2,3-dihydroxybenzoyl-AMP onto the phosphopantetheinylated EntB (holo-EntB) to form DHB-holo-EntB. Then this product will serve in the formation of the amide bond between 2,3-dihydroxybenzoate (DHB) and L-serine Biosynthesis of siderophore group nonribosomal peptides : Metabolism of terpenoids and polyketides : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_03342 entB ko01053,ko01110,ko01130,map01053,map01110,map01130 ko:K01252 3.3.2.1,6.3.2.14 Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2 ) atoms. EntB is a bifunctional protein that serves as an isochorismate lyase and an aryl carrier protein (ArCP). Catalyzes the conversion of isochorismate to 2,3-dihydro-2,3- dihydroxybenzoate (2,3-diDHB), the precursor of 2,3- dihydroxybenzoate (DHB). In the enterobactin assembly, EntB functions as an aryl carrier protein phosphopantetheinylated near the C terminus by EntD to yield holo-EntB, which is then acylated by EntE with 2,3-dihydroxybenzoyl-AMP to form DHB-holo-EntB. Then this product will serve in the formation of the amide bond between 2,3-dihydroxybenzoate (DHB) and L-serine Biosynthesis of siderophore group nonribosomal peptides : Metabolism of terpenoids and polyketides : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_03344 entH ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K19222 3.1.2.28 Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_03345 cstA ko:K06200 carbon starvation protein NA C2_03347 gldA ko00010,ko00071,ko00350,ko00561,ko00625,ko00626,ko00640,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00561,map00625,map00626,map00640,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 ko:K00001,ko:K00005,ko:K08317 1.1.1.1,1.1.1.6 Iron-containing alcohol dehydrogenase Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Fatty acid degradation : Lipid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Chloroalkane and chloroalkene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Naphthalene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Retinol metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolism of xenobiotics by cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_03348 ybdL ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 ko:K14267,ko:K14287 2.6.1.17,2.6.1.88 aminotransferase Lysine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03349 ibrB ko:K03497 ParB-like nuclease domain NA C2_03352 dsbG ko:K03805,ko:K03981 5.3.4.1 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process NA C2_03353 ahpC ko04214,map04214 ko:K03386 1.11.1.15 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides Apoptosis - fly : Cell growth and death : Cellular Processes C2_03354 ahpF ko:K03387 Alkyl hydroperoxide reductase NA C2_03355 uspG ko:K11932,ko:K14061 Belongs to the universal stress protein A family NA C2_03356 ybdR ko00040,ko00051,ko01100,map00040,map00051,map01100 ko:K00008 1.1.1.14 zinc ion binding Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03358 rnk ko:K03624,ko:K06140 May act as an anti-Gre factor NA C2_03359 rna ko:K01166,ko:K01169 3.1.27.1,3.1.27.6 Belongs to the RNase T2 family NA C2_03360 citT ko02020,map02020 ko:K03319,ko:K09477,ko:K11106 Responsible for the uptake of citrate in exchange with the efflux of succinate, fumarate or tartrate. Has a relatively broad specificity for C(4)-dicarboxylates and tricarboxylates Two-component system : Signal transduction : Environmental Information Processing C2_03361 citG ko02020,map02020 ko:K05966,ko:K13927,ko:K13930 2.4.2.52,2.7.7.61 Catalyzes the formation of 2-(5''-triphosphoribosyl)-3'- dephosphocoenzyme-A, the precursor of the prosthetic group of the holo-acyl carrier protein (gamma chain) of citrate lyase, from ATP and dephospho-CoA Two-component system : Signal transduction : Environmental Information Processing C2_03362 citX ko02020,map02020 ko:K05964,ko:K13927 2.4.2.52,2.7.7.61 Transfers 2-(5''-triphosphoribosyl)-3'- dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein Two-component system : Signal transduction : Environmental Information Processing C2_03363 citF ko02020,map02020 ko:K01643 2.8.3.10 Citrate (pro-3S)-lyase alpha chain Two-component system : Signal transduction : Environmental Information Processing C2_03364 citE ko00660,ko01100,ko02020,map00660,map01100,map02020 ko:K01644,ko:K18292 4.1.3.25,4.1.3.34 Belongs to the HpcH HpaI aldolase family C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_03365 citD ko02020,map02020 ko:K01646 Covalent carrier of the coenzyme of citrate lyase Two-component system : Signal transduction : Environmental Information Processing C2_03366 citC ko02020,map02020 ko:K01910 6.2.1.22 Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase Two-component system : Signal transduction : Environmental Information Processing C2_03367 dpiB ko02020,map02020 ko:K02476,ko:K07700,ko:K07701,ko:K11614 2.7.13.3 Member of the two-component regulatory system DpiA DpiB, which is essential for expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. Could be involved in response to both the presence of citrate and external redox conditions. Functions as a sensor kinase that phosphorylates DpiA in the presence of citrate Two-component system : Signal transduction : Environmental Information Processing C2_03368 dpiA ko02020,map02020 ko:K02475,ko:K07702,ko:K07703 Member of the two-component regulatory system DpiA DpiB, which is essential for expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. Could be involved in response to both the presence of citrate and external redox conditions Two-component system : Signal transduction : Environmental Information Processing C2_03369 dcuC ko:K03326 Responsible for the transport of C4-dicarboxylates during anaerobic growth NA C2_03370 pagP ko01503,ko05133,map01503,map05133 ko:K12973 2.3.1.251 Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Pertussis : Infectious disease: bacterial : Human Diseases C2_03371 cspE ko:K03704 Ribonuclease B OB domain NA C2_03372 crcB ko:K06199 Important for reducing fluoride concentration in the cell, thus reducing its toxicity NA C2_03373 ybeM ko00250,map00250 ko:K11206,ko:K13566 3.5.1.3 terminal fragment. The intact protein (AC A0A140NCB4) hydrolyzes deaminated glutathione (dGSH, 2-oxoglutaramate) to alpha- ketoglutarate (alpha-KG) and cysteinylglycine, has less activity against alpha-ketoglutaramate (a-KGM) and no activity on glutathione or L-glutamine (By similarity). May function as a metabolite repair enzyme (By similarity) Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism C2_03374 tatE ko03060,ko03070,map03060,map03070 ko:K03116,ko:K03425 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_03375 lipA ko00785,ko01100,map00785,map01100 ko:K03644 2.8.1.8 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives Lipoic acid metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03377 lipB ko00785,ko01100,map00785,map01100 ko:K03801 2.3.1.181 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate Lipoic acid metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03378 ybeD ko:K09158 Belongs to the UPF0250 family NA C2_03379 dacA ko00550,ko01100,map00550,map01100 ko:K07258 3.4.16.4 Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03380 rlpA ko:K03642 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides NA C2_03381 mrdB ko:K05837 Peptidoglycan polymerase that is essential for cell wall elongation NA C2_03382 mrdA ko00550,ko01501,map00550,map01501 ko:K05515 3.4.16.4 Catalyzes cross-linking of the peptidoglycan cell wall Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases C2_03383 rlmH ko:K00783 2.1.1.177 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA NA C2_03384 rsfS ko00760,ko01100,map00760,map01100 ko:K00969,ko:K09710 2.7.7.18 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03385 cobC ko00860,ko01100,map00860,map01100 ko:K02226 3.1.3.73 Belongs to the phosphoglycerate mutase family Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03386 nadD ko00230,ko00760,ko01100,ko05340,map00230,map00760,map01100,map05340 ko:K00969,ko:K01488,ko:K03574 2.7.7.18,3.5.4.4,3.6.1.55 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) Purine metabolism : Nucleotide metabolism : Metabolism;Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Primary immunodeficiency : Immune disease : Human Diseases C2_03387 holA ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02340 2.7.7.7 dna polymerase III delta subunit Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing C2_03388 lptE ko:K03643 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane NA C2_03389 leuS ko00970,map00970 ko:K01869 6.1.1.4 Belongs to the class-I aminoacyl-tRNA synthetase family Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_03390 ybeL ko00230,ko00240,ko01100,ko02025,ko04113,ko04213,map00230,map00240,map01100,map02025,map04113,map04213 ko:K00525,ko:K01768 1.17.4.1,4.6.1.1 Zinc-ribbon containing domain Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Meiosis - yeast : Cell growth and death : Cellular Processes;Longevity regulating pathway - multiple species : Aging : Organismal Systems C2_03391 ybeQ ko:K07126 COG0790 FOG TPR repeat, SEL1 subfamily NA C2_03395 ybeT ko:K07126 Sel1-like repeats. NA C2_03398 hscC ko:K04045 heat shock protein 70 NA C2_03399 rihA ko00230,ko00240,ko01100,map00230,map00240,map01100 ko:K01250,ko:K10213,ko:K12700 3.2.2.8 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03400 gltL ko02010,ko02020,map02010,map02020 ko:K02028,ko:K09972,ko:K10004 3.6.3.21 Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Probably responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing C2_03401 gltK ko02010,ko02020,map02010,map02020 ko:K02029,ko:K10002 Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Probably responsible for the translocation of the substrate across the membrane ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing C2_03402 gltJ ko02010,ko02020,map02010,map02020 ko:K02029,ko:K10003,ko:K10040 Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Probably responsible for the translocation of the substrate across the membrane ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing C2_03403 gltI ko02010,ko02020,map02010,map02020 ko:K10001 Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Binds to both glutamate and aspartate ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing C2_03404 aarA ko:K19225 3.4.21.105 membrane protein (homolog of Drosophila rhomboid) NA C2_03405 lnt ko:K03820 Transfers the fatty acyl group on membrane lipoproteins NA C2_03406 corC ko:K06189 Magnesium and cobalt efflux protein CorC NA C2_03407 ybeY ko00240,ko00750,ko00983,ko01100,map00240,map00750,map00983,map01100 ko:K01489,ko:K03474,ko:K03595,ko:K07042 2.6.99.2,3.5.4.5 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03408 ybeZ ko:K06217 phosphate starvation-inducible protein PhoH NA C2_03409 miaB ko:K06168 2.8.4.3 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine NA C2_03410 ubiF ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K03184,ko:K03185,ko:K18800 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_03418 asnB ko00250,ko01100,ko01110,map00250,map01100,map01110 ko:K01953 6.3.5.4 Asparagine synthetase B Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_03419 yibF ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 ko:K00799 2.5.1.18 Glutathione S-transferase, C-terminal domain Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolism of xenobiotics by cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Platinum drug resistance : Drug resistance: antineoplastic : Human Diseases;Pathways in cancer : Cancer: overview : Human Diseases;Chemical carcinogenesis : Cancer: overview : Human Diseases;Hepatocellular carcinoma : Cancer: specific types : Human Diseases;Fluid shear stress and atherosclerosis : Cardiovascular disease : Human Diseases C2_03420 selA ko00450,ko00970,map00450,map00970 ko:K01042 2.9.1.1 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_03421 selB ko:K03833 Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP NA C2_03422 yiaY ko00010,ko00071,ko00350,ko00625,ko00626,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map01100,map01110,map01120,map01130,map01220 ko:K13954 1.1.1.1 L-threonine 3-dehydrogenase activity Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Fatty acid degradation : Lipid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Chloroalkane and chloroalkene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Naphthalene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_03423 aldB ko00010,ko00620,ko00640,ko01100,ko01110,ko01120,map00010,map00620,map00640,map01100,map01110,map01120 ko:K00138,ko:K18370 Belongs to the aldehyde dehydrogenase family Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03425 yiaV ko:K03543,ko:K15548,ko:K15549 membrane NA C2_03427 yiaT ko:K07274 May serve as a scaffold protein required for the formation of a complex with MrcB PonB and MltA, this complex could play a role in enlargement and septation of the murein sacculus NA C2_03428 araD ko00040,ko00051,ko00053,ko01100,ko01120,map00040,map00051,map00053,map01100,map01120 ko:K01628,ko:K01629,ko:K03077,ko:K22130 4.1.1.104,4.1.2.17,4.1.2.19,5.1.3.4 L-ribulose-5-phosphate 4-epimerase Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03429 sgbU ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120 ko:K03079 5.1.3.22 Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate (Potential). May be involved in the utilization of 2,3-diketo-L-gulonate Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03430 sgbH ko00030,ko00040,ko00053,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00040,map00053,map00680,map01100,map01120,map01200,map01230 ko:K03078,ko:K08093 4.1.1.85,4.1.2.43 Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. May be involved in the utilization of 2,3- diketo-L-gulonate Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03431 lyx ko00040,ko00051,ko00053,ko01100,ko01120,ko02024,map00040,map00051,map00053,map01100,map01120,map02024 ko:K00848,ko:K00854,ko:K00879,ko:K00880,ko:K11216 2.7.1.17,2.7.1.189,2.7.1.5,2.7.1.51,2.7.1.53 Catalyzes the phosphorylation of L-xylulose and 3-keto- L-gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_03432 yiaO ko:K21395 Part of the tripartite ATP-independent periplasmic (TRAP) transport system YiaMNO involved in the uptake of 2,3- diketo-L-gulonate. This protein specifically binds 2,3-diketo-L- gulonate. Is not able to bind either L-ascorbate or dehydroascorbate NA C2_03433 yiaN ko:K21393 2,3-diketo-L-gulonate TRAP transporter large permease protein YiaN NA C2_03434 yiaM ko02020,map02020 ko:K11689,ko:K21394 TRAP transporter small permease Two-component system : Signal transduction : Environmental Information Processing C2_03435 yiaL ko00052,ko00511,ko01100,map00052,map00511,map01100 ko:K12112,ko:K19334 response to radiation Galactose metabolism : Carbohydrate metabolism : Metabolism;Other glycan degradation : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03436 dlgD ko00040,ko00053,map00040,map00053 ko:K08092,ko:K13574 1.1.1.130 Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism C2_03437 yiaJ ko:K19333,ko:K21602 transcriptional NA C2_03438 ysaA ko:K05796,ko:K12136,ko:K15827 4Fe-4S binding domain NA C2_03439 avtA ko00290,ko01100,ko01110,ko01130,map00290,map01100,map01110,map01130 ko:K00835 2.6.1.66 Valine--pyruvate aminotransferase Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_03440 malS ko00500,ko01100,ko04973,map00500,map01100,map04973 ko:K01176 3.2.1.1 Since only maltooligosaccharides up to a chain length of 6 glucose units are actively transported through the cytoplasmic membrane via the membrane-bound complex of three proteins, MalF, MalG, and MalK, longer maltooligosaccharides must first be degraded by the periplasmic alpha-amylase, the MalS protein Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Carbohydrate digestion and absorption : Digestive system : Organismal Systems C2_03441 bax ko:K03796 amidase activity NA C2_03442 xylR ko00040,ko01100,map00040,map01100 ko:K01812,ko:K02529,ko:K16210 5.3.1.12 Regulatory protein for the xylBAFGHR operon Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03443 xylH ko02010,map02010 ko:K10544 Part of the binding-protein-dependent transport system for D-xylose. Probably responsible for the translocation of the substrate across the membrane ABC transporters : Membrane transport : Environmental Information Processing C2_03444 xylG ko02010,map02010 ko:K10545 3.6.3.17 Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_03445 xylF ko02010,map02010 ko:K10543 D-xylose metabolic process ABC transporters : Membrane transport : Environmental Information Processing C2_03446 xylA ko00040,ko00051,ko01100,map00040,map00051,map01100 ko:K01805 5.3.1.5 Belongs to the xylose isomerase family Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03447 xylB ko00040,ko00051,ko01100,ko01120,map00040,map00051,map01100,map01120 ko:K00848,ko:K00854 2.7.1.17,2.7.1.5 xylulose kinase Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03452 glyQ ko00970,map00970 ko:K01878,ko:K14164 6.1.1.14 glycyl-tRNA synthetase alpha subunit Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_03453 glyS ko00970,map00970 ko:K01879,ko:K14164 6.1.1.14 Glycyl-tRNA synthetase beta subunit Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_03454 hokA ko:K18919,ko:K18920 PFAM Hok gef NA C2_03455 cspA ko:K03704 SMART Cold shock protein NA C2_03456 yiaG ko:K07726 HTH-type transcriptional regulator YiaG NA C2_03458 ghrB ko00030,ko00260,ko00480,ko00620,ko00630,ko01100,ko01110,ko01120,map00030,map00260,map00480,map00620,map00630,map01100,map01110,map01120 ko:K00015,ko:K00032,ko:K00090 1.1.1.215,1.1.1.26,1.1.1.43,1.1.1.79,1.1.1.81 Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Glutathione metabolism : Metabolism of other amino acids : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03460 bisC ko00780,ko00920,ko01100,ko02020,map00780,map00920,map01100,map02020 ko:K07306,ko:K07811,ko:K07812,ko:K08351 1.7.2.3,1.8.5.3 This enzyme may serve as a scavenger, allowing the cell to utilize biotin sulfoxide as a biotin source. It reduces a spontaneous oxidation product of biotin, D-biotin D-sulfoxide (BSO or BDS), back to biotin. Also exhibits methionine-(S)-sulfoxide (Met-S-SO) reductase activity, acting specifically on the (S) enantiomer in the free, but not the protein-bound form. It thus plays a role in assimilation of oxidized methionines Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_03461 yiaC ko00220,ko01210,ko01230,map00220,map01210,map01230 ko:K03826,ko:K16704,ko:K22476 2.3.1.1,2.3.1.210 acetyltransferase Arginine biosynthesis : Amino acid metabolism : Metabolism;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03462 tag ko03410,map03410 ko:K01246 3.2.2.20 glycosylase I Base excision repair : Replication and repair : Genetic Information Processing C2_03463 yhjY ko:K12287,ko:K12686 outer membrane autotransporter NA C2_03464 yhjX ko:K08177 Part of a nutrient-sensing regulatory network composed of the two-component regulatory systems BtsS BtsR and YpdA YpdB, and their respective target proteins, YjiY and YhjX NA C2_03465 eptB ko00540,ko01503,map00540,map01503 ko:K03760,ko:K12975,ko:K19353 2.7.8.42,2.7.8.43 Catalyzes the addition of a phosphoethanolamine (pEtN) moiety to the outer 3-deoxy-D-manno-octulosonic acid (Kdo) residue of a Kdo(2)-lipid A. Phosphatidylethanolamines with one unsaturated acyl group functions as pEtN donors and the reaction releases diacylglycerol Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_03468 dppA ko02010,ko02024,ko02030,map02010,map02024,map02030 ko:K02035,ko:K12368 Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Bacterial chemotaxis : Cell motility : Cellular Processes C2_03469 dppB ko02010,ko02024,map02010,map02024 ko:K02033,ko:K12369 probably responsible for the translocation of the substrate across the membrane ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_03470 dppC ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02034,ko:K12370,ko:K13891,ko:K15582,ko:K15586 probably responsible for the translocation of the substrate across the membrane beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_03471 dppD ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02031,ko:K02032,ko:K12371,ko:K15583,ko:K15587 3.6.3.24 Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_03472 dppF ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02032,ko:K10823,ko:K12372 Belongs to the ABC transporter superfamily beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_03473 yhjV ko:K03834,ko:K03835,ko:K03836,ko:K03837,ko:K03838 amino acid transmembrane transport NA C2_03474 ko:K18862 Toxin Ldr, type I toxin-antitoxin system NA C2_03476 ko:K18862 Toxin Ldr, type I toxin-antitoxin system NA C2_03477 ko:K18862 Toxin Ldr, type I toxin-antitoxin system NA C2_03478 ko:K18862 Toxin Ldr, type I toxin-antitoxin system NA C2_03479 kbaA ko00540,ko01503,map00540,map01503 ko:K03760,ko:K06349,ko:K12975,ko:K19353 2.7.8.42,2.7.8.43 cellulose biosynthetic process Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_03483 yhjQ ko:K03496 Cellulose synthase NA C2_03484 bcsA ko00500,ko01100,ko02026,map00500,map01100,map02026 ko:K00694 2.4.1.12 Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose, which is produced as an extracellular component for mechanical and chemical protection at the onset of the stationary phase, when the cells exhibit multicellular behavior (rdar morphotype). Coexpression of cellulose and thin aggregative fimbriae Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_03485 bcsB ko:K20541 Binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP) NA C2_03486 bcsZ ko00500,ko01100,map00500,map01100 ko:K01179,ko:K20542 3.2.1.4 Belongs to the glycosyl hydrolase 8 (cellulase D) family Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03487 bcsC ko00450,ko02025,ko03070,ko05111,ko05152,map00450,map02025,map03070,map05111,map05152 ko:K00384,ko:K02453,ko:K11912,ko:K14949,ko:K20543 1.8.1.9,2.7.11.1 cellulose synthase operon protein C Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes;Tuberculosis : Infectious disease: bacterial : Human Diseases C2_03489 dctA ko02020,map02020 ko:K11102,ko:K11103 Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate across the membrane Two-component system : Signal transduction : Environmental Information Processing C2_03490 yhjJ ko:K07263 metallopeptidase activity NA C2_03491 kdgK ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 ko:K00874 2.7.1.45 2-dehydro-3-deoxygluconokinase activity Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_03492 yhjH ko02026,map02026 ko:K21086 3.1.4.52 A bis-(3'-5') cyclic diguanylic acid (c-di-GMP) phosphodiesterase involved in regulating the levels of c-di-GMP that control cell motility (the flagella) and adhesion (adhesive curli fimbriae). The YhjH effect on flagella is controlled via the c-di-GMP-binding flagellar brake protein YcgR, however curli expression is not regulated via YcgR. Forms a network with different diguanylate cyclases (DosC, YeaJ, YedQ, YegE have been identified) to regulate c-di-GMP levels. Flagellar activity is high at low c-di-GMP levels whereas curli fimbria are induced at high c-di-GMP levels. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_03493 yhjG ko:K07289,ko:K07290 regulation of protein targeting NA C2_03494 yhjE ko:K03761,ko:K03762,ko:K08172,ko:K08173 transmembrane transporter activity NA C2_03495 yhjD ko:K07058 lipopolysaccharide transmembrane transporter activity NA C2_03496 yhjC ko:K18900 transcriptional regulator NA C2_03498 treF ko00500,ko01100,map00500,map01100 ko:K01194,ko:K03931 3.2.1.28 Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03499 yhjA ko:K00428 1.11.1.5 cytochrome C peroxidase NA C2_03500 rhlE ko03018,map03018 ko:K11927 3.6.4.13 DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA RNA degradation : Folding, sorting and degradation : Genetic Information Processing C2_03502 ybhG ko:K01993 UPF0194 membrane protein YbhG NA C2_03503 ybhF ko:K01990,ko:K13926 (ABC) transporter NA C2_03504 ybhS ko:K01992 transmembrane transport NA C2_03505 ybhR ko:K01992 efflux transmembrane transporter activity NA C2_03508 clsB ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 ko:K00998,ko:K06131,ko:K06132 2.7.8.8 Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_03509 mprF ko01503,ko02020,ko05150,map01503,map02020,map05150 ko:K07027,ko:K14205 2.3.2.3 Lysylphosphatidylglycerol synthase TM region Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing;Staphylococcus aureus infection : Infectious disease: bacterial : Human Diseases C2_03510 ybhM ko:K06890,ko:K19416 Belongs to the BI1 family NA C2_03511 ybhL ko:K06890,ko:K19416 Inhibitor of apoptosis-promoting Bax1 NA C2_03512 moaE ko00790,ko01100,ko04122,map00790,map01100,map04122 ko:K03635 2.8.1.12 Converts molybdopterin precursor Z to molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_03513 moaD ko00790,ko01100,ko04122,map00790,map01100,map04122 ko:K03636,ko:K03752,ko:K21142 2.7.7.77,2.8.1.12 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_03514 moaC ko00790,ko01100,ko04122,map00790,map01100,map04122 ko:K03637 4.6.1.17 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_03515 moaB ko00790,ko01100,ko04122,map00790,map01100,map04122 ko:K03638,ko:K03831 2.7.7.75 May be involved in the biosynthesis of molybdopterin Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_03516 moaA ko00790,ko01100,ko04122,map00790,map01100,map04122 ko:K03639 4.1.99.22 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_03518 uvrB ko03420,map03420 ko:K03702,ko:K08999 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage Nucleotide excision repair : Replication and repair : Genetic Information Processing C2_03519 bioD ko00780,ko01100,map00780,map01100 ko:K01935 6.3.3.3 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03520 bioC ko00780,ko01100,map00780,map01100 ko:K02169 2.1.1.197 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03521 bioF ko00780,ko01100,map00780,map01100 ko:K00652,ko:K01012 2.3.1.47,2.8.1.6 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03522 bioB ko00780,ko01100,map00780,map01100 ko:K01012 2.8.1.6 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03523 bioA ko00780,ko01100,map00780,map01100 ko:K00833 2.6.1.62 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03524 ybhB ko:K06910 Phosphatidylethanolamine-binding protein NA C2_03525 ybhC ko00040,ko01100,ko02024,map00040,map01100,map02024 ko:K01051,ko:K01728,ko:K10297 3.1.1.11,4.2.2.2 Pectinesterase Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_03526 ybhJ ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 ko:K01681 4.2.1.3 response to oxidative stress Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03527 ybhI ko02020,map02020 ko:K03319,ko:K09477,ko:K11106 sodium ion transport Two-component system : Signal transduction : Environmental Information Processing C2_03530 pgl ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 ko:K07404 3.1.1.31 Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_03532 modC ko02010,map02010 ko:K02017 3.6.3.29 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_03533 modB ko02010,map02010 ko:K02017,ko:K02018,ko:K15496 3.6.3.29 Molybdenum transport system permease protein ModB ABC transporters : Membrane transport : Environmental Information Processing C2_03534 modA ko02010,map02010 ko:K02020 Molybdate-binding periplasmic ABC transporters : Membrane transport : Environmental Information Processing C2_03536 modE ko02010,map02010 ko:K02019,ko:K05772 The ModE-Mo complex acts as a repressor of the modABC operon, involved in the transport of molybdate. Upon binding molybdate, the conformation of the protein changes, promoting dimerization of ModE-Mo. The protein dimer is then competent to bind a DNA region, upstream of the modABC operon ABC transporters : Membrane transport : Environmental Information Processing C2_03537 modF ko02010,map02010 ko:K02013,ko:K02028,ko:K05776 3.6.3.21,3.6.3.34 Involved in the transport of molybdenum into the cell. Involved in photorepair. Could act on UV-induced DNA damage other than pyrimidine dimers ABC transporters : Membrane transport : Environmental Information Processing C2_03538 galE ko00052,ko00520,ko01100,map00052,map00520,map01100 ko:K01784 5.1.3.2 UDP-glucose 4-epimerase Galactose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03539 galT ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 ko:K00965 2.7.7.12 Belongs to the galactose-1-phosphate uridylyltransferase type 1 family Galactose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Prolactin signaling pathway : Endocrine system : Organismal Systems C2_03540 galK ko00052,ko00520,ko01100,map00052,map00520,map01100 ko:K00849 2.7.1.6 Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) Galactose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03541 galM ko00010,ko00052,ko00520,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map00520,map01100,map01110,map01120,map01130 ko:K00849,ko:K01785 2.7.1.6,5.1.3.3 converts alpha-aldose to the beta-anomer Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA C2_03542 gpmA ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 ko:K01834 5.4.2.11 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Glucagon signaling pathway : Endocrine system : Organismal Systems;Central carbon metabolism in cancer : Cancer: overview : Human Diseases C2_03543 aroG ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 ko:K01626 2.5.1.54 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_03545 zitB ko:K16264 Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc NA C2_03546 pnuC ko:K03811 nicotinamide mononucleotide transporter NA C2_03547 nadA ko00760,ko01100,map00760,map01100 ko:K03517 2.5.1.72 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03555 cpoB ko01503,map01503 ko:K01448 3.5.1.28 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_03556 pal ko:K03640 Thought to play a role in bacterial envelope integrity. Very strongly associated with the peptidoglycan NA C2_03557 tolB ko:K03641 Involved in the TonB-independent uptake of NA C2_03558 tolA ko:K03646 Involved in the TonB-independent uptake of group A colicins (colicins A, E1, E2, E3, and K). Necessary for the colicins to reach their respective targets after initial binding to the bacteria. Also involved in the translocation of bacteriophage DNA NA C2_03559 tolR ko:K03560 involved in the tonB-independent uptake of group A colicins NA C2_03560 tolQ ko01120,map01120 ko:K03562 Involved in the TonB-independent uptake of Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03561 ybgC ko:K07107,ko:K12500 Thioesterase-like superfamily NA C2_03563 ybgT ko00190,ko02020,map00190,map02020 ko:K00424 1.10.3.14 Cyd operon protein YbgT Oxidative phosphorylation : Energy metabolism : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_03564 cydB ko00190,ko01100,ko02020,map00190,map01100,map02020 ko:K00426 1.10.3.14 A terminal oxidase that produces a proton motive force by the vectorial transfer of protons across the inner membrane. It is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at low aeration. Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O, transferring 1 proton electron Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_03565 cydA ko00190,ko01100,ko02020,map00190,map01100,map02020 ko:K00425 1.10.3.14 A terminal oxidase that produces a proton motive force by the vectorial transfer of protons across the inner membrane. It is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at low aeration. Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O, transferring 1 proton electron Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_03566 mngB ko:K15524 3.2.1.170 Alpha-Mannosidase NA C2_03567 hrsA ko00051,ko00052,ko00053,ko01100,ko01120,ko02060,map00051,map00052,map00053,map01100,map01120,map02060 ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02798,ko:K02806,ko:K02821,ko:K08483,ko:K11189,ko:K11198,ko:K11199,ko:K11200,ko:K11201,ko:K18531 2.7.1.194,2.7.1.195,2.7.1.197,2.7.1.200,2.7.1.202,2.7.3.9 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannosyl-D-glycerate transport. Also involved in thermoinduction of ompC Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_03568 mngR ko:K03482,ko:K03710,ko:K11922 Transcriptional regulator NA C2_03569 sucD ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 ko:K01902,ko:K02381 6.2.1.5 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_03570 sucC ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 ko:K01903 6.2.1.5 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_03571 sucB ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 ko:K00658 2.3.1.61 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Lysine degradation : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_03572 sucA ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 ko:K00164,ko:K01616 1.2.4.2,4.1.1.71 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Lysine degradation : Amino acid metabolism : Metabolism;Tryptophan metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_03573 sdhB ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 ko:K00240,ko:K00245 1.3.5.1,1.3.5.4 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Oxidative phosphorylation : Energy metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_03574 sdhA ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 ko:K00239 1.3.5.1,1.3.5.4 the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Oxidative phosphorylation : Energy metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Legionellosis : Infectious disease: bacterial : Human Diseases C2_03575 sdhD ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 ko:K00242 Succinate dehydrogenase hydrophobic membrane anchor subunit Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Oxidative phosphorylation : Energy metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_03576 sdhC ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 ko:K00241 Succinate dehydrogenase cytochrome b556 subunit Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Oxidative phosphorylation : Energy metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_03578 gltA ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 ko:K01647 2.3.3.1 Belongs to the citrate synthase family Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03579 ybgD ko05133,map05133 ko:K07345 cell adhesion Pertussis : Infectious disease: bacterial : Human Diseases C2_03581 ybgP ko:K07346,ko:K07353 chaperone NA C2_03583 abrB ko:K07120 Ammonia monooxygenase NA C2_03584 nei ko03410,map03410 ko:K05522 4.2.99.18 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates Base excision repair : Replication and repair : Genetic Information Processing C2_03585 ybgL ko:K07160 Belongs to the UPF0271 (lamB) family NA C2_03586 ybgK ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120 ko:K01457,ko:K01941 3.5.1.54,6.3.4.6 5-oxoprolinase (ATP-hydrolyzing) activity Arginine biosynthesis : Amino acid metabolism : Metabolism;Atrazine degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03587 kipI ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120 ko:K01457,ko:K06351,ko:K07160 3.5.1.54 5-oxoprolinase (ATP-hydrolyzing) activity Arginine biosynthesis : Amino acid metabolism : Metabolism;Atrazine degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03588 ybgI ko00790,ko01100,map00790,map01100 ko:K22391 3.5.4.16 Provides significant protection from radiation damage and may be involved in the degradation of radiation-damaged nucleotides Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03589 dtpD ko:K03305 Proton-dependent permease that transports di- and tripeptides NA C2_03590 phrB ko:K01669 4.1.99.3 Deoxyribodipyrimidine photo-lyase NA C2_03594 stbD ko:K18923 Antitoxin Phd_YefM, type II toxin-antitoxin system NA C2_03595 relE ko:K06218 Cytotoxic translational repressor of toxin-antitoxin stability system NA C2_03600 appY ko02020,map02020 ko:K03755,ko:K07780,ko:K11920,ko:K21905,ko:K21906 Helix-turn-helix domain Two-component system : Signal transduction : Environmental Information Processing C2_03601 ompC ko01501,ko02020,map01501,map02020 ko:K09475 Forms pores that allow passive diffusion of small molecules across the outer membrane beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing C2_03606 ko:K04763,ko:K07357 Phage integrase family NA C2_03607 ko:K03496 ATPase MipZ NA C2_03609 yegD ko:K04046,ko:K18640 PFAM StbA family protein NA C2_03611 umuC ko:K02346,ko:K03502 2.7.7.7 DNA polymerase NA C2_03612 ko:K03503 Belongs to the peptidase S24 family NA C2_03613 ko:K12149 DinI-like family NA C2_03615 ko:K00571,ko:K07319 2.1.1.72 Belongs to the N(4) N(6)-methyltransferase family NA C2_03622 ssb ko03030,ko03430,ko03440,map03030,map03430,map03440 ko:K03111 Single-strand binding protein family DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing C2_03624 yubM ko:K03497 ParB-like nuclease domain NA C2_03639 icmO ko:K12217 Type IV secretory pathway VirD4 NA C2_03640 ssb ko03030,ko03430,ko03440,map03030,map03430,map03440 ko:K03111 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing C2_03642 ko:K12228 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process NA C2_03643 icmP ko:K12218 NA C2_03644 topB ko:K03168,ko:K03169,ko:K07479 5.99.1.2 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone NA C2_03645 hokA ko:K18919,ko:K18920 PFAM Hok gef NA C2_03652 icmB ko:K12206 type IV secretory pathway VirB4 NA C2_03654 nuc ko00564,ko01100,map00564,map01100 ko:K06131 PLD-like domain Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03657 ko:K12211 NA C2_03658 ko:K12209 Bacterial conjugation TrbI-like protein NA C2_03659 icmK ko:K12213 Putative outer membrane core complex of type IVb secretion NA C2_03660 icmL ko:K12214 Type-IV b secretion system, inner-membrane complex component NA C2_03662 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 ko:K01921,ko:K06919,ko:K08086,ko:K08307 6.3.2.4 Tfp pilus assembly protein FimV D-Alanine metabolism : Metabolism of other amino acids : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases C2_03663 ko:K12222 NA C2_03664 dotB ko:K12203 Type II/IV secretion system protein NA C2_03665 dotC ko:K12204 Type IV secretory system, conjugal DNA-protein transfer NA C2_03666 ko:K12205 DotD protein NA C2_03676 pilR ko03070,ko05110,ko05111,map03070,map05110,map05111 ko:K02455,ko:K10934 Type II secretion system (T2SS), protein F Bacterial secretion system : Membrane transport : Environmental Information Processing;Vibrio cholerae infection : Infectious disease: bacterial : Human Diseases;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_03682 pilL ko01502,ko02020,map01502,map02020 ko:K02487,ko:K18353 Integrating conjugative element protein PilL Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing C2_03689 nusG ko:K02601,ko:K05785 Participates in transcription elongation, termination and antitermination NA C2_03693 yifE ko:K09897 Belongs to the UPF0438 family NA C2_03695 ilvG ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 ko:K01652 2.2.1.6 Thiamine pyrophosphate enzyme, central domain Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03696 ilvM ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 ko:K01653,ko:K11258 2.2.1.6 acetolactate synthase activity Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03697 ilvE ko00270,ko00280,ko00290,ko00310,ko00330,ko00360,ko00472,ko00473,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00310,map00330,map00360,map00472,map00473,map00770,map01100,map01110,map01130,map01210,map01230 ko:K00824,ko:K00826 2.6.1.21,2.6.1.42 Acts on leucine, isoleucine and valine Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Lysine degradation : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;Phenylalanine metabolism : Amino acid metabolism : Metabolism;D-Arginine and D-ornithine metabolism : Metabolism of other amino acids : Metabolism;D-Alanine metabolism : Metabolism of other amino acids : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03698 ilvD ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 ko:K01687 4.2.1.9 Dihydroxy-acid dehydratase Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03699 ilvA ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 ko:K01751,ko:K01754 4.3.1.15,4.3.1.19 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03700 ilvY ko:K02521 transcriptional regulator IlvY NA C2_03701 ilvC ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 ko:K00053 1.1.1.86 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03702 ppiC ko:K03769 5.2.1.8 PPIC-type PPIASE domain NA C2_03704 rep ko03420,ko03430,map03420,map03430 ko:K03656,ko:K03657 3.6.4.12 it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction Nucleotide excision repair : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing C2_03705 gppA ko00230,map00230 ko:K01524 3.6.1.11,3.6.1.40 Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the stringent response , an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities Purine metabolism : Nucleotide metabolism : Metabolism C2_03706 rhlB ko03018,map03018 ko:K03732 3.6.4.13 DEAD-box RNA helicase involved in RNA degradation : Folding, sorting and degradation : Genetic Information Processing C2_03707 trxA ko04621,ko05418,map04621,map05418 ko:K03671 Thioredoxin NOD-like receptor signaling pathway : Immune system : Organismal Systems;Fluid shear stress and atherosclerosis : Cardiovascular disease : Human Diseases C2_03708 rho ko03010,ko03018,map03010,map03018 ko:K02887,ko:K03628 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template Ribosome : Translation : Genetic Information Processing;RNA degradation : Folding, sorting and degradation : Genetic Information Processing C2_03709 wecA ko00520,ko01100,ko05111,map00520,map01100,map05111 ko:K01791,ko:K02851 2.7.8.33,2.7.8.35,5.1.3.14 Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55) Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_03710 wzzE ko:K05789,ko:K05790 Modulates the polysaccharide chain length of enterobacterial common antigen (ECA) NA C2_03711 wecB ko00520,ko01100,ko05111,map00520,map01100,map05111 ko:K01791 5.1.3.14 Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_03712 wecC ko00520,ko05111,map00520,map05111 ko:K02472,ko:K02474 1.1.1.336 Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD( ) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_03713 rffG ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 ko:K01710 4.2.1.46 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily Streptomycin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Polyketide sugar unit biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Acarbose and validamycin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Biosynthesis of vancomycin group antibiotics : Metabolism of terpenoids and polyketides : Metabolism;NA : NA : NA C2_03714 rfbA ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 ko:K00973 2.7.7.24 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis Streptomycin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Polyketide sugar unit biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Acarbose and validamycin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;NA : NA : NA C2_03715 wecD ko:K03826,ko:K16704 2.3.1.210 Catalyzes the acetylation of dTDP-fucosamine (dTDP-4- amino-4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA) NA C2_03716 wecE ko:K02805 2.6.1.59 Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D- galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D- Glc4O) and L-glutamate NA C2_03717 wzxE ko:K03328,ko:K16693 Mediates the transbilayer movement of Und-PP-GlcNAc- ManNAcA-Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA) NA C2_03718 rffT ko:K11055,ko:K12582 2.4.1.325 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis NA C2_03719 wzyE ko:K02853 Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units NA C2_03720 rffM ko05111,map05111 ko:K02852,ko:K05946 2.4.1.180,2.4.1.187 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_03721 yifK ko:K03293 transport protein NA C2_03726 aslB ko:K06871 protein maturation NA C2_03727 aslA ko00140,ko00600,map00140,map00600 ko:K01130 3.1.6.1 arylsulfatase activity Steroid hormone biosynthesis : Lipid metabolism : Metabolism;Sphingolipid metabolism : Lipid metabolism : Metabolism C2_03728 hemY ko:K02498 Involved in a late step of protoheme IX synthesis NA C2_03729 hemX ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 ko:K02496,ko:K06313,ko:K13543 2.1.1.107,4.2.1.75 HemX, putative uroporphyrinogen-III C-methyltransferase Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03730 hemD ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 ko:K01719,ko:K01749,ko:K02496,ko:K13542,ko:K13543 2.1.1.107,2.5.1.61,4.2.1.75 Uroporphyrinogen-III synthase Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03731 hemC ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 ko:K01749,ko:K13542 2.1.1.107,2.5.1.61,4.2.1.75 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03732 cyaA ko00230,ko02026,ko05111,map00230,map02026,map05111 ko:K05851 4.6.1.1 Belongs to the adenylyl cyclase class-1 family Purine metabolism : Nucleotide metabolism : Metabolism;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_03733 cyaY ko00860,map00860 ko:K06202,ko:K19054 1.16.3.1 Belongs to the frataxin family Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism C2_03738 dapF ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 ko:K01778 5.1.1.7 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan Lysine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03739 yigA ko:K09921 Protein of unknown function, DUF484 NA C2_03740 xerC ko:K03733 Belongs to the 'phage' integrase family. XerC subfamily NA C2_03741 yigB ko00010,ko00740,ko01100,ko01110,ko01120,map00010,map00740,map01100,map01110,map01120 ko:K07025,ko:K20862,ko:K20866 3.1.3.10,3.1.3.102,3.1.3.104 Hydrolase Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03742 uvrD ko03420,ko03430,map03420,map03430 ko:K03656,ko:K03657 3.6.4.12 A helicase with DNA-dependent ATPase activity. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand. Initiates unwinding more efficiently from a nicked substrate than ds duplex DNA. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair, and probably also in repair of alkylated DNA Nucleotide excision repair : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing C2_03744 corA ko:K03284,ko:K16074 Mediates influx of magnesium ions NA C2_03746 lytH ko:K06401,ko:K21472 Protein of unknown function (DUF3289) NA C2_03749 rarD ko:K05786 EamA-like transporter family NA C2_03751 pldA ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110 ko:K01058 3.1.1.32,3.1.1.4 hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Ether lipid metabolism : Lipid metabolism : Metabolism;Arachidonic acid metabolism : Lipid metabolism : Metabolism;Linoleic acid metabolism : Lipid metabolism : Metabolism;alpha-Linolenic acid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_03752 recQ ko03018,map03018 ko:K03654 3.6.4.12 ATP-dependent DNA helicase RNA degradation : Folding, sorting and degradation : Genetic Information Processing C2_03753 rhtC ko:K05835 Threonine efflux protein NA C2_03754 rhtB ko:K05834 Conducts the efflux of homoserine and homoserine lactone NA C2_03755 pldB ko00564,map00564 ko:K01048 3.1.1.5 Lysophospholipase L2 Glycerophospholipid metabolism : Lipid metabolism : Metabolism C2_03756 yigL ko:K11938 Catalyzes Strongly the dephosphorylation of pyridoxal- phosphate (PLP) and moderately the dephosphorylation of 2- deoxyglucose 6-phosphate (2bGLU6P) and beta-glucose 6-phosphate (bGlu6P). Also hydrolyzes both purines (GMP and IMP) and pyrimidines as secondary substrates NA C2_03758 metR ko:K03576 MetR is a positive activator of the metA, metE and metH genes NA C2_03759 metE ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 ko:K00549 2.1.1.14 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03760 ysgA ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 ko:K01061 3.1.1.45 Dienelactone hydrolase Chlorocyclohexane and chlorobenzene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Fluorobenzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Toluene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA C2_03761 udp ko00240,ko00983,ko01100,map00240,map00983,map01100 ko:K00757 2.4.2.3 Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03762 rmuC ko:K09760 DNA recombination protein RmuC NA C2_03763 ubiE ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K03183 2.1.1.163,2.1.1.201 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_03764 yigP ko:K03690 protein conserved in bacteria NA C2_03765 ubiB ko:K03688 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis NA C2_03766 tatA ko03060,ko03070,map03060,map03070 ko:K03116,ko:K03425 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_03767 tatB ko03060,ko03070,map03060,map03070 ko:K03116,ko:K03117 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_03768 tatC ko03060,ko03070,map03060,map03070 ko:K03118 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_03769 tatD ko:K03424 3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair NA C2_03770 rfaH ko:K02601,ko:K05785 Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho- dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains NA C2_03771 ubiD ko00130,ko00627,ko01100,ko01110,ko01120,map00130,map00627,map01100,map01110,map01120 ko:K03182,ko:K16239 4.1.1.61,4.1.1.98 Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Aminobenzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03772 fre ko00240,ko00520,ko00627,ko00740,ko00860,ko01100,ko01120,ko02024,map00240,map00520,map00627,map00740,map00860,map01100,map01120,map02024 ko:K00523,ko:K02823,ko:K05368,ko:K18248,ko:K20256 1.16.1.3,1.17.1.1,1.5.1.41 Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides. Seems to reduce the complexed Fe(3 ) iron of siderophores to Fe(2 ), thus releasing it from the chelator Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Aminobenzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_03773 fadA ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 ko:K00632 2.3.1.16 Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed Fatty acid degradation : Lipid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Geraniol degradation : Metabolism of terpenoids and polyketides : Metabolism;Benzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;alpha-Linolenic acid metabolism : Lipid metabolism : Metabolism;Ethylbenzene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Fatty acid metabolism : Global and overview maps : Metabolism C2_03774 fadB ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 ko:K00074,ko:K01782,ko:K01825 1.1.1.157,1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate Fatty acid degradation : Lipid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Geraniol degradation : Metabolism of terpenoids and polyketides : Metabolism;Lysine degradation : Amino acid metabolism : Metabolism;Phenylalanine metabolism : Amino acid metabolism : Metabolism;Benzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Tryptophan metabolism : Amino acid metabolism : Metabolism;beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Limonene and pinene degradation : Metabolism of terpenoids and polyketides : Metabolism;Caprolactam degradation : Xenobiotics biodegradation and metabolism : Metabolism;Biosynthesis of unsaturated fatty acids : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism C2_03775 pepQ ko:K01262,ko:K01271 3.4.11.9,3.4.13.9 Splits dipeptides with a prolyl residue in the C- terminal position NA C2_03776 yigZ ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 ko:K00560,ko:K01271 2.1.1.45,3.4.13.9 Uncharacterized protein family UPF0029 Pyrimidine metabolism : Nucleotide metabolism : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Antifolate resistance : Drug resistance: antineoplastic : Human Diseases C2_03777 trkH ko:K03498,ko:K03499 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA NA C2_03778 hemG ko00860,ko01100,ko01110,map00860,map01100,map01110 ko:K00230 1.3.5.3 Protoporphyrinogen oxidase Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_03781 selU ko:K06917 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA NA C2_03782 allS ko:K10972 Transcriptional regulator NA C2_03783 allA ko00230,ko01100,map00230,map01100 ko:K01483 4.3.2.3 Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the anaerobic utilization of allantoin as sole nitrogen source. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03784 allR ko:K10973,ko:K13641 IclR helix-turn-helix domain NA C2_03785 gcl ko00630,ko01100,map00630,map01100 ko:K01608 4.1.1.47 Catalyzes the condensation of two molecules of glyoxylate to give 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03786 hyi ko00630,ko01100,map00630,map01100 ko:K01816,ko:K22131 5.3.1.22,5.3.1.35 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). Does not catalyze the isomerization of D-fructose to D-glucose or that of D-xylulose to D-xylose. Also does not catalyze racemization of serine, alanine, glycerate or lactate Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03787 glxR ko00630,ko01100,map00630,map01100 ko:K00042 1.1.1.60 2-hydroxy-3-oxopropionate reductase Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03788 ybbW ko:K03457,ko:K10975 Allantoin transport protein NA C2_03789 allB ko00230,ko01100,ko01120,map00230,map01100,map01120 ko:K01466 3.5.2.5 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03791 glxK ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130 ko:K00865 2.7.1.165 Belongs to the glycerate kinase type-1 family Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA C2_03792 ylbA ko00230,ko01120,map00230,map01120 ko:K14977 3.5.3.26 Involved in the anaerobic nitrogen utilization via the assimilation of allantoin. Catalyzes the second stereospecific hydrolysis reaction (deamination) of the allantoin degradation pathway, producing S-ureidoglycolate and ammonia from S- ureidoglycine Purine metabolism : Nucleotide metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03793 allC ko00230,ko00240,ko01100,ko01120,map00230,map00240,map01100,map01120 ko:K02083,ko:K06016 3.5.1.6,3.5.1.87,3.5.3.9 Involved in the anaerobic nitrogen utilization via the assimilation of allantoin. Catalyzes specifically the hydrolysis of allantoate to yield CO2, NH3 and S-ureidoglycine, which is unstable and readily undergoes a second deamination by S-ureidoglycine aminohydrolase AllE to yield S-ureidoglycolate and NH3. In vivo, the spontaneous release of S-ureidoglycolate and ammonia from S- ureidoglycine appears to be too slow to sustain an efficient flux of nitrogen Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03794 allD ko00040,ko00053,ko00230,ko01120,map00040,map00053,map00230,map01120 ko:K00073,ko:K08092,ko:K13574 1.1.1.130,1.1.1.350 AllD plays a pivotal role as a metabolic branch-point enzyme in nitrogen utilization via the assimilation of allantoin. It is able to utilize allantoin as a sole source of nitrogen under anaerobic conditions. Catalyzes the oxidation of ureidoglycolate to oxalurate Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Purine metabolism : Nucleotide metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03795 sucD ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 ko:K01902,ko:K02381 6.2.1.5 multicopy suppressor of dominant negative ftsH Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_03796 sucD ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 ko:K01902,ko:K02381 6.2.1.5 Protein of unknown function (DUF1116) Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_03798 arcC ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 ko:K00926 2.7.2.2 Belongs to the carbamate kinase family Arginine biosynthesis : Amino acid metabolism : Metabolism;Purine metabolism : Nucleotide metabolism : Metabolism;Nitrogen metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_03799 purK ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 ko:K01589 6.3.4.18 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_03800 purE ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 ko:K01588 5.4.99.18 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_03801 lpxH ko00540,ko01100,map00540,map01100 ko:K03269 3.6.1.54 Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03802 ppiB ko01503,ko04217,map01503,map04217 ko:K03767,ko:K03768,ko:K08884 2.7.11.1,5.2.1.8 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Necroptosis : Cell growth and death : Cellular Processes C2_03803 cysS ko00970,map00970 ko:K01883,ko:K15526 6.1.1.16,6.3.1.13 Belongs to the class-I aminoacyl-tRNA synthetase family Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_03804 ybcI ko:K07038 LexA-binding, inner membrane-associated putative hydrolase NA C2_03805 yaaA ko:K14761 translation NA C2_03806 folD ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 ko:K01491 1.5.1.5,3.5.4.9 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_03807 fimA ko05133,map05133 ko:K07345,ko:K07352 Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes Pertussis : Infectious disease: bacterial : Human Diseases C2_03809 sfmD ko05133,map05133 ko:K07347,ko:K07354 Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. Probably involved in the export and assembly of fimbrial subunits across the outer membrane Pertussis : Infectious disease: bacterial : Human Diseases C2_03810 fimH ko:K07350,ko:K07356 Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes NA C2_03811 fimF ko:K07348,ko:K07355 Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes NA C2_03812 fimZ ko02020,ko05111,ko05133,map02020,map05111,map05133 ko:K02282,ko:K07686,ko:K07688,ko:K07690,ko:K13246 3.1.4.52 intracellular signal transduction Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes;Pertussis : Infectious disease: bacterial : Human Diseases C2_03816 ko02026,map02026 ko:K06204 Phage conjugal plasmid C-4 type zinc finger protein, TraR family Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_03821 bet ko:K07455 RecT family NA C2_03836 rusA ko:K01160 3.1.22.4 Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of NA C2_03839 blc ko:K03098,ko:K07071 Lipocalin-like domain NA C2_03841 ko:K03755,ko:K11920,ko:K21905,ko:K21906 Transcriptional regulator NA C2_03843 rrrD ko:K01185 3.2.1.17 Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity. Exhibits lytic activity against E.coli and S.typhi cell wall substrate NA C2_03848 nohB ko:K22014 DNA packaging NA C2_03849 A ko:K21512 3.1.21.4 Phage terminase large subunit (GpA) NA C2_03852 sppA ko:K04773,ko:K21511 Peptidase family S49 NA C2_03865 JD73_18915 ko:K01449,ko:K21471 3.5.1.28 NlpC/P60 family NA C2_03867 clpB ko04213,map04213 ko:K03694,ko:K03695 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE Longevity regulating pathway - multiple species : Aging : Organismal Systems C2_03868 yfiH ko:K05810 Belongs to the multicopper oxidase YfiH RL5 family NA C2_03869 rluD ko:K06177,ko:K06180 5.4.99.23,5.4.99.28,5.4.99.29 Responsible for synthesis of pseudouridine from uracil NA C2_03870 bamD ko:K05807,ko:K08309 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery NA C2_03871 hpf ko:K05808,ko:K05809 During stationary phase prevents 70S dimer formation, probably in order to regulate translation efficiency during transition between the exponential and the stationary phases. During environmental stress such as cold shock or excessive cell density at stationary phase, stabilizes the 70S ribosome against dissociation, inhibits translation elongation and increases translation accuracy. When normal growth conditions are restored, is quickly released from the ribosome. Has been suggested to inhibit translation elongation by blocking the A-site (aminoacyl-tRNA site). Has also been suggested to inhibit translation initiation by blocking the A-site and P-site (peptidyl-tRNA site) of the ribosome. At 15 degrees Celsius binds 30S subunits and stimulates their association with 50S subunits into idle 70S ribosomes. Crystallization with T.thermophilus 70S ribosomes shows it binds in the channel between the head and body of the 30S subunit, where mRNA, tRNAs, initiation factors IF1 and IF3 and elongation factor G would bind NA C2_03872 pheA ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 ko:K00661,ko:K03856,ko:K04092,ko:K04093,ko:K04516,ko:K04518,ko:K14170,ko:K14187 1.3.1.12,2.3.1.79,2.5.1.54,4.2.1.51,5.4.99.5 Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation dehydration of prephenate to phenylpyruvate Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Novobiocin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03873 tyrA ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 ko:K00210,ko:K00211,ko:K00220,ko:K04092,ko:K04093,ko:K04517,ko:K14187 1.3.1.12,1.3.1.13,1.3.1.43,5.4.99.5 T-protein Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Novobiocin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_03874 aroF ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 ko:K01626 2.5.1.54 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_03877 yfiN ko02025,map02025 ko:K21021 2.7.7.65 cellular response to cell envelope stress Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes C2_03878 yfiB ko:K03286 Belongs to the ompA family NA C2_03879 rplS ko03010,map03010 ko:K02884 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site Ribosome : Translation : Genetic Information Processing C2_03880 trmD ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko:K00554,ko:K01770 2.1.1.228,4.6.1.12 Belongs to the RNA methyltransferase TrmD family Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_03881 rimM ko:K02860 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes NA C2_03882 rpsP ko03010,map03010 ko:K02959 In addition to being a ribosomal protein, S16 also has a cation-dependent endonuclease activity Ribosome : Translation : Genetic Information Processing C2_03883 ffh ko02024,ko03060,ko03070,map02024,map03060,map03070 ko:K03106 3.6.5.4 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_03885 yfjD ko:K03699 flavin adenine dinucleotide binding NA C2_03886 grpE ko:K03687 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ NA C2_03887 nadK ko00760,ko01100,map00760,map01100 ko:K00858 2.7.1.23 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03888 recN ko:K03631 May be involved in recombinational repair of damaged DNA NA C2_03889 bamE ko:K06186 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane NA C2_03890 rnfH ko04122,map04122 ko:K03154,ko:K09801 RnfH family Ubiquitin Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_03891 ratA ko:K18588 Toxic component of a type II toxin-antitoxin (TA) system. Binds to 50S ribosomal subunits, preventing them from associating with 30S subunits to form 70S ribosomes and reducing polysomes. It does not cause ribosomes to dissociate however. The antibiotic paromomycin blocks the anti-association activity of RatA. Overexpression results in inhibition of growth in liquid cultures, and in a decrease in protein translation. The other gene of this operon, ratB, is not the cognate antitoxin in this strain NA C2_03892 smpB ko:K03664 the nascent peptide is terminated with the tag peptide encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans- translation NA C2_03895 ligA ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 ko:K01972 6.5.1.2 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA DNA replication : Replication and repair : Genetic Information Processing;Base excision repair : Replication and repair : Genetic Information Processing;Nucleotide excision repair : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing C2_03896 ko:K06905 Phage late control gene D protein (GPD) NA C2_03897 gpU ko:K06906 Phage P2 GpU NA C2_03900 FII ko:K06908 Phage tail tube protein FII NA C2_03901 ko:K06907 Phage tail sheath C-terminal domain NA C2_03908 w3 ko:K06903 Gene 25-like lysozyme NA C2_03914 nucD ko:K01185 3.2.1.17 lysozyme NA C2_03926 ko:K12149 DinI-like family NA C2_03930 ko02026,map02026 ko:K06204 Prokaryotic dksA/traR C4-type zinc finger Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_03942 mutL ko00270,ko01100,ko01503,ko02020,ko02026,ko03430,ko05206,map00270,map01100,map01503,map02020,map02026,map03430,map05206 ko:K00558,ko:K03572,ko:K07637,ko:K07638,ko:K07717 2.1.1.37,2.7.13.3 Histidine kinase Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Mismatch repair : Replication and repair : Genetic Information Processing;MicroRNAs in cancer : Cancer: overview : Human Diseases C2_03946 uspF ko:K11932,ko:K14061 Universal stress protein family NA C2_03947 ompN ko:K14062 Outer membrane protein N NA C2_03948 nifJ ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 ko:K03737 1.2.7.1 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_03949 ydbJ ko05143,map05143 ko:K09712,ko:K14475 Domain of unknown function (DUF333) African trypanosomiasis : Infectious disease: parasitic : Human Diseases C2_03950 hslJ ko:K03668 Heat shock protein HslJ NA C2_03951 ldhA ko00620,ko01120,map00620,map01120 ko:K03778 1.1.1.28 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03952 ydbH ko:K07114 Dicarboxylate transport NA C2_03954 ydbL ko:K09978 Protein of unknown function (DUF1318) NA C2_03955 feaR ko:K14063 transcriptional regulator NA C2_03956 feaB ko00360,ko00643,ko01100,ko01120,map00360,map00643,map01100,map01120 ko:K00146 1.2.1.39 belongs to the aldehyde dehydrogenase family Phenylalanine metabolism : Amino acid metabolism : Metabolism;Styrene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03957 feaB ko00360,ko00643,ko01100,ko01120,map00360,map00643,map01100,map01120 ko:K00146 1.2.1.39 belongs to the aldehyde dehydrogenase family Phenylalanine metabolism : Amino acid metabolism : Metabolism;Styrene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03958 tynA ko00260,ko00350,ko00360,ko00410,ko00950,ko00960,ko01100,ko01110,map00260,map00350,map00360,map00410,map00950,map00960,map01100,map01110 ko:K00276 1.4.3.21 amine oxidase Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Phenylalanine metabolism : Amino acid metabolism : Metabolism;beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Isoquinoline alkaloid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Tropane, piperidine and pyridine alkaloid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_03959 paaN ko00360,ko01120,map00360,map01120 ko:K02618 1.2.1.91,3.3.2.12 Aldehyde dehydrogenase Phenylalanine metabolism : Amino acid metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03960 paaA ko00360,ko01120,map00360,map01120 ko:K02609 1.14.13.149 Phenylacetate-CoA oxygenase Phenylalanine metabolism : Amino acid metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03961 paaB ko00360,ko01120,map00360,map01120 ko:K02610 Phenylacetate-CoA oxygenase Phenylalanine metabolism : Amino acid metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03962 paaC ko00360,ko01120,map00360,map01120 ko:K02611 1.14.13.149 Phenylacetate-CoA oxygenase, PaaI subunit Phenylalanine metabolism : Amino acid metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03963 paaD ko00360,ko01120,map00360,map01120 ko:K02612 phenylacetate-CoA oxygenase, PaaJ subunit Phenylalanine metabolism : Amino acid metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03964 paaE ko00360,ko01120,map00360,map01120 ko:K02613 COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Phenylalanine metabolism : Amino acid metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03965 paaF ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 ko:K01692 4.2.1.17 Belongs to the enoyl-CoA hydratase isomerase family Fatty acid degradation : Lipid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Geraniol degradation : Metabolism of terpenoids and polyketides : Metabolism;Lysine degradation : Amino acid metabolism : Metabolism;Phenylalanine metabolism : Amino acid metabolism : Metabolism;Benzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Tryptophan metabolism : Amino acid metabolism : Metabolism;beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Aminobenzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Limonene and pinene degradation : Metabolism of terpenoids and polyketides : Metabolism;Caprolactam degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Fatty acid metabolism : Global and overview maps : Metabolism C2_03966 paaG ko00360,ko01120,map00360,map01120 ko:K15866 5.3.3.18 Enoyl-CoA hydratase Phenylalanine metabolism : Amino acid metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03967 paaH ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 ko:K00074,ko:K01782,ko:K01825 1.1.1.157,1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 3-hydroxyacyl-CoA dehydrogenase Fatty acid degradation : Lipid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Geraniol degradation : Metabolism of terpenoids and polyketides : Metabolism;Lysine degradation : Amino acid metabolism : Metabolism;Phenylalanine metabolism : Amino acid metabolism : Metabolism;Benzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Tryptophan metabolism : Amino acid metabolism : Metabolism;beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Limonene and pinene degradation : Metabolism of terpenoids and polyketides : Metabolism;Caprolactam degradation : Xenobiotics biodegradation and metabolism : Metabolism;Biosynthesis of unsaturated fatty acids : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism C2_03968 paaI ko00360,map00360 ko:K02614 phenylacetic acid degradation protein Phenylalanine metabolism : Amino acid metabolism : Metabolism C2_03969 paaJ ko00071,ko00072,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00360,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 ko:K00626,ko:K00632,ko:K02615 2.3.1.16,2.3.1.174,2.3.1.223,2.3.1.9 Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed Fatty acid degradation : Lipid metabolism : Metabolism;Synthesis and degradation of ketone bodies : Lipid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Geraniol degradation : Metabolism of terpenoids and polyketides : Metabolism;Lysine degradation : Amino acid metabolism : Metabolism;Phenylalanine metabolism : Amino acid metabolism : Metabolism;Benzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Tryptophan metabolism : Amino acid metabolism : Metabolism;alpha-Linolenic acid metabolism : Lipid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Ethylbenzene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_03970 paaK ko00360,ko01120,ko05111,map00360,map01120,map05111 ko:K01912 6.2.1.30 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) Phenylalanine metabolism : Amino acid metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_03971 paaX ko:K02616 phenylacetic acid degradation operon negative regulatory protein NA C2_03972 paaY ko:K02617,ko:K08279 Phenylacetic acid degradation protein PaaY NA C2_03973 ydbC ko00750,ko01100,ko01120,map00750,map01100,map01120 ko:K05275 1.1.1.65 Catalyzes the NAD(P)H-dependent reduction of pyridoxal to pyridoxine in vitro. Is not able to reduce 4-pyridoxate, and to oxidize pyridoxine or pyridoxamine. Has Kemp eliminase activity towards the non-physiological substrate 5- nitrobenzisoxazole, producing 4-nitro-2-cyanophenol Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03975 ynbA ko00564,ko01100,map00564,map01100 ko:K00995 2.7.8.5 phosphotransferase activity, for other substituted phosphate groups Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_03976 cdsA ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 ko:K00981 2.7.7.41 peptidoglycan-based cell wall biogenesis Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Phosphatidylinositol signaling system : Signal transduction : Environmental Information Processing C2_03977 ynbD ko:K01090 3.1.3.16 protein tyrosine phosphatase activity NA C2_03978 azoR ko:K01118 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity NA C2_03979 hrpA ko:K03578 3.6.4.13 helicase HrpA NA C2_03981 aldA ko00620,ko00630,ko01120,map00620,map00630,map01120 ko:K07248 1.2.1.21,1.2.1.22 dehydrogenase Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_03982 gap ko00010,ko00710,ko00750,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map00750,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 ko:K00134,ko:K03472 1.2.1.12,1.2.1.72 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;HIF-1 signaling pathway : Signal transduction : Environmental Information Processing;Alzheimer disease : Neurodegenerative disease : Human Diseases C2_03983 cybB ko:K12262 Cytochrome b(561) NA C2_03984 ydcA ko:K03646 NA C2_03985 hokB ko:K18919,ko:K18920,ko:K18921 Hok/gef family NA C2_03986 trg ko02020,ko02030,map02020,map02030 ko:K03406,ko:K05874,ko:K05875,ko:K05876,ko:K05877 Mediates taxis to the sugars ribose and galactose via an interaction with the periplasmic ribose- or galactose-binding proteins Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes C2_03987 pcaQ ko:K02623 transcriptional regulator NA C2_03989 mdoD ko:K03670 Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs) NA C2_03990 ydcH ko:K09794 Protein of unknown function (DUF465) NA C2_03991 rimL ko:K03817 N-terminal peptidyl-serine acetylation NA C2_03992 ydcK ko:K02617,ko:K08279 transferase activity, transferring acyl groups NA C2_03993 tehA ko:K03304 PFAM C4-dicarboxylate transporter malic acid transport protein NA C2_03994 tehB ko:K16868 2.1.1.265 Tellurite resistance NA C2_04005 ybbJ ko:K07340 membrane NA C2_04011 ko03070,map03070 ko:K03201 TrbL/VirB6 plasmid conjugal transfer protein Bacterial secretion system : Membrane transport : Environmental Information Processing C2_04012 ko03070,map03070 ko:K03200 Type IV secretion system proteins Bacterial secretion system : Membrane transport : Environmental Information Processing C2_04014 xseA ko03430,map03430 ko:K03601 3.1.11.6 exodeoxyribonuclease VII activity Mismatch repair : Replication and repair : Genetic Information Processing C2_04016 ko:K11894 Toxin co-regulated pilus biosynthesis protein Q NA C2_04019 virB1 ko03070,map03070 ko:K03194 Transglycosylase SLT domain Bacterial secretion system : Membrane transport : Environmental Information Processing C2_04022 lvhB4 ko02024,ko03070,map02024,map03070 ko:K03199,ko:K20530 type IV secretory pathway, VirB4 components Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_04024 ko03070,map03070 ko:K03203 VirB8 protein Bacterial secretion system : Membrane transport : Environmental Information Processing C2_04025 virB9 ko03070,map03070 ko:K03204 Conjugal transfer protein Bacterial secretion system : Membrane transport : Environmental Information Processing C2_04026 virB10 ko03070,map03070 ko:K03195,ko:K12082 Bacterial conjugation TrbI-like protein Bacterial secretion system : Membrane transport : Environmental Information Processing C2_04027 virB11 ko03070,ko05120,map03070,map05120 ko:K02283,ko:K03196 COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis Bacterial secretion system : Membrane transport : Environmental Information Processing;Epithelial cell signaling in Helicobacter pylori infection : Infectious disease: bacterial : Human Diseases C2_04028 virD4 ko03070,map03070 ko:K03205 Type IV secretory pathway, VirD4 components Bacterial secretion system : Membrane transport : Environmental Information Processing C2_04030 mshL ko03070,ko05111,map03070,map05111 ko:K02453,ko:K02666,ko:K12282 Secretin N-terminal domain Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_04034 pilR ko03070,ko05110,ko05111,map03070,map05110,map05111 ko:K02455,ko:K02505,ko:K10934 protein transport across the cell outer membrane Bacterial secretion system : Membrane transport : Environmental Information Processing;Vibrio cholerae infection : Infectious disease: bacterial : Human Diseases;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_04038 pilV ko03070,ko05110,ko05111,map03070,map05110,map05111 ko:K02457,ko:K02458,ko:K10926,ko:K10930,ko:K10931 Bacterial shufflon protein, N-terminal constant region Bacterial secretion system : Membrane transport : Environmental Information Processing;Vibrio cholerae infection : Infectious disease: bacterial : Human Diseases;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_04039 pilV ko03070,ko05110,ko05111,map03070,map05110,map05111 ko:K02457,ko:K02458,ko:K10926,ko:K10930,ko:K10931 Bacterial shufflon protein, N-terminal constant region Bacterial secretion system : Membrane transport : Environmental Information Processing;Vibrio cholerae infection : Infectious disease: bacterial : Human Diseases;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_04042 ko:K01174 3.1.31.1 nuclease NA C2_04045 topB ko:K03168,ko:K03169,ko:K07479 5.99.1.2 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone NA C2_04053 ko03070,map03070 ko:K03203 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD Bacterial secretion system : Membrane transport : Environmental Information Processing C2_04056 traL ko:K03496 conjugal transfer protein TraL NA C2_04073 ko:K03496 plasmid maintenance NA C2_04075 proQ ko:K03607 RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities NA C2_04077 ydeQ ko:K07350 cell adhesion NA C2_04078 ydeR ko:K07349 cell adhesion NA C2_04079 ydeS ko:K07348 Fimbrial protein NA C2_04080 ydeT ko05133,map05133 ko:K07347 Outer membrane usher protein fimD Pertussis : Infectious disease: bacterial : Human Diseases C2_04081 ko:K07346,ko:K07353,ko:K15540 chaperone NA C2_04082 fimA ko05133,map05133 ko:K07345,ko:K07352 Fimbrial protein Pertussis : Infectious disease: bacterial : Human Diseases C2_04084 hipA ko:K07154 2.7.11.1 Toxic component of a type II toxin-antitoxin (TA) system, first identified by mutations that increase production of persister cells, a fraction of cells that are phenotypic variants not killed by antibiotics, which lead to multidrug tolerance. Persistence may be ultimately due to global remodeling of the persister cell's ribosomes. Phosphorylates Glu-tRNA-ligase (AC P04805, gltX, on 'Ser-239') in vivo. Phosphorylation of GltX prevents it from being charged, leading to an increase in uncharged tRNA(Glu). This induces amino acid starvation and the stringent response via RelA SpoT and increased (p)ppGpp levels, which inhibits replication, transcription, translation and cell wall synthesis, reducing growth and leading to persistence and multidrug resistance. Once the level of HipA exceeds a threshold cells become dormant, and the length of dormancy is determined by how much HipA levels exceed the threshold. The hipA7 mutation (a double G22S D291A mutation) leads to increased generation of persister cells (cells that survive antibiotic treatment) probably by entering into a dormant state, as well as cold-sensitivity. Wild-type cells produce persisters at a frequency of 10(-6) to 10(-5) whereas hipA7 cells produce about 100-fold more persisters. hipA7 decreases the affinity for antitoxin HipB, leading to increased HipA levels and persistence NA C2_04085 lsrK ko00040,ko00051,ko00053,ko01100,ko01120,ko02024,map00040,map00051,map00053,map01100,map01120,map02024 ko:K00848,ko:K00854,ko:K00879,ko:K00880,ko:K11216 2.7.1.17,2.7.1.189,2.7.1.5,2.7.1.51,2.7.1.53 Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3- dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_04086 lsrR ko02024,ko02026,map02024,map02026 ko:K11531 transcriptional regulator Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_04087 lsrA ko02010,ko02024,map02010,map02024 ko:K10441,ko:K10558 3.6.3.17 Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_04088 lsrC ko02010,ko02024,map02010,map02024 ko:K10556 Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_04089 lsrD ko02010,ko02024,map02010,map02024 ko:K10557 Belongs to the binding-protein-dependent transport system permease family ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_04090 lsrB ko02010,ko02024,map02010,map02024 ko:K10555 Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_04091 lsrF ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko02024,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map02024 ko:K08321,ko:K11645 2.3.1.245,4.1.2.13 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5-phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_04092 lsrG ko02024,map02024 ko:K11530 5.3.1.32 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5- phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5- phosphonooxypentane-2,4-dione (P-HPD) Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_04093 tam ko00780,ko01100,map00780,map01100 ko:K00598,ko:K02169 2.1.1.144,2.1.1.197 Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_04094 yneE ko:K08994 Bestrophin, RFP-TM, chloride channel NA C2_04095 uxaB ko00040,ko00051,ko01100,map00040,map00051,map01100 ko:K00009,ko:K00040,ko:K00041 1.1.1.17,1.1.1.57,1.1.1.58 Belongs to the mannitol dehydrogenase family. UxaB subfamily Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_04098 glsA ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230 ko:K01425 3.5.1.2 Belongs to the glutaminase family Arginine biosynthesis : Amino acid metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;D-Glutamine and D-glutamate metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Glutamatergic synapse : Nervous system : Organismal Systems;GABAergic synapse : Nervous system : Organismal Systems;Proximal tubule bicarbonate reclamation : Excretory system : Organismal Systems;MicroRNAs in cancer : Cancer: overview : Human Diseases;Central carbon metabolism in cancer : Cancer: overview : Human Diseases C2_04099 sad ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 ko:K00135,ko:K08324 1.2.1.16,1.2.1.20,1.2.1.24,1.2.1.79 Catalyzes the NAD( )-dependent oxidation of succinate semialdehyde to succinate. It acts preferentially with NAD as cosubstrate but can also use NADP. Prevents the toxic accumulation of succinate semialdehyde (SSA) and plays an important role when arginine and putrescine are used as the sole nitrogen or carbon sources Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Lysine degradation : Amino acid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_04103 sotB ko:K03445,ko:K08159 Major facilitator Superfamily NA C2_04104 marC ko:K05595 UPF0056 membrane protein NA C2_04105 marR ko:K03712,ko:K15974 Multiple antibiotic resistance protein MarR NA C2_04106 soxS ko01503,map01503 ko:K05804,ko:K13631,ko:K13632,ko:K18325,ko:K19056 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_04107 marB ko:K13630 response to antibiotic NA C2_04108 bglA ko00010,ko00500,map00010,map00500 ko:K01223 3.2.1.86 Glycosyl hydrolase family 1 Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism C2_04109 bglH ko:K02024,ko:K10124 Maltoporin periplasmic N-terminal extension NA C2_04110 celC ko00500,ko02060,map00500,map02060 ko:K02759 2.7.1.196,2.7.1.205 PTS system, Lactose/Cellobiose specific IIA subunit Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_04111 chbC ko00500,ko02060,map00500,map02060 ko:K02761 The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_04112 gmuB_2 ko00500,ko02060,map00500,map02060 ko:K02760 2.7.1.196,2.7.1.205 PTS system, Lactose/Cellobiose specific IIB subunit Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_04113 ko:K03482,ko:K03710 UTRA NA C2_04114 eamA ko:K03298,ko:K15268 May be an export pump for cysteine and other metabolites of the cysteine pathway (such as N-acetyl-L-serine (NAS) and O- acetyl-L-serine (OAS)), and for other amino acids and their metabolites NA C2_04117 ydeH ko:K13069 2.7.7.65 swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria NA C2_04119 cinA ko00760,map00760 ko:K03742,ko:K03743 3.5.1.42 Competence-damaged protein Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism C2_04120 dcp ko:K01284,ko:K01414 3.4.15.5,3.4.24.70 metalloendopeptidase activity NA C2_04121 ydfG ko00240,ko00260,ko01100,map00240,map00260,map01100 ko:K16066 1.1.1.381 NADP-dependent dehydrogenase with broad substrate specificity acting on 3-hydroxy acids. Catalyzes the NADP- dependent oxidation of L-allo-threonine to L-2-amino-3-keto- butyrate, which is spontaneously decarboxylated into aminoacetone. Also acts on D-threonine, L-serine, D-serine, D-3- hydroxyisobutyrate, L-3-hydroxyisobutyrate, D-glycerate and L- glycerate. Able to catalyze the reduction of the malonic semialdehyde to 3-hydroxypropionic acid. YdfG is apparently supplementing RutE, the presumed malonic semialdehyde reductase involved in pyrimidine degradation since both are able to detoxify malonic semialdehyde Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_04122 ydfH ko:K22293 transcriptional regulator NA C2_04124 mtlK ko00040,ko00051,ko01100,map00040,map00051,map01100 ko:K00009,ko:K00040,ko:K00041,ko:K00045,ko:K00854,ko:K19633 1.1.1.17,1.1.1.289,1.1.1.57,1.1.1.58,1.1.1.67,2.7.1.17 Belongs to the mannitol dehydrogenase family Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_04125 ydfJ ko:K03761,ko:K03762,ko:K08172,ko:K08173 Sugar (and other) transporter NA C2_04127 pinR ko:K14060 recombinase activity NA C2_04130 yhhJ ko:K01992 ABC-type multidrug transport system, permease component NA C2_04131 rbbA ko:K01990,ko:K13926 Exhibits an intrinsic ATPase activity that is stimulated by both 70S ribosomes and 30S ribosomal subunits. Could be involved in protein-chain elongation and in release of deacyl-tRNA from ribosomes after peptide bond synthesis. Stimulates the synthesis of polyphenylalanine in vitro NA C2_04132 yhiI ko:K01993 protein secretion NA C2_04137 yhiN ko:K07007 HI0933-like protein NA C2_04138 pitA ko:K03306,ko:K16322 Low-affinity inorganic phosphate transport. Can also transport arsenate NA C2_04139 uspB ko:K06144 response to ethanol NA C2_04140 uspA ko:K06149,ko:K14064 Required for resistance to DNA-damaging agents NA C2_04141 dtpB ko:K03305 Proton-dependent permease that transports di- and tripeptides NA C2_04142 rsmJ ko:K15984 2.1.1.242 Specifically methylates the guanosine in position 1516 of 16S rRNA NA C2_04143 prlC ko:K01284,ko:K01414 3.4.15.5,3.4.24.70 May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) NA C2_04144 rlmJ ko:K07115 2.1.1.266 Specifically methylates the adenine in position 2030 of 23S rRNA NA C2_04145 gor ko00480,ko04918,map00480,map04918 ko:K00383 1.8.1.7 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family Glutathione metabolism : Metabolism of other amino acids : Metabolism;Thyroid hormone synthesis : Endocrine system : Organismal Systems C2_04147 arsR ko:K03892,ko:K21903 Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsE is alleviated by oxyions of III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)) (By similarity) NA C2_04148 arsB ko:K03893 Involved in arsenical resistance. Thought to form the channel of an arsenite pump NA C2_04149 arsC ko:K00537 1.20.4.1 arsenate reductase NA C2_04150 ko01100,map01100 ko:K03696,ko:K03892 transcriptional Metabolic pathways : Global and overview maps : Metabolism C2_04151 ko:K07089 permease NA C2_04153 slp ko:K07285 Outer membrane protein slp NA C2_04154 dctR ko:K21901 May act as a transcriptional regulator of dctA NA C2_04155 yhiD ko:K07507 MgtC family NA C2_04156 hdeB ko:K19778 Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment of the host stomach. Exhibits a chaperone-like activity at acidic pH by preventing the aggregation of many different periplasmic proteins NA C2_04157 hdeA ko:K19777 Required for optimal acid stress protection. Exhibits a chaperone-like activity only at low pH by suppressing non- specifically the aggregation of denaturated periplasmic proteins NA C2_04158 hdeD ko:K21908 response to pH NA C2_04159 gadE ko:K21907,ko:K21963 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci NA C2_04161 mdtE ko01501,ko01503,map01501,map01503 ko:K03585,ko:K18141,ko:K18898 Part of the tripartite efflux system MdtEF-TolC, which confers resistance to beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_04162 acrB ko01501,ko01503,map01501,map01503 ko:K18138,ko:K18142,ko:K18899 Part of the tripartite efflux system MdtEF-TolC, which confers resistance to beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_04164 gadW ko:K03755,ko:K11920,ko:K21905,ko:K21906 Depending on the conditions (growth phase and medium), acts as a positive or negative regulator of gadA and gadBC. Repression occurs directly or via the repression of the expression of gadX. Activation occurs directly by the binding of GadW to the gadA and gadBC promoters NA C2_04165 gadX ko:K03755,ko:K11920,ko:K21905,ko:K21906 Porin thermoregulatory protein envY NA C2_04166 gadC ko02024,map02024 ko:K20265 amino acid Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_04167 yddW ko02026,map02026 ko:K11931 catalytic activity Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_04168 dosC ko:K13069 2.7.7.65 Globin-coupled heme-based oxygen sensor protein displaying diguanylate cyclase (DGC) activity in response to oxygen availability. Thus, catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules NA C2_04169 dosP ko:K13243 3.1.4.52 Heme-based oxygen sensor protein displaying phosphodiesterase (PDE) activity toward c-di-GMP in response to oxygen availability. Involved in the modulation of intracellular c-di-GMP levels, in association with DosC which catalyzes the biosynthesis of c-di-GMP (diguanylate cyclase activity). Cyclic- di-GMP is a second messenger which controls cell surface- associated traits in bacteria. Has very poor PDE activity on cAMP but is not active with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate. Via its PDE activity on c-di-GMP, DosP regulates biofilm formation through the repression of transcription of the csgBAC operon, which encodes curli structural subunits NA C2_04170 ddpX ko01502,ko02020,map01502,map02020 ko:K07282,ko:K08641 3.4.13.22 Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing C2_04171 ddpA ko02024,map02024 ko:K02035 Extracellular solute-binding protein, family 5 Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_04172 ddpB ko02024,map02024 ko:K02033 probably responsible for the translocation of the substrate across the membrane Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_04173 ddpC ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02034,ko:K12370,ko:K13891,ko:K15582,ko:K15586 Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for the translocation of the substrate across the membrane beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_04174 ddpD ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02031,ko:K02032,ko:K12371,ko:K15583,ko:K15587 3.6.3.24 Belongs to the ABC transporter superfamily beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_04175 ddpF ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02032,ko:K10823,ko:K12372 Belongs to the ABC transporter superfamily beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_04176 osmC ko:K04063 redox protein regulator of disulfide bond formation NA C2_04178 sra ko:K02972 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein NA C2_04179 maeA ko00620,ko01200,ko02020,map00620,map01200,map02020 ko:K00027 1.1.1.38 Malic enzyme Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_04180 adhP ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 ko:K00001,ko:K13953 1.1.1.1 acetaldehyde catabolic process Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Fatty acid degradation : Lipid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Chloroalkane and chloroalkene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Naphthalene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Retinol metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolism of xenobiotics by cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_04181 yddM ko:K21498 sequence-specific DNA binding NA C2_04182 fdnI ko00630,ko00680,ko01100,ko01120,ko01200,ko02020,map00630,map00680,map01100,map01120,map01200,map02020 ko:K00127,ko:K08350 to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. Subunit gamma is the cytochrome b556 component of the formate dehydrogenase-N, and also contains a menaquinone reduction site that receives electrons from the beta subunit (FdnH), through its hemes. Formate Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_04183 fdnH ko00630,ko00680,ko01100,ko01120,ko01200,ko02020,map00630,map00680,map01100,map01120,map01200,map02020 ko:K00124,ko:K08349 formate dehydrogenase Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_04184 fdnG ko00630,ko00680,ko01100,ko01120,ko01200,ko02020,map00630,map00680,map01100,map01120,map01200,map02020 ko:K00123,ko:K08348 1.17.1.9,1.17.5.3 Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The alpha subunit FdnG contains the formate oxidation site. Electrons are transferred from formate to menaquinone in the gamma subunit (FdnI), through the 4Fe-4S clusters in the beta subunit (FdnH). Formate dehydrogenase-N is part of a system that generates proton motive force, together with the dissimilatory nitrate reductase (Nar) Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_04185 fdnG ko00630,ko00680,ko01100,ko01120,ko01200,ko02020,map00630,map00680,map01100,map01120,map01200,map02020 ko:K00123,ko:K08348 1.17.1.9,1.17.5.3 Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The alpha subunit FdnG contains the formate oxidation site. Electrons are transferred from formate to menaquinone in the gamma subunit (FdnI), through the 4Fe-4S clusters in the beta subunit (FdnH). Formate dehydrogenase-N is part of a system that generates proton motive force, together with the dissimilatory nitrate reductase (Nar) Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_04187 yddL ko:K14062,ko:K16076 Belongs to the Gram-negative porin family NA C2_04189 narU ko00910,map00910 ko:K02575 Catalyzes nitrate uptake, nitrite uptake and nitrite export across the cytoplasmic membrane. May function as a nitrate H( ) and nitrite H( ) channel. Could confer a selective advantage during severe nutrient starvation or slow growth Nitrogen metabolism : Energy metabolism : Metabolism C2_04190 narG ko00910,ko01120,ko02020,map00910,map01120,map02020 ko:K00370,ko:K17050 1.7.5.1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family Nitrogen metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_04191 narH ko00910,ko01120,ko02020,map00910,map01120,map02020 ko:K00371 1.7.5.1 This is a second nitrate reductase enzyme which can substitute for the NRA enzyme and allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The beta chain is an electron transfer unit containing four cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit Nitrogen metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_04192 narJ ko00910,ko01120,ko02020,map00910,map01120,map02020 ko:K00370,ko:K00373,ko:K17052 1.7.5.1 nitrate reductase 2 Nitrogen metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_04193 narI ko00910,ko01120,ko02020,map00910,map01120,map02020 ko:K00370,ko:K00374,ko:K02575 1.7.5.1 This is a second nitrate reductase enzyme which can substitute for the NRA enzyme and allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The gamma chain is a membrane-embedded heme-iron unit resembling cytochrome b, which transfers electrons from quinones to the beta subunit Nitrogen metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_04194 yddE ko00405,ko01130,ko02024,map00405,map01130,map02024 ko:K06998 5.3.3.17 isomerase activity Phenazine biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;NA : NA : NA;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_04195 nhoA ko00232,ko00633,ko00983,ko01100,ko01110,ko01120,ko05204,map00232,map00633,map00983,map01100,map01110,map01120,map05204 ko:K00622,ko:K00675 2.3.1.118,2.3.1.5 Catalyzes the acetyl-CoA-dependent N-acetylation of aromatic amines, and, probably, the O-acetylation of N- hydroxyarylamines. In vitro, catalyzes the N-acetylation of various arylamines such as aminobenzoic acid, aminophenol, aminotoluene, phenetidine, anisidine, aniline, isoniazid and 2- amino-fluorene. N-hydroxyarylamine O-acetyltransferase activity has not been assayed directly, however, NhoA activity is required for the mutagenicity of nitroaromatic compounds, suggesting that it also has O-acetyltransferase activity Caffeine metabolism : Biosynthesis of other secondary metabolites : Metabolism;Nitrotoluene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Chemical carcinogenesis : Cancer: overview : Human Diseases C2_04197 pptA ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220 ko:K01821 5.3.2.6 Belongs to the 4-oxalocrotonate tautomerase family. PptA subfamily Benzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Dioxin degradation : Xenobiotics biodegradation and metabolism : Metabolism;Xylene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_04200 ko:K07726 transcriptional regulator NA C2_04202 ko:K01066 alpha/beta hydrolase fold NA C2_04203 yiiD ko:K06323 protein acetylation NA C2_04204 dtd ko:K07560 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality NA C2_04205 rbn ko:K07058 UPF0761 membrane protein YihY NA C2_04206 yihX ko00010,ko01120,map00010,map01120 ko:K20866 3.1.3.10 hydrolase Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_04207 JD73_05665 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 ko:K01785 5.1.3.3 Aldose 1-epimerase Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA C2_04208 GJ11_24635 ko:K03761,ko:K03762,ko:K08172,ko:K08173 MFS/sugar transport protein NA C2_04209 JD73_05655 ko:K08138 MFS/sugar transport protein NA C2_04210 ko00650,map00650 ko:K00004 1.1.1.303,1.1.1.4 Alcohol dehydrogenase GroES-like domain Butanoate metabolism : Carbohydrate metabolism : Metabolism C2_04211 lacD ko00052,ko01100,ko02024,map00052,map01100,map02024 ko:K01635,ko:K01671 4.1.2.40,4.1.2.57 Cleaves 6-deoxy-6-sulfo-D-fructose 1-phosphate (SFP) to form dihydroxyacetone phosphate (DHAP) and 3-sulfolactaldehyde (SLA) Galactose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_04212 yihU ko00650,ko01100,ko01200,map00650,map01100,map01200 ko:K08318,ko:K08319 1.1.1.373,1.1.1.411,1.1.1.61 Reduces 3-sulfolactaldehyde (SLA) to 2,3- dihydroxypropane 1-sulfonate (DHPS) Butanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_04213 yihV ko00030,map00030 ko:K00852,ko:K18478 2.7.1.15,2.7.1.184 Phosphorylates 6-deoxy-6-sulfo-D-fructose (SF) to 6- deoxy-6-sulfo-D-fructose 1-phosphate (SFP) Pentose phosphate pathway : Carbohydrate metabolism : Metabolism C2_04217 yihL ko:K03710 HTH-type transcriptional regulator YihL NA C2_04218 typA ko:K06207 Probably interacts with the ribosomes in a GTP dependent manner NA C2_04219 glnA ko00220,ko00250,ko00627,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00627,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 ko:K01915,ko:K20712 5.4.4.3,6.3.1.2 Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia Arginine biosynthesis : Amino acid metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Aminobenzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Nitrogen metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing;Necroptosis : Cell growth and death : Cellular Processes;Glutamatergic synapse : Nervous system : Organismal Systems;GABAergic synapse : Nervous system : Organismal Systems C2_04220 glnL ko02020,map02020 ko:K07708,ko:K07710 2.7.13.3 Member of the two-component regulatory system NtrB NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Under conditions of nitrogen limitation, NtrB autophosphorylates and transfers the phosphoryl group to NtrC. In the presence of nitrogen, acts as a phosphatase that dephosphorylates and inactivates NtrC Two-component system : Signal transduction : Environmental Information Processing C2_04221 glnG ko02020,map02020 ko:K07712 Member of the two-component regulatory system NtrB NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter- sigma54-RNA polymerase complexes Two-component system : Signal transduction : Environmental Information Processing C2_04223 hemN ko00860,ko01100,ko01110,map00860,map01100,map01110 ko:K02495,ko:K21936 1.3.98.3,2.1.1.342 Belongs to the anaerobic coproporphyrinogen-III oxidase family Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_04224 yihI ko:K09894 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis NA C2_04225 engB ko:K03978 Necessary for normal cell division and for the maintenance of normal septation NA C2_04226 polA ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 ko:K01146,ko:K02335 2.7.7.7 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Base excision repair : Replication and repair : Genetic Information Processing;Nucleotide excision repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing C2_04229 dsbA ko01503,map01503 ko:K03673 Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_04231 yihD ko:K09896 Protein of unknown function (DUF1040) NA C2_04232 mobA ko00790,ko01100,map00790,map01100 ko:K03750,ko:K03752,ko:K13818 2.10.1.1,2.7.7.77 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_04233 mobB ko00790,ko01100,map00790,map01100 ko:K02379,ko:K03750,ko:K03752,ko:K03753,ko:K13818 2.10.1.1,2.7.7.77 GTP-binding protein that is not required for the biosynthesis of Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor, and not necessary for the formation of active molybdoenzymes using this form of molybdenum cofactor. May act as an adapter protein to achieve the efficient biosynthesis and utilization of MGD. Displays a weak intrinsic GTPase activity. Is also able to bind the nucleotides ATP, TTP and GDP, but with lower affinity than GTP Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_04234 dkgB ko:K06222 1.1.1.346 Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG) NA C2_04238 mltD ko:K08307,ko:K12204 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division (By similarity) NA C2_04239 gloB ko00620,map00620 ko:K01069 3.1.2.6 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid Pyruvate metabolism : Carbohydrate metabolism : Metabolism C2_04241 rnhA ko03030,map03030 ko:K03469 3.1.26.4 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids DNA replication : Replication and repair : Genetic Information Processing C2_04242 dnaQ ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02342,ko:K14159 2.7.7.7,3.1.26.4 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing C2_04247 ko:K06887 Type VI secretion system effector, Hcp NA C2_04248 ko:K11911 ImpA domain protein NA C2_04249 icmF ko02025,ko03070,map02025,map03070 ko:K11891,ko:K12210 ImcF-related N-terminal domain Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_04250 vasJ ko:K11910 protein conserved in bacteria NA C2_04251 vasI ko:K11909 Type VI secretion-associated protein, VC_A0118 family NA C2_04252 clpV ko01100,ko02025,ko03070,map01100,map02025,map03070 ko:K03696,ko:K11907 C-terminal, D2-small domain, of ClpB protein Metabolic pathways : Global and overview maps : Metabolism;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_04253 vasF ko03070,map03070 ko:K11892 Type VI secretion system protein DotU Bacterial secretion system : Membrane transport : Environmental Information Processing C2_04254 impJ ko02025,map02025 ko:K11893 Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes C2_04255 vasD ko03070,map03070 ko:K11906 protein conserved in bacteria Bacterial secretion system : Membrane transport : Environmental Information Processing C2_04256 impI ko02025,ko03070,map02025,map03070 ko:K11894,ko:K11913 conserved protein, contains FHA domain Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_04257 impH ko02025,map02025 ko:K11895 type VI secretion protein Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes C2_04258 vasA ko:K11896 Type VI secretion system, TssF NA C2_04259 ko:K11905 protein conserved in bacteria NA C2_04260 evpB ko02025,map02025 ko:K11900 Type VI secretion protein, EvpB/VC_A0108, tail sheath Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes C2_04262 impB ko02025,map02025 ko:K11901 Type VI secretion system, VipA, VC_A0107 or Hcp2 Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes C2_04263 hcp ko02025,ko03070,map02025,map03070 ko:K11903 Type VI secretion system effector, Hcp Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_04264 vgrG ko03070,map03070 ko:K11904 Phage late control gene D protein (GPD) Bacterial secretion system : Membrane transport : Environmental Information Processing C2_04266 gldA ko00561,ko00640,ko01100,map00561,map00640,map01100 ko:K00005,ko:K08317 1.1.1.6 Catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone (glycerone). Allows microorganisms to utilize glycerol as a source of carbon under anaerobic conditions. In E.coli, an important role of GldA is also likely to regulate the intracellular level of dihydroxyacetone by catalyzing the reverse reaction, i.e. the conversion of dihydroxyacetone into glycerol. Possesses a broad substrate specificity, since it is also able to oxidize 1,2-propanediol and to reduce glycolaldehyde, methylglyoxal and hydroxyacetone into ethylene glycol, lactaldehyde and 1,2-propanediol, respectively Glycerolipid metabolism : Lipid metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_04267 tal ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 ko:K00616,ko:K08313,ko:K08314 2.2.1.2 Catalyzes the reversible formation of fructose 6- phosphate from dihydroxyacetone and D-glyceraldehyde 3-phosphate via an aldolization reaction Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_04268 ptsA ko00051,ko00052,ko00053,ko00561,ko01100,ko01120,ko02060,map00051,map00052,map00053,map00561,map01100,map01120,map02060 ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02784,ko:K02798,ko:K02806,ko:K02821,ko:K05881,ko:K08483,ko:K08485,ko:K11183,ko:K11184,ko:K11189,ko:K11201,ko:K18531 2.7.1.121,2.7.1.194,2.7.1.197,2.7.1.200,2.7.1.202,2.7.3.9 Multifunctional protein that includes general (non sugar-specific) and sugar-specific components of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrwABC PTS system is involved in fructose transport Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_04269 frwC ko:K11201,ko:K11202,ko:K11203 The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane NA C2_04270 frwB ko:K11202 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrwABC PTS system is involved in fructose transport NA C2_04271 pflD ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 ko:K00656 2.3.1.54 formate C-acetyltransferase activity Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_04272 pflC ko:K04069 1.97.1.4 Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine NA C2_04273 fruA ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 ko:K00882,ko:K02768,ko:K02769,ko:K02770,ko:K11202 2.7.1.202,2.7.1.56 pts system Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_04275 cptA ko00540,ko01503,map00540,map01503 ko:K03760,ko:K12975,ko:K19353 2.7.8.42,2.7.8.43 Catalyzes the addition of a phosphoethanolamine moiety to the outer membrane lipopolysaccharide core Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases C2_04276 ppc ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 ko:K01595 4.1.1.31 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism C2_04277 argE ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 ko:K01438 3.5.1.16 Displays a broad specificity and can also deacylate substrates such as acetylarginine, acetylhistidine or acetylglutamate semialdehyde Arginine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_04278 argC ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 ko:K00145 1.2.1.38 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde Arginine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_04279 argB ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 ko:K00930,ko:K14682 2.3.1.1,2.7.2.8 Catalyzes the ATP-dependent phosphorylation of N-acetyl- L-glutamate Arginine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_04280 argH ko00220,ko00250,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map01100,map01110,map01130,map01210,map01230 ko:K01755,ko:K14681 2.3.1.1,4.3.2.1 argininosuccinate lyase Arginine biosynthesis : Amino acid metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_04281 rspA ko00040,ko01100,map00040,map01100 ko:K08323 4.2.1.8 Belongs to the mandelate racemase muconate lactonizing enzyme family Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_04283 oxyR ko02026,map02026 ko:K04761 Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstream of its own coding sequence. OxyR is inactivated by reduction of its essential disulfide bond by the product of GrxA, itself positively regulated by OxyR. Has also a positive regulatory effect on the production of surface proteins that control the colony morphology and auto-aggregation ability Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_04284 sthA ko00760,ko01100,map00760,map01100 ko:K00322 1.6.1.1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_04285 fabR ko:K22105 fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer NA C2_04287 trmA ko:K00557,ko:K03215 2.1.1.190,2.1.1.35 Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA) NA C2_04288 btuB ko:K16092 Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB NA C2_04289 murI ko00471,ko01100,map00471,map01100 ko:K01776 5.1.1.3 Provides the (R)-glutamate required for cell wall biosynthesis D-Glutamine and D-glutamate metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_04290 secE ko02024,ko03060,ko03070,map02024,map03060,map03070 ko:K03073 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_04291 nusG ko:K02601,ko:K05785 Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA NA C2_04292 rplK ko03010,map03010 ko:K02867 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors Ribosome : Translation : Genetic Information Processing C2_04293 rplA ko03010,map03010 ko:K02863 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release Ribosome : Translation : Genetic Information Processing C2_04294 rplJ ko03010,map03010 ko:K02864,ko:K02935 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors Ribosome : Translation : Genetic Information Processing C2_04295 rplL ko03010,map03010 ko:K02935 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation Ribosome : Translation : Genetic Information Processing C2_04296 rpoB ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 ko:K03043,ko:K13797 2.7.7.6 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;RNA polymerase : Transcription : Genetic Information Processing C2_04297 rpoC ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 ko:K03046,ko:K13797 2.7.7.6 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;RNA polymerase : Transcription : Genetic Information Processing C2_04298 thiH ko00730,ko01100,map00730,map01100 ko:K03150 4.1.99.19 2-iminoacetate synthase activity Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_04299 thiG ko00730,ko01100,map00730,map01100 ko:K03149 2.8.1.10 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_04300 thiS ko00730,ko01100,ko04122,map00730,map01100,map04122 ko:K03149,ko:K03154 2.8.1.10 thiamine biosynthesis protein ThiS Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_04301 thiF ko00730,ko01100,ko04122,map00730,map01100,map04122 ko:K03148,ko:K21029 2.7.7.73,2.7.7.80 COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing C2_04302 thiE ko00730,ko01100,map00730,map01100 ko:K00788,ko:K14153 2.5.1.3,2.7.1.49,2.7.4.7 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_04303 thiC ko00730,ko01100,map00730,map01100 ko:K03147 4.1.99.17 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_04304 rsd ko:K07740 Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase NA C2_04305 nudC ko00760,ko01100,ko01120,ko04146,map00760,map01100,map01120,map04146 ko:K03426,ko:K20449 1.3.7.1,3.6.1.22 Belongs to the Nudix hydrolase family. NudC subfamily Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Peroxisome : Transport and catabolism : Cellular Processes C2_04306 hemE ko00860,ko01100,ko01110,map00860,map01100,map01110 ko:K01599 4.1.1.37 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_04307 nfi ko:K05982 3.1.21.7 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA NA C2_04308 yjaG ko:K09891 Protein of unknown function (DUF416) NA C2_04309 hupA ko:K03530,ko:K05787 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions NA C2_04311 zraP ko02020,map02020 ko:K07803 Binds zinc. Could be an important component of the zinc- balancing mechanism Two-component system : Signal transduction : Environmental Information Processing C2_04313 zraS ko02020,map02020 ko:K07709 2.7.13.3 Member of the two-component regulatory system ZraS ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium Two-component system : Signal transduction : Environmental Information Processing C2_04314 zraR ko02020,map02020 ko:K07713 Member of the two-component regulatory system ZraS ZraR. When activated by ZraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon Two-component system : Signal transduction : Environmental Information Processing C2_04315 purD ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 ko:K01945 6.3.4.13 Belongs to the GARS family Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_04316 purH ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 ko:K00602 2.1.2.3,3.5.4.10 bifunctional purine biosynthesis protein purh Purine metabolism : Nucleotide metabolism : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Antifolate resistance : Drug resistance: antineoplastic : Human Diseases C2_04318 kdpA ko02020,map02020 ko:K01546 3.6.3.12 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane Two-component system : Signal transduction : Environmental Information Processing C2_04319 kdpB ko02020,map02020 ko:K01547 3.6.3.12 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system Two-component system : Signal transduction : Environmental Information Processing C2_04320 kdpC ko02020,map02020 ko:K01548 3.6.3.12 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex Two-component system : Signal transduction : Environmental Information Processing C2_04324 speF ko00310,ko00330,ko00480,ko00960,ko01100,ko01110,ko01130,map00310,map00330,map00480,map00960,map01100,map01110,map01130 ko:K01581,ko:K01582,ko:K01584,ko:K01585 4.1.1.17,4.1.1.18,4.1.1.19 Ornithine decarboxylase Lysine degradation : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;Glutathione metabolism : Metabolism of other amino acids : Metabolism;Tropane, piperidine and pyridine alkaloid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA C2_04325 potE ko:K03294,ko:K03756,ko:K03757,ko:K03759 Catalyzes both the uptake and excretion of putrescine. The uptake of putrescine is dependent on the membrane potential and the excretion involves putrescine-ornithine antiporter activity NA C2_04326 pgm ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 ko:K01835 5.4.2.2 phosphoglucomutase activity Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Purine metabolism : Nucleotide metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Streptomycin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA C2_04327 seqA ko:K03645 Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated NA C2_04328 ybfF ko:K01175 Alpha beta hydrolase NA C2_04330 fldA ko:K03839,ko:K03840 Low-potential electron donor to a number of redox enzymes NA C2_04331 fur ko02024,map02024 ko:K03711,ko:K09823 Acts as a global negative controlling element, employing Fe(2 ) as a cofactor to bind the operator of the repressed genes. Regulates the expression of several outer-membrane proteins including the iron transport operon Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_04334 glnS ko00970,ko01100,map00970,map01100 ko:K01886 6.1.1.18 glutaminyl-tRNA aminoacylation Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing;Metabolic pathways : Global and overview maps : Metabolism C2_04336 nagE ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 ko:K02749,ko:K02750,ko:K02752,ko:K02753,ko:K02777,ko:K02778,ko:K02779,ko:K02790,ko:K02791,ko:K02802,ko:K02803,ko:K02804,ko:K02818,ko:K02819,ko:K11191,ko:K11192,ko:K20107,ko:K20108,ko:K20116,ko:K20117,ko:K20118 2.7.1.192,2.7.1.193,2.7.1.199,2.7.1.201,2.7.1.208 PTS system, N-acetylglucosamine-specific Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes C2_04337 nagB ko00030,ko00052,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00052,map00520,map01100,map01110,map01120,map01130,map01200 ko:K01057,ko:K02080,ko:K02564 3.1.1.31,3.5.99.6 Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism C2_04338 nagA ko00520,ko01130,map00520,map01130 ko:K01443 3.5.1.25 Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6-phosphate and acetate. In vitro, can also hydrolyze substrate analogs such as N-thioacetyl-D-glucosamine-6-phosphate, N-trifluoroacetyl-D-glucosamine-6-phosphate, N-acetyl-D- glucosamine-6-sulfate, N-acetyl-D-galactosamine-6-phosphate, and N-formyl-D-glucosamine-6-phosphate Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;NA : NA : NA C2_04339 nagC ko:K02565,ko:K15545 Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon NA C2_04340 nagD ko:K02566 Catalyzes the dephosphorylation of an unusually broad range of substrate including deoxyribo- and ribonucleoside tri-, di-, and monophosphates, as well as polyphosphate and glucose-1-P (Glu1P) NA C2_04341 yrdA ko:K08279,ko:K08699 protein homotrimerization NA C2_04343 aroE ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko:K00014,ko:K05887 1.1.1.25,1.1.1.282 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_04344 tsaC ko:K07479,ko:K07566 2.7.7.87 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate NA C2_04345 yrdD ko:K07479 DNA topological change NA C2_04346 smg ko:K03747 Belongs to the Smg family NA C2_04347 dprA ko:K04096 Partially complements natural chromosomal DNA transformation defect of an H.influenzae dprA disruption mutant. May help load RecA onto ssDNA (By similarity) NA C2_04348 def ko:K01462 3.5.1.88 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions NA C2_04349 fmt ko00670,ko00970,map00670,map00970 ko:K00604,ko:K03500 2.1.1.176,2.1.2.9 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_04350 sun ko:K03500 2.1.1.176 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA NA C2_04351 trkA ko:K03499,ko:K05571 Part of the constitutive potassium transport systems TrkG and TrkH. May regulate the transport activity of TrkG and TrkH systems. Binds to NAD( ) and NADH NA C2_04352 mscL ko:K03282 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell NA C2_04353 arfA ko:K09890 Rescues ribosomes stalled at the 3' end of non-stop mRNAs. This activity is crucial when the stalled ribosome cannot be rescued by the SsrA(tmRNA)- SmpB quality control system. Binds the 30S subunit, contacting 16S rRNA with the N-terminus near the decoding center and its C-terminus in the mRNA entry channel NA C2_04354 zntR ko:K13638,ko:K19591 Transcriptional regulator NA C2_04356 rplQ ko03010,map03010 ko:K02879,ko:K16193 Ribosomal protein L17 Ribosome : Translation : Genetic Information Processing C2_04357 rpoA ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 ko:K03040 2.7.7.6 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;RNA polymerase : Transcription : Genetic Information Processing C2_04358 rpsD ko03010,map03010 ko:K02986 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit Ribosome : Translation : Genetic Information Processing C2_04359 rpsK ko03010,map03010 ko:K02948 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome Ribosome : Translation : Genetic Information Processing C2_04360 rpsM ko03010,map03010 ko:K02952 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Ribosome : Translation : Genetic Information Processing C2_04361 rpmJ ko03010,map03010 ko:K02919 Belongs to the bacterial ribosomal protein bL36 family Ribosome : Translation : Genetic Information Processing C2_04362 secY ko02024,ko03060,ko03070,map02024,map03060,map03070 ko:K03076 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing C2_04363 rplO ko03010,map03010 ko:K02876 binds to the 23S rRNA Ribosome : Translation : Genetic Information Processing C2_04364 rpmD ko03010,map03010 ko:K02907 structural constituent of ribosome Ribosome : Translation : Genetic Information Processing C2_04365 rpsE ko03010,map03010 ko:K02988 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body Ribosome : Translation : Genetic Information Processing C2_04366 rplR ko03010,map03010 ko:K02881 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance Ribosome : Translation : Genetic Information Processing C2_04367 rplF ko03010,map03010 ko:K02933 is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center Ribosome : Translation : Genetic Information Processing C2_04368 rpsH ko03010,map03010 ko:K02994 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit Ribosome : Translation : Genetic Information Processing C2_04369 rpsN ko03010,map03010 ko:K02954 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site Ribosome : Translation : Genetic Information Processing C2_04370 rplE ko03010,map03010 ko:K02931 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Ribosome : Translation : Genetic Information Processing C2_04371 rplX ko03010,map03010 ko:K02895 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit Ribosome : Translation : Genetic Information Processing C2_04372 rplN ko03010,map03010 ko:K02874 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome Ribosome : Translation : Genetic Information Processing C2_04373 rpsQ ko03010,map03010 ko:K02961 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA Ribosome : Translation : Genetic Information Processing C2_04374 rpmC ko03010,map03010 ko:K02904 ribosomal protein L29 Ribosome : Translation : Genetic Information Processing C2_04375 rplP ko03010,map03010 ko:K02878 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs Ribosome : Translation : Genetic Information Processing C2_04376 rpsC ko03010,map03010 ko:K02982 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation Ribosome : Translation : Genetic Information Processing C2_04377 rplV ko03010,map03010 ko:K02890 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome Ribosome : Translation : Genetic Information Processing C2_04378 rpsS ko03010,map03010 ko:K02965 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA Ribosome : Translation : Genetic Information Processing C2_04379 rplB ko03010,map03010 ko:K02886 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Ribosome : Translation : Genetic Information Processing C2_04380 rplW ko03010,map03010 ko:K02892 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome Ribosome : Translation : Genetic Information Processing C2_04381 rplD ko03010,map03010 ko:K02926,ko:K16193 Forms part of the polypeptide exit tunnel Ribosome : Translation : Genetic Information Processing C2_04382 rplC ko03010,map03010 ko:K02906 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit Ribosome : Translation : Genetic Information Processing C2_04383 rpsJ ko03010,map03010 ko:K02946 Involved in the binding of tRNA to the ribosomes Ribosome : Translation : Genetic Information Processing C2_04384 hopD ko03070,map03070 ko:K02464,ko:K02506,ko:K02654 3.4.23.43 Type IV leader peptidase family Bacterial secretion system : Membrane transport : Environmental Information Processing C2_04385 bfr ko00860,map00860 ko:K03594 1.16.3.1 Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism C2_04386 bfd ko:K02192 could be a general redox and or regulatory component participating in the iron storage mobilization functions of BFR. Could participate in the release or the delivery of iron from to bacterioferritin (or other iron complexes) NA C2_04388 kdgT ko:K02526 The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system NA C2_04389 sodA ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 ko:K04564 1.15.1.1 radicals which are normally produced within the cells and which are toxic to biological systems MAPK signaling pathway - fly : Signal transduction : Environmental Information Processing;FoxO signaling pathway : Signal transduction : Environmental Information Processing;Peroxisome : Transport and catabolism : Cellular Processes;Longevity regulating pathway : Aging : Organismal Systems;Longevity regulating pathway - worm : Aging : Organismal Systems;Longevity regulating pathway - multiple species : Aging : Organismal Systems;Huntington disease : Neurodegenerative disease : Human Diseases C2_04391 rhaR ko:K02854,ko:K02855 Activates expression of the rhaSR operon in response to L-rhamnose NA C2_04392 rhaS ko:K02855 Activates expression of the rhaBAD and rhaT operons NA C2_04393 rhaB ko00040,ko00051,ko01100,ko01120,ko02024,map00040,map00051,map01100,map01120,map02024 ko:K00848,ko:K00854,ko:K00879,ko:K01813,ko:K11216 2.7.1.17,2.7.1.189,2.7.1.5,2.7.1.51,5.3.1.14 Involved in the catabolism of L-rhamnose (6-deoxy-L- mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_04394 rhaA ko00040,ko00051,ko01120,map00040,map00051,map01120 ko:K00848,ko:K01813 2.7.1.5,5.3.1.14 L-rhamnose isomerase activity Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_04395 rhaD ko00040,ko00051,ko00053,ko01100,ko01120,map00040,map00051,map00053,map01100,map01120 ko:K01628,ko:K01629,ko:K03077,ko:K22130 4.1.1.104,4.1.2.17,4.1.2.19,5.1.3.4 Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_04396 rhaM ko:K03534 5.1.3.32 Involved in the anomeric conversion of L-rhamnose NA C2_04397 lamB ko:K02024 Porin-like glycoporin RafY NA C2_04398 frvA ko00051,ko00052,ko00053,ko01100,ko01120,ko02060,map00051,map00052,map00053,map01100,map01120,map02060 ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02798,ko:K02806,ko:K02821,ko:K08483,ko:K11189,ko:K11198,ko:K11199,ko:K11200,ko:K11201,ko:K18531 2.7.1.194,2.7.1.195,2.7.1.197,2.7.1.200,2.7.1.202,2.7.3.9 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrvAB PTS system is involved in fructose transport Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_04399 frvB ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 ko:K02768,ko:K02769,ko:K02770,ko:K11202,ko:K11203 2.7.1.202 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrvAB PTS system is involved in fructose transport Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_04400 frvX ko:K18530 aminopeptidase NA C2_04401 frvR ko00051,ko00052,ko00053,ko01100,ko01120,ko02060,map00051,map00052,map00053,map01100,map01120,map02060 ko:K02538,ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02798,ko:K02806,ko:K02821,ko:K03483,ko:K08483,ko:K09685,ko:K11189,ko:K11198,ko:K11199,ko:K11200,ko:K11201,ko:K18531 2.7.1.194,2.7.1.195,2.7.1.197,2.7.1.200,2.7.1.202,2.7.3.9 Frv operon regulatory protein Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing C2_04403 fdhD ko:K02379 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH NA C2_04404 fdoG ko00630,ko00680,ko01100,ko01120,ko01200,ko02020,map00630,map00680,map01100,map01120,map01200,map02020 ko:K00123,ko:K08348 1.17.1.9,1.17.5.3 Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The alpha subunit FdnG contains the formate oxidation site. Electrons are transferred from formate to menaquinone in the gamma subunit (FdnI), through the 4Fe-4S clusters in the beta subunit (FdnH). Formate dehydrogenase-N is part of a system that generates proton motive force, together with the dissimilatory nitrate reductase (Nar) Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_04405 fdoG ko00630,ko00680,ko01100,ko01120,ko01200,ko02020,map00630,map00680,map01100,map01120,map01200,map02020 ko:K00123,ko:K08348 1.17.1.9,1.17.5.3 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_04406 fdoH ko00630,ko00680,ko01100,ko01120,ko01200,ko02020,map00630,map00680,map01100,map01120,map01200,map02020 ko:K00124,ko:K08349 formate dehydrogenase Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_04407 fdoI ko00630,ko00680,ko01100,ko01120,ko01200,ko02020,map00630,map00680,map01100,map01120,map01200,map02020 ko:K00127,ko:K08350 Allows to use formate as major electron donor during aerobic respiration. Subunit gamma is probably the cytochrome b556(FDO) component of the formate dehydrogenase Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing C2_04408 fdhE ko:K02380 Necessary for formate dehydrogenase activity NA C2_04410 yncG ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 ko:K00799,ko:K11208,ko:K11209 2.5.1.18 disulfide oxidoreductase activity Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolism of xenobiotics by cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Platinum drug resistance : Drug resistance: antineoplastic : Human Diseases;Pathways in cancer : Cancer: overview : Human Diseases;Chemical carcinogenesis : Cancer: overview : Human Diseases;Hepatocellular carcinoma : Cancer: specific types : Human Diseases;Fluid shear stress and atherosclerosis : Cardiovascular disease : Human Diseases C2_04411 ansP ko:K03293,ko:K11738 amino acid transport NA C2_04413 yncD ko:K02014 siderophore transport NA C2_04414 mcbR ko:K13654 Important for biofilm formation. Represses expression of McbA by binding to its promoter region, which prevents colanic acid overproduction and mucoidy NA C2_04415 yncB ko:K07119 Catalyzes the metal-independent reduction of curcumin to dihydrocurcumin (DHC) as an intermediate product, followed by further reduction to tetrahydrocurcumin (THC) as an end product. It also acts on 3-octene-2-one, 3-hepten-2-one, resveratrol, and trans-2-octenal NA C2_04416 yncA ko00440,ko01130,map00440,map01130 ko:K03823 2.3.1.183 Acyltransferase that appears to be required for E.coli optimal growth rate and yield via the formation of N-acetylated amino acids. Catalyzes the acylation of L-methionine using acetyl- CoA or propanoyl-CoA as acyl donors, and the acetylation of L- phenylglycine. Is also able to N-acylate other free L-amino acids and their derivatives using a CoA thioester as cosubstrate. Using acetyl-CoA as an acyl donor, substrate specificity is methionine sulfone methionine sulfoximine methionine sulfoxide methionine. Asparagine, lysine, glutamine, aspartate and glutamate are very poor substrates. Using methionine as a substrate, acyl donor preference is propanoyl-CoA acetyl- CoA butyryl-CoA (Ref.4). Likely plays a role in the resistance against the toxic effects of L-methionine sulfoximine (MSX), via its ability to catalyze its acetylation Phosphonate and phosphinate metabolism : Metabolism of other amino acids : Metabolism;NA : NA : NA C2_04417 ydcZ ko02024,map02024 ko:K09936 Putative inner membrane exporter, YdcZ Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_04420 vat ko:K03802,ko:K18234 6.3.2.29,6.3.2.30 COG0110 Acetyltransferase (isoleucine patch superfamily) NA C2_04421 vat ko:K03802,ko:K18234 6.3.2.29,6.3.2.30 COG0110 Acetyltransferase (isoleucine patch superfamily) NA C2_04422 prr ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 ko:K00128,ko:K00137 1.2.1.19,1.2.1.3 Catalyzes the oxidation of 1-pyrroline, which is spontaneously formed from 4-aminobutanal, leading to 4- aminobutanoate (GABA) Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Fatty acid degradation : Lipid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Lysine degradation : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;Histidine metabolism : Amino acid metabolism : Metabolism;Tryptophan metabolism : Amino acid metabolism : Metabolism;beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Chloroalkane and chloroalkene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Limonene and pinene degradation : Metabolism of terpenoids and polyketides : Metabolism;Insect hormone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA C2_04423 ydcV ko02010,ko02024,map02010,map02024 ko:K02053,ko:K11070 ABC transporter permease protein ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_04424 ydcU ko02010,ko02024,map02010,map02024 ko:K02054,ko:K11071 ABC transporter permease ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_04425 ydcT ko02010,ko02024,map02010,map02024 ko:K02052,ko:K11072 3.6.3.31 Belongs to the ABC transporter superfamily ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_04426 ydcS ko02024,map02024 ko:K02055 ABC transporter Quorum sensing : Cellular community - prokaryotes : Cellular Processes C2_04427 ydcR ko02025,map02025 ko:K21023 2.7.7.65 Transcriptional regulator Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes C2_04428 hicB ko:K18843 Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin NA C2_04429 hicA ko:K07339 this blockage is overcome (after 90 minutes) by subsequent expression of antitoxin HicB. Overexpression causes cleavage of a number of mRNAs and tmRNA, in a translation-independent fashion, suggesting this is an mRNA interferase. mRNA interferases play a role in bacterial persistence to antibiotics NA C2_04431 ydcP ko05120,map05120 ko:K08303 peptidase activity Epithelial cell signaling in Helicobacter pylori infection : Infectious disease: bacterial : Human Diseases C2_04433 ydcO ko:K05782 benzoate transport NA C2_04434 rpmE ko03010,map03010 ko:K02909 Binds the 23S rRNA Ribosome : Translation : Genetic Information Processing C2_04435 priA ko03440,map03440 ko:K04066 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA Homologous recombination : Replication and repair : Genetic Information Processing C2_04436 cytR ko:K05499 transcriptional NA C2_04437 ftsN ko:K03591 Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases NA C2_04438 hslV ko:K01419 3.4.25.2 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery NA C2_04439 hslU ko:K03667 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis NA C2_04440 menA ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K02548 2.5.1.74 Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK) Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_04441 rraA ko:K02553 Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome NA C2_04442 zapB ko02020,ko02030,map02020,map02030 ko:K09892,ko:K13924 2.1.1.80,3.1.1.61 Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes C2_04443 glpF ko:K02440,ko:K06188 Transporter of glycerol across the cytoplasmic membrane, with limited permeability to water and small uncharged compounds such as polyols NA C2_04444 glpK ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 ko:K00864 2.7.1.30 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate Glycerolipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;PPAR signaling pathway : Endocrine system : Organismal Systems;Plant-pathogen interaction : Environmental adaptation : Organismal Systems C2_04445 glpX ko00010,ko00030,ko00051,ko00680,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 ko:K00615,ko:K02446,ko:K11532 2.2.1.1,3.1.3.11,3.1.3.37 Fructose-1,6-bisphosphatase Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Biosynthesis of ansamycins : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_04446 fpr ko00362,ko00364,ko00622,ko01100,ko01120,ko01220,map00362,map00364,map00622,map01100,map01120,map01220 ko:K00528,ko:K05784 1.18.1.2,1.19.1.1 COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Benzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Fluorobenzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Xylene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_04447 uspD ko:K06149,ko:K14065 Required for resistance to DNA-damaging agents NA C2_04451 tpiA ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 ko:K01803 5.3.1.1 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Inositol phosphate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_04452 cdh ko00564,ko01110,map00564,map01110 ko:K01521 3.6.1.26 CDP-diacylglycerol catabolic process Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_04453 sbp ko00920,ko02010,map00920,map02010 ko:K02048 sulfate ABC transporter Sulfur metabolism : Energy metabolism : Metabolism;ABC transporters : Membrane transport : Environmental Information Processing C2_04454 pfkA ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 ko:K00850 2.7.1.11 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;RNA degradation : Folding, sorting and degradation : Genetic Information Processing;AMPK signaling pathway : Signal transduction : Environmental Information Processing;Central carbon metabolism in cancer : Cancer: overview : Human Diseases C2_04455 fieF ko:K13283 Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2 ) in a proton- dependent manner NA C2_04456 cpxP ko:K06006 overexpression decreases Cpx pathway activity. Some periplasmic stimulii (shown for P pili subunit PapE and probably 0.3 M NaCl) increase CpxP's susceptibility to DegP, leading to CpxP degradation, inducing the Cpx pathway. Aids in combating extracytoplasmic protein- mediated toxicity. Overexpression leads to degradation by DegP of misfolded P pili subunits in the periplasm (tested using PapE). Inhibits autophosphorylation of CpxA in reconstituted liposomes by 50 but has no effect on phosphatase activity of CpxA. Has mild protein chaperone activity NA C2_04460 Z012_08285 ko:K07486 Transposase NA C2_04464 ko:K07733 transcriptional regulator NA C2_04467 ko:K06946 GTP-binding protein NA C2_04468 flu ko02026,map02026 ko:K12687 Adhesin of bacterial autotransporter system, probable stalk Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_04469 yeeR ko00100,ko00920,ko01100,ko01130,map00100,map00920,map01100,map01130 ko:K00223,ko:K21310 1.3.1.71,2.1.1.334 methyltransferase activity Steroid biosynthesis : Lipid metabolism : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;NA : NA : NA C2_04473 ybbP ko:K02004 FtsX-like permease family NA C2_04474 ybbA ko:K02003 ATP-binding protein YbbA NA C2_04475 tesA ko01040,map01040 ko:K10804 3.1.1.5 TesA is a multifunctional esterase that can act as a thioesterase, lysophospholipase and protease. TesA functions as a thioesterase specific for fatty acyl thioesters of greater than ten carbons, with highest activity on palmitoyl-CoA, cis-vaccenyl-CoA and palmitoleoyl-CoA. TesA also possesses an arylesterase activity towards short acyl-chain aromatic esters such as alpha-naphthyl acetate, alpha-naphthyl butyrate, benzyl acetate and phenyl acetate. Also able to hydrolyze short acyl-chain triacylglycerols such as triacetin and tributyrin, and p- nitrophenyl esters such as p-nitrophenyl hexanoate and p- nitrophenyl butyrate. The protease activity is mainly active on small peptides. TesA is also able to hydrolyze p-nitrophenyl esters of N- substituted amino acids such as N-benzyloxycarbonyl-L-Phe-p- nitrophenyl ester (Z-L-Phe-ONp) and N-benzyloxycarbonyl-L-Tyr-p- nitrophenyl ester (Z-L-Tyr-ONp), however it is unable to hydrolyze N-acetyl-L-Phe ethyl ester and its Tyr analog. TesA also hydrolyzes N- benzyloxycarbonyl-L-Phe beta-nitrophenyl ester (Cbz-Phe-ONap) and N-acetyl-DL-Phe-2-naphthyl ester (chymotrypsin-like specificity). Shows a slow proteolytic activity against denatured casein. The lysophospholipase activity of TesA is able to hydrolyze 1- palmitoyl-sn-glycero-3-phosphocholine, 1-acyl-sn-glycero-3- phosphoglycerol, 1- and 2-acyl-sn-glycero-3-phosphoethanolamine Biosynthesis of unsaturated fatty acids : Lipid metabolism : Metabolism C2_04477 ybbN ko:K05838 protein disulfide oxidoreductase activity NA C2_04478 ybbM ko:K02069 Part of the ABC transporter complex FetAB, which is probably involved in iron export and enhances resistance to H(2)O(2)-mediated oxidative stress. Probably responsible for the translocation of the substrate across the membrane NA C2_04479 ybbL ko02010,map02010 ko:K02065,ko:K02068 Part of the ABC transporter complex FetAB, which is probably involved in iron export and enhances resistance to H(2)O(2)-mediated oxidative stress. Probably responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_04481 ybbJ ko:K07340 NfeD-like C-terminal, partner-binding NA C2_04482 cueR ko:K19591 Transcriptional regulator NA C2_04483 ybaT ko:K16263 transport protein NA C2_04484 glsA ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230 ko:K01425 3.5.1.2 Belongs to the glutaminase family Arginine biosynthesis : Amino acid metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;D-Glutamine and D-glutamate metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Glutamatergic synapse : Nervous system : Organismal Systems;GABAergic synapse : Nervous system : Organismal Systems;Proximal tubule bicarbonate reclamation : Excretory system : Organismal Systems;MicroRNAs in cancer : Cancer: overview : Human Diseases;Central carbon metabolism in cancer : Cancer: overview : Human Diseases C2_04485 copA ko01524,ko04016,map01524,map04016 ko:K17686 3.6.3.54 Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily Platinum drug resistance : Drug resistance: antineoplastic : Human Diseases;MAPK signaling pathway - plant : Signal transduction : Environmental Information Processing C2_04488 ko:K07493 silverDB NA C2_04489 ko:K07484 zinc-finger binding domain of transposase IS66 NA C2_04490 ko:K07484 zinc-finger binding domain of transposase IS66 NA C2_04491 ko:K07484 zinc-finger binding domain of transposase IS66 NA C2_04493 yddV ko:K13069 2.7.7.65 Protoglobin NA C2_04494 ko:K05799,ko:K13637 FCD domain NA C2_04495 insG ko:K07495 COG3385 FOG Transposase and inactivated derivatives NA C2_04496 ko:K07483 Transposase IS3 IS911 family protein NA C2_04497 ko:K07497 DDE domain NA C2_04498 ko:K07483,ko:K07497 Integrase core domain NA C2_04499 ko:K07279,ko:K12678 Autotransporter beta-domain NA C2_04500 ko:K07093 Phosphatase NA C2_04502 ko:K07483 Putative ATPase subunit of terminase (gpP-like) NA C2_04505 ko02026,map02026 ko:K12687 Adhesin of bacterial autotransporter system, probable stalk Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes C2_04506 ko:K06946 50S ribosome-binding GTPase NA C2_04510 ko:K07733 Prophage CP4-57 regulatory protein (AlpA) NA C2_04514 ko04112,map04112 ko:K01338 3.4.21.53 ATP-dependent Lon-type protease Cell cycle - Caulobacter : Cell growth and death : Cellular Processes C2_04515 ko:K07497 Transposase and inactivated derivatives NA C2_04517 appY ko02020,map02020 ko:K03755,ko:K07780,ko:K11920,ko:K21905,ko:K21906 Helix-turn-helix domain Two-component system : Signal transduction : Environmental Information Processing C2_04518 ompT ko:K01355,ko:K08566,ko:K13520 3.4.23.48,3.4.23.49 Protease that can cleave T7 RNA polymerase, ferric enterobactin receptor protein (FEP), antimicrobial peptide protamine and other proteins. This protease has a specificity for paired basic residues NA C2_04519 envY ko:K03755,ko:K11920,ko:K21905,ko:K21906 Porin thermoregulatory protein EnvY NA C2_04521 nfrA ko:K11739 Bacteriophage N4 adsorption protein A NA C2_04522 nfrB ko00561,ko01100,ko04320,map00561,map01100,map04320 ko:K02359,ko:K11740,ko:K19003 2.4.1.336 Bacteriophage N4 adsorption protein B Glycerolipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Dorso-ventral axis formation : Development and regeneration : Organismal Systems C2_04524 ydeO ko:K03755,ko:K11920,ko:K21905,ko:K21906 Induces the expression of gadE and mdtEF. Could also regulate the expression of other genes involved in acid resistance NA C2_04525 ydeN ko:K01138 sulfuric ester hydrolase activity NA C2_04526 ydeM ko:K06871 protein maturation NA C2_04527 yddA ko02010,map02010 ko:K02471 ATPase activity, coupled to movement of substances ABC transporters : Membrane transport : Environmental Information Processing C2_04529 pqqL ko:K07263 Belongs to the peptidase M16 family NA C2_04533 insA ko:K07480,ko:K07489 InsA C-terminal domain NA C2_04535 metJ ko:K03764 This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis NA C2_04536 metB ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 ko:K01739,ko:K01760 2.5.1.48,4.4.1.8 Catalyzes the formation of L-cystathionine from O- succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma- replacement reaction. In the absence of thiol, catalyzes gamma- elimination to form 2-oxobutanoate, succinate and ammonia Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_04537 metL ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 ko:K00003,ko:K00928,ko:K12524,ko:K12525 1.1.1.3,2.7.2.4 Homoserine dehydrogenase II Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Lysine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism C2_04538 metF ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 ko:K00297 1.5.1.20 Methylenetetrahydrofolate reductase One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;Antifolate resistance : Drug resistance: antineoplastic : Human Diseases C2_04539 katG ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 ko:K03782 1.11.1.21 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity Phenylalanine metabolism : Amino acid metabolism : Metabolism;Tryptophan metabolism : Amino acid metabolism : Metabolism;Phenylpropanoid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_04541 yijF ko:K09974 Domain of unknown function (DUF1287) NA C2_04542 kgtP ko:K02625,ko:K03761,ko:K03762,ko:K08173 transporter NA C2_04543 yfiM ko:K05811 Predicted periplasmic lipoprotein (DUF2279) NA C2_04544 pssA ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 ko:K00998,ko:K06131,ko:K06132 2.7.8.8 CDP-diacylglycerol-serine O-phosphatidyltransferase activity Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism C2_04545 yfiQ ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 ko:K01905,ko:K09181,ko:K22224 6.2.1.13 Acetylates RNase R in exponential phase cells. Also required for the glucose-dependent acetylation on multiple lysines of alpha, beta and beta' RNAP subunits. May acetylate Acs and inhibit its activity Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_04546 yfiP ko:K05812 DTW NA C2_04547 trxC ko:K03672 1.8.1.8 Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin NA C2_04548 yfiF ko:K00556,ko:K03214,ko:K03218 2.1.1.185,2.1.1.34 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family NA C2_04549 ung ko03410,ko05340,map03410,map05340 ko:K03648 3.2.2.27 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine Base excision repair : Replication and repair : Genetic Information Processing;Primary immunodeficiency : Immune disease : Human Diseases C2_04550 grcA ko00623,ko00625,ko01100,ko01120,ko01220,map00623,map00625,map01100,map01120,map01220 ko:K06866,ko:K15763,ko:K22361 1.14.13.236 Acts as a radical domain for damaged PFL and possibly other radical proteins Toluene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Chloroalkane and chloroalkene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism C2_04551 eamB ko:K11249 Cysteine O-acetylserine efflux protein NA C2_04558 vgrG ko03070,map03070 ko:K11904 TIGRFAM type VI secretion system Vgr family protein Bacterial secretion system : Membrane transport : Environmental Information Processing C2_04559 gmhB ko00300,ko00340,ko00540,ko00550,ko01100,ko01110,ko01230,ko01502,map00300,map00340,map00540,map00550,map01100,map01110,map01230,map01502 ko:K01089,ko:K01929,ko:K03273 3.1.3.15,3.1.3.82,3.1.3.83,4.2.1.19,6.3.2.10 by removing the phosphate group at the C-7 position Lysine biosynthesis : Amino acid metabolism : Metabolism;Histidine metabolism : Amino acid metabolism : Metabolism;Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases C2_04560 metN ko02010,map02010 ko:K02071 Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing C2_04561 metI ko02010,map02010 ko:K02072 Part of the binding-protein-dependent transport system for D-methionine and the toxic methionine analog alpha-methyl- methionine. Probably responsible for the translocation of the substrate across the membrane ABC transporters : Membrane transport : Environmental Information Processing C2_04562 metQ ko02010,map02010 ko:K02072,ko:K02073 Belongs to the NlpA lipoprotein family ABC transporters : Membrane transport : Environmental Information Processing C2_04563 rcsF ko02020,map02020 ko:K06080 Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the histidine kinase RcsC. May detect outer membrane defects Two-component system : Signal transduction : Environmental Information Processing C2_04565 proS ko00970,map00970 ko:K01881 6.1.1.15 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing C2_04567 hemB ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 ko:K01698 4.2.1.24 Belongs to the ALAD family Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism C2_04568 tauD ko00430,ko00920,map00430,map00920 ko:K03119 1.14.11.17 Catalyzes the conversion of taurine and alpha ketoglutarate to sulfite, aminoacetaldehyde and succinate. Required for the utilization of taurine (2-aminoethanesulfonic acid) as an alternative sulfur source. Pentane-sulfonic acid, 3- (N-morpholino)propanesulfonic acid and 1,3-dioxo-2- isoindolineethanesulfonic acid are also substrates for this enzyme Taurine and hypotaurine metabolism : Metabolism of other amino acids : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism C2_04569 tauC ko00920,ko02010,map00920,map02010 ko:K15552 ABC-type nitrate sulfonate bicarbonate transport system permease component Sulfur metabolism : Energy metabolism : Metabolism;ABC transporters : Membrane transport : Environmental Information Processing C2_04570 tauB ko00920,ko02010,map00920,map02010 ko:K02049,ko:K10831 3.6.3.36 Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system Sulfur metabolism : Energy metabolism : Metabolism;ABC transporters : Membrane transport : Environmental Information Processing C2_04571 tauA ko00920,ko02010,map00920,map02010 ko:K15551 Sulfate starvation-induced protein 1 Sulfur metabolism : Energy metabolism : Metabolism;ABC transporters : Membrane transport : Environmental Information Processing C2_04576 coaA ko00770,ko01100,map00770,map01100 ko:K00867 2.7.1.33 Pantothenic acid kinase Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_04577 birA ko00770,ko00780,ko01100,map00770,map00780,map01100 ko:K01947,ko:K03524,ko:K04096 2.7.1.33,6.3.4.15 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_04578 murB ko00520,ko00550,ko01100,map00520,map00550,map01100 ko:K00075 1.3.1.98 cell wall formation Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism C2_04605 vgrG ko03070,map03070 ko:K11904 TIGRFAM type VI secretion system Vgr family protein Bacterial secretion system : Membrane transport : Environmental Information Processing C2_04606 ko:K07483,ko:K07497 DNA integration NA C2_04607 insC ko:K07483 transposase activity NA C2_04609 ko:K07483 transposase activity NA C2_04613 insI1 ko:K07482 Transposase insI for insertion sequence element NA C2_04623 ko:K07491 Transposase NA